RU2019143572A - Композиции для лечения посттравматического стрессового расстройства - Google Patents
Композиции для лечения посттравматического стрессового расстройства Download PDFInfo
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- RU2019143572A RU2019143572A RU2019143572A RU2019143572A RU2019143572A RU 2019143572 A RU2019143572 A RU 2019143572A RU 2019143572 A RU2019143572 A RU 2019143572A RU 2019143572 A RU2019143572 A RU 2019143572A RU 2019143572 A RU2019143572 A RU 2019143572A
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- antagonist
- antidepressant
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- 239000000203 mixture Substances 0.000 title claims 20
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- 239000005557 antagonist Substances 0.000 claims 16
- 239000000935 antidepressant agent Substances 0.000 claims 11
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Claims (19)
1. Композиция для применения для лечения посттравматического стрессового расстройства (PTSD) или его симптомов, содержащая терапевтически эффективное количество антагониста глицинового сайта NMDAR.
2. Композиция для применения для лечения PTSD или его симптомов, содержащая антагонист глицинового сайта NMDAR и антидепрессант или антипсихотический агент.
3. Композиция по п. 1 или 2, отличающаяся тем, что антагонист NMDAR представляет собой конкурентный антагонист NMDAR.
4. Композиция по п. 1 или 2, отличающаяся тем, что антагонист NMDAR представляет собой антагонист на сайте распознавания глицина, глутамата или редокс/полиамина.
5. Композиция по п. 1 или 2, отличающаяся тем, что антагонист NMDAR представляет собой неселективный антагонист или селективный антагонист у NMDAR, содержащего специфические субъединицы NR2A или NR2B.
6. Композиция по п. 1 или 2, отличающаяся тем, что антагонист NMDAR представляет собой D-циклосерин, который вводят в дозе от ≥500 мг/сутки до ≤1000 мг/сутки, и составлен так, чтобы обеспечивать содержание в крови более 25 микрограмм (мкг)/мл.
7. Композиция по п. 1 или 2, отличающаяся тем, что антагонист глицинового сайта NMDAR выбран из группы, состоящей из гавестинела, рапастинела и D-циклосерина, составленного так, чтобы обеспечивать концентрации в плазме более 25 мкг/мл.
8. Композиция по п. 2, отличающаяся тем, что антидепрессант выбран из группы, состоящей из тетрациклинового антидепрессанта (TeCA), селективного ингибитора обратного захвата серотонина (SSRI), ингибитора обратного захвата серотонина/норэпинефрина (SNRI), норадренергического и специфического серотонинергического агента (NaSSa), атипичного антидепрессанта, антагониста 5-HT2A и их комбинаций.
9. Композиция по п. 2, отличающаяся тем, что антидепрессант или антипсихотический агент выбран из группы, состоящей из сертралина, пароксетина и кветиапина.
10. Композиция по п. 2, отличающаяся тем, что антидепрессант выбран из группы, состоящей из имипрамина, амитриптилина, амоксапина, бупропиона, циталопрама, кломипрамина, дезипрамина, дезвенлафаксина, дулоксетина, эскиталопрама, флуоксетина, флувоксамина, левомилнаципрана, мапротилина, миансерина, милнаципрана, миртазапина, нефазодона, пароксетина, сертралина, сетиптилина, тразодона, венлафаксина, венлафаксина XR, дапоксетина, индалпина, вилазодона и вортиоксетина.
11. Композиция по п. 2, отличающаяся тем, что антидепрессант выбран из группы, состоящей из S-(+)-миртазапина, R-(-)-миртазапина и их рацемической смеси.
12. Композиция по п. 2, отличающаяся тем, что антидепрессант или антипсихотический агент представляет собой селективный антагонист или обратный агонист рецептора 5-HT2A.
13. Композиция по п. 2, отличающаяся тем, что антидепрессант или антипсихотический агент выбран из группы, состоящей из волинансерина (MDL100,907, также известного как M100907), прувансерина (EMD281014), эпливансерина (SR-46349, Citryri), CYR-101 и пимавансерина (ACP-103).
14. Композиция по п. 2, отличающаяся тем, что антидепрессант или антипсихотический агент выбран из группы, состоящей из агомелатина, Lu AA21004, F2695, SEP-227162, LuAA24530, SEP-225289, эпливансерина, SR46349, LY12624803, HY10275, TIK-301/LY156735, лонасена, LU-31-130, SLV313, эдивоксетина, OPC-34712, лисдексамфетамина, сакомелина, колурацетама, BMS-82036 и M100907.
15. Композиция по п. 2, дополнительно предусматривающая парентеральное введение субъекту кетамина перед введением антагониста NMDAR и антидепрессантов.
16. Композиция по п. 15, отличающаяся тем, что кетамин вводят внутривенно, интраназально или подкожно.
17. Композиция по п. 15, отличающаяся тем, что кетамин представляет собой конкретный энантиомер, S-кетамин или R-кетамин.
18. Фармацевтическая композиция, содержащая количество D-циклосерина, эффективное для того, чтобы D-циклосерин действовал как фактический антагонист; и S-(+)-миртазапин, R-(-)-миртазапин или их рацемическую смесь, причем указанное количество D-циклосерина, эффективное для того, чтобы D-циклосерин действовал как фактический антагонист, представляет собой дозу от ≥500 мг/сутки до ≤1000 мг/сутки, и составлено так, чтобы обеспечивать содержание в крови более 25 микрограмм (мкг)/мл.
19. Фармацевтическая композиция по п. 18, отличающаяся тем, что количество D-циклосерина, эффективное для того, чтобы D-циклосерин действовал как фактический антагонист, представляет собой дозу, равную или более 10 мг/кг.
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| AU2019262197A1 (en) | 2018-05-04 | 2020-11-26 | Perception Neuroscience, Inc. | Methods of treating substance abuse |
| US20210386689A1 (en) * | 2018-10-31 | 2021-12-16 | Sunovion Pharmaceuticals Inc. | Methods of treating central nervous system disorders |
| JP2022526427A (ja) * | 2019-04-09 | 2022-05-24 | ヴィスタゲン セラピューティクス、インコーポレイテッド | 神経障害の治療への反応に関連する遺伝的変異体 |
| US20230017786A1 (en) * | 2020-01-03 | 2023-01-19 | University Of Padova | Dextromethadone as a disease-modifying treatment for neuropsychiatric disorders and diseases |
| CN115677519A (zh) * | 2021-07-22 | 2023-02-03 | 立科时代(武汉)生物科技有限公司 | L-4-溴-犬尿氨酸及其在制备治疗抑郁症药物中的应用 |
| CN113648320A (zh) * | 2021-08-16 | 2021-11-16 | 中国人民解放军军事科学院军事医学研究院 | 赛洛西宾抗创伤后应激障碍的医药用途 |
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