JP2009542820A5 - - Google Patents
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- Publication number
- JP2009542820A5 JP2009542820A5 JP2009530701A JP2009530701A JP2009542820A5 JP 2009542820 A5 JP2009542820 A5 JP 2009542820A5 JP 2009530701 A JP2009530701 A JP 2009530701A JP 2009530701 A JP2009530701 A JP 2009530701A JP 2009542820 A5 JP2009542820 A5 JP 2009542820A5
- Authority
- JP
- Japan
- Prior art keywords
- combination
- selective antagonist
- antidepressant
- selective
- telenzepine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000005557 antagonist Substances 0.000 claims description 41
- 239000000935 antidepressant agent Substances 0.000 claims description 27
- 229940005513 antidepressants Drugs 0.000 claims description 27
- 230000001430 anti-depressive effect Effects 0.000 claims description 24
- VSWPGAIWKHPTKX-UHFFFAOYSA-N 1-methyl-10-[2-(4-methyl-1-piperazinyl)-1-oxoethyl]-5H-thieno[3,4-b][1,5]benzodiazepin-4-one Chemical compound C1CN(C)CCN1CC(=O)N1C2=CC=CC=C2NC(=O)C2=CSC(C)=C21 VSWPGAIWKHPTKX-UHFFFAOYSA-N 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 15
- 229950004351 telenzepine Drugs 0.000 claims description 15
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 claims description 14
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 claims description 14
- 239000003775 serotonin noradrenalin reuptake inhibitor Substances 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 230000004580 weight loss Effects 0.000 claims description 10
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 claims description 8
- 229940121991 Serotonin and norepinephrine reuptake inhibitor Drugs 0.000 claims description 8
- 229960001653 citalopram Drugs 0.000 claims description 8
- 229960002073 sertraline Drugs 0.000 claims description 8
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 claims description 8
- 229960004688 venlafaxine Drugs 0.000 claims description 8
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 230000001737 promoting effect Effects 0.000 claims description 5
- 239000000883 anti-obesity agent Substances 0.000 claims description 4
- 229940125710 antiobesity agent Drugs 0.000 claims description 4
- 239000000221 dopamine uptake inhibitor Substances 0.000 claims description 4
- 238000012423 maintenance Methods 0.000 claims description 4
- 230000036528 appetite Effects 0.000 claims description 3
- 235000019789 appetite Nutrition 0.000 claims description 3
- 230000037396 body weight Effects 0.000 claims description 3
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 claims description 2
- GJJFMKBJSRMPLA-HIFRSBDPSA-N (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenyl-1-cyclopropanecarboxamide Chemical compound C=1C=CC=CC=1[C@@]1(C(=O)N(CC)CC)C[C@@H]1CN GJJFMKBJSRMPLA-HIFRSBDPSA-N 0.000 claims description 2
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 claims description 2
- ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 claims description 2
- 229940123685 Monoamine oxidase inhibitor Drugs 0.000 claims description 2
- KYYIDSXMWOZKMP-UHFFFAOYSA-N O-desmethylvenlafaxine Chemical compound C1CCCCC1(O)C(CN(C)C)C1=CC=C(O)C=C1 KYYIDSXMWOZKMP-UHFFFAOYSA-N 0.000 claims description 2
- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 claims description 2
- 229940123445 Tricyclic antidepressant Drugs 0.000 claims description 2
- 229960001623 desvenlafaxine Drugs 0.000 claims description 2
- 229960002866 duloxetine Drugs 0.000 claims description 2
- -1 ecitalopram Chemical compound 0.000 claims description 2
- 229960002464 fluoxetine Drugs 0.000 claims description 2
- 229960004038 fluvoxamine Drugs 0.000 claims description 2
- CJOFXWAVKWHTFT-XSFVSMFZSA-N fluvoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 CJOFXWAVKWHTFT-XSFVSMFZSA-N 0.000 claims description 2
- 229960000600 milnacipran Drugs 0.000 claims description 2
- 229960001785 mirtazapine Drugs 0.000 claims description 2
- RONZAEMNMFQXRA-UHFFFAOYSA-N mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 claims description 2
- 239000002899 monoamine oxidase inhibitor Substances 0.000 claims description 2
- 239000002767 noradrenalin uptake inhibitor Substances 0.000 claims description 2
- 229940127221 norepinephrine reuptake inhibitor Drugs 0.000 claims description 2
- 229960002296 paroxetine Drugs 0.000 claims description 2
- RMHMFHUVIITRHF-UHFFFAOYSA-N pirenzepine Chemical compound C1CN(C)CCN1CC(=O)N1C2=NC=CC=C2NC(=O)C2=CC=CC=C21 RMHMFHUVIITRHF-UHFFFAOYSA-N 0.000 claims description 2
- 229960004633 pirenzepine Drugs 0.000 claims description 2
- 229940002612 prodrug Drugs 0.000 claims description 2
- 239000000651 prodrug Substances 0.000 claims description 2
- 239000000952 serotonin receptor agonist Substances 0.000 claims description 2
- 230000000697 serotonin reuptake Effects 0.000 claims description 2
- 239000003772 serotonin uptake inhibitor Substances 0.000 claims description 2
- 229960004425 sibutramine Drugs 0.000 claims description 2
- UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical compound C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 claims description 2
- 239000003029 tricyclic antidepressant agent Substances 0.000 claims description 2
- 239000003174 triple reuptake inhibitor Substances 0.000 claims description 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims 2
- 229940094659 Dopamine reuptake inhibitor Drugs 0.000 claims 1
- 229940111055 Serotonin-norepinephrine-dopamine reuptake inhibitor Drugs 0.000 claims 1
- 230000008485 antagonism Effects 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 229960002748 norepinephrine Drugs 0.000 claims 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 claims 1
- 229940053544 other antidepressants in atc Drugs 0.000 claims 1
- 229940076279 serotonin Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 description 20
- 230000002195 synergetic effect Effects 0.000 description 3
- 206010033307 Overweight Diseases 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80506606P | 2006-06-16 | 2006-06-16 | |
| US60/805,066 | 2006-06-16 | ||
| US82922506P | 2006-10-12 | 2006-10-12 | |
| US60/829,225 | 2006-10-12 | ||
| US11/763,313 US8748419B2 (en) | 2006-06-16 | 2007-06-14 | Treating obesity with muscarinic receptor M1 antagonists |
| US11/763,313 | 2007-06-14 | ||
| PCT/US2007/071374 WO2007147134A2 (en) | 2006-06-16 | 2007-06-15 | Treating obesity with muscarinic receptor m1 antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013001003A Division JP2013079277A (ja) | 2006-06-16 | 2013-01-08 | ムスカリン性受容体ｍ１拮抗薬による肥満の処置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009542820A JP2009542820A (ja) | 2009-12-03 |
| JP2009542820A5 true JP2009542820A5 (enExample) | 2011-07-14 |
| JP5371762B2 JP5371762B2 (ja) | 2013-12-18 |
Family
ID=38832915
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009530701A Expired - Fee Related JP5371762B2 (ja) | 2006-06-16 | 2007-06-15 | ムスカリン性受容体ｍ１拮抗薬による肥満の処置 |
| JP2013001003A Withdrawn JP2013079277A (ja) | 2006-06-16 | 2013-01-08 | ムスカリン性受容体ｍ１拮抗薬による肥満の処置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013001003A Withdrawn JP2013079277A (ja) | 2006-06-16 | 2013-01-08 | ムスカリン性受容体ｍ１拮抗薬による肥満の処置 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8748419B2 (enExample) |
| EP (1) | EP2031964B1 (enExample) |
| JP (2) | JP5371762B2 (enExample) |
| KR (1) | KR101442525B1 (enExample) |
| AU (1) | AU2007260642B2 (enExample) |
| BR (1) | BRPI0713728A2 (enExample) |
| CA (1) | CA2655323C (enExample) |
| IL (1) | IL195858A (enExample) |
| MX (1) | MX2008015886A (enExample) |
| NZ (1) | NZ573571A (enExample) |
| SG (1) | SG172711A1 (enExample) |
| WO (1) | WO2007147134A2 (enExample) |
| ZA (1) | ZA200810681B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110021507A1 (en) * | 2009-07-22 | 2011-01-27 | Theracos, Inc. | Inhibiting antipsychotic-induced weight gain |
| WO2011163231A2 (en) * | 2010-06-21 | 2011-12-29 | Theracos, Inc. | Combination therapy for the treatment of diabetes |
| PL2632468T3 (pl) * | 2010-10-25 | 2018-04-30 | University Of Manitoba | Kompozycje terapeutyczne do leczenia symetrycznej polineuropatii cukrzycowej |
| WO2013151596A2 (en) * | 2012-04-05 | 2013-10-10 | Finch Linda Duerler | System and method of losing weight |
| WO2017158355A1 (en) | 2016-03-15 | 2017-09-21 | Queen Mary University Of London | Method of treatment of obesity |
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| DE1795183B1 (de) | 1968-08-20 | 1972-07-20 | Thomae Gmbh Dr K | 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-on-derivate und Arzneimittel |
| US4172831A (en) | 1974-11-26 | 1979-10-30 | Lilly Industries Limited | Thieno-benzodiazepines |
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| US4933438A (en) | 1984-02-29 | 1990-06-12 | University Of Florida | Brain-specific analogues of centrally acting amines |
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| EP0386145A1 (de) | 1987-12-22 | 1990-09-12 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Thienotricyclen zur behandlung von erkrankungen der bronchien |
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-
2007
- 2007-06-14 US US11/763,313 patent/US8748419B2/en not_active Expired - Fee Related
- 2007-06-15 AU AU2007260642A patent/AU2007260642B2/en not_active Ceased
- 2007-06-15 CA CA2655323A patent/CA2655323C/en not_active Expired - Fee Related
- 2007-06-15 WO PCT/US2007/071374 patent/WO2007147134A2/en not_active Ceased
- 2007-06-15 JP JP2009530701A patent/JP5371762B2/ja not_active Expired - Fee Related
- 2007-06-15 NZ NZ573571A patent/NZ573571A/en not_active IP Right Cessation
- 2007-06-15 KR KR1020097000755A patent/KR101442525B1/ko not_active Expired - Fee Related
- 2007-06-15 BR BRPI0713728-1A patent/BRPI0713728A2/pt not_active IP Right Cessation
- 2007-06-15 EP EP07812168.8A patent/EP2031964B1/en not_active Not-in-force
- 2007-06-15 SG SG2011043874A patent/SG172711A1/en unknown
- 2007-06-15 MX MX2008015886A patent/MX2008015886A/es active IP Right Grant
-
2008
- 2008-12-11 IL IL195858A patent/IL195858A/en active IP Right Grant
- 2008-12-18 ZA ZA2008/10681A patent/ZA200810681B/en unknown
-
2013
- 2013-01-08 JP JP2013001003A patent/JP2013079277A/ja not_active Withdrawn
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