SI1539157T1 - Rapamicin za uporabo pri inhibiciji ali preprečevanju horoidalne neovaskularizacije - Google Patents
Rapamicin za uporabo pri inhibiciji ali preprečevanju horoidalne neovaskularizacijeInfo
- Publication number
- SI1539157T1 SI1539157T1 SI200332304T SI200332304T SI1539157T1 SI 1539157 T1 SI1539157 T1 SI 1539157T1 SI 200332304 T SI200332304 T SI 200332304T SI 200332304 T SI200332304 T SI 200332304T SI 1539157 T1 SI1539157 T1 SI 1539157T1
- Authority
- SI
- Slovenia
- Prior art keywords
- rapamycin
- inhibiting
- choroidal neovascularization
- preventing choroidal
- preventing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41208802P | 2002-09-18 | 2002-09-18 | |
EP03754653.8A EP1539157B1 (en) | 2002-09-18 | 2003-09-18 | Rapamycin for use in inhibiting or preventing choroidal neovascularization |
PCT/US2003/029188 WO2004027027A2 (en) | 2002-09-18 | 2003-09-18 | Method of inhibiting choroidal neovascularization |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1539157T1 true SI1539157T1 (sl) | 2013-11-29 |
Family
ID=32030800
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200332304T SI1539157T1 (sl) | 2002-09-18 | 2003-09-18 | Rapamicin za uporabo pri inhibiciji ali preprečevanju horoidalne neovaskularizacije |
Country Status (10)
Country | Link |
---|---|
US (3) | US8163726B2 (sl) |
EP (2) | EP2514420B1 (sl) |
JP (2) | JP2006511475A (sl) |
AU (2) | AU2003272471B2 (sl) |
CA (1) | CA2498191C (sl) |
DK (1) | DK1539157T3 (sl) |
ES (2) | ES2494791T3 (sl) |
PT (1) | PT1539157E (sl) |
SI (1) | SI1539157T1 (sl) |
WO (1) | WO2004027027A2 (sl) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8568766B2 (en) * | 2000-08-24 | 2013-10-29 | Gattadahalli M. Anantharamaiah | Peptides and peptide mimetics to treat pathologies associated with eye disease |
PT1548032E (pt) | 2002-09-12 | 2009-08-13 | Oncotherapy Science Inc | Péptidos kdr e vacinas que os contêm |
SI1539157T1 (sl) | 2002-09-18 | 2013-11-29 | Trustees Of The University Of Pennsylvania | Rapamicin za uporabo pri inhibiciji ali preprečevanju horoidalne neovaskularizacije |
US20040091455A1 (en) * | 2002-10-31 | 2004-05-13 | Zeldis Jerome B. | Methods of using and compositions comprising immunomodulatory compounds for treatment and management of macular degeneration |
EP1562597A4 (en) * | 2002-10-31 | 2008-05-14 | Celgene Corp | COMPOSITIONS COMPRISING IMMUNOMODULATORY COMPOUNDS FOR THE TREATMENT AND MANAGEMENT OF MACULAR DEGENERATION AND METHODS OF USE THEREOF |
US7354574B2 (en) | 2002-11-07 | 2008-04-08 | Advanced Ocular Systems Limited | Treatment of ocular disease |
US7083802B2 (en) * | 2003-07-31 | 2006-08-01 | Advanced Ocular Systems Limited | Treatment of ocular disease |
US7585517B2 (en) * | 2003-09-18 | 2009-09-08 | Macusight, Inc. | Transscleral delivery |
US7083803B2 (en) | 2003-09-19 | 2006-08-01 | Advanced Ocular Systems Limited | Ocular solutions |
US7087237B2 (en) | 2003-09-19 | 2006-08-08 | Advanced Ocular Systems Limited | Ocular solutions |
AR045957A1 (es) * | 2003-10-03 | 2005-11-16 | Novartis Ag | Composicion farmaceutica y combinacion |
US20050261243A1 (en) * | 2004-04-21 | 2005-11-24 | Peyman Gholam A | Antiprostaglandins for the treatment of ocular pathologies |
WO2005110374A1 (en) * | 2004-04-30 | 2005-11-24 | Allergan, Inc. | Intraocular drug delivery systems containing a therapeutic component, a cyclodextrin, and a polymeric component |
US8313763B2 (en) * | 2004-10-04 | 2012-11-20 | Tolmar Therapeutics, Inc. | Sustained delivery formulations of rapamycin compounds |
EP1804751A2 (en) * | 2004-10-04 | 2007-07-11 | QLT USA, Inc. | Ocular delivery of polymeric delivery formulations |
US8663639B2 (en) | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
GB2438544A (en) * | 2005-02-09 | 2007-11-28 | Cooper Internat Corp | Liquid formulations for treatment of diseases or conditions |
CN101137369A (zh) * | 2005-02-09 | 2008-03-05 | 马库赛特公司 | 用于眼治疗的制剂 |
AU2012200274B2 (en) * | 2005-02-09 | 2013-12-05 | Santen Pharmaceutical Co., Ltd. | Liquid formulations for treatment of diseases or conditions |
BRPI0609432A2 (pt) * | 2005-03-21 | 2010-04-06 | Macusight Inc | sistemas de distribuição de fármacos para tratamento de doenças ou condições |
JP2008539276A (ja) * | 2005-04-27 | 2008-11-13 | ユニバーシティ オブ フロリダ リサーチ ファウンデーション,インコーポレイティド | ヒト疾患に関連する変異体タンパク質の分解能を改善するための材料及び方法 |
WO2006119211A2 (en) * | 2005-05-02 | 2006-11-09 | Genaera Corporation | Methods and compositions for treating ocular disorders |
AU2006270041B2 (en) | 2005-07-18 | 2011-08-18 | Minu, Llc | Enhanced ocular neuroprotection/neurostimulation |
KR20140093764A (ko) | 2006-02-09 | 2014-07-28 | 산텐 세이야꾸 가부시키가이샤 | 안정한 제제와 그 제조 및 사용 방법 |
WO2007112052A2 (en) | 2006-03-23 | 2007-10-04 | Macusight, Inc. | Formulations and methods for vascular permeability-related diseases or conditions |
RU2010104916A (ru) * | 2006-08-16 | 2011-08-20 | Михаил В. Благосклонный (US) | Способ профилактики и лечения возрастных заболеваний |
JP5470558B2 (ja) * | 2007-02-16 | 2014-04-16 | オンコセラピー・サイエンス株式会社 | 脈絡膜新生血管のワクチン療法 |
KR20100055482A (ko) * | 2007-08-16 | 2010-05-26 | 마커사이트, 인코포레이티드 | 안질환 또는 안이상의 치료를 위한 제제 |
AU2008296478B9 (en) | 2007-08-28 | 2015-03-19 | The Uab Research Foundation | Synthetic apolipoprotein E mimicking polypeptides and methods of use |
CN102427728A (zh) | 2009-03-13 | 2012-04-25 | 阿布拉科斯生物科学有限公司 | 用硫代秋水仙碱衍生物进行联合治疗 |
EP2965763B8 (en) * | 2009-04-10 | 2018-08-15 | Haiyan Qi | Anti-aging agents |
TW201109029A (en) | 2009-06-11 | 2011-03-16 | Oncotherapy Science Inc | Vaccine therapy for choroidal neovascularization |
US20110189174A1 (en) * | 2010-02-01 | 2011-08-04 | Afshin Shafiee | Compositions and methods for treating, reducing, ameliorating, alleviating, or inhibiting progression of, pathogenic ocular neovascularization |
WO2011161295A2 (es) | 2010-06-23 | 2011-12-29 | Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii | Uso de compuestos anticalcineurina para el tratamiento de patologías que cursan con neovascularización ocular |
US8912215B2 (en) | 2011-12-13 | 2014-12-16 | Everon Biosciences, Inc. | Rapamycin composition |
AU2013217110B2 (en) | 2012-02-06 | 2016-05-12 | William L. Pridgen | Antiviral compound and COX-2 inhibitor combination therapy for functional somatic syndromes, including combination of famciclovir and celecoxib |
US20160022648A1 (en) | 2013-03-13 | 2016-01-28 | Santen Pharmaceutical Co., Ltd. | Therapeutic agent for meibomian gland dysfunction |
EP3013790A1 (en) | 2013-06-27 | 2016-05-04 | Mylan Laboratories Ltd. | Process for the preparation of nepafenac |
KR101674457B1 (ko) * | 2013-11-04 | 2016-11-09 | 아주대학교산학협력단 | 다사티닙 또는 이의 약학적으로 허용되는 염을 유효성분으로 포함하는 혈관 투과성 관련 질환의 예방 또는 치료용 약학적 조성물 |
US10010447B2 (en) | 2013-12-18 | 2018-07-03 | Novartis Ag | Systems and methods for subretinal delivery of therapeutic agents |
WO2015103480A1 (en) * | 2014-01-02 | 2015-07-09 | Massachusetts Eye & Ear Infirmary | Treating ocular neovascularization |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
US10653747B2 (en) | 2014-07-31 | 2020-05-19 | Uab Research Foundation | ApoE mimetic peptides and higher potency to clear plasma cholesterol |
SG11201805420SA (en) | 2015-12-30 | 2018-07-30 | Kodiak Sciences Inc | Antibodies and conjugates thereof |
RU2765728C2 (ru) | 2016-05-25 | 2022-02-02 | Сантен Фармасьютикал Ко., Лтд. | Применение сиролимуса для лечения экссудативной возрастной макулярной дегенерации с персистирующим отеком |
US10682340B2 (en) | 2016-06-30 | 2020-06-16 | Durect Corporation | Depot formulations |
TWI765898B (zh) | 2016-06-30 | 2022-06-01 | 美商杜瑞克公司 | 儲積調製劑 |
KR101906494B1 (ko) * | 2017-06-08 | 2018-12-05 | 인제대학교 산학협력단 | 콜라겐 타입 ι 및 색소 상피성 인자 펩타이드를 유효성분으로 함유하는 신생혈관질환 예방 또는 치료용 약학조성물 |
CN110944668A (zh) | 2017-06-16 | 2020-03-31 | 学校法人同志社 | 用于治疗或预防眼部症状、障碍或疾病的包含mTOR抑制剂的药物及其应用 |
WO2020080275A1 (ja) * | 2018-10-15 | 2020-04-23 | 国立大学法人大阪大学 | 網膜および/または光受容に関連する症状の改善または予防用医薬ならびに網膜および/または光受容に関連する症状を改善または予防する物質のスクリーニング方法 |
EP4041312A4 (en) | 2019-10-10 | 2023-12-20 | Kodiak Sciences Inc. | METHOD FOR TREATING AN EYE DISORDER |
CA3219432A1 (en) * | 2021-05-26 | 2022-12-01 | Unity Biotechnology, Inc. | Methods of treating retinal vasculopathies |
Family Cites Families (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU543727B2 (en) | 1980-06-02 | 1985-05-02 | Ayerst Mckenna & Harrison Inc. | Injectable composition of rapamycin |
IT1141715B (it) | 1980-06-06 | 1986-10-08 | Sadepan Chimica Spa | Collante a base di resina urea-formaldeide additivato con ligninsolfonato di calcio e/o ammonio,resina urea formaldeide modificata con ligninsolfonato di calcio e/o ammonio e metodo di produzione degli stessi,per la preparazione di pannelli agglomerati di legno |
EP0356399A3 (en) * | 1988-08-26 | 1991-03-20 | Sandoz Ag | Substituted 4-azatricyclo (22.3.1.04.9) octacos-18-ene derivatives, their preparation and pharmaceutical compositions containing them |
US5100899A (en) * | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
US5883082A (en) * | 1990-08-14 | 1999-03-16 | Isis Pharmaceuticals, Inc. | Compositions and methods for preventing and treating allograft rejection |
US5192773A (en) * | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
IE65341B1 (en) * | 1990-11-08 | 1995-10-18 | Fujisawa Pharmaceutical Co | Suspensions containing tricyclic compounds |
US5378475A (en) * | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
US5078999A (en) * | 1991-02-22 | 1992-01-07 | American Home Products Corporation | Method of treating systemic lupus erythematosus |
WO1992019278A1 (en) * | 1991-04-26 | 1992-11-12 | Kurume University | Use of macrolide compounds for eye diseases |
US5565560A (en) * | 1991-05-13 | 1996-10-15 | Merck & Co., Inc. | O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity |
ZA924953B (en) * | 1991-07-25 | 1993-04-28 | Univ Louisville Res Found | Method of treating ocular inflammation |
US5189042A (en) * | 1991-08-22 | 1993-02-23 | Merck & Co. Inc. | Fluoromacrolides having immunosuppressive activity |
US5457111A (en) * | 1991-09-05 | 1995-10-10 | Abbott Laboratories | Macrocyclic immunomodulators |
AU681579B2 (en) * | 1992-03-30 | 1997-09-04 | Wyeth | Rapamycin formulation for IV injection |
GB9221220D0 (en) * | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
US5258389A (en) * | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
DK0669127T3 (da) * | 1992-11-18 | 1999-12-06 | Fujisawa Pharmaceutical Co | Farmaceutisk præparat med forlænget virkning |
CA2156065A1 (en) | 1993-03-17 | 1994-09-29 | Rolf Wagner | Macrocyclic amide and urea immunomodulators |
ATE502625T1 (de) * | 1993-07-19 | 2011-04-15 | Angiotech Pharm Inc | Anti-angiogene mittel und verfahren zu deren verwendung |
IL111004A (en) * | 1993-09-30 | 1998-06-15 | American Home Prod | Oral formulations of rapamycin |
US5516770A (en) * | 1993-09-30 | 1996-05-14 | American Home Products Corporation | Rapamycin formulation for IV injection |
IL111003A0 (en) * | 1993-09-30 | 1994-11-28 | American Home Prod | Multi-component oral rapamycin formulation |
US5616588A (en) * | 1993-09-30 | 1997-04-01 | American Home Products Corporation | Rapamycin formulation for IV injection |
US5527907A (en) | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
EP0729471A1 (en) * | 1993-11-19 | 1996-09-04 | Abbott Laboratories | Semisynthetic analogs of rapamycin (macrolides) being immunomodulators |
US5621108A (en) * | 1994-12-05 | 1997-04-15 | Trustees Of The University Of Pennsylvania | Processes and intermediates for preparing macrocycles |
WO1996041865A1 (en) | 1995-06-07 | 1996-12-27 | Ariad Gene Therapeutics, Inc. | Rapamcycin-based regulation of biological events |
ATE254450T1 (de) | 1995-09-19 | 2003-12-15 | Fujisawa Pharmaceutical Co | Aerosolzusammensetzungen |
US5773019A (en) * | 1995-09-27 | 1998-06-30 | The University Of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
EP0877554A1 (en) | 1995-10-31 | 1998-11-18 | Merck & Co., Inc. | Triterpene derivatives with immunosuppressant activity |
EP1208847B8 (en) * | 1996-07-30 | 2007-02-14 | Novartis AG | Pharmaceutical compositions for the treatment of transplant rejection, as well as autoimmune or inflammatory conditions |
US5800807A (en) * | 1997-01-29 | 1998-09-01 | Bausch & Lomb Incorporated | Ophthalmic compositions including glycerin and propylene glycol |
TW450810B (en) * | 1997-02-20 | 2001-08-21 | Fujisawa Pharmaceutical Co | Macrolides antibiotic pharmaceutical composition for preventing and treating skin diseases |
US6015815A (en) * | 1997-09-26 | 2000-01-18 | Abbott Laboratories | Tetrazole-containing rapamycin analogs with shortened half-lives |
US6890546B2 (en) * | 1998-09-24 | 2005-05-10 | Abbott Laboratories | Medical devices containing rapamycin analogs |
US20030190286A1 (en) | 1997-10-01 | 2003-10-09 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating allergies or asthma |
KR20060066753A (ko) | 1997-10-22 | 2006-06-16 | 젠스 포니카우 | 진균류에 의한 점막염을 국소 치료하기 위한 항진균제의용도 |
ZA989885B (en) | 1997-10-31 | 1999-05-05 | Abbott Lab | Use of macrolides for the treatment of cancer and macular degeneration |
CZ287497B6 (cs) | 1997-12-30 | 2000-12-13 | Galena, A. S. | Topické oční přípravky s imunosupresivními látkami |
WO1999037667A1 (en) | 1998-01-23 | 1999-07-29 | Microcide Pharmaceuticals, Inc. | Efflux pump inhibitors |
WO1999058126A1 (en) * | 1998-05-11 | 1999-11-18 | The Endowment For Research In Human Biology, Inc. | Use of neomycin for treating angiogenesis-related diseases |
US6399629B1 (en) * | 1998-06-01 | 2002-06-04 | Microcide Pharmaceuticals, Inc. | Efflux pump inhibitors |
US6376517B1 (en) | 1998-08-14 | 2002-04-23 | Gpi Nil Holdings, Inc. | Pipecolic acid derivatives for vision and memory disorders |
US6632836B1 (en) * | 1998-10-30 | 2003-10-14 | Merck & Co., Inc. | Carbocyclic potassium channel inhibitors |
ES2217819T3 (es) | 1998-11-17 | 2004-11-01 | Ortho-Mcneil Pharmaceutical, Inc. | Derivados anticonvulsivos para el tratamiento de transtornos de estres post-traumaticos. |
NZ513111A (en) | 1998-12-24 | 2003-10-31 | R Tech Ueno Ltd | Agent for treating visual cell function disorder |
WO2000040089A1 (en) | 1999-01-05 | 2000-07-13 | Massachusetts Eye And Ear Infirmary | Targeted transscleral controlled release drug delivery to the retina and choroid |
US7374779B2 (en) | 1999-02-26 | 2008-05-20 | Lipocine, Inc. | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
US6254860B1 (en) * | 1999-04-13 | 2001-07-03 | Allergan Sales, Inc. | Ocular treatment using cyclosporin-A derivatives |
US7063857B1 (en) * | 1999-04-30 | 2006-06-20 | Sucampo Ag | Use of macrolide compounds for the treatment of dry eye |
US6576224B1 (en) * | 1999-07-06 | 2003-06-10 | Sinuspharma, Inc. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
AU784350B2 (en) * | 1999-10-22 | 2006-03-16 | Biogen Idec Ma Inc. | Use of a CD40:CD154 binding interruptor to treat immunological complications of the eye |
US6531464B1 (en) * | 1999-12-07 | 2003-03-11 | Inotek Pharmaceutical Corporation | Methods for the treatment of neurodegenerative disorders using substituted phenanthridinone derivatives |
SK8562002A3 (en) | 1999-12-23 | 2003-10-07 | Pfizer Prod Inc | Pharmaceutical compositions providing enhanced drug concentrations |
US20030018044A1 (en) * | 2000-02-18 | 2003-01-23 | Peyman Gholam A. | Treatment of ocular disease |
GB0003932D0 (en) * | 2000-02-18 | 2000-04-12 | Novartis Ag | Pharmaceutical compositions |
CN1127955C (zh) | 2000-07-07 | 2003-11-19 | 中山医科大学中山眼科中心 | 一种眼前段及眼表免疫相关性疾病治疗药物 |
WO2002028387A1 (en) | 2000-10-03 | 2002-04-11 | Oncopharmaceutical, Inc. | Inhibitors of angiogenesis and tumor growth for local and systemic administration |
US20040018228A1 (en) * | 2000-11-06 | 2004-01-29 | Afmedica, Inc. | Compositions and methods for reducing scar tissue formation |
US6534693B2 (en) * | 2000-11-06 | 2003-03-18 | Afmedica, Inc. | Surgically implanted devices having reduced scar tissue formation |
AU2002236495B2 (en) * | 2000-11-29 | 2006-05-11 | Allergan, Inc. | Intraocular implants for preventing transplant rejection in the eye |
AP2003002828A0 (en) | 2001-01-16 | 2003-09-30 | Vascular Therapies Llc | Implantable device containing resorbable matrix material and anti-proliferative drugs for preventing or treating failure of hemodialysis vascular access and other vascular grafts. |
US6713081B2 (en) | 2001-03-15 | 2004-03-30 | The United States Of America As Represented By The Department Of Health And Human Services | Ocular therapeutic agent delivery devices and methods for making and using such devices |
WO2002089767A1 (en) * | 2001-05-03 | 2002-11-14 | Massachusetts Eye And Ear Infirmary | Implantable drug delivery device and use thereof |
US6812220B2 (en) * | 2001-08-29 | 2004-11-02 | University Of British Columbia | Pharmaceutical compositions and methods relating to fucans |
GB0122318D0 (en) * | 2001-09-14 | 2001-11-07 | Novartis Ag | Organic compounds |
US6939376B2 (en) | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
IL163808A0 (en) | 2002-03-01 | 2005-12-18 | Yissum Res Dev Co | Self emulsifying drug delivery systems for poorly soluble drugs |
JP2005527508A (ja) | 2002-03-07 | 2005-09-15 | ヴェクトゥラ リミテッド | 経口デリバリー用急速溶融多粒子製剤 |
EP1531804A1 (en) * | 2002-05-03 | 2005-05-25 | The Queen Elizabeth Hospital Research Foundation Inc., | Method of inhibiting angiogenesis |
US20040057958A1 (en) * | 2002-05-17 | 2004-03-25 | Waggoner David W. | Immunogenicity-enhancing carriers and compositions thereof and methods of using the same |
PT1553940E (pt) * | 2002-07-30 | 2008-05-09 | Wyeth Corp | Formulações parentéricas contendo um hidroxi-éster de rapamicina |
SI1539157T1 (sl) | 2002-09-18 | 2013-11-29 | Trustees Of The University Of Pennsylvania | Rapamicin za uporabo pri inhibiciji ali preprečevanju horoidalne neovaskularizacije |
JP2006507368A (ja) | 2002-09-29 | 2006-03-02 | サーモディックス,インコーポレイティド | ステロイド含有治療剤の網膜下投与方法;脈絡膜及び網膜に薬力学作用を局在化するための方法;並びに網膜疾患の治療及び/又は予防のための関連する方法 |
US7354574B2 (en) | 2002-11-07 | 2008-04-08 | Advanced Ocular Systems Limited | Treatment of ocular disease |
CA2516022C (en) | 2003-02-17 | 2012-05-29 | Cold Spring Harbor Laboratory | Model for studying the role of genes in tumor resistance to chemotherapy |
EP2044959A1 (en) * | 2003-06-26 | 2009-04-08 | pSivida Inc | In-situ gelling drug delivery system |
US7083802B2 (en) * | 2003-07-31 | 2006-08-01 | Advanced Ocular Systems Limited | Treatment of ocular disease |
US7585517B2 (en) * | 2003-09-18 | 2009-09-08 | Macusight, Inc. | Transscleral delivery |
EP1684819A2 (en) | 2003-11-20 | 2006-08-02 | Angiotech International Ag | Polymer compositions and methods for their use |
-
2003
- 2003-09-18 SI SI200332304T patent/SI1539157T1/sl unknown
- 2003-09-18 PT PT37546538T patent/PT1539157E/pt unknown
- 2003-09-18 WO PCT/US2003/029188 patent/WO2004027027A2/en active Application Filing
- 2003-09-18 CA CA2498191A patent/CA2498191C/en not_active Expired - Lifetime
- 2003-09-18 EP EP12004712.1A patent/EP2514420B1/en not_active Expired - Lifetime
- 2003-09-18 EP EP03754653.8A patent/EP1539157B1/en not_active Expired - Lifetime
- 2003-09-18 AU AU2003272471A patent/AU2003272471B2/en not_active Expired
- 2003-09-18 US US10/665,203 patent/US8163726B2/en active Active
- 2003-09-18 DK DK03754653.8T patent/DK1539157T3/da active
- 2003-09-18 ES ES12004712.1T patent/ES2494791T3/es not_active Expired - Lifetime
- 2003-09-18 JP JP2004537893A patent/JP2006511475A/ja not_active Withdrawn
- 2003-09-18 ES ES03754653T patent/ES2428354T3/es not_active Expired - Lifetime
-
2008
- 2008-10-02 US US12/244,655 patent/US20090036479A1/en not_active Abandoned
-
2010
- 2010-09-15 AU AU2010221791A patent/AU2010221791A1/en not_active Abandoned
- 2010-10-01 JP JP2010223994A patent/JP5395024B2/ja not_active Expired - Lifetime
-
2012
- 2012-03-29 US US13/433,739 patent/US8618088B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1539157A2 (en) | 2005-06-15 |
JP5395024B2 (ja) | 2014-01-22 |
CA2498191C (en) | 2012-04-10 |
PT1539157E (pt) | 2013-10-04 |
ES2428354T3 (es) | 2013-11-07 |
EP1539157A4 (en) | 2008-09-03 |
US8163726B2 (en) | 2012-04-24 |
US20120190705A1 (en) | 2012-07-26 |
DK1539157T3 (da) | 2013-10-07 |
US20090036479A1 (en) | 2009-02-05 |
EP2514420B1 (en) | 2014-08-13 |
AU2003272471A1 (en) | 2004-04-08 |
WO2004027027A3 (en) | 2004-05-21 |
US8618088B2 (en) | 2013-12-31 |
WO2004027027A2 (en) | 2004-04-01 |
CA2498191A1 (en) | 2004-04-01 |
EP1539157B1 (en) | 2013-08-21 |
AU2010221791A1 (en) | 2010-11-18 |
JP2006511475A (ja) | 2006-04-06 |
JP2011001380A (ja) | 2011-01-06 |
US20050187241A1 (en) | 2005-08-25 |
EP2514420A2 (en) | 2012-10-24 |
EP2514420A3 (en) | 2012-11-28 |
AU2003272471B2 (en) | 2010-10-07 |
ES2494791T3 (es) | 2014-09-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SI1539157T1 (sl) | Rapamicin za uporabo pri inhibiciji ali preprečevanju horoidalne neovaskularizacije | |
HUE048419T2 (hu) | Gyógyszerhordozó és kit gyógyszerhordozó kit fibrózis gátlására | |
EP1718307A4 (en) | IMMUNE REPRESENTING COMPOUNDS AND COMPOSITIONS | |
EP1633718A4 (en) | COMPOSITIONS AND METHODS FOR INHIBITING TGF-S | |
EP1603485A4 (en) | BIOACTIVE STENTS AND METHOD OF USE THEREOF | |
HK1090639A1 (en) | Immunosuppressant compounds and compositions | |
HK1087929A1 (zh) | 免疫抑制劑化合物和組合物 | |
IL183216A0 (en) | Nepetalactams and n-substituted derivatives thereof | |
EP1804906A4 (en) | CORRECTION DEVICE PROTECTION | |
EP1718604A4 (en) | COMPOUNDS AND COMPOSITIONS OF IMMUNOSUPPRESSANTS | |
ZA200607912B (en) | Tetracyclic Lactam Derivatives and uses thereof | |
IL183217A0 (en) | Dihydronepetalactams and n-substituted derivatives thereof | |
EP1686927A4 (en) | GAMMA-TOCOPHEROL THERAPY FOR THE PREVENTION OF RESTENOSIS | |
ZA200604994B (en) | Methods and agents for inhibiting dynamin-dependent endocytosis | |
GB0612313D0 (en) | Methods and agents for inhibiting dynamin-dependent endocytosis | |
EP1648873A4 (en) | NEUROPROTECTIVE MACROCYCLIC COMPOUNDS AND METHODS OF USING THE SAME | |
GB2430606B (en) | Hip protector | |
GB2414745C (en) | Euroblock - flood prevention specification | |
KR200335423Y1 (ko) | 낙하방지용 방호장치 | |
GB0402614D0 (en) | The stoma protection belt | |
GB0309021D0 (en) | Protective sock | |
GB0313322D0 (en) | Bio-degradable condom | |
GB0406582D0 (en) | Disabled badge protector | |
GB0400811D0 (en) | Immunosuppressant | |
IL169830A0 (en) | Stent |