JP2009542820A5 - - Google Patents
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- Publication number
- JP2009542820A5 JP2009542820A5 JP2009530701A JP2009530701A JP2009542820A5 JP 2009542820 A5 JP2009542820 A5 JP 2009542820A5 JP 2009530701 A JP2009530701 A JP 2009530701A JP 2009530701 A JP2009530701 A JP 2009530701A JP 2009542820 A5 JP2009542820 A5 JP 2009542820A5
- Authority
- JP
- Japan
- Prior art keywords
- combination
- selective antagonist
- antidepressant
- selective
- telenzepine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003042 antagnostic Effects 0.000 claims description 42
- 239000005557 antagonist Substances 0.000 claims description 41
- 239000000203 mixture Substances 0.000 claims description 32
- 230000001430 anti-depressive Effects 0.000 claims description 27
- 239000000935 antidepressant agent Substances 0.000 claims description 27
- 239000003772 serotonin uptake inhibitor Substances 0.000 claims description 16
- VSWPGAIWKHPTKX-UHFFFAOYSA-N Telenzepine Chemical compound C1CN(C)CCN1CC(=O)N1C2=CC=CC=C2NC(=O)C2=CSC(C)=C21 VSWPGAIWKHPTKX-UHFFFAOYSA-N 0.000 claims description 15
- 229950004351 Telenzepine Drugs 0.000 claims description 15
- 239000003775 serotonin noradrenalin reuptake inhibitor Substances 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 230000004580 weight loss Effects 0.000 claims description 10
- WSEQXVZVJXJVFP-UHFFFAOYSA-N Citalopram Chemical compound O1CC2=CC(C#N)=CC=C2C1(CCCN(C)C)C1=CC=C(F)C=C1 WSEQXVZVJXJVFP-UHFFFAOYSA-N 0.000 claims description 8
- 229960002073 Sertraline Drugs 0.000 claims description 8
- VGKDLMBJGBXTGI-SJCJKPOMSA-N Sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 claims description 8
- 229960001653 citalopram Drugs 0.000 claims description 8
- 229960004688 venlafaxine Drugs 0.000 claims description 8
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 5
- 229940079593 drugs Drugs 0.000 claims description 5
- 230000001737 promoting Effects 0.000 claims description 5
- 239000000883 anti-obesity agent Substances 0.000 claims description 4
- 239000000221 dopamine uptake inhibitor Substances 0.000 claims description 4
- 229940005513 ANTIDEPRESSANTS Drugs 0.000 claims description 3
- 230000036528 appetite Effects 0.000 claims description 3
- 235000019789 appetite Nutrition 0.000 claims description 3
- 230000037396 body weight Effects 0.000 claims description 3
- AHOUBRCZNHFOSL-YOEHRIQHSA-N Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 claims description 2
- KYYIDSXMWOZKMP-UHFFFAOYSA-N Desvenlafaxine Chemical compound C1CCCCC1(O)C(CN(C)C)C1=CC=C(O)C=C1 KYYIDSXMWOZKMP-UHFFFAOYSA-N 0.000 claims description 2
- ZEUITGRIYCTCEM-KRWDZBQOSA-N Duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 claims description 2
- 229960002464 Fluoxetine Drugs 0.000 claims description 2
- 229960004038 Fluvoxamine Drugs 0.000 claims description 2
- 229960000600 Milnacipran Drugs 0.000 claims description 2
- GJJFMKBJSRMPLA-HIFRSBDPSA-N Milnacipran Chemical compound C=1C=CC=CC=1[C@@]1(C(=O)N(CC)CC)C[C@@H]1CN GJJFMKBJSRMPLA-HIFRSBDPSA-N 0.000 claims description 2
- 229960001785 Mirtazapine Drugs 0.000 claims description 2
- RONZAEMNMFQXRA-UHFFFAOYSA-N Mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 claims description 2
- RTHCYVBBDHJXIQ-UHFFFAOYSA-N N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine Chemical compound C=1C=CC=CC=1C(CCNC)OC1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-UHFFFAOYSA-N 0.000 claims description 2
- RMHMFHUVIITRHF-UHFFFAOYSA-N Pirenzepine Chemical compound C1CN(C)CCN1CC(=O)N1C2=NC=CC=C2NC(=O)C2=CC=CC=C21 RMHMFHUVIITRHF-UHFFFAOYSA-N 0.000 claims description 2
- UNAANXDKBXWMLN-UHFFFAOYSA-N Sibutramine Chemical compound C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 claims description 2
- 229960001623 desvenlafaxine Drugs 0.000 claims description 2
- 229960002866 duloxetine Drugs 0.000 claims description 2
- -1 ecitalopram Chemical compound 0.000 claims description 2
- CJOFXWAVKWHTFT-XSFVSMFZSA-N fluvoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 CJOFXWAVKWHTFT-XSFVSMFZSA-N 0.000 claims description 2
- 239000002899 monoamine oxidase inhibitor Substances 0.000 claims description 2
- 239000002767 noradrenalin uptake inhibitor Substances 0.000 claims description 2
- 229960002296 paroxetine Drugs 0.000 claims description 2
- 229960004633 pirenzepine Drugs 0.000 claims description 2
- 239000000651 prodrug Substances 0.000 claims description 2
- 229940002612 prodrugs Drugs 0.000 claims description 2
- 239000000952 serotonin receptor agonist Substances 0.000 claims description 2
- 230000000697 serotonin reuptake Effects 0.000 claims description 2
- 229960004425 sibutramine Drugs 0.000 claims description 2
- 239000003029 tricyclic antidepressant agent Substances 0.000 claims description 2
- 239000003174 triple reuptake inhibitor Substances 0.000 claims description 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims 2
- SFLSHLFXELFNJZ-MRVPVSSYSA-N L-Noradrenaline Natural products NC[C@@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-MRVPVSSYSA-N 0.000 claims 1
- 229960002748 Norepinephrine Drugs 0.000 claims 1
- 229940053544 Other antidepressants in ATC Drugs 0.000 claims 1
- 229940076279 Serotonin Drugs 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000002195 synergetic Effects 0.000 description 3
- 206010033307 Overweight Diseases 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000020825 overweight Nutrition 0.000 description 2
- 230000000996 additive Effects 0.000 description 1
- 230000002459 sustained Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80506606P | 2006-06-16 | 2006-06-16 | |
| US60/805,066 | 2006-06-16 | ||
| US82922506P | 2006-10-12 | 2006-10-12 | |
| US60/829,225 | 2006-10-12 | ||
| US11/763,313 US8748419B2 (en) | 2006-06-16 | 2007-06-14 | Treating obesity with muscarinic receptor M1 antagonists |
| US11/763,313 | 2007-06-14 | ||
| PCT/US2007/071374 WO2007147134A2 (en) | 2006-06-16 | 2007-06-15 | Treating obesity with muscarinic receptor m1 antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013001003A Division JP2013079277A (ja) | 2006-06-16 | 2013-01-08 | ムスカリン性受容体ｍ１拮抗薬による肥満の処置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009542820A JP2009542820A (ja) | 2009-12-03 |
| JP2009542820A5 true JP2009542820A5 (ru) | 2011-07-14 |
| JP5371762B2 JP5371762B2 (ja) | 2013-12-18 |
Family
ID=38832915
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009530701A Expired - Fee Related JP5371762B2 (ja) | 2006-06-16 | 2007-06-15 | ムスカリン性受容体ｍ１拮抗薬による肥満の処置 |
| JP2013001003A Withdrawn JP2013079277A (ja) | 2006-06-16 | 2013-01-08 | ムスカリン性受容体ｍ１拮抗薬による肥満の処置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013001003A Withdrawn JP2013079277A (ja) | 2006-06-16 | 2013-01-08 | ムスカリン性受容体ｍ１拮抗薬による肥満の処置 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8748419B2 (ru) |
| EP (1) | EP2031964B1 (ru) |
| JP (2) | JP5371762B2 (ru) |
| KR (1) | KR101442525B1 (ru) |
| AU (1) | AU2007260642B2 (ru) |
| BR (1) | BRPI0713728A2 (ru) |
| CA (1) | CA2655323C (ru) |
| IL (1) | IL195858A (ru) |
| MX (1) | MX2008015886A (ru) |
| NZ (1) | NZ573571A (ru) |
| SG (1) | SG172711A1 (ru) |
| WO (1) | WO2007147134A2 (ru) |
| ZA (1) | ZA200810681B (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110021507A1 (en) * | 2009-07-22 | 2011-01-27 | Theracos, Inc. | Inhibiting antipsychotic-induced weight gain |
| US8440655B2 (en) | 2010-06-21 | 2013-05-14 | Theracos, Inc. | Combination therapy for the treatment of diabetes |
| CA2804797C (en) * | 2010-10-25 | 2014-12-23 | University Of Manitoba | Therapeutic compositions for diabetic symmetrical polyneuropathy and/or tactile allodynia |
| WO2013151596A2 (en) * | 2012-04-05 | 2013-10-10 | Finch Linda Duerler | System and method of losing weight |
| EP3429625B1 (en) * | 2016-03-15 | 2023-04-26 | Queen Mary University of London | Method of treatment of obesity |
Family Cites Families (64)
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|---|---|---|---|---|
| DE1795183B1 (de) | 1968-08-20 | 1972-07-20 | Thomae Gmbh Dr K | 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-on-derivate und Arzneimittel |
| US4172831A (en) | 1974-11-26 | 1979-10-30 | Lilly Industries Limited | Thieno-benzodiazepines |
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| US4168269A (en) | 1978-04-12 | 1979-09-18 | American Cyanamid Company | Substituted thieno-benzodiazepines |
| US4381301A (en) | 1980-05-07 | 1983-04-26 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Substituted tricyclic thieno compounds, their synthesis, their use, their compositions and their medicaments |
| US4933438A (en) | 1984-02-29 | 1990-06-12 | University Of Florida | Brain-specific analogues of centrally acting amines |
| US6150354A (en) | 1987-01-15 | 2000-11-21 | Bonnie Davis | Compounds for the treatment of Alzheimer's disease |
| AU2824289A (en) | 1987-12-22 | 1989-07-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Thienotricyclene for the treatment of bronchial diseases |
| US5585347A (en) * | 1988-05-10 | 1996-12-17 | Ergo Science Incorporated | Methods for the determination and adjustment of prolactin daily rhythms |
| US5668155A (en) | 1988-05-10 | 1997-09-16 | The General Hospital Corporation | Administration of pirenzepine, methyl scopolamine and other muscarinic receptor antagonists for treatment of lipid metabolism disorders |
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| IE61928B1 (en) | 1988-11-29 | 1994-11-30 | Boots Co Plc | Treatment of obesity |
| US5133974A (en) | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
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| EP0515301A3 (en) | 1991-05-14 | 1993-06-16 | Ernir Snorrason | Improvements in benzodiazepine treatment by cholinesterterase inhibitors |
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| US5324832A (en) | 1991-07-03 | 1994-06-28 | The United States Of America As Represented By The Department Of Health And Human Services | Muscarinic antagonists |
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| FR2710265B1 (fr) | 1993-09-22 | 1995-10-20 | Adir | Composition pharmaceutique bioadhésive pour la libération contrôlée de principes actifs. |
| US6548084B2 (en) | 1995-07-20 | 2003-04-15 | Smithkline Beecham Plc | Controlled release compositions |
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| DE19541260A1 (de) | 1995-11-06 | 1997-05-07 | Lohmann Therapie Syst Lts | Therapeutische Zubereitung zur transdermalen Applikation von Wirkstoffen durch die Haut |
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| EP1874356A2 (en) * | 2005-04-15 | 2008-01-09 | Board of Trustees of Michigan State University | Aminergic pharmaceutical compositions and methods |
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| EP1997083B1 (en) | 2006-03-14 | 2013-12-18 | Nxp B.V. | Automatically configurable smart card and method of automatically configuring a smart card |
| CN101472571B (zh) | 2006-06-16 | 2012-11-14 | 泰拉科斯有限公司 | 毒蕈碱型受体m1拮抗剂在制备治疗心理学病况药物中的应用 |
| US7893053B2 (en) | 2006-06-16 | 2011-02-22 | Theracos, Inc. | Treating psychological conditions using muscarinic receptor M1 antagonists |
-
2007
- 2007-06-14 US US11/763,313 patent/US8748419B2/en not_active Expired - Fee Related
- 2007-06-15 KR KR1020097000755A patent/KR101442525B1/ko not_active IP Right Cessation
- 2007-06-15 EP EP07812168.8A patent/EP2031964B1/en not_active Not-in-force
- 2007-06-15 CA CA2655323A patent/CA2655323C/en not_active Expired - Fee Related
- 2007-06-15 MX MX2008015886A patent/MX2008015886A/es active IP Right Grant
- 2007-06-15 BR BRPI0713728-1A patent/BRPI0713728A2/pt not_active IP Right Cessation
- 2007-06-15 WO PCT/US2007/071374 patent/WO2007147134A2/en active Application Filing
- 2007-06-15 NZ NZ573571A patent/NZ573571A/en not_active IP Right Cessation
- 2007-06-15 SG SG2011043874A patent/SG172711A1/en unknown
- 2007-06-15 JP JP2009530701A patent/JP5371762B2/ja not_active Expired - Fee Related
- 2007-06-15 AU AU2007260642A patent/AU2007260642B2/en not_active Ceased
-
2008
- 2008-12-11 IL IL195858A patent/IL195858A/en active IP Right Grant
- 2008-12-18 ZA ZA2008/10681A patent/ZA200810681B/en unknown
-
2013
- 2013-01-08 JP JP2013001003A patent/JP2013079277A/ja not_active Withdrawn
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