PE20020667A1 - Derivados de piperazina como ligandos del receptor 5ht2 - Google Patents
Derivados de piperazina como ligandos del receptor 5ht2Info
- Publication number
- PE20020667A1 PE20020667A1 PE2001001247A PE2001001247A PE20020667A1 PE 20020667 A1 PE20020667 A1 PE 20020667A1 PE 2001001247 A PE2001001247 A PE 2001001247A PE 2001001247 A PE2001001247 A PE 2001001247A PE 20020667 A1 PE20020667 A1 PE 20020667A1
- Authority
- PE
- Peru
- Prior art keywords
- aryl
- piperazine
- cycloalkyl
- aralkyl
- alkyl
- Prior art date
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
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- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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Abstract
SE REFIERE A DERIVADOS DE PIPERAZINA DE FORMULA I DONDE R1 Y R2 SON H, ALQUILO, CICLOALQUILO, ARILO, ARALQUILO O FORMAN UN ANILLO CARBOCICLICO DE 3-8 MIEMBROS OPCIONALMENTE SUSTITUIDO POR ALQUILO; R3 Y R4 SON H, ALQUILO, CICLOALQUILO, ARILO, ARALQUILO; A1 ES O, S; A1 ES O, A2 ES FENILO SIN SUSTITUIR UNO DE R1, R2, R3, R4 NO ES H; A2 ES ARILO, HETEROARILO, CICLOALQUILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALQUILO, CICLOALQUILO, ARILO, ARALQUILO, ALCOXILO, ENTRE OTROS; n ES 1-2; m ES 0-1; EXCEPTO EL COMPUESTO ESTER (4-NITROFENIL)-METILICO DEL ACIDO 2 METIL-1-PIPERAZINACARBOXILICO ESTER (4-(TRIFLUOROMETIL)FENIL)METILICO DEL ACIDO 1-PIPERAZINA CARBOXILICO. SON COMPUESTOS PREFERIDOS PIPERAZINA-1-TIOCARBOXILATO DE S-4-[(2-PROPILAMINO)-CARBONIL]OXIBENCILO; PIPERAZINA-1-TIOCARBOXILATO DE S-4-[(BENCILAMINO)-CARBONIL]OXIBENCILO, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. TAMBIEN SE REFIERE AL USO CON UN INHIBIDOR DE LIPASAS COMO ORLISTAT. LOS COMPUESTOS SON LIGANDOS DEL RECEPTOR 5HT2 Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE TRASTORNOS ALIMENTARIOS, DIABETES, SISTEMA NERVIOSO CENTRAL, CARDIOVASCULARES, GASTROINTESTINALES, APNEA DEL SUENO, OBESIDAD
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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GBGB0030710.8A GB0030710D0 (en) | 2000-12-15 | 2000-12-15 | Piperazine derivatives |
Publications (1)
Publication Number | Publication Date |
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PE20020667A1 true PE20020667A1 (es) | 2002-07-27 |
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PE2001001247A PE20020667A1 (es) | 2000-12-15 | 2001-12-13 | Derivados de piperazina como ligandos del receptor 5ht2 |
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DE (1) | DE60134338D1 (es) |
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PA (1) | PA8534801A1 (es) |
PE (1) | PE20020667A1 (es) |
UY (1) | UY27075A1 (es) |
WO (1) | WO2002048124A2 (es) |
ZA (1) | ZA200304346B (es) |
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2000
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2001
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- 2001-12-06 CA CA002430601A patent/CA2430601C/en not_active Expired - Fee Related
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- 2001-12-06 MX MXPA03005270A patent/MXPA03005270A/es unknown
- 2001-12-06 DE DE60134338T patent/DE60134338D1/de not_active Expired - Lifetime
- 2001-12-06 JP JP2002549655A patent/JP4047724B2/ja not_active Expired - Fee Related
- 2001-12-06 AU AU2962602A patent/AU2962602A/xx active Pending
- 2001-12-06 EP EP01990522A patent/EP1343775B1/en not_active Expired - Lifetime
- 2001-12-06 CN CNB018206115A patent/CN1277824C/zh not_active Expired - Fee Related
- 2001-12-06 KR KR1020037008003A patent/KR100623833B1/ko not_active IP Right Cessation
- 2001-12-06 ES ES01990522T patent/ES2306736T3/es not_active Expired - Lifetime
- 2001-12-06 WO PCT/EP2001/014343 patent/WO2002048124A2/en active IP Right Grant
- 2001-12-07 US US10/010,058 patent/US20020143020A1/en not_active Abandoned
- 2001-12-12 AR ARP010105788A patent/AR035517A1/es not_active Application Discontinuation
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- 2001-12-13 PE PE2001001247A patent/PE20020667A1/es not_active Application Discontinuation
- 2001-12-14 UY UY27075A patent/UY27075A1/es not_active Application Discontinuation
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CA2430601A1 (en) | 2002-06-20 |
BR0116201A (pt) | 2004-03-02 |
WO2002048124A3 (en) | 2003-06-05 |
KR100623833B1 (ko) | 2006-09-18 |
EP1343775A2 (en) | 2003-09-17 |
AR035517A1 (es) | 2004-06-02 |
JP4047724B2 (ja) | 2008-02-13 |
WO2002048124A2 (en) | 2002-06-20 |
PA8534801A1 (es) | 2002-08-26 |
DE60134338D1 (de) | 2008-07-17 |
US20040235859A1 (en) | 2004-11-25 |
UY27075A1 (es) | 2002-07-31 |
CN1533382A (zh) | 2004-09-29 |
ES2306736T3 (es) | 2008-11-16 |
EP1343775B1 (en) | 2008-06-04 |
US20020143020A1 (en) | 2002-10-03 |
KR20030072563A (ko) | 2003-09-15 |
MXPA03005270A (es) | 2003-09-25 |
GB0030710D0 (en) | 2001-01-31 |
AU2962602A (en) | 2002-06-24 |
ATE397595T1 (de) | 2008-06-15 |
CA2430601C (en) | 2008-05-06 |
ZA200304346B (en) | 2004-09-03 |
JP2004519438A (ja) | 2004-07-02 |
US7022707B2 (en) | 2006-04-04 |
CN1277824C (zh) | 2006-10-04 |
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