JP2004522735A5 - - Google Patents
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- JP2004522735A5 JP2004522735A5 JP2002557412A JP2002557412A JP2004522735A5 JP 2004522735 A5 JP2004522735 A5 JP 2004522735A5 JP 2002557412 A JP2002557412 A JP 2002557412A JP 2002557412 A JP2002557412 A JP 2002557412A JP 2004522735 A5 JP2004522735 A5 JP 2004522735A5
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- 150000001413 amino acids Chemical group 0.000 claims 71
- 239000000203 mixture Substances 0.000 claims 54
- 239000000427 antigen Substances 0.000 claims 41
- 102000036639 antigens Human genes 0.000 claims 35
- 108091007433 antigens Proteins 0.000 claims 35
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 28
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 28
- 230000000890 antigenic effect Effects 0.000 claims 27
- 239000012634 fragment Substances 0.000 claims 25
- 101710132601 Capsid protein Proteins 0.000 claims 15
- 101710094648 Coat protein Proteins 0.000 claims 15
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 claims 15
- 101710125418 Major capsid protein Proteins 0.000 claims 15
- 101710141454 Nucleoprotein Proteins 0.000 claims 15
- 101710083689 Probable capsid protein Proteins 0.000 claims 15
- 239000007771 core particle Substances 0.000 claims 15
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- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 4
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- ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical group CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 claims 2
- 239000004471 Glycine Substances 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 101001011645 Homo sapiens Muellerian-inhibiting factor Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 102000015439 Phospholipases Human genes 0.000 claims 2
- 108010064785 Phospholipases Proteins 0.000 claims 2
- 102100021669 Stromal cell-derived factor 1 Human genes 0.000 claims 2
- 230000003302 anti-idiotype Effects 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
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- 102000015427 Angiotensins Human genes 0.000 claims 1
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- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 1
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- 108010061629 Dermatophagoides pteronyssinus antigen p 1 Proteins 0.000 claims 1
- 102100037241 Endoglin Human genes 0.000 claims 1
- 108010036395 Endoglin Proteins 0.000 claims 1
- 241000709737 Enterobacteria phage GA Species 0.000 claims 1
- 241001261579 Enterobacteria phage M11 Species 0.000 claims 1
- 241001278075 Enterobacteria phage MX1 Species 0.000 claims 1
- 241001278054 Enterobacteria phage NL95 Species 0.000 claims 1
- 241000709747 Enterobacteria phage R17 Species 0.000 claims 1
- 241000709743 Enterobacteria phage SP Species 0.000 claims 1
- 241000709739 Enterobacteria phage f2 Species 0.000 claims 1
- 241000709744 Enterobacterio phage MS2 Species 0.000 claims 1
- 102100023688 Eotaxin Human genes 0.000 claims 1
- 101710139422 Eotaxin Proteins 0.000 claims 1
- 208000004262 Food Hypersensitivity Diseases 0.000 claims 1
- 206010016946 Food allergy Diseases 0.000 claims 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 101000713085 Homo sapiens C-C motif chemokine 21 Proteins 0.000 claims 1
- 101000950847 Homo sapiens Macrophage migration inhibitory factor Proteins 0.000 claims 1
- 101000904173 Homo sapiens Progonadoliberin-1 Proteins 0.000 claims 1
- 101000617130 Homo sapiens Stromal cell-derived factor 1 Proteins 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 102100026011 Interleukin-13 Human genes 0.000 claims 1
- 108090000176 Interleukin-13 Proteins 0.000 claims 1
- 102000013691 Interleukin-17 Human genes 0.000 claims 1
- 108050003558 Interleukin-17 Proteins 0.000 claims 1
- 102100039897 Interleukin-5 Human genes 0.000 claims 1
- 108010002616 Interleukin-5 Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 108060004872 MIF Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 241000223960 Plasmodium falciparum Species 0.000 claims 1
- 241000223810 Plasmodium vivax Species 0.000 claims 1
- 102000011195 Profilin Human genes 0.000 claims 1
- 108050001408 Profilin Proteins 0.000 claims 1
- 102100024028 Progonadoliberin-1 Human genes 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 241000709749 Pseudomonas phage PP7 Species 0.000 claims 1
- 102000014128 RANK Ligand Human genes 0.000 claims 1
- 108010025832 RANK Ligand Proteins 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 102100022831 Somatoliberin Human genes 0.000 claims 1
- 101710142969 Somatoliberin Proteins 0.000 claims 1
- 101001039853 Sonchus yellow net virus Matrix protein Proteins 0.000 claims 1
- 108010090804 Streptavidin Proteins 0.000 claims 1
- 101710088580 Stromal cell-derived factor 1 Proteins 0.000 claims 1
- 101000996723 Sus scrofa Gonadotropin-releasing hormone receptor Proteins 0.000 claims 1
- 241000223996 Toxoplasma Species 0.000 claims 1
- 108091008605 VEGF receptors Proteins 0.000 claims 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000013566 allergen Substances 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 102000023732 binding proteins Human genes 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000000234 capsid Anatomy 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 235000020932 food allergy Nutrition 0.000 claims 1
- XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 229940100602 interleukin-5 Drugs 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 244000144972 livestock Species 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26237901P | 2001-01-19 | 2001-01-19 | |
| US28854901P | 2001-05-04 | 2001-05-04 | |
| US32699801P | 2001-10-05 | 2001-10-05 | |
| US33104501P | 2001-11-07 | 2001-11-07 | |
| PCT/IB2002/000166 WO2002056905A2 (en) | 2001-01-19 | 2002-01-21 | Molecular antigen array |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008274671A Division JP5175160B2 (ja) | 2001-01-19 | 2008-10-24 | 分子抗原アレイ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004522735A JP2004522735A (ja) | 2004-07-29 |
| JP2004522735A5 true JP2004522735A5 (https=) | 2005-12-22 |
Family
ID=27500737
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002557412A Withdrawn JP2004522735A (ja) | 2001-01-19 | 2002-01-21 | 分子抗原アレイ |
| JP2002557414A Expired - Fee Related JP4489349B2 (ja) | 2001-01-19 | 2002-01-21 | 分子抗原アレイ |
| JP2008274671A Expired - Fee Related JP5175160B2 (ja) | 2001-01-19 | 2008-10-24 | 分子抗原アレイ |
| JP2012179555A Withdrawn JP2013028608A (ja) | 2001-01-19 | 2012-08-13 | 分子抗原アレイ |
| JP2015094858A Withdrawn JP2015205881A (ja) | 2001-01-19 | 2015-05-07 | 分子抗原アレイ |
| JP2017083363A Pending JP2017171666A (ja) | 2001-01-19 | 2017-04-20 | 分子抗原アレイ |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002557414A Expired - Fee Related JP4489349B2 (ja) | 2001-01-19 | 2002-01-21 | 分子抗原アレイ |
| JP2008274671A Expired - Fee Related JP5175160B2 (ja) | 2001-01-19 | 2008-10-24 | 分子抗原アレイ |
| JP2012179555A Withdrawn JP2013028608A (ja) | 2001-01-19 | 2012-08-13 | 分子抗原アレイ |
| JP2015094858A Withdrawn JP2015205881A (ja) | 2001-01-19 | 2015-05-07 | 分子抗原アレイ |
| JP2017083363A Pending JP2017171666A (ja) | 2001-01-19 | 2017-04-20 | 分子抗原アレイ |
Country Status (13)
| Country | Link |
|---|---|
| US (10) | US7264810B2 (https=) |
| EP (4) | EP1353691B1 (https=) |
| JP (6) | JP2004522735A (https=) |
| CN (2) | CN1301133C (https=) |
| AT (1) | ATE421332T1 (https=) |
| AU (1) | AU2002226603B2 (https=) |
| BR (2) | BR0206566A (https=) |
| CA (2) | CA2433316C (https=) |
| DE (1) | DE60230963D1 (https=) |
| DK (1) | DK1353691T3 (https=) |
| ES (1) | ES2321382T3 (https=) |
| RU (2) | RU2295973C2 (https=) |
| WO (2) | WO2002056907A2 (https=) |
Families Citing this family (150)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7632983B2 (en) | 2000-07-31 | 2009-12-15 | Biolex Therapeutics, Inc. | Expression of monoclonal antibodies in duckweed |
| US8022270B2 (en) * | 2000-07-31 | 2011-09-20 | Biolex Therapeutics, Inc. | Expression of biologically active polypeptides in duckweed |
| US7094409B2 (en) * | 2001-01-19 | 2006-08-22 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
| US7264810B2 (en) * | 2001-01-19 | 2007-09-04 | Cytos Biotechnology Ag | Molecular antigen array |
| US7128911B2 (en) * | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
| US7629309B2 (en) | 2002-05-29 | 2009-12-08 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| WO2002087510A2 (en) | 2001-04-30 | 2002-11-07 | Symbiontics, Inc. | Subcellular targeting of therapeutic proteins |
| US7560424B2 (en) | 2001-04-30 | 2009-07-14 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| DE60234375D1 (de) | 2001-09-14 | 2009-12-24 | Cytos Biotechnology Ag | VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG |
| CA2492823A1 (en) * | 2001-09-14 | 2003-03-27 | Cytos Biotechnology Ag | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
| US7115266B2 (en) | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| MXPA04002644A (es) | 2001-10-05 | 2004-07-08 | Cytos Biotechnology Ag | Conjugados que portan un peptido de angiotensina y usos de los mismos. |
| US20030072761A1 (en) | 2001-10-16 | 2003-04-17 | Lebowitz Jonathan | Methods and compositions for targeting proteins across the blood brain barrier |
| US20050287159A1 (en) * | 2002-03-25 | 2005-12-29 | Drivas Dimitrios T | Treatment methods for eotaxin mediated inflammatory conditons |
| US7138252B2 (en) * | 2002-07-17 | 2006-11-21 | Cytos Biotechnology Ag | Molecular antigen arrays |
| CA2487849A1 (en) * | 2002-07-18 | 2004-01-29 | Cytos Biotechnology Ag | Hapten-carrier conjugates comprising virus like particles and uses thereof |
| EP2338510A1 (en) * | 2002-07-19 | 2011-06-29 | Novartis Pharma AG | Vaccine compositions containing amyloid beta1-6 antigen arrays |
| ATE441429T1 (de) * | 2002-07-19 | 2009-09-15 | Cytos Biotechnology Ag | Ghrelin-träger-konjugate |
| CN100455600C (zh) * | 2002-08-14 | 2009-01-28 | 阿维迪斯公司 | 包含支架,佐剂和抗原的异源多聚体化合物及其用途 |
| DE60327786D1 (de) | 2002-09-12 | 2009-07-09 | Oncotherapy Science Inc | Kdr-peptide und diese enthaltende impfstoffe |
| KR20050071498A (ko) * | 2002-09-18 | 2005-07-07 | 상트르 오스피딸리에 드 루니버시떼 드 몬트리알 | 성장 호르몬 방출 호르몬 유사체 |
| WO2004042003A2 (en) * | 2002-11-01 | 2004-05-21 | Promega Corporation | Cell lysis compositions, methods of use, apparatus, and kit |
| EP1419786A1 (en) * | 2002-11-13 | 2004-05-19 | Bracco Imaging S.p.A. | Method for the selective and quantitative functionalization of immunoglobulin fab fragments, conjugate compounds obtained with the same and compositions thereof |
| JP2011516026A (ja) * | 2002-11-26 | 2011-05-26 | ジェネンテック・インコーポレーテッド | 免疫関連疾患の治療のための組成物と方法 |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| JP2007525436A (ja) * | 2003-03-24 | 2007-09-06 | マーシア・ファーマ・インコーポレイテッド | 炎症症状を処置および予防するための方法および組成物 |
| US7537767B2 (en) | 2003-03-26 | 2009-05-26 | Cytis Biotechnology Ag | Melan-A- carrier conjugates |
| AU2004224761A1 (en) | 2003-03-26 | 2004-10-07 | Cytos Biotechnology Ag | HIV-peptide-carrier-conjugates |
| RU2375076C2 (ru) * | 2003-07-10 | 2009-12-10 | Цитос Биотехнологи Аг | Укомплектованные вирусоподобные частицы |
| PT1685251E (pt) * | 2003-10-10 | 2014-04-15 | Powderject Vaccines Inc | Construções de ácido nucleico |
| US7923109B2 (en) * | 2004-01-05 | 2011-04-12 | Board Of Regents, The University Of Texas System | Inorganic nanowires |
| CA2553594A1 (en) * | 2004-01-20 | 2005-07-28 | Cytos Biotechnology Ag | Particle-induced ghrelin immune response |
| CA2553955C (en) | 2004-02-10 | 2012-08-28 | Zystor Therapeutics, Inc. | Acid alpha-glucosidase and fragments thereof |
| KR101013999B1 (ko) * | 2004-03-19 | 2011-02-14 | 재단법인서울대학교산학협력재단 | 표면에 골조직 형성 증진 펩타이드가 고정된 차폐막 및임플란트 |
| KR20070058426A (ko) * | 2004-06-02 | 2007-06-08 | 사이토스 바이오테크놀로지 아게 | 비-인간 tnf-펩티드의 담체 콘쥬게이트의 의학적 용도 |
| EP1751186A2 (en) * | 2004-06-02 | 2007-02-14 | Cytos Biotechnology AG | Carrier conjugates of tnf-peptides |
| MX2007003171A (es) * | 2004-09-21 | 2007-05-23 | Cytos Biotechnology Ag | Particulas tipo virus que comprenden una proteina de fusion de la proteina de cubierta de ap205 y un polipeptido antigenico. |
| US7959928B2 (en) * | 2004-10-05 | 2011-06-14 | Cytos Biotechnology Ag | VLP-antigen conjugates and their uses as vaccines |
| AU2005298689A1 (en) * | 2004-10-25 | 2006-05-04 | Cytos Biotechnology Ag | Gastric inhibitory polypeptide (GIP) antigen arrays and uses thereof |
| WO2006045849A1 (en) * | 2004-10-29 | 2006-05-04 | Cytos Biotechnology Ag | T-cadherin antigen arrays and uses thereof |
| AU2011253800B2 (en) * | 2004-11-05 | 2013-08-22 | Novartis Ag | Composition comprising VLP and amyloid-beta peptide |
| GB0424563D0 (en) * | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
| EP1824886B1 (en) | 2004-11-17 | 2010-12-22 | Amgen Inc. | Fully human monoclonal antibodies to il-13 |
| ZA200707413B (en) | 2005-03-18 | 2009-01-28 | Cytos Biotechnology Ag | Cat allergen fusion proteins and uses thereof |
| CA2608579C (en) | 2005-05-26 | 2019-09-10 | Cytos Biotechnology Ag | Scalable fermentation process |
| EP1746165A1 (en) | 2005-07-21 | 2007-01-24 | Cytos Biotechnology AG | Scalable fermentation process |
| EP1736538A1 (en) | 2005-06-21 | 2006-12-27 | Cytos Biotechnology AG | Process for the preparative purification of virus-like-particles (VLPs) |
| NZ566971A (en) * | 2005-09-28 | 2011-06-30 | Cytos Biotechnology Ag | Vaccine containing a virus like particle linked with an interleukin-1 molecule |
| US8691224B2 (en) | 2005-11-30 | 2014-04-08 | Abbvie Inc. | Anti-Aβ globulomer 5F7 antibodies |
| HRP20140240T4 (hr) * | 2005-11-30 | 2017-02-24 | Abbvie Inc. | Monoklonalna antitijela protiv amiloidnih beta proteina i njihova upotreba |
| CA2636139A1 (en) | 2005-12-14 | 2007-06-21 | Cytos Biotechnology Ag | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
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2002
- 2002-01-18 US US10/050,902 patent/US7264810B2/en not_active Expired - Lifetime
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- 2002-01-21 CA CA2433316A patent/CA2433316C/en not_active Expired - Lifetime
- 2002-01-21 EP EP10012605A patent/EP2364727A3/en not_active Withdrawn
- 2002-01-21 WO PCT/IB2002/000166 patent/WO2002056905A2/en not_active Ceased
- 2002-01-21 JP JP2002557412A patent/JP2004522735A/ja not_active Withdrawn
- 2002-01-21 EP EP02710211.0A patent/EP1370290B1/en not_active Expired - Lifetime
- 2002-01-21 RU RU2006141850/10A patent/RU2438701C2/ru not_active IP Right Cessation
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- 2002-01-21 EP EP09150831A patent/EP2055312A1/en not_active Withdrawn
- 2002-01-21 BR BRPI0206565A patent/BRPI0206565A8/pt active Search and Examination
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- 2002-01-21 AT AT02716207T patent/ATE421332T1/de not_active IP Right Cessation
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2012
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- 2012-12-07 US US13/708,259 patent/US20130315949A1/en not_active Abandoned
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2013
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2014
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