JP2004527213A5 - - Google Patents
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- JP2004527213A5 JP2004527213A5 JP2002518253A JP2002518253A JP2004527213A5 JP 2004527213 A5 JP2004527213 A5 JP 2004527213A5 JP 2002518253 A JP2002518253 A JP 2002518253A JP 2002518253 A JP2002518253 A JP 2002518253A JP 2004527213 A5 JP2004527213 A5 JP 2004527213A5
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- Prior art keywords
- polypeptide
- nucleic acid
- acid molecule
- antigen
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 description 41
- 229920001184 polypeptide Polymers 0.000 description 34
- 102000004196 processed proteins & peptides Human genes 0.000 description 34
- 150000007523 nucleic acids Chemical class 0.000 description 21
- 108020004707 nucleic acids Proteins 0.000 description 17
- 102000039446 nucleic acids Human genes 0.000 description 17
- 210000004027 cell Anatomy 0.000 description 14
- 238000000034 method Methods 0.000 description 12
- 239000000427 antigen Substances 0.000 description 10
- 102000036639 antigens Human genes 0.000 description 10
- 108091007433 antigens Proteins 0.000 description 10
- 230000004927 fusion Effects 0.000 description 9
- 108010006519 Molecular Chaperones Proteins 0.000 description 8
- 230000000890 antigenic effect Effects 0.000 description 7
- 239000013604 expression vector Substances 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- 108091028043 Nucleic acid sequence Proteins 0.000 description 6
- 210000000612 antigen-presenting cell Anatomy 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 102100021868 Calnexin Human genes 0.000 description 4
- 108010056891 Calnexin Proteins 0.000 description 4
- 102000004082 Calreticulin Human genes 0.000 description 4
- 108090000549 Calreticulin Proteins 0.000 description 4
- 102100028082 Tapasin Human genes 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 108010059434 tapasin Proteins 0.000 description 4
- 102100039328 Endoplasmin Human genes 0.000 description 3
- 102000043129 MHC class I family Human genes 0.000 description 3
- 108091054437 MHC class I family Proteins 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 230000028993 immune response Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 241000701806 Human papillomavirus Species 0.000 description 2
- 101000767631 Human papillomavirus type 16 Protein E7 Proteins 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 125000000539 amino acid group Chemical group 0.000 description 2
- 210000004443 dendritic cell Anatomy 0.000 description 2
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 2
- 108010017007 glucose-regulated proteins Proteins 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000013598 vector Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 101000793651 Homo sapiens Calreticulin Proteins 0.000 description 1
- 101000812663 Homo sapiens Endoplasmin Proteins 0.000 description 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 1
- 241000710960 Sindbis virus Species 0.000 description 1
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 description 1
- 210000001130 astrocyte Anatomy 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical group [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 102000053922 human CALR Human genes 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 230000002601 intratumoral effect Effects 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 210000000274 microglia Anatomy 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 231100001221 nontumorigenic Toxicity 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22290200P | 2000-08-03 | 2000-08-03 | |
| US60/222,902 | 2000-08-03 | ||
| PCT/US2001/024134 WO2002012281A2 (en) | 2000-08-03 | 2001-08-02 | Molecular vaccine linking an endoplasmic reticulum chaperone polypeptide to an antigen |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008197856A Division JP2009017883A (ja) | 2000-08-03 | 2008-07-31 | 抗原に小胞体シャペロンポリペプチドを連結した分子ワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004527213A JP2004527213A (ja) | 2004-09-09 |
| JP2004527213A5 true JP2004527213A5 (https=) | 2008-09-18 |
| JP5087201B2 JP5087201B2 (ja) | 2012-12-05 |
Family
ID=22834209
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002518253A Expired - Lifetime JP5087201B2 (ja) | 2000-08-03 | 2001-08-02 | 抗原に小胞体シャペロンポリペプチドを連結した分子ワクチン |
| JP2008197856A Pending JP2009017883A (ja) | 2000-08-03 | 2008-07-31 | 抗原に小胞体シャペロンポリペプチドを連結した分子ワクチン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008197856A Pending JP2009017883A (ja) | 2000-08-03 | 2008-07-31 | 抗原に小胞体シャペロンポリペプチドを連結した分子ワクチン |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7342002B2 (https=) |
| EP (1) | EP1363938B1 (https=) |
| JP (2) | JP5087201B2 (https=) |
| AU (1) | AU2001278117A1 (https=) |
| CA (1) | CA2417214C (https=) |
| DK (1) | DK1363938T3 (https=) |
| ES (1) | ES2454640T3 (https=) |
| WO (1) | WO2002012281A2 (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050100928A1 (en) * | 1999-09-16 | 2005-05-12 | Zycos Inc., A Delaware Corporation | Nucleic acids encoding polyepitope polypeptides |
| US8128922B2 (en) * | 1999-10-20 | 2012-03-06 | Johns Hopkins University | Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen |
| AU2001290520A1 (en) * | 2000-08-01 | 2002-02-13 | The Johns Hokpins University | Intercellular transport protein linked to an antigen as a molecular vaccine |
| EP1363938B1 (en) | 2000-08-03 | 2013-12-11 | Johns Hopkins University | Molecular vaccine linking an endoplasmic reticulum chaperone polypeptide to an antigen |
| AU2002242016A1 (en) | 2001-02-01 | 2002-08-12 | The Johns Hopkins University | Nucleic acid derived vaccine that encodes an antigen linked to a polypeptide that promotes antigen presentation |
| WO2004092221A1 (ja) * | 2003-04-18 | 2004-10-28 | Sekisui Chemical Co. Ltd. | 免疫原及び免疫用組成物、並びにそれらを使用する抗体の製造方法 |
| EP1644048B1 (en) * | 2003-05-05 | 2015-04-29 | Johns Hopkins University | Anti-cancer dna vaccine employing plasmids encoding signal sequence, mutant oncoprotein antigen, and heat shock protein |
| CA2526720C (en) | 2003-05-22 | 2013-10-22 | Fraunhofer Usa, Inc. | Recombinant carrier molecule for expression, delivery and purification of target polypeptides |
| WO2005081716A2 (en) * | 2003-11-24 | 2005-09-09 | The Johns Hopkins University | DNA VACCINES TARGETING ANTIGENS OF THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS (SARS-CoV) |
| JP2007528838A (ja) * | 2003-12-24 | 2007-10-18 | ライデン ユニバーシティ メディカル センター | 腫瘍特異的ワクチンとしての合成タンパク質 |
| AU2005292852B2 (en) | 2004-10-15 | 2011-02-03 | Joe Chiba | Method of immunizing animal, composition for immunization, method of producing antibody, method of producing hybridoma and method of producing monoclonal antibody |
| WO2006073970A2 (en) | 2005-01-06 | 2006-07-13 | The Johns Hopkins University | Rna interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by dna and transfected dendritic cell vaccines |
| WO2006081323A2 (en) * | 2005-01-26 | 2006-08-03 | The Johns Hopkins University | Anti-cancer dna vaccine employing plasmids encoding mutant oncoprotein antigen and calreticulin |
| WO2007117264A2 (en) * | 2005-08-03 | 2007-10-18 | Fraunhofer Usa, Inc. | Compositions and methods for production of immunoglobulins |
| JP2009526780A (ja) * | 2006-02-13 | 2009-07-23 | フラウンホーファー ユーエスエー， インコーポレイテッド | Ｈｐｖ抗原、ワクチン組成物、および関連する方法 |
| WO2008048344A2 (en) * | 2006-02-13 | 2008-04-24 | Fraunhofer Usa, Inc. | Bacillus anthracis antigens, vaccine compositions, and related methods |
| US20100330105A1 (en) * | 2006-08-22 | 2010-12-30 | John Hopkins University | Anticancer Combination Therapies |
| WO2008046251A1 (fr) | 2006-10-19 | 2008-04-24 | Sunbio Biotech Pharmaceuticals(Tianjin) Co., Ltd. | Protéines hybrides contenant un domaine n de la calréticuline humaine et des protéines e6 ou e7 du papillomavirus humain de type 16, et utilisations associées |
| US9085638B2 (en) | 2007-03-07 | 2015-07-21 | The Johns Hopkins University | DNA vaccine enhancement with MHC class II activators |
| US20080260765A1 (en) * | 2007-03-15 | 2008-10-23 | Johns Hopkins University | HPV DNA Vaccines and Methods of Use Thereof |
| WO2008119024A1 (en) * | 2007-03-27 | 2008-10-02 | University Of Florida Research Foundation Inc. | Modified antigen presenting cells and methods of use |
| EP2178558B1 (en) * | 2007-07-11 | 2014-04-30 | iBio, Inc. | Yersinia pestis antigens, vaccine compositions, and related methods |
| JP2011518115A (ja) * | 2008-01-28 | 2011-06-23 | タップイミューン インコーポレイテッド | 免疫応答を増強するためのタパシン増加 |
| DK2257301T3 (da) | 2008-03-03 | 2014-04-28 | Univ Miami | Immunterapi baseret på allogene cancerceller. |
| KR20110017356A (ko) | 2008-03-20 | 2011-02-21 | 유니버시티 오브 마이애미 | 열충격 단백질 ｇｐ96 백신접종 및 이를 사용하는 방법 |
| US20090285861A1 (en) * | 2008-04-17 | 2009-11-19 | Tzyy-Choou Wu | Tumor cell-based cancer immunotherapeutic compositions and methods |
| CA2736498C (en) * | 2008-09-11 | 2017-05-23 | Calretex, Llc | Compositions and methods for purifying calreticulin |
| US8734803B2 (en) | 2008-09-28 | 2014-05-27 | Ibio Inc. | Humanized neuraminidase antibody and methods of use thereof |
| US8784819B2 (en) | 2009-09-29 | 2014-07-22 | Ibio Inc. | Influenza hemagglutinin antibodies, compositions and related methods |
| PL2591114T3 (pl) * | 2010-07-06 | 2017-08-31 | Glaxosmithkline Biologicals Sa | Immunizacja dużych ssaków małymi dawkami rna |
| EP2678031A4 (en) * | 2011-02-23 | 2015-09-02 | Univ Miami | COMBINED VACCINATION WITH CELL-BASED GP96-IG-SIV / HIV AND THE RECOMBINANT PROTEIN GP120 FOR PROTECTION AGAINST SIV / HIV |
| HRP20211595T1 (hr) | 2011-05-24 | 2022-01-21 | BioNTech SE | Individualizirana cjepiva protiv raka |
| JP5981921B2 (ja) * | 2011-09-02 | 2016-08-31 | 株式会社カネカ | 小胞体シャペロンプロモータを用いた外来遺伝子を発現するトランスジェニック鳥類 |
| WO2013093629A2 (en) * | 2011-12-20 | 2013-06-27 | Netherlands Cancer Institute | Modular vaccines, methods and compositions related thereto |
| WO2014082729A1 (en) | 2012-11-28 | 2014-06-05 | Biontech Ag | Individualized vaccines for cancer |
| US9993534B2 (en) * | 2013-03-12 | 2018-06-12 | Wisconsin Alumni Research Foundation | Method of treating fungal infection |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| WO2017155981A1 (en) * | 2016-03-07 | 2017-09-14 | Massachusetts Institute Of Technology | Protein-chaperoned t-cell vaccines |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| WO2018224166A1 (en) | 2017-06-09 | 2018-12-13 | Biontech Rna Pharmaceuticals Gmbh | Methods for predicting the usefulness of disease specific amino acid modifications for immunotherapy |
| RU2020103379A (ru) | 2017-07-04 | 2021-08-04 | Куревак Аг | Новые молекулы нуклеиновых кислот |
| CN109182339A (zh) * | 2018-09-06 | 2019-01-11 | 青岛农业大学 | 一种许氏平鮋钙网蛋白基因及应用 |
| KR20220115569A (ko) | 2019-11-18 | 2022-08-17 | 얀센 바이오테크 인코포레이티드 | 돌연변이 calr 및 jak2에 기반한 백신 및 이의 용도 |
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| EP1363938B1 (en) | 2000-08-03 | 2013-12-11 | Johns Hopkins University | Molecular vaccine linking an endoplasmic reticulum chaperone polypeptide to an antigen |
| JP3930243B2 (ja) * | 2000-11-06 | 2007-06-13 | 本田技研工業株式会社 | マグネットポンプ |
| US20040259247A1 (en) * | 2000-12-01 | 2004-12-23 | Thomas Tuschl | Rna interference mediating small rna molecules |
| US7892730B2 (en) * | 2000-12-22 | 2011-02-22 | Sagres Discovery, Inc. | Compositions and methods for cancer |
| AU2002242016A1 (en) * | 2001-02-01 | 2002-08-12 | The Johns Hopkins University | Nucleic acid derived vaccine that encodes an antigen linked to a polypeptide that promotes antigen presentation |
| AU2002306736A1 (en) | 2001-03-16 | 2002-10-03 | Johns Hopkins University | A replication-defective alphavirus vaccine linking antigen with an immunogenicity-potentiating polypeptide and a method of delivery the same |
| US20030144221A1 (en) | 2001-07-17 | 2003-07-31 | Isis Pharmaceuticals Inc. | Antisense modulation of BCL2-associated X protein expression |
| EP1417353A4 (en) * | 2001-07-20 | 2005-08-03 | Univ Texas | METHODS AND COMPOSITIONS ASSOCIATED WITH HPV ASSOCIATED PENCILS AND CANNULAR WELLS, INCLUDING CIN |
| US20060040262A1 (en) | 2002-12-27 | 2006-02-23 | Morris David W | Novel compositions and methods in cancer |
| EP1539189A4 (en) | 2002-03-25 | 2007-05-09 | Univ Boston | METHOD OF USE OF ANTI-APOPTOSIS FACTORS IN GENE EXPRESSION |
| MXPA05003395A (es) | 2002-10-03 | 2005-06-22 | Wyeth Corp | Polipeptidos de virus de papiloma humano y composiciones inmunogenas. |
| WO2005047501A1 (en) | 2003-02-24 | 2005-05-26 | Johns Hopkins University | Molecular vaccines employing nucleic acid encoding anti-apoptotic proteins |
| EP1644048B1 (en) | 2003-05-05 | 2015-04-29 | Johns Hopkins University | Anti-cancer dna vaccine employing plasmids encoding signal sequence, mutant oncoprotein antigen, and heat shock protein |
| WO2005081716A2 (en) | 2003-11-24 | 2005-09-09 | The Johns Hopkins University | DNA VACCINES TARGETING ANTIGENS OF THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS (SARS-CoV) |
| WO2006073970A2 (en) | 2005-01-06 | 2006-07-13 | The Johns Hopkins University | Rna interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by dna and transfected dendritic cell vaccines |
| WO2006081323A2 (en) | 2005-01-26 | 2006-08-03 | The Johns Hopkins University | Anti-cancer dna vaccine employing plasmids encoding mutant oncoprotein antigen and calreticulin |
-
2001
- 2001-08-02 EP EP01956081.2A patent/EP1363938B1/en not_active Expired - Lifetime
- 2001-08-02 AU AU2001278117A patent/AU2001278117A1/en not_active Abandoned
- 2001-08-02 JP JP2002518253A patent/JP5087201B2/ja not_active Expired - Lifetime
- 2001-08-02 DK DK01956081.2T patent/DK1363938T3/en active
- 2001-08-02 WO PCT/US2001/024134 patent/WO2002012281A2/en not_active Ceased
- 2001-08-02 US US10/343,448 patent/US7342002B2/en not_active Expired - Lifetime
- 2001-08-02 CA CA2417214A patent/CA2417214C/en not_active Expired - Lifetime
- 2001-08-02 ES ES01956081.2T patent/ES2454640T3/es not_active Expired - Lifetime
-
2008
- 2008-01-15 US US12/014,541 patent/US8007781B2/en not_active Expired - Fee Related
- 2008-07-31 JP JP2008197856A patent/JP2009017883A/ja active Pending
-
2012
- 2012-05-03 US US13/463,250 patent/US20130203961A1/en not_active Abandoned
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