|
EP1285914B1
(en)
*
|
2001-08-13 |
2007-12-19 |
PheneX Pharmaceuticals AG |
Nr1h4 nuclear receptor binding compounds
|
|
US6953787B2
(en)
|
2002-04-12 |
2005-10-11 |
Arena Pharmaceuticals, Inc. |
5HT2C receptor modulators
|
|
MXPA04012711A
(es)
|
2002-06-19 |
2005-03-23 |
Biovitrum Ab |
Nuevos compuestos, su uso y preparacion.
|
|
US7105526B2
(en)
|
2002-06-28 |
2006-09-12 |
Banyu Pharmaceuticals Co., Ltd. |
Benzimidazole derivatives
|
|
TW200504033A
(en)
*
|
2002-10-23 |
2005-02-01 |
Procter & Gamble |
Melanocortin receptor ligands
|
|
KR100547109B1
(ko)
*
|
2002-11-14 |
2006-01-26 |
삼성전자주식회사 |
자외선 흡수 치환기를 포함한 기능성 첨가제 및 이를포함하는잉크 조성물
|
|
US7772188B2
(en)
|
2003-01-28 |
2010-08-10 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
|
CL2004000826A1
(es)
|
2003-04-25 |
2005-03-04 |
Pfizer |
Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129
|
|
EP2332920A3
(en)
|
2003-06-17 |
2011-12-21 |
Arena Pharmaceuticals, Inc. |
Processes for preparing 3-benzazepines
|
|
ES2571220T3
(es)
|
2003-06-17 |
2016-05-24 |
Arena Pharm Inc |
Clorhidrato de 8-cloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazepina
|
|
JP2007523861A
(ja)
*
|
2003-06-20 |
2007-08-23 |
アリーナ ファーマシューティカルズ, インコーポレイテッド |
N−フェニル−ピペラジン誘導体および5ht2cレセプター関連疾患の予防方法または処置方法
|
|
CA2551037A1
(en)
|
2003-09-22 |
2005-03-31 |
Banyu Pharmaceutical Co., Ltd. |
Novel piperidine derivative
|
|
WO2005097127A2
(en)
|
2004-04-02 |
2005-10-20 |
Merck & Co., Inc. |
Method of treating men with metabolic and anthropometric disorders
|
|
EP1586560A1
(en)
*
|
2004-04-13 |
2005-10-19 |
Cephalon, Inc. |
Thio-substituted arylmethanesulfinyl derivatives
|
|
US7297817B2
(en)
*
|
2004-04-13 |
2007-11-20 |
Cephalon France |
Thio-substituted arylmethanesulfinyl derivatives
|
|
EP2248524A3
(en)
|
2004-08-25 |
2011-03-09 |
Takeda Pharmaceutical Company Limited |
Preventives/remedies for stress urinary incontinence and method of screening the same
|
|
CA2584806C
(en)
|
2004-11-01 |
2014-06-17 |
Amylin Pharmaceuticals, Inc. |
Treatment of obesity and related disorders
|
|
GT200500317A
(es)
*
|
2004-11-05 |
2006-10-27 |
|
Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos
|
|
WO2006062110A1
(ja)
*
|
2004-12-06 |
2006-06-15 |
Banyu Pharmaceutical Co., Ltd. |
ピペラジン誘導体
|
|
JPWO2006064780A1
(ja)
*
|
2004-12-14 |
2008-06-12 |
塩野義製薬株式会社 |
便秘治療剤
|
|
JP5270167B2
(ja)
|
2004-12-21 |
2013-08-21 |
アリーナ ファーマシューティカルズ, インコーポレイテッド |
(r)−8−クロロ−1−メチル−2,3,4,5−テトラヒドロ−1h−3−ベンザゼピン塩酸塩の結晶形
|
|
US7737155B2
(en)
|
2005-05-17 |
2010-06-15 |
Schering Corporation |
Nitrogen-containing heterocyclic compounds and methods of use thereof
|
|
ES2574014T3
(es)
|
2005-05-30 |
2016-06-14 |
Msd K.K. |
Derivado de piperidina novedoso
|
|
AR054849A1
(es)
*
|
2005-07-26 |
2007-07-18 |
Wyeth Corp |
Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
|
|
AU2006277253A1
(en)
|
2005-08-10 |
2007-02-15 |
Msd K.K. |
Pyridone compound
|
|
EP2330125A3
(en)
|
2005-08-11 |
2012-12-12 |
Amylin Pharmaceuticals, Inc. |
Hybrid polypeptides with selectable properties
|
|
AU2006279680B2
(en)
|
2005-08-11 |
2012-12-06 |
Amylin Pharmaceuticals, Llc |
Hybrid polypeptides with selectable properties
|
|
WO2007024004A1
(ja)
|
2005-08-24 |
2007-03-01 |
Banyu Pharmaceutical Co., Ltd. |
フェニルピリドン誘導体
|
|
AU2006288153A1
(en)
|
2005-09-07 |
2007-03-15 |
Msd K.K. |
Bicyclic aromatic substituted pyridone derivative
|
|
KR20080048502A
(ko)
|
2005-09-29 |
2008-06-02 |
머크 앤드 캄파니 인코포레이티드 |
멜라노코르틴-4 수용체 조절제로서의 아실화스피로피페리딘 유도체
|
|
KR20080059233A
(ko)
|
2005-10-21 |
2008-06-26 |
노파르티스 아게 |
레닌 억제제, 및 항이상지질혈증제 및/또는 항비만제의조합물
|
|
WO2007049798A1
(ja)
|
2005-10-27 |
2007-05-03 |
Banyu Pharmaceutical Co., Ltd. |
新規ベンゾオキサチイン誘導体
|
|
BRPI0618354B8
(pt)
|
2005-11-10 |
2021-05-25 |
Banyu Pharma Co Ltd |
composto e seu uso, composição farmacêutica, preventivo ou remédio
|
|
TW200734334A
(en)
*
|
2006-01-13 |
2007-09-16 |
Wyeth Corp |
Treatment of substance abuse
|
|
MX2008012094A
(es)
*
|
2006-03-24 |
2008-10-03 |
Wyeth Corp |
Nuevas combinaciones terapeuticas para el tratamiento de la depresion.
|
|
US8168782B2
(en)
|
2006-04-03 |
2012-05-01 |
Arena Pharmaceuticals, Inc. |
Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates related thereto
|
|
WO2007132841A1
(ja)
|
2006-05-16 |
2007-11-22 |
Takeda Pharmaceutical Company Limited |
縮合複素環化合物およびその用途
|
|
EP2698157B1
(en)
|
2006-09-22 |
2015-05-20 |
Merck Sharp & Dohme Corp. |
Method of treatment using fatty acid synthesis inhibitors
|
|
US20090247560A1
(en)
|
2006-09-28 |
2009-10-01 |
Banyu Pharmaceutical Co., Ltd. |
Diaryl ketimine derivative
|
|
CN101547892B
(zh)
|
2006-12-05 |
2014-08-20 |
艾尼纳制药公司 |
制备(r)-8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓的方法和其中间体
|
|
EP2118279B1
(en)
|
2007-01-16 |
2017-11-22 |
Ipintl, Llc |
Novel composition for treating metabolic syndrome
|
|
WO2008120653A1
(ja)
|
2007-04-02 |
2008-10-09 |
Banyu Pharmaceutical Co., Ltd. |
インドールジオン誘導体
|
|
US8815852B2
(en)
|
2007-05-14 |
2014-08-26 |
Sk Biopharmaceuticals Co., Ltd. |
Carbamoyloxy arylalkan arylpiperazine analgesics
|
|
CN103601792B
(zh)
|
2007-06-04 |
2016-06-29 |
协同医药品公司 |
有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂
|
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
|
CL2008002777A1
(es)
*
|
2007-09-21 |
2010-01-22 |
Wyeth Corp |
Metodo de preparacion de compuestos diazepinoquinolinicos quirales por recristalizacion en un sistema de solvente ternario.
|
|
JP5520051B2
(ja)
|
2007-11-15 |
2014-06-11 |
武田薬品工業株式会社 |
縮合ピリジン誘導体およびその用途
|
|
RU2010126842A
(ru)
|
2007-12-05 |
2012-01-10 |
Астразенека Аб (Se) |
Производные пиперазина и их применение в качестве модуляторов рецептора лептина
|
|
JP5491421B2
(ja)
|
2008-03-04 |
2014-05-14 |
アリーナ ファーマシューティカルズ, インコーポレイテッド |
5−ht2cアゴニストである(r)−8−クロロ−1−メチル−2,3,4,5−テトラヒドロ−1h−3−ベンゾアゼピンに関連する中間体の調製のためのプロセス
|
|
WO2009110510A1
(ja)
|
2008-03-06 |
2009-09-11 |
萬有製薬株式会社 |
アルキルアミノピリジン誘導体
|
|
CA2717384A1
(en)
|
2008-03-28 |
2009-10-01 |
Banyu Pharmaceutical Co., Ltd. |
Diarylmethylamide derivative having melanin-concentrating hormone receptor antagonism
|
|
CA2666036C
(en)
|
2008-05-16 |
2017-09-12 |
Chien-Hung Chen |
Novel compositions and methods for treating hyperproliferative diseases
|
|
CN102245183A
(zh)
*
|
2008-06-04 |
2011-11-16 |
阿斯利康(瑞典)有限公司 |
新化合物v
|
|
AU2009256157B2
(en)
|
2008-06-04 |
2014-12-18 |
Bausch Health Ireland Limited |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
|
US20110071129A1
(en)
|
2008-06-19 |
2011-03-24 |
Makoto Ando |
Spirodiamine-diaryl ketoxime derivative
|
|
ES2624828T3
(es)
|
2008-07-16 |
2017-07-17 |
Synergy Pharmaceuticals Inc. |
Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
|
|
JPWO2010013595A1
(ja)
|
2008-07-30 |
2012-01-12 |
Msd株式会社 |
5員−5員又は5員−6員縮環シクロアルキルアミン誘導体
|
|
MX2011004258A
(es)
|
2008-10-22 |
2011-06-01 |
Merck Sharp & Dohme |
Derivados de bencimidazol ciclicos novedosos utiles como agentes anti-diabeticos.
|
|
BRPI0919876A8
(pt)
|
2008-10-30 |
2016-02-10 |
Merck Sharp & Dohme |
Composto, composição farmacêutica, uso de um composto, e, método para intensificar a qualidade do sono, para tratar insônia, e para tratar ou controlar obesidade em um paciente mamífero que necessita do mesmo.
|
|
CA2741672A1
(en)
|
2008-10-31 |
2010-05-06 |
Merck Sharp & Dohme Corp. |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents
|
|
EP2379562A1
(en)
|
2008-12-16 |
2011-10-26 |
Schering Corporation |
Bicyclic pyranone derivatives as nicotinic acid receptor agonists
|
|
US20110245209A1
(en)
|
2008-12-16 |
2011-10-06 |
Schering Corporation |
Pyridopyrimidine derivatives and methods of use thereof
|
|
WO2010148207A2
(en)
|
2009-06-18 |
2010-12-23 |
Arena Pharmaceuticals, Inc. |
Processes for the preparation of 5-ht2c receptor agonists
|
|
WO2011071136A1
(ja)
|
2009-12-11 |
2011-06-16 |
アステラス製薬株式会社 |
線維筋痛症治療剤
|
|
CA2786314A1
(en)
|
2010-02-25 |
2011-09-01 |
Merck Sharp & Dohme Corp. |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents
|
|
WO2011153206A1
(en)
|
2010-06-02 |
2011-12-08 |
Arena Pharmaceuticals, Inc. |
Processes for the preparation of 5-ht2c receptor agonists
|
|
SG10201506870PA
(en)
|
2010-09-01 |
2015-10-29 |
Arena Pharm Inc |
Salts of lorcaserin with optically active acids
|
|
BR112013004707A2
(pt)
|
2010-09-01 |
2016-05-10 |
Arena Pharm Inc |
administração de um composto antiobesidade a indivíduos com comprometimento renal
|
|
SG188361A1
(en)
|
2010-09-01 |
2013-04-30 |
Arena Pharm Inc |
Non-hygroscopic salts of 5-ht2c agonists
|
|
KR101913442B1
(ko)
|
2010-09-01 |
2018-10-30 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
체중 관리에 유용한 5-ht2c 작동제의 변형-방출 투여 형태
|
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
|
CA2813189C
(en)
*
|
2010-09-29 |
2020-04-28 |
Sk Biopharmaceuticals Co., Ltd. |
Novel methylcyclohexane derivatives and uses thereof
|
|
SG192941A1
(en)
|
2011-02-25 |
2013-09-30 |
Merck Sharp & Dohme |
Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
|
|
MX357121B
(es)
|
2011-03-01 |
2018-06-27 |
Synergy Pharmaceuticals Inc Star |
Proceso de preparacion de agonistas c de guanilato ciclasa.
|
|
AR088352A1
(es)
|
2011-10-19 |
2014-05-28 |
Merck Sharp & Dohme |
Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
|
|
KR20150036245A
(ko)
|
2012-08-02 |
2015-04-07 |
머크 샤프 앤드 돔 코포레이션 |
항당뇨병 트리시클릭 화합물
|
|
US20150297610A1
(en)
|
2012-10-09 |
2015-10-22 |
Arena Pharmaceuticals, Inc. |
Method of weight management
|
|
EP2970119B1
(en)
|
2013-03-14 |
2021-11-03 |
Merck Sharp & Dohme Corp. |
Novel indole derivatives useful as anti-diabetic agents
|
|
WO2014151206A1
(en)
|
2013-03-15 |
2014-09-25 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase and their uses
|
|
US9486494B2
(en)
|
2013-03-15 |
2016-11-08 |
Synergy Pharmaceuticals, Inc. |
Compositions useful for the treatment of gastrointestinal disorders
|
|
CN103265498A
(zh)
*
|
2013-05-14 |
2013-08-28 |
广州科瑞生物技术有限公司 |
反式2,6-二甲基哌嗪的新工艺
|
|
EP4424697A3
(en)
|
2013-06-05 |
2024-12-25 |
Bausch Health Ireland Limited |
Ultra-pure agonists of guanylate cyclase c, method of making and using same
|
|
WO2015066344A1
(en)
|
2013-11-01 |
2015-05-07 |
Arena Pharmaceuticals, Inc. |
5-ht2c receptor agonists and compositions and methods of use
|
|
JP6769963B2
(ja)
|
2014-08-29 |
2020-10-14 |
ティエエッセ ファルマ ソチエタ レスポンサビリタ リミタータ |
α−アミノ−β−カルボキシムコン酸セミアルデヒド脱炭酸酵素の阻害剤
|
|
AU2017342083A1
(en)
|
2016-10-14 |
2019-04-11 |
Tes Pharma S.R.L. |
Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
|
|
WO2019131902A1
(ja)
|
2017-12-27 |
2019-07-04 |
武田薬品工業株式会社 |
腹圧性尿失禁および便失禁の治療薬
|
|
CA3119509A1
(en)
|
2018-11-20 |
2020-05-28 |
Tes Pharma S.R.L |
Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxxylase
|
|
WO2020167706A1
(en)
|
2019-02-13 |
2020-08-20 |
Merck Sharp & Dohme Corp. |
5-alkyl pyrrolidine orexin receptor agonists
|
|
WO2020167701A1
(en)
|
2019-02-13 |
2020-08-20 |
Merck Sharp & Dohme Corp. |
Pyrrolidine orexin receptor agonists
|
|
WO2021026047A1
(en)
|
2019-08-08 |
2021-02-11 |
Merck Sharp & Dohme Corp. |
Heteroaryl pyrrolidine and piperidine orexin receptor agonists
|
|
CN111646949B
(zh)
*
|
2020-06-12 |
2021-03-30 |
上海馨远医药科技有限公司 |
一种2,6-二甲基哌嗪二盐酸盐的制备方法
|
|
PE20231384A1
(es)
|
2020-08-18 |
2023-09-12 |
Merck Sharp And Dohme Llc |
Agonistas de bicicloheptano pirrolidina de los receptores de orexina
|