JP2013537887A5 - - Google Patents
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- Publication number
- JP2013537887A5 JP2013537887A5 JP2013527651A JP2013527651A JP2013537887A5 JP 2013537887 A5 JP2013537887 A5 JP 2013537887A5 JP 2013527651 A JP2013527651 A JP 2013527651A JP 2013527651 A JP2013527651 A JP 2013527651A JP 2013537887 A5 JP2013537887 A5 JP 2013537887A5
- Authority
- JP
- Japan
- Prior art keywords
- trpm8
- ethyl
- methyl
- isopropyl
- carboxamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201031341A ES2377785B2 (es) | 2010-09-08 | 2010-09-08 | Composición farmacéutica para el tratamiento del ojo seco. |
| ESP201031341 | 2010-09-08 | ||
| PCT/ES2011/070627 WO2012032209A2 (es) | 2010-09-08 | 2011-09-08 | Composición farmacéutica para el tratamiento del ojo seco |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016190040A Division JP2017036298A (ja) | 2010-09-08 | 2016-09-28 | ドライアイの治療用医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013537887A JP2013537887A (ja) | 2013-10-07 |
| JP2013537887A5 true JP2013537887A5 (enExample) | 2015-08-13 |
Family
ID=45811010
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013527651A Withdrawn JP2013537887A (ja) | 2010-09-08 | 2011-09-08 | ドライアイの治療用医薬組成物 |
| JP2016190040A Withdrawn JP2017036298A (ja) | 2010-09-08 | 2016-09-28 | ドライアイの治療用医薬組成物 |
| JP2019094210A Pending JP2019131621A (ja) | 2010-09-08 | 2019-05-20 | ドライアイの治療用医薬組成物 |
| JP2021068077A Ceased JP2021107422A (ja) | 2010-09-08 | 2021-04-14 | ドライアイの治療用医薬組成物 |
| JP2024039617A Pending JP2024069452A (ja) | 2010-09-08 | 2024-03-14 | ドライアイの治療用医薬組成物 |
| JP2025143562A Pending JP2025172101A (ja) | 2010-09-08 | 2025-08-29 | ドライアイの治療用医薬組成物 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016190040A Withdrawn JP2017036298A (ja) | 2010-09-08 | 2016-09-28 | ドライアイの治療用医薬組成物 |
| JP2019094210A Pending JP2019131621A (ja) | 2010-09-08 | 2019-05-20 | ドライアイの治療用医薬組成物 |
| JP2021068077A Ceased JP2021107422A (ja) | 2010-09-08 | 2021-04-14 | ドライアイの治療用医薬組成物 |
| JP2024039617A Pending JP2024069452A (ja) | 2010-09-08 | 2024-03-14 | ドライアイの治療用医薬組成物 |
| JP2025143562A Pending JP2025172101A (ja) | 2010-09-08 | 2025-08-29 | ドライアイの治療用医薬組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US9095609B2 (enExample) |
| EP (2) | EP4268814A3 (enExample) |
| JP (6) | JP2013537887A (enExample) |
| ES (1) | ES2377785B2 (enExample) |
| WO (1) | WO2012032209A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2377785B2 (es) * | 2010-09-08 | 2012-09-26 | Universidad Miguel Hernández De Elche | Composición farmacéutica para el tratamiento del ojo seco. |
| JP6110124B2 (ja) * | 2012-04-18 | 2017-04-05 | 花王株式会社 | 運動神経活性化用皮膚塗布剤 |
| CN103040976B (zh) * | 2012-12-31 | 2014-01-15 | 刘建贞 | 一种促进面神经损伤外科吻合术后康复的药物 |
| EP3060569B8 (en) * | 2013-10-22 | 2021-11-24 | IVIEW Therapeutics, Inc. | Di-isopropyl-phosphinoyl-alkane (dapa) compounds as topical agents for the treatment of sensory discomfort |
| JP6692162B2 (ja) * | 2014-01-17 | 2020-05-13 | キッセイ薬品工業株式会社 | α−置換グリシンアミド誘導体 |
| US20150290029A1 (en) * | 2014-04-11 | 2015-10-15 | Edward Tak Wei | Delivery Systems for Agents to treat Ocular Discomfort |
| MX2017005046A (es) * | 2014-10-31 | 2017-07-04 | Avent Inc | Metodo y articulos para inhibir las contracciones vesicales. |
| WO2017062570A1 (en) * | 2015-10-06 | 2017-04-13 | Ora, Inc. | Transient receptor potential cation channel subfamily m member 8 (trpm8) antagonists and methods of use |
| EP3184524A1 (en) | 2015-12-21 | 2017-06-28 | Dompé farmaceutici S.p.A. | 4-hydroxy-2-phenyl-1,3-thiazol-5-yl methanone derivatives as trpm8 antagonists |
| ES2625393A1 (es) * | 2016-01-19 | 2017-07-19 | Universidad Miguel Hernandez De Elche | Compuestos agonistas del receptor trpm8 y sus aplicaciones |
| JP2020531473A (ja) * | 2017-08-18 | 2020-11-05 | ザ スケペンス アイ リサーチ インスティテュート,インコーポレイテッド | ドライアイの処置のための組成物およびその使用の方法 |
| EP3781175A1 (en) | 2018-04-18 | 2021-02-24 | i.com Medical GmbH | High molecular weight hyaluronic acid for treatment and prevention of severe ocular surface disease |
| GB201807305D0 (en) * | 2018-05-03 | 2018-06-20 | Nicoventures Trading Ltd | Vaporisable formulation |
| JP6564498B2 (ja) * | 2018-06-06 | 2019-08-21 | エドワード タク ウェイWEI, Edward Tak | 感覚的不快感の治療向け局所薬としてのジ−イソプロピル−アルカン(dapa)化合物 |
| WO2020157570A1 (en) | 2019-01-31 | 2020-08-06 | i.com medical GmbH | Hyaluronic acid for relief of idiopathic ocular pain |
| WO2020160464A1 (en) * | 2019-02-01 | 2020-08-06 | Marshall University Research Corporation | Transient receptor potential melastatin 8 (trpm8) antagonists and related methods |
| WO2021195256A1 (en) * | 2020-03-24 | 2021-09-30 | Aerie Pharmaceuticals, Inc. | Pharmaceutical preparation |
| US20220087997A1 (en) * | 2020-09-22 | 2022-03-24 | Fertin Pharma A/S | Oral Antagonist Compositions For Nicotine Burning Relief |
| WO2022105986A1 (de) * | 2020-11-17 | 2022-05-27 | Symrise Ag | Neue kühlstoffe und zubereitungen, die diese enthalten |
| US12397518B2 (en) * | 2021-04-29 | 2025-08-26 | Coopervision International Limited | WS12-releasing contact lens |
| WO2022257981A1 (zh) * | 2021-06-08 | 2022-12-15 | 广州岐微生物医药科技有限公司 | 化合物在抑制或杀灭螨虫及治疗干眼症中的应用 |
| IL313616A (en) * | 2021-12-17 | 2024-08-01 | Aerie Pharmaceuticals Inc | Ophthalmic pharmaceutical compositions and uses thereof |
| US20230350228A1 (en) | 2022-04-28 | 2023-11-02 | Coopervision International Limited | Contact lens |
| GB2629125B (en) | 2022-10-31 | 2025-06-25 | Coopervision Int Ltd | WS12-releasing contact lens |
| WO2024220876A1 (en) * | 2023-04-19 | 2024-10-24 | Alcon Inc. | N-substituted c6 cyclyl carboxamide compounds and uses thereof |
| TW202534349A (zh) | 2023-10-27 | 2025-09-01 | 英商庫博光學國際有限公司 | 隱形眼鏡 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57179121A (en) | 1981-04-27 | 1982-11-04 | Showa Kagaku Kogyo Kk | Remedy for oculopathy |
| US4902505A (en) | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US4904582A (en) | 1987-06-11 | 1990-02-27 | Synthetic Genetics | Novel amphiphilic nucleic acid conjugates |
| US5176996A (en) | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
| US5256775A (en) | 1989-06-05 | 1993-10-26 | Gilead Sciences, Inc. | Exonuclease-resistant oligonucleotides |
| US5264564A (en) | 1989-10-24 | 1993-11-23 | Gilead Sciences | Oligonucleotide analogs with novel linkages |
| JPH1067684A (ja) * | 1996-06-17 | 1998-03-10 | Mitsubishi Chem Corp | 涙液分泌促進剤 |
| HUP9904697A3 (en) | 1996-10-11 | 2001-06-28 | Bristol Myers Squibb Company P | Methods and compositions for immunomodulation |
| CN1199617A (zh) | 1996-12-18 | 1998-11-25 | 虎发光 | 一种治疗眼病的中成药 |
| JPH10236972A (ja) * | 1997-02-28 | 1998-09-08 | Mitsubishi Chem Corp | 涙液分泌促進剤 |
| JP4591728B2 (ja) * | 1998-12-28 | 2010-12-01 | 大正製薬株式会社 | 眼精疲労改善用点眼剤 |
| JP3142842B1 (ja) * | 1999-10-22 | 2001-03-07 | ライオン株式会社 | 眼科用組成物及びソフトコンタクトレンズへの吸着抑制方法 |
| AU1731101A (en) * | 1999-12-07 | 2001-06-18 | Rohto Pharmaceutical Co., Ltd. | Ophthalmic compositions |
| US7651686B2 (en) | 2001-10-09 | 2010-01-26 | Mayo Foundation For Medical Education And Research | Enhancement of immune responses by 4-1bb-binding agents |
| WO2003064602A2 (en) * | 2002-01-25 | 2003-08-07 | The Regents Of The University Of California | Methods of modulating cold sensory perception |
| US6919348B2 (en) * | 2002-05-02 | 2005-07-19 | Edward T. Wei | Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith |
| BR0311337A (pt) | 2002-05-28 | 2005-03-15 | Altana Pharma Ag | Uso oftalmológico de roflumilast para o tratamento de doenças do olho |
| JP2005536511A (ja) | 2002-07-15 | 2005-12-02 | マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ | 4−1bb結合物質を用いる治療及び予防 |
| EP1539237A4 (en) | 2002-07-30 | 2006-05-24 | Bristol Myers Squibb Co | HUMANIZED ANTIBODIES AGAINST HUMAN 4-1BB |
| IL152486A0 (en) * | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
| DE10259619A1 (de) * | 2002-12-18 | 2004-07-08 | Metagen Pharmaceuticals Gmbh | Verwendung einer TRPM8 aktivierenden Substanz zur Tumorbehandlung |
| JP4601265B2 (ja) * | 2003-05-14 | 2010-12-22 | ロート製薬株式会社 | 局所適用製剤 |
| CA2530884C (en) * | 2003-07-02 | 2016-01-12 | Genentech, Inc. | Trp-p8 active compounds and therapeutic treatment methods |
| CN1565501A (zh) | 2003-07-08 | 2005-01-19 | 毛友昌 | 明目地黄新的制备工艺及其制剂 |
| US20050137166A1 (en) * | 2003-12-19 | 2005-06-23 | Alcon, Inc. | Use of cooling agents to relieve mild ocular irritation and enhance comfort |
| WO2006040136A1 (en) | 2004-10-13 | 2006-04-20 | Bayer Healthcare Ag | Substituted 4-benzyloxy-phenylmethylamide derivatives as cold menthol receptor-1 (cmr-1) antagonists for the treatment of urological disorder |
| WO2006062731A1 (en) * | 2004-11-19 | 2006-06-15 | University Of North Texas Health Science Center At Fort Worth | Phenanthroline and derivatives thereof used to lower intraocular pressure in an affected eye |
| JP5078254B2 (ja) * | 2004-12-17 | 2012-11-21 | ロート製薬株式会社 | 眼科用組成物 |
| EP2399935A3 (en) | 2005-02-15 | 2012-02-22 | GTC Biotherapeutics, Inc. | An anti-CD137 antibody as an agent in the treatment of cancer and glycosylation variants thereof |
| GB0504194D0 (en) * | 2005-03-02 | 2005-04-06 | Givaudan Sa | Organic compounds |
| WO2007017092A1 (en) | 2005-08-04 | 2007-02-15 | Bayer Healthcare Ag | Substituted 4-benzyloxy-benzoic acid amide derivatives |
| CN1775261A (zh) | 2005-11-18 | 2006-05-24 | 北京阜康仁生物制药科技有限公司 | 明目地黄制剂及新的制备方法 |
| CN1775263A (zh) | 2005-11-18 | 2006-05-24 | 北京阜康仁生物制药科技有限公司 | 杞菊地黄制剂及新的制备方法 |
| US7727516B2 (en) * | 2006-02-28 | 2010-06-01 | The Procter & Gamble Company | Reduction of hair growth |
| RU2305517C1 (ru) | 2006-03-09 | 2007-09-10 | Сергей Васильевич Широков | Способ лечения эпифоры |
| WO2007108541A1 (ja) * | 2006-03-23 | 2007-09-27 | Senju Pharmaceutical Co., Ltd. | キサンタンガムおよびブドウ糖を含有する眼科用組成物 |
| WO2008066644A1 (en) | 2006-11-02 | 2008-06-05 | Riolan Technologies, Inc. | Methods of treating epiphora |
| GB2451503B (en) * | 2007-08-01 | 2011-10-12 | Lrc Products | Stimulating gel comprising a cyclic carboxamide coolant |
| CN101612199A (zh) | 2008-06-28 | 2009-12-30 | 孙斌 | 治疗眼睛红肿和遇风流泪的冲洗液 |
| FR2934778B1 (fr) * | 2008-08-11 | 2012-09-28 | Natura Cosmeticos Sa | Compositions d'anti-transpirants et procedes permettant de reduire la transpiration chez les humains |
| US8653099B2 (en) * | 2008-08-19 | 2014-02-18 | Janssen Pharmaceutica | Cold menthol receptor antagonists |
| ES2377785B2 (es) * | 2010-09-08 | 2012-09-26 | Universidad Miguel Hernández De Elche | Composición farmacéutica para el tratamiento del ojo seco. |
-
2010
- 2010-09-08 ES ES201031341A patent/ES2377785B2/es active Active
-
2011
- 2011-09-08 US US13/821,840 patent/US9095609B2/en active Active
- 2011-09-08 WO PCT/ES2011/070627 patent/WO2012032209A2/es not_active Ceased
- 2011-09-08 EP EP23183121.5A patent/EP4268814A3/en active Pending
- 2011-09-08 JP JP2013527651A patent/JP2013537887A/ja not_active Withdrawn
- 2011-09-08 EP EP11823113.3A patent/EP2614860A4/en not_active Ceased
-
2015
- 2015-04-29 US US14/699,873 patent/US9433679B2/en active Active
-
2016
- 2016-08-03 US US15/227,436 patent/US9901549B2/en active Active
- 2016-09-28 JP JP2016190040A patent/JP2017036298A/ja not_active Withdrawn
- 2016-11-14 US US15/350,938 patent/US10028920B2/en active Active
-
2019
- 2019-05-20 JP JP2019094210A patent/JP2019131621A/ja active Pending
-
2021
- 2021-04-14 JP JP2021068077A patent/JP2021107422A/ja not_active Ceased
-
2024
- 2024-03-14 JP JP2024039617A patent/JP2024069452A/ja active Pending
-
2025
- 2025-08-29 JP JP2025143562A patent/JP2025172101A/ja active Pending
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