JP2010534676A5 - - Google Patents
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- JP2010534676A5 JP2010534676A5 JP2010518369A JP2010518369A JP2010534676A5 JP 2010534676 A5 JP2010534676 A5 JP 2010534676A5 JP 2010518369 A JP2010518369 A JP 2010518369A JP 2010518369 A JP2010518369 A JP 2010518369A JP 2010534676 A5 JP2010534676 A5 JP 2010534676A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- post
- patient
- traumatic stress
- stress disorder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940126062 Compound A Drugs 0.000 claims 19
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 19
- 208000028173 post-traumatic stress disease Diseases 0.000 claims 12
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 10
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 8
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 8
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 208000024891 symptom Diseases 0.000 claims 6
- 229940121991 Serotonin and norepinephrine reuptake inhibitor Drugs 0.000 claims 5
- 239000005557 antagonist Substances 0.000 claims 5
- 239000002767 noradrenalin uptake inhibitor Substances 0.000 claims 5
- 229940127221 norepinephrine reuptake inhibitor Drugs 0.000 claims 5
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 claims 5
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 claims 5
- 239000003775 serotonin noradrenalin reuptake inhibitor Substances 0.000 claims 5
- 208000011580 syndromic disease Diseases 0.000 claims 5
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 claims 4
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 claims 4
- 102000012289 Corticotropin-Releasing Hormone Human genes 0.000 claims 4
- 108010022152 Corticotropin-Releasing Hormone Proteins 0.000 claims 4
- 108010015720 Dopamine beta-Hydroxylase Proteins 0.000 claims 4
- 102100033156 Dopamine beta-hydroxylase Human genes 0.000 claims 4
- 229940123685 Monoamine oxidase inhibitor Drugs 0.000 claims 4
- 239000000674 adrenergic antagonist Substances 0.000 claims 4
- 239000000556 agonist Substances 0.000 claims 4
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 4
- 239000002899 monoamine oxidase inhibitor Substances 0.000 claims 4
- 230000002093 peripheral effect Effects 0.000 claims 4
- 239000011734 sodium Substances 0.000 claims 4
- 210000004556 brain Anatomy 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- YZZVIKDAOTXDEB-JTQLQIEISA-N nepicastat Chemical compound NCC1=CNC(=S)N1[C@@H]1CC2=CC(F)=CC(F)=C2CC1 YZZVIKDAOTXDEB-JTQLQIEISA-N 0.000 claims 3
- 229950005868 nepicastat Drugs 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- -1 5,7-difluoro-1,2,3,4-tetrahydronaphth-2-yl Chemical group 0.000 claims 2
- 229940123702 Adenosine A2a receptor antagonist Drugs 0.000 claims 2
- 229940127291 Calcium channel antagonist Drugs 0.000 claims 2
- 108091006146 Channels Proteins 0.000 claims 2
- 229940122439 Hydroxylase inhibitor Drugs 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 2
- 108010040718 Neurokinin-1 Receptors Proteins 0.000 claims 2
- 102100037346 Substance-P receptor Human genes 0.000 claims 2
- 229940123445 Tricyclic antidepressant Drugs 0.000 claims 2
- 239000002467 adenosine A2a receptor antagonist Substances 0.000 claims 2
- 239000000695 adrenergic alpha-agonist Substances 0.000 claims 2
- 102000004305 alpha Adrenergic Receptors Human genes 0.000 claims 2
- 108090000861 alpha Adrenergic Receptors Proteins 0.000 claims 2
- 230000001773 anti-convulsant effect Effects 0.000 claims 2
- 230000001430 anti-depressive effect Effects 0.000 claims 2
- 230000000561 anti-psychotic effect Effects 0.000 claims 2
- 239000001961 anticonvulsive agent Substances 0.000 claims 2
- 239000000935 antidepressant agent Substances 0.000 claims 2
- 229940005513 antidepressants Drugs 0.000 claims 2
- 229960003965 antiepileptics Drugs 0.000 claims 2
- 102000012740 beta Adrenergic Receptors Human genes 0.000 claims 2
- 108010079452 beta Adrenergic Receptors Proteins 0.000 claims 2
- 239000000480 calcium channel blocker Substances 0.000 claims 2
- 150000003943 catecholamines Chemical class 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- AUZONCFQVSMFAP-UHFFFAOYSA-N disulfiram Chemical compound CCN(CC)C(=S)SSC(=S)N(CC)CC AUZONCFQVSMFAP-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000002464 receptor antagonist Substances 0.000 claims 2
- 229940044551 receptor antagonist Drugs 0.000 claims 2
- 229940076279 serotonin Drugs 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- 239000003029 tricyclic antidepressant agent Substances 0.000 claims 2
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 claims 1
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 claims 1
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 claims 1
- ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 claims 1
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims 1
- 208000007848 Alcoholism Diseases 0.000 claims 1
- 206010013654 Drug abuse Diseases 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- 206010029412 Nightmare Diseases 0.000 claims 1
- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 206010001584 alcohol abuse Diseases 0.000 claims 1
- 208000025746 alcohol use disease Diseases 0.000 claims 1
- 229960002430 atomoxetine Drugs 0.000 claims 1
- VHGCDTVCOLNTBX-QGZVFWFLSA-N atomoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=CC=C1C VHGCDTVCOLNTBX-QGZVFWFLSA-N 0.000 claims 1
- 229940049706 benzodiazepine Drugs 0.000 claims 1
- 229960001058 bupropion Drugs 0.000 claims 1
- SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical group CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 claims 1
- 229960001653 citalopram Drugs 0.000 claims 1
- 229960002563 disulfiram Drugs 0.000 claims 1
- 229960002866 duloxetine Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 229960002464 fluoxetine Drugs 0.000 claims 1
- 229930195712 glutamate Natural products 0.000 claims 1
- 229940049906 glutamate Drugs 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 230000009545 invasion Effects 0.000 claims 1
- 230000007595 memory recall Effects 0.000 claims 1
- 229960001785 mirtazapine Drugs 0.000 claims 1
- RONZAEMNMFQXRA-UHFFFAOYSA-N mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 claims 1
- 229960002296 paroxetine Drugs 0.000 claims 1
- 230000003252 repetitive effect Effects 0.000 claims 1
- 229960002073 sertraline Drugs 0.000 claims 1
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 230000000472 traumatic effect Effects 0.000 claims 1
- 229960004688 venlafaxine Drugs 0.000 claims 1
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93503607P | 2007-07-23 | 2007-07-23 | |
| PCT/US2008/070948 WO2009015248A1 (en) | 2007-07-23 | 2008-07-23 | Treatment of post-traumatic stress disorder |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010534676A JP2010534676A (ja) | 2010-11-11 |
| JP2010534676A5 true JP2010534676A5 (enExample) | 2011-08-18 |
Family
ID=40281815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010518369A Pending JP2010534676A (ja) | 2007-07-23 | 2008-07-23 | 心的外傷後ストレス障害の治療 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20090054403A1 (enExample) |
| EP (1) | EP2182952A4 (enExample) |
| JP (1) | JP2010534676A (enExample) |
| CN (1) | CN101951912A (enExample) |
| AU (1) | AU2008279091A1 (enExample) |
| CA (1) | CA2707858A1 (enExample) |
| CO (1) | CO6260078A2 (enExample) |
| MX (1) | MX2010000937A (enExample) |
| NZ (1) | NZ583193A (enExample) |
| RU (1) | RU2458691C2 (enExample) |
| SG (1) | SG183069A1 (enExample) |
| WO (1) | WO2009015248A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009015236A1 (en) * | 2007-07-23 | 2009-01-29 | Synosia Therapeutics | 4-hydroxy-4-methyl-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide for the treatment of post-traumatic stress disorder |
| AU2016208412A1 (en) * | 2007-08-06 | 2016-08-18 | Biotie Therapies, Inc. | Methods for treating dependence |
| MX391921B (es) * | 2007-08-06 | 2025-03-21 | Biotie Therapies Inc | Nepicastat para usarse en el tratamiento de dependencia |
| WO2011062614A1 (en) * | 2009-11-20 | 2011-05-26 | Tonix Pharmaceuticals, Inc. | Methods and compositions for treating symptoms associated with post-traumatic stress disorder using cyclobenzaprine |
| US20110319389A1 (en) | 2010-06-24 | 2011-12-29 | Tonix Pharmaceuticals, Inc. | Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine |
| US11998516B2 (en) | 2011-03-07 | 2024-06-04 | Tonix Pharma Holdings Limited | Methods and compositions for treating depression using cyclobenzaprine |
| HRP20200055T1 (hr) | 2013-03-15 | 2020-04-03 | Tonix Pharma Holdings Limited | Eutektičke formulacije ciklobenzaprin-klorovodika i manitola |
| JP6364488B2 (ja) * | 2013-11-26 | 2018-07-25 | ユニバーシティー オブ ノース テキサス ヘルス サイエンス センター アット フォートワースＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｎｏｒｔｈ Ｔｅｘａｓ Ｈｅａｌｔｈ Ｓｃｉｅｎｃｅ Ｃｅｎｔｅｒ Ａｔ Ｆｏｒｔ Ｗｏｒｔｈ | 認知欠損を治療するための個別化医療的手法 |
| JP6614724B2 (ja) | 2014-09-18 | 2019-12-04 | トニックス ファーマ ホールディングス リミテッド | シクロベンザプリン塩酸塩の共融製剤 |
| RU2614697C1 (ru) * | 2016-04-12 | 2017-03-28 | Общество с ограниченной ответственностью "Нормофарм" | Нейропротекторное средство |
| JOP20190049A1 (ar) | 2016-09-23 | 2019-03-20 | Bial Portela & C? S A | مثبطات دوبامين-b-هيدروكسيلاز |
| US10588890B2 (en) * | 2017-05-30 | 2020-03-17 | Biommunity, Inc. | Compositions and methods to regulate hormonal cascades in stress disorders |
| US11284934B2 (en) * | 2017-07-05 | 2022-03-29 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for treating sleep disorders in patients via renal neuromodulation |
| EP3720856A1 (en) | 2017-12-04 | 2020-10-14 | BIAL - PORTELA & Cª, S.A. | Dopamine-& x392;-hydroxylase inhibitors |
| JP2021505629A (ja) | 2017-12-11 | 2021-02-18 | トニックス ファーマ ホールディングス リミテッド | 認知症および神経変性状態における興奮、精神病および認知機能低下のためのシクロベンザプリン処置 |
| CN109966281B (zh) * | 2019-04-11 | 2021-04-27 | 北京大学 | PAO作为Pi4KIIα抑制剂在制备治疗创伤后应激障碍药物中的应用 |
| US20220313647A1 (en) * | 2019-07-25 | 2022-10-06 | Tokyo University Of Science Foundation | Agent for treating, preventing or improving psychiatric and nervous system disorders or symptoms |
| KR20250116086A (ko) * | 2022-11-30 | 2025-07-31 | 블링크랩 리미티드 | 안검 추적을 이용한 정신약리학적 시스템 및 방법 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6391922B1 (en) * | 1998-01-13 | 2002-05-21 | Synchroneuron, Llc | Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders |
| EP1425017A1 (en) * | 2001-09-13 | 2004-06-09 | Schering Corporation | Combination of an adenosine a2a receptor antagonist and an antidepressant or anxiolytic |
| EP1336406A1 (en) * | 2002-02-14 | 2003-08-20 | Solvay Pharmaceuticals B.V. | Partial dopamine-D2 receptor agonist plus serotonin and/or noradrenaline inhibitory activity |
| CA2483093A1 (en) * | 2002-04-24 | 2003-11-06 | Cypress Bioscience, Inc. | Use of milnacipran or a pharmaceutically acceptable salt thereof for treating chronic low back pain |
| US20050209218A1 (en) * | 2004-02-13 | 2005-09-22 | Meyerson Laurence R | Methods and compositions for the treatment of psychiatric conditions |
| JP2008531714A (ja) * | 2005-03-04 | 2008-08-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 不安障害の治療用及び／又は予防用の医薬組成物 |
| EP1898915A4 (en) * | 2005-07-06 | 2009-01-21 | Sepracor Inc | COMBINATIONS OF ESZOPICLON AND ANTIDEPRESSIVE |
| AU2008229203B2 (en) * | 2007-03-16 | 2014-05-29 | Emory University | Methods and compositions for treatment of drug addiction |
| WO2009015244A1 (en) * | 2007-07-23 | 2009-01-29 | Synosia Therapeutics | Rufinamide for the treatment of post-traumatic stress disorder |
-
2008
- 2008-07-23 AU AU2008279091A patent/AU2008279091A1/en not_active Abandoned
- 2008-07-23 WO PCT/US2008/070948 patent/WO2009015248A1/en not_active Ceased
- 2008-07-23 CA CA2707858A patent/CA2707858A1/en not_active Abandoned
- 2008-07-23 EP EP08796518A patent/EP2182952A4/en not_active Withdrawn
- 2008-07-23 US US12/178,513 patent/US20090054403A1/en not_active Abandoned
- 2008-07-23 CN CN200880108123XA patent/CN101951912A/zh active Pending
- 2008-07-23 JP JP2010518369A patent/JP2010534676A/ja active Pending
- 2008-07-23 SG SG2012054540A patent/SG183069A1/en unknown
- 2008-07-23 MX MX2010000937A patent/MX2010000937A/es not_active Application Discontinuation
- 2008-07-23 RU RU2010106014/15A patent/RU2458691C2/ru not_active IP Right Cessation
- 2008-07-23 NZ NZ583193A patent/NZ583193A/en not_active IP Right Cessation
-
2010
- 2010-02-19 CO CO10019664A patent/CO6260078A2/es not_active Application Discontinuation
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