US20180338956A1 - Combined therapy for nmdar antagonist-responsive neuropsychiatric disorders - Google Patents

Combined therapy for nmdar antagonist-responsive neuropsychiatric disorders Download PDF

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US20180338956A1
US20180338956A1 US15/987,941 US201815987941A US2018338956A1 US 20180338956 A1 US20180338956 A1 US 20180338956A1 US 201815987941 A US201815987941 A US 201815987941A US 2018338956 A1 US2018338956 A1 US 2018338956A1
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cycloserine
depression
mirtazapine
dose
disorder
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Daniel C. Javitt
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GLYTECH LLC
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Definitions

  • an oral dosage regimen for the treatment of NMDAR-related neuropsychiatric disorders such as depression and obsessive compulsive disorder
  • the treatment includes an NMDAR antagonist, such as D-cycloserine formulated to produce plasma levels in excess of 25 microgram/mL, combined with more recently developed antidepressants.
  • Major depression is a clinical syndrome that includes a persistent sad mood or loss of interest in activities, which persists for at least two weeks in the absence of treatment. Symptoms of major depression are typically measured using rating scales such as the Hamilton Depression Rating Scale (HAM-D) or the Beck Depression Inventory (BDI). In addition to including symptoms relevant to depressed mood, the HAM-D also contains symptoms sensitive to psychosis, including items for guilt, depersonalization/derealization and paranoia.
  • Major depression may also be associated with symptoms of anxiety, which may be measured with rating scales such as the Hamilton Rating Scale for Anxiety (HAM-A). Depressive disorders are divided into major depression (MDD) and bipolar depression (BPD). Major depression may also occur with and without melancholic features. In addition, depressive symptoms may occur in the context of anxiety disorders such as generalized anxiety disorder, dissociative disorders, personality disorders or adjustment disorders with depressed mood (DSM-IV).
  • Bipolar depression may be divided into Bipolar I and Bipolar II subtypes based upon presence or absence of manic episodes.
  • depressive symptoms can occur in the context of either a depressive episode, or a mixed state in which symptoms of mania and depression occur simultaneously or in rapid sequence. Rapid cycling between mania and depressive episodes may also occur in some individuals.
  • TeCAs tetracyclic antidepressants
  • SSRI serotonin
  • SNRI serotonin/norephinephrine
  • MAOIs and TCAs are considered “broader spectrum” agents than SSRIs/SNRIs that were developed subsequently.
  • Glutamate is an alternative brain neurotransmitter that has been studied to a limited degree in relationship to depression or other affective disorders. Glutamate binds to several receptor types including N-methyl-D-aspartate type glutamate receptors (NMDAR). NMDAR contain multiple binding sites including an agonist site for glutamate and an allosteric modulatory site (aka glycineB receptor, strychnine-insensitive glycine receptor) sensitive to the endogenous brain amino acids glycine and D-serine. Agonists at the glycine site increase NMDAR activation in response to glutamate while antagonists decrease NMDAR activation.
  • NMDAR N-methyl-D-aspartate type glutamate receptors
  • Functional agonists and antagonists at the glycine site can be identified using well-validated electrophysiological assays such as modulation of NMDAR-mediated responses to NMDAR glutamate-site agonists, or radio-receptor assays, such as modulation of binding to the NMDAR PCP-receptor channel binding site.
  • Glycine site agonists and antagonists can also be distinguished based upon both electrophysiology and receptor binding from compounds such as phencyclidine (PCP) or ketamine that bind to the channel site (aka PCP receptor, uncompetitive antagonist site) of the NMDAR.
  • Effective agonists and antagonists may be identified, for example, as compounds with ⁇ 100 nM affinity for their target and >10-fold selectivity vs. other relevant targets.
  • Partial agonists are defined as compounds that have reduced efficacy for inducing conformational change in receptors (typically 40-80%) relative to full agonists, and which may induce agonist effects at low dose but antagonist effects at high dose.
  • treatment-refractory depression refers to a form of depression that responds poorly to currently available treatments (e.g., see nimh.nih.gov/trials/practical/stard/index.shtml June 2011) and which may have different underlying etiopathological mechanisms compared with other forms of depression.
  • Combinations of antidepressants have not been shown to be superior to monotherapy for refractory depression and typically increase risk of side effects and are not recommended.
  • Newer SNRIs and atypical antidepressants differ from traditional medications in that they have higher specificity for targets other than the serotonin transporter, and thus are relatively more similar to TCAs in having balanced modulation of serotonergic and noradrenergic symptoms.
  • the newer agents have efficacy similar to those of more traditional SSRIs and SNRIs, but differential side effect profiles (Wagner et al., Journal of Affective Disorders 228:1-12, 2018). Their relative interaction with ketamine or other NMDAR-based antidepression agents has not been previously studied.
  • formulations containing a NMDAR antagonistcombined with an anti-depressant that is drawn from a list that includes levomilnacipran, milnacipran, vilazadone, vortioxetine, S-mirtazapine and R-mirtazapine.
  • compositions in methods for treatment of depression, OCD, and anxiety disorders, and for preparation of a medicament for use in such treatments are also described.
  • FIG. 1 is a graph showing the effect of indicated mg/kg (mpk) doses of D-cycloserine (DCS) on immobility time in the forced swim test (FST) following oral (PO) administration relative to control (ctl) or active comparator (sertraline).
  • DCS D-cycloserine
  • FST forced swim test
  • PO oral
  • ctl active comparator
  • FIG. 2 is a graph showing the effect of DCS in combination with indicated antidepression agents. As indicted, *p ⁇ 0.05, **p ⁇ 0.01, ***p ⁇ 0.001 No DCS vs. 300 mg/kg. #p ⁇ 0.05 vs. DCS 300 mg/kg alone.
  • FIG. 3 shows the synergistic effects of DCS and mirtazapine on marble burying ***p ⁇ 0.001 vs. Vehicle. #p ⁇ 0.05 mirtazapine+DCS 300 mg/kg vs. mirtazapine alone. 10 mice were treated with either Vehicle (control), Paroxetine (5 mg/kg), Mirtazapine (5.5 mg/kg), D-cycloserine (30 mg/kg), D-cycloserine (300 mg/kg) or D-cycloserine (300 mg/kg)+(Mirtazapine 5.5 mg/kg) which was administered by IP 30 minutes prior to test. Distance traveled during the test was captured by cameras and quantified using Video Tracker Software (ViewPoint Life Sciences Software, France). At the end of the test mice were removed from the cages and the number of unburied marbles was counted. A marble was considered buried if it was covered at least two thirds with bedding. An effect was considered significant if p ⁇ 0.05.
  • FIG. 4 shows the relative effects of R- and S-isomers of mirtazapine on marble burying, showing greater effects of R- vs S-isomer. ***p ⁇ 0.001 vs. racemic mirtazapine.
  • 10 mice were treated with either Vehicle (control), Paroxetine (5 mg/kg), S-Mirtazapine (1, 2.5, 5.0, and 10 mg/kg), R-Mirtazapine (1, 2.5, 5.0, and 10 mg/kg), R-Mirtazapine (2.5 mg/kg)+D-cycloserine (300 mg/kg) which was administered by IP 30 minutes prior to test. Distance traveled during the test was captured by cameras and quantified using Video Tracker Software (ViewPoint Life Sciences Software, France). At the end of the test mice were removed from the cages and the number of unburied marbles was counted. A marble was considered buried if it was covered at least two thirds with bedding. An effect was considered significant if p ⁇ 0.05.
  • compositions means “includes.” “Consisting essentially of” indicates a composition, method, or process that includes only those listed features as the active or essential elements, but can include non-active elements in addition.
  • the abbreviation, “e.g.” is derived from the Latin exempli gratia, and is used herein to indicate a non-limiting example. Thus, the abbreviation “e.g.” is synonymous with the term “for example.”
  • Administration The introduction of a composition into a subject by a chosen route.
  • Administration of an active compound or composition can be by any route known to one of skill in the art.
  • Administration can be local or systemic.
  • Systemic administration includes any route of administration designed to distribute an active compound or composition widely throughout the body via the circulatory system.
  • systemic administration includes, but is not limited to oral, intra-arterial and intravenous administration.
  • Analog, derivative or mimetic An analog is a molecule that differs in chemical structure from a parent compound, for example a homolog (differing by an increment in the chemical structure, such as a difference in the length of an alkyl chain), a molecular fragment, a structure that differs by one or more functional groups, a change in ionization. Structural analogs are often found using quantitative structure activity relationships (QSAR), with techniques such as those disclosed in Remington ( The Science and Practice of Pharmacology, 19 th Edition (1995), chapter 28).
  • a derivative is a biologically active molecule derived from the base structure.
  • a mimetic is a molecule that mimics the activity of another molecule, such as a biologically active molecule.
  • Biologically active molecules can include chemical structures that mimic the biological activities of a compound. It is acknowledged that these terms may overlap in some circumstances. It is to be understood that the active agents described herein can be substituted by functionally equivalent derivatives and analogs to similar effect.
  • Antagonist A molecule or compound that tends to nullify the action of another, or in some instances that blocks the ability of a given chemical to bind to its receptor or other interacting molecule, preventing a biological response.
  • Effective amount or a therapeutically effective amount indicates a nontoxic but sufficient amount of the same to provide the desired effect.
  • an “effective amount” of one component of the combination is the amount of that compound that is effective to provide the desired effect when used in combination with the other components of the combination.
  • the amount that is “effective” will vary from subject to subject, depending on the age and general condition of the individual, the particular active agent or agents, and the like. Thus, it is not always possible to specify an exact “effective amount.” However, an appropriate “effective” amount in any individual case may be determined by one of ordinary skill in the art using routine experimentation.
  • D-cycloserine refers to the chemical D-cycloserine (CA Index Name: 3-Isoxazolidinone, 4-amino-, (4R)-(9CI); CAS Registry No. 68-41-7), or pharmaceutically acceptable salts thereof.
  • DCS is an FDA (United States Food and Drug Administration)-approved drug for treatment of tuberculosis, and is sold by Eli Lilly and Company under the trade name Seromycin®.
  • DCS is a structural analog of D-alanine, and is a broad-spectrum antibiotic produced by some strains of Streptomyces orchidaceus and S. garphalus . DCS is also described herein as “cycloserine.”
  • parenteral Administered outside of the intestine, for example, not via the alimentary tract.
  • parenteral formulations are those that will be administered through any possible mode except ingestion. This term especially refers to injections, whether administered intravenously, intrathecally, intramuscularly, intraperitoneally, or subcutaneously, and various surface applications including intranasal, intradermal, and topical application, for instance.
  • compositions and formulations suitable for pharmaceutical delivery of the compounds herein disclosed are conventional. Remington's Pharmaceutical Sciences , by E. W. Martin, Mack Publishing Co., Easton, Pa., 15th Edition (1975), describes compositions and formulations suitable for pharmaceutical delivery of the compounds herein disclosed. In general, the nature of the carrier will depend on the particular mode of administration being employed. For instance, parenteral formulations usually comprise injectable fluids that include pharmaceutically and physiologically acceptable fluids such as water, physiological saline, balanced salt solutions, aqueous dextrose, glycerol or the like as a vehicle.
  • non-toxic solid carriers can include, for example, pharmaceutical grades of mannitol, lactose, starch, or magnesium stearate.
  • pharmaceutical compositions to be administered can contain minor amounts of non-toxic auxiliary substances, such as wetting or emulsifying agents, preservatives, and pH buffering agents and the like, for example sodium acetate or sorbitan monolaurate.
  • Pharmaceutical agent A chemical compound or composition capable of inducing a desired therapeutic or prophylactic effect when properly administered to a subject or a cell.
  • Subject Living multi-cellular organisms, including vertebrate organisms, a category that includes both human and non-human mammals.
  • the human subjects described herein are also referred to as “patients.”
  • Subject susceptible to a disease or condition A subject capable of, prone to, or predisposed to developing a disease or condition. It is understood that a subject already having or showing symptoms of a disease or condition is considered “susceptible” since they have already developed it. For example, it is appreciated that patients suffering from depression are susceptible to suicidality.
  • Treating and Treatment refer to reduction in severity and/or frequency of symptoms, elimination of symptoms and/or their underlying cause, prevention of the occurrence of symptoms and/or their underlying cause, and improvement or remediation of damage.
  • “treating” a patient involves prevention of a particular disorder or adverse physiological event in a susceptible individual as well as treatment of a clinically symptomatic individual.
  • compositions for use in treatment of a NMDA receptor neuropsychiatric disorder in a human subject which includes a therapeutic effective amount of a first agent that is a NMDA receptor antagonist; and a second agent that is an anti-depressant selected from levomilnacipran, milnacipran, vilazadone, vortioxetine, S-mirtazapine and R-mirtazapine, and wherein the NMDA receptor neuropsychiatric disorder is selected from depression, obsessive compulsive disorder, and anxiety disorders.
  • the first agent is D-cycloserine provided at a net antagonistic dose, such as a dose of ⁇ 500 mg/day to ⁇ 1000 mg/day and is formulated to produce an average plasma level in the subject of greater than 25 ⁇ g/mL, and more particularly a dose of 7.5-12.5 mg/kg/day.
  • a net antagonistic dose such as a dose of ⁇ 500 mg/day to ⁇ 1000 mg/day and is formulated to produce an average plasma level in the subject of greater than 25 ⁇ g/mL, and more particularly a dose of 7.5-12.5 mg/kg/day.
  • the first agent is selected from ketamine, GlyX-13, NRX-1074, NYX-2925, AGN-241751 and Gavestinel.
  • the described composition is used in treatments of depression that is major depression, major depressive disorder, atypical, agitated, melancholic depression or dysthymic disorder.
  • the depression is bipolar disorder, such as bipolar type I or bipolar type 2 depressive disorder or is associated with depressive or mixed episodes associated with bipolar depression.
  • the described composition reduces symptoms of depression, reduces suicide incidence or treats suicide ideation in the subject.
  • the disorder is associated with suicidality.
  • composition that includes a first agent that is a NMDA receptor antagonist; and a second agent that is an antidepressant selected from levomilnacipran, milnacipran, vilazadone, vortioxetine, S-mirtazapine and R-mirtazapine.
  • the first agent is D-cycloserine provided at a net antagonistic dose, such as ⁇ 500 mg/day to ⁇ 1000 mg/day and to produce an average plasma level in a subject of greater than 25 mg/mL, and such as 7.5-12.5 mg/kg/day.
  • the first agent is selected from ketamine, GlyX-13, AGN-241751 and Gavestinel.
  • the described composition is formulated in a sustained release formulation.
  • NMDA receptor-responsive neuropsychiatric disorder selected from depression, obsessive compulsive disorder, and anxiety disorders
  • compositions in the preparation of a medicament for treatment of the described conditions.
  • described composition includes two active ingredients, wherein the first of the two active ingredients is an NMDAR antagonist agent, such as D-cycloserine formulated to produce sustained plasma D-cycloserine levels of >25 microgram/mL and wherein the second of the two active ingredients is an antidepressant, which in certain embodiments can be selected from levomilnacipran, milnacipran, vilazadone, vortioxetine, S-mirtazapine and R-mirtazapine.
  • NMDAR antagonist agent such as D-cycloserine formulated to produce sustained plasma D-cycloserine levels of >25 microgram/mL
  • an antidepressant which in certain embodiments can be selected from levomilnacipran, milnacipran, vilazadone, vortioxetine, S-mirtazapine and R-mirtazapine.
  • NMDARs are a type of neuronal receptor for the brain neurotransmitter glutamate. NMDARs participate in a range of brain functions including sensory processing, cognition, and emotion regulation. NMDARs are comprised of multiple subunits termed GluN1, GluN2 and GluN3 (formerly NR1, NR2, NR3). Multiple forms of GluN1, GluN2 and GluN3 exist. An NMDAR may consist of various combinations of GluN1, GluN2 and GluN3 subunits in various amounts. Agonists and antagonists may affect all NMDARs equivalently, or may be selective for an NMDAR containing specific subunit types. The methods described herein include use of NMDAR antagonists.
  • non-competitive NMDAR antagonist ketamine has also been shown to have antidepressant effects in humans when tested in individuals with treatment-resistant depression.
  • the compound shows similar effects in both unipolar and bipolar depression.
  • Other non-competitive NMDAR antagonists such as MK-801 also show anti-depressant effects in animal models.
  • antidepressant effects induced by ketamine are associated with exacerbation of psychosis, which greatly reduces their utility in clinical situations.
  • NMDARs contain binding sites for the neurotransmitter glutamate and for the endogenous modulatory amino acids glycine and D-serine. NMDARs also are sensitive to the redox state of the surrounding tissue via a redox site/polyamine binding site. Agents that bind to these sites and reduce NMDAR activity are termed competitive inhibitors.
  • the NMDAR glutamate binding site selectively binds the synthetic glutamate derivative N-methyl-D-aspartate with high affinity. This site is alternately referred to as the glutamate recognition site or the NMDA recognition site of the NMDAR.
  • the NMDAR glycine/D-serine binding site has been referred to as the glycine modulatory site, the allosteric modulatory site or the glycine-B receptor.
  • NMDARs form an ion channel that is blocked by several drugs of abuse, such as phencyclidine (PCP), ketamine, or dizocilpine (MK-801). These compounds bind to a site that has been termed the PCP receptor.
  • PCP phencyclidine
  • MK-801 ketamine
  • MK-8801 dizocilpine
  • NMDAR channel blockers Blockade of NMDARs by channel blockers leads to a clinical psychotic state that closely resembles schizophrenia.
  • NMDARs may also be inhibited by antagonists that bind to the glutamate recognition sites, the glycine recognition site, or the polyamine binding site.
  • antagonists that bind to the glutamate recognition sites, the glycine recognition site, or the polyamine binding site.
  • high affinity NMDAR antagonists have been used in multiple clinical settings.
  • CNS19755 is an example of an antagonist that binds to the glutamate recognition site.
  • CNS indications such as stroke or epilepsy.
  • these compounds When used at doses sufficient to significantly inhibit NMDAR, these compounds, like channel blockers, lead to clinical psychotomimetic symptoms.
  • Additional compounds that function as antagonists of the glutamate recognition site include aptiganel (Cerestat, CNS-1102) and related compounds as described in Reddy et al., J Med Chem 37:260-7. 1994). Additional compounds that function as antagonists of the glutamate recognition site include alpha.-amino-carboxylic acid and phosphonic acid functionalities separated by a variety of spacer units. An unembellished example is 2-amino-5-phosphonovaleric acid (AP5) (Watkins, J. C.; Evans, R. H., Annu. Rev. Pharmacol. Toxicol. 1981, 21, 165), which contains a saturated carbon chain.
  • AP5 2-amino-5-phosphonovaleric acid
  • CPP cis-4-(phosphonomethyl)-2-piperidinecarboxylic acid
  • CGP-37849 (E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid (CGP-37849)
  • CGP-37849 (Schmutz, M. et al., Abs. Soc. Neurosci. 1988, 14, 864). See U.S. Pat. No. 7,345,032, issued Mar. 18, 2008 and U.S. Pat. No. 5,168,103, incorporated herein by reference in its entirety.
  • NMDARs may also be inhibited by antagonists that bind to the glycine recognition site.
  • such inhibition is by D-cycloserine, administered at an antagonist producing dosage.
  • D-cycloserine is a compound currently approved for treatment of tuberculosis (TB).
  • TB tuberculosis
  • Psychiatric effects of cycloserine were noted in the late 1950's in patients being treated for TB.
  • effects of cycloserine were noted on symptoms such as anorexia, asthenia and insominia.
  • no formal psychiatric diagnoses were made.
  • cycloserine was recommended primarily for treatments of tension and insomnia, as opposed to depression.
  • D-cycloserine Because of its ability to bind to NMDAR and because of theories linking NMDAR to schizophrenia, D-cycloserine has been studied in treatment resistant schizophrenia. At low doses, D-cycloserine has been found to produce beneficial effects in some but not all studies, and may exacerbate symptoms in individuals receiving clozapine. Furthermore, at higher doses ( ⁇ 250 mg), however, D-cycloserine exacerbates psychosis and so according to package label insert is contra-indicated in schizophrenia, depression and anxiety disorders. Research with D-cycloserine in preclinical models has also not suggested its usefulness at high dose in treatment of depression.
  • NMDAR 1-aminocyclopropanecarboxylic acid
  • ACPC 1-aminocyclopropanecarboxylic acid
  • D-cycloserine reported for use at a dose of 250 mg/day was found to be without significant effect on symptoms of major depression and moreover, commonly available prescribing information states that D-cycloserine use is contraindicated in individuals with a history of epilepsy, depression, severe anxiety, or psychosis (Lilly. Seromycin (cycloserine) capsules prescribing information. Indianapolis, Ind.; 2005 Apr. 28).
  • D-cycloserine produces primarily agonist effects at doses up to approximately 100 mg, and primarily antagonist effects at doses above 500 mg, with intermediate effects at intermediate doses.
  • Plasma concentrations associated with primarily agonist effects are primarily ⁇ 10 ⁇ g/mL.
  • Plasma concentrations associated with antagonist effects are >25 ⁇ g/ml. Increased liability for toxicity is observed at plasma levels >35 ⁇ g/mL.
  • D-cycloserine is typically administered for the treatment of tuberculosis at doses of 250-1000 mg.
  • typical doses are 250 mg, 500 mg, 750 mg or 1000 mg.
  • Intermediate doses such as 550, 600, 650, 700, 800, 850 or 900 mg are also possible.
  • D-cycloserine is administered to a subject at a dose of greater than 500 mg/day to less than or equal to 1000 mg/day, including but not limited to the above intermediate doses.
  • Effective doses of D-cycloserine for the intended use in humans require sustained plasma levels exceed >25 ug/ml, which in particular embodiments is provided by a dosage of greater than or equal to 10 mg/kg in an adult subject.
  • DCS is given at a dose between 10 mg/kg/day-25 mg/kg/day. In other particular embodiments, it is also understood that depending on the metabolism of the subject, the DCS can be given at a dose of 7.5-12.5 mg/kg/day.
  • PK Pharmacokinetics of D-cycloserine in humans after a dose of 500 mg have been previously studied.
  • Critical parameters include maximum (peak) concentration achieved (Cmax), time to maximum concentration (Tmax) and area under the curve (AUC) during the dosing interval.
  • Zhu et al. (Zhu M, Nix D E, Adam R D, Childs J M, Peloquin C A. Pharmacokinetics of cycloserine under fasting conditions and with high-fat meal, orange juice, and antacids. Pharmacotherapy. 2001; 21(8):891-7) showed median Cmax values of 14.8 microgram/mL under fasting conditions, with a range of 12.1-30.6 microgram/mL. Median AUC levels over 24 hr were 214 microgram-hr/mL with a range of 163-352, corresponding to median sustained plasma levels of 8.9 microgram/mL with a range of 6.8-14.7 microgram/mL.
  • sustained plasma doses following 500 mg administration of D-cycloserine are consistently below 25 microgram/mL.
  • the antidepressant effects of D-cycloserine are observed at dosages above 25 microgram/mL.
  • the daily dose for producing such plasma levels will necessarily be above 500 mg/day, as described herein.
  • Such doses include amounts greater than 10 mg/kg/day, such as 10, 12, 14, 16, and 18 mg/kg/day.
  • Felbamate is another example of a compound that may act via the glycine binding site, and which can be used in the described methods. When administered to humans, felbamate produces psychotic effects that limit its clinical utility (e.g. Besag F M, Expert Opin Drug Saf 3:1-8, 2004).
  • Gavestinel (GV-150,526) is another example of an antagonist at the glycine binding site for use as described herein.
  • Other similarly useful compounds are described in DiFabrio et al., J Med Chem 40:841-50, 1997, which is hereby incorporated by reference.
  • Other examples of glycine site antagonists that are suitable for use in the pharmaceutical compositions and methods described herein are those referred to in the following: U.S. Pat. No. 6,667,317 which was issued on Dec. 23, 2003; U.S. Pat. No. 6,080,743 which was issued Jun. 27, 2000; U.S. Pat. No. 5,990,108, which was issued on Nov. 23, 1999; U.S. Pat. No. 5,942,540, which issued on Aug.
  • GlyX-13 (Rapastinel) is a tetra-peptide (threonine-proline-proline-threonine) that functions as a mixed agonist/antagonist at the glycine site.
  • NRX-1074 (apostimel) is an orally available molecule with similar properties to GlyX-13.
  • NYX-2925 ((2S, 3R)-3-hydroxy-2-((R)-5-isobutyryl-1-oxo-2,5-diazaspiro [3.4]octan-2-yl)butanamide) is a small molecule designed based on effect of GlyX-3.
  • AGN-241751 (Allergan) is an oral; available, small molecule analog of GlyX-13.
  • CERC-301 (Rislenemdaz) is an oral active, selective NMDAR subunit 2B antagonist.
  • AZD-6765 (Lanicemine) is a low-trapping NMDAR antagonist.
  • S-ketamine (esketamine) is the S-isomer of racemic ketamine
  • R-ketamine is the R-isomer of racemic ketamine.
  • AV-101 (4-Chlorokynurenine (4-Cl Kyn) is an orally active small molecule prodrug of 7-chlorokynurenic acid, which acts as an NMDAR glycine-site antagonist.
  • glycine site antagonists that can be used in the pharmaceutical composition and methods described herein are N-(6,7-dichloro-2,3-dioxo-1,2,3,4-tetrahydro-quinoxalin-5-yl)-N-(2-hydroxy-ethyl)-methanesulfonamide and 6,7-dichloro-5-[3-methoxymethyl-5-(1-oxypyridin-3-yl)-[1,2,4]triazol-4-yl]-1,4-dihydro-quinoxa-line-2,3-dione.
  • NMDAR antagonists for use herein are described in Schiene et al., U.S. Pat. Appl. No. US2001/0306674 A1, which is incorporated herein by reference in its entirety, and include without being limited thereto, N-containing phosphonic acids, such as norvaline (AP5), D-norvaline (D-AP5), 4-(3-phosphono-propyl)-piperazine-2-carboxylic acid (CPP), D-(E)-4-(3-phosphonoprop-2-enyl)piperazine-2-carboxylic acid (D-CPPene), cis-4-(phosphonomethyl)-2-piperidine carboxylic acid (Selfotel, CGS 19755), SDZ-220581, PD-134705, LY-274614 and WAY-126090; quinolinic acids, such as kynurenic acid, 7-chloro-kynurenic acid, 7-chloro-thiokynurenic acid and 5,7-d
  • NMDAR-Antagonists are, for example, disclosed in “Analgesics,” edited by H. Buschmann, T Christoph, E. Friderichs, C. Maul, B. Sundermann, 2002, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, in particular pages 389-428. The respective parts of the description are hereby incorporated by reference and form part of the present disclosure.
  • NMDAR antagonists can be identified using well-validated electrophysiological assays such as modulation of NMDAR-mediated responses to NMDAR glutamate-site agonists, or radioreceptor assays, such as modulation of binding to the NMDAR PCP-receptor channel binding site.
  • Glycine site agonists and antagonists can also be distinguished based upon both electrophysiology and receptor binding from compounds such as phencyclidine (PCP) or ketamine that bind to the channel site.
  • Partial agonists are defined as compounds that have reduced efficacy for inducing conformational change in receptors (typically 40-80%) relative to full agonists.
  • Mixed agonists/antagonists are compounds that may induce agonist effects at low dose but antagonist effects at high dose.
  • the described methods relate to DCS provided in dosages intended to produce blood and/or plasma concentrations above 25 microgram/mL. It will be understood D-cycloserine levels in blood and/or plasma may be determined using standard analytic techniques such as high-pressure liquid chromatography.
  • Plasma levels associated with anti-depressant effects of D-cycloserine can be determined using rodent behavioral tests such as the forced swim test (FST), which has previously been shown to sensitive to effects of NMDAR glycine site antagonists such as 1-aminocyclopropanecarboxylate ACPC (Trullas et al., Eur J Pharmacol. 1991; 203:379-385).
  • FST forced swim test
  • NMDAR glycine site antagonists such as 1-aminocyclopropanecarboxylate ACPC
  • locomotor hyperactivity is considered a rodent analog of psychotomimetic effect.
  • a prior study did not find significant increases in locomotor activity in mice when D-cycloserine was given at doses of up to 160 mg/kg. Nevertheless, D-cycloserine potentiated the effects of a low dose of the non-competitive NMDAR antagonist MK-801 (Carlsson M L, Engberg G, Carlsson A. Effects of D-cycloserine and (+)-HA-966 on the locomotor stimulation induced by NMDARantagonists and clonidine in monoamine-depleted mice. J Neural Transm Gen Sect. 1994; 95(3):223-233).
  • the second of the two active agents in the described pharmaceutical compositions is an antidepression agent.
  • the antidepressant is a tetracyclic antidepressant (TeCA), selective serotonin reuptake inhibitor (SSRI), a serotonin/norephinephrine reuptake inhibitor (SNRI), an antipsychotic approved for treatment of depression or a combination thereof.
  • TeCA tetracyclic antidepressant
  • SSRI selective serotonin reuptake inhibitor
  • SNRI serotonin/norephinephrine reuptake inhibitor
  • an antipsychotic approved for treatment of depression or a combination thereof an antipsychotic approved for treatment of depression or a combination thereof.
  • antidepressants for use in the described compositions and methods include monoamine oxidase inhibitors (MAOI), TCAs such as, but not limited to imipramine, amitryptiline, desipramine, clomipramine, TeCAs such as mianserin, mirtazapine, serotonin (SSRI) and serotonin/norephinephrine (SNRI) reuptake inhibitors, such as fluoxetine, fluvoxamine, paroxetine, citalopram, escitalopram, duloxetine, venlafaxine and others, as will be appreciated by the skilled artisan.
  • MAOI monoamine oxidase inhibitors
  • TCAs such as, but not limited to imipramine, amitryptiline, desipramine, clomipramine
  • TeCAs such as mianserin, mirtazapine, serotonin (SSRI) and serotonin/norephinephrine (SNRI)
  • TCAs tetracyclic antidepressants
  • SSRI serotonin
  • SNRI serotonin/norephinephrine
  • MAOIs and TCAs are considered “broader spectrum” agents than SSRIs/SNRIs that were developed subsequently.
  • Bupropion is an antidepressant medication that works as a norepinephrine-dopamine reuptake inhibitor (NDRI) and is also approved for smoking cessation.
  • NDRI norepinephrine-dopamine reuptake inhibitor
  • SNRIs may differ in relative specificity for serotonin (SERT) vs. norepinephrine (NET) transporters.
  • SERT serotonin
  • NET norepinephrine
  • traditional SNRI agents such as venlafaxine, duloxetine and desvenlafaxine show substantially greater affinity for SERT versus NET transporters
  • newer agents such as milnacipram and levomilnacipran show more balanced affinity for NET vs. SERT transporters.
  • These compounds thus have serotonin:norepinephrine reuptake ratios more similar to those of TCAs than SSRIs or other SNRIs.
  • Vilazodone is considered an atypical antidepressant in that it functions as both an SSRI and a partial agonist at 5HT1A receptors and has thus been termed a serotonin partial agonist and reuptake inhibitor (SPARI) (Schwartz et al., Vilazodone: A Brief Pharmacological and Clinical Review of the Novel Serotonin Partial Agonist and Reuptake Inhibitor, Ther Adv Psychopharmacol. 1:81-87, 2011).
  • SPARI serotonin partial agonist and reuptake inhibitor
  • the combination of serotonin reuptake inhibition and 5-HT1A agonist is believed to function as an antidepressant at lower levels of serotonin transporter occupancy than otherwise (Kohler et al., J Psychopharmacogy, 30:13-22, 2016).
  • Vortioxetine is considered a multimodal antidepressant in that it functions as 1) a serotonin transport inhibitor, 2) a partial agonist at 5-HT1A receptors, and 3) a partial antagonist of 5-HT1B, 5HT1D and 5-HT7 receptors (Stahl S M, Modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (MMA): enhancing serotonin release by combining serotonin (5HT) transporter inhibition with actions at 5HT receptors (5HT1A, 5HT1B, 5HT1D, 5HT7 receptors) CNS Spectrums (2015), 20, 93-97)
  • Levopmilnacipran and milnacipran while considered SNRIs, have a much lower ratio of serotonin:norephinephrine ratio than previously marketed SNRI agents.
  • venlafaxine, duloxetine, and desvenlafaxine all have serotonin:noepinephrine ratios of 10:1 or greater
  • levomilnacipran has a ratio of only 1.2:1
  • milnacipran has a ratio of only 1.6:1 (Sansone R A, Sansone L A Serotonin norepinephrine reuptake inhibitors: a pharmacological comparison. Innov Clin Neurosci. 11 (3-4): 37-42). Binding profiles of milnacipran and levomilnacipran are thus more similar to TCAs than to other SNRIs.
  • Mirtazapine is a racemic mixture of S(+)mirtazapine (also called S-mirtazapine) and R( ⁇ )mirtazapine (also called R-mirtazapine) that functions as a noradrenergic and specific serotonergic antidepressant (NaSSA). Both the S(+)mirtazapine and R ( ⁇ ) mirtazapine enantiomers are pharmacologically active, but may have offsetting effects.
  • racemic mirtazapine produced biphasic effects in a rodent nociception assay, whereas R( ⁇ )mirtazapine produced only anti-nociceptive effects and S(+)mirtazapine exerted pro-nociceptive effects (Freynhagen et al., Brain Res Bull 69:168-173, 2006). Differences in binding profile are also observed between the enantiomers that confer differential effects on specific aspects of binding, that may confer advantages over the racemate for treatment of specific disorders.
  • Approved dosing levels for the antidepressant agents described herein can be determined from standard sources, such as packaged inserts approved by the US Food and Drug Administration (FDA).
  • FDA US Food and Drug Administration
  • the second therapeutic agent is provided at a subtherapeutic dose, if the second therapeutic agent were provided alone.
  • compositions can be used in methods for treating depression, OCD, and anxiety disorders in a subject in need thereof, in which the subject is administer an oral dose of the described composition as herein described.
  • the two active ingredients of the described composition are provided in a single pharmaceutical composition. In other embodiments, the active agents are provided separately.
  • the subject has previously received treatment with an anti-depressant agent.
  • the said anti-depressant agent is ketamine.
  • the anti-depressant agent is an anti-NMDAR agent.
  • the subject suffers from mania, or in some embodiments, the subject suffers from bipolar disorder.
  • the invention provides a method for reducing the incidence or treating suicide or suicide ideation in a subject or population in need thereof, the method comprising providing the subject with an oral dosage regimen as herein described.
  • the methods further include administering a second therapeutic agent for the treatment of depression or for the reduction of the incidence or treatment of suicide or suicide ideation in a subject or population in need thereof.
  • the regimen comprises administering a second therapeutic agent which is an anti-depressant, and said dosage is in accordance with standard prescribing guidelines.
  • the regimen comprises a second therapeutic agent which is a psychotropic medication.
  • the pharmaceutical compositions can be administered to the patient by any, or a combination, of several routes, for example, whereas D-cycloserine may be administered orally, the second therapeutic agent administered, as herein described may be administered by any appropriate route, for example, such second therapeutic agent may be provided as an oral, intravenous, trans-mucosal (e.g. nasal, vaginal, etc.), pulmonary, transdermal, ocular, buccal, sublingual, intraperitoneal, intrathecal, intramuscular, or long term depot preparation.
  • trans-mucosal e.g. nasal, vaginal, etc.
  • pulmonary, transdermal, ocular, buccal, sublingual, intraperitoneal, intrathecal, intramuscular, or long term depot preparation e.g. nasal, vaginal, etc.
  • solid compositions for oral administration can contain suitable carriers or excipients, such as corn starch, gelatin, lactose, acacia, sucrose, microcrystalline cellulose, kaolin, mannitol, dicalcium phosphate, calcium carbonate, sodium chloride, lipids, alginic acid, or ingredients for controlled slow release.
  • suitable carriers or excipients such as corn starch, gelatin, lactose, acacia, sucrose, microcrystalline cellulose, kaolin, mannitol, dicalcium phosphate, calcium carbonate, sodium chloride, lipids, alginic acid, or ingredients for controlled slow release.
  • Disintegrators that can be used include, without limitation, micro-crystalline cellulose, corn starch, sodium starch glycolate and alginic acid.
  • Tablet binders that may be used include, without limitation, acacia, methylcellulose, sodium carboxymethylcellulose, polyvinylpyrrolidone (Povidone), hydroxypropyl methylcellulose, suc
  • liquid compositions for oral administration prepared in water or other aqueous vehicles can include solutions, emulsions, syrups, and elixirs containing, together with the active compound(s), wetting agents, sweeteners, coloring agents, and flavoring agents.
  • Various liquid and powder compositions can be prepared by conventional methods for inhalation into the lungs of the patient to be treated.
  • the second therapeutic agent may be formulated as an injectable composition, which may contain various carriers such as vegetable oils, dimethylacetamide, dimethylformamide, ethyl lactate, ethyl carbonate, isopropyl myristate, ethanol, polyols (glycerol, propylene glycol, liquid polyethylene glycol, and the like).
  • various carriers such as vegetable oils, dimethylacetamide, dimethylformamide, ethyl lactate, ethyl carbonate, isopropyl myristate, ethanol, polyols (glycerol, propylene glycol, liquid polyethylene glycol, and the like).
  • the second therapeutic agent may be formulated as an intravenous injection, the compounds may be administered by the drip method, whereby a pharmaceutical composition containing the active compound(s) and a physiologically acceptable excipient is infused.
  • Physiologically acceptable excipients may include, for example, 5% dextrose, to 0.9% saline, Ringer's solution or other suitable excipients.
  • a sterile composition of a suitable soluble salt form of the compound can be dissolved and administered in a pharmaceutical excipient such as Water-for-Injection, 0.9% saline, or 5% glucose solution, or depot forms of the compounds (e.g., decanoate, palmitate, undecylenic, enanthate) can be dissolved in sesame oil.
  • the pharmaceutical composition can be formulated as a chewing gum, lollipop, or the like.
  • the dosage regimen and methods described herein represent an optimum arrived at by administering the D-cycloserine orally, it will be appreciated by the skilled artisan that a lower dosage may be accomplished with the same achieved plasma level by administering the D-cycloserine by a route that does not undergo first pass metabolism. According to this aspect, the dosage can be adjusted to be staggered accordingly, as presented for the oral dosage regimens described herein, with proportionately lower dosages, to accommodate a non-oral administration route, and such alterations are to be considered to be an embodied regimen of this invention.
  • a lower dosage may be accomplished with the same achieved plasma level by administering the D-cycloserine in a formulation that undergoes reduced gastric degradation, for example by applying an enteric coating.
  • the formulations as herein described, in particular with regard to oral formulations are envisioned to comprise slow release tablet formulations.
  • Such slow release tablet formulations may, for example, comprise commercially available formulations containing known anti-depressant medications, such as, for example, Effexor (venlafaxine) or Seroquel (quetiapine), both of which are already available in extended length (XR) formulations, however the formulation may be modified to further incorporate D-cycloserine.
  • the formulations as herein described, in particular with regard to oral formulations are envisioned to comprise both short acting and extended release formulations.
  • Extended release formulations have the advantage inter alia of minimizing the difference between peak and trough levels of drug, and thereby to increase effectiveness and/or reduce side effects of a medication.
  • D-cycloserine has a relatively short half-life in man, and therefore is presently used in BID dosing.
  • BID dosing is envisioned. According to this aspect, and in some embodiments, such consideration will nonetheless ensure that the daily dosage described for the regimens defined herein are not exceeded.
  • D-cycloserine is microencapsulated to increase its circulating half-life.
  • the microencapsulated compound would then be combined either with an anti-depressant medication that is already administered once daily (e.g. sertraline, citalopram, aripiprazole) to insure that cycloserine cannot be taken without accompanying antidepressant (which would increase risk of CNS side effects).
  • an anti-depressant medication e.g. sertraline, citalopram, aripiprazole
  • the drug could be combined with an anti-depressant compound that is already typically given in divided doses (e.g.
  • venlafaxine, quetiapine and the two drugs could then be microencapsulated in common to yield a once-daily formulation with similar half-life between the two ingredients.
  • Microencapsulation using standard approaches for cf. Doshi D H, Oral Drug Delivery Systems, in Gibaldi's Drug Delivery Systems in Pharmaceutical Care, Desai A & Lee M (eds), Bethesda, Md.: American Society of Health-System Pharmacists, 2007. pp. 23-43) such as use of coating materials or matrix-based oral delivery systems.
  • drugs are mixed with a gelling agent, such as hydroxypropylmethylcellulose or hydroxylpropylcellulose, which form a hydrophilic matrix (gel) upon contact with water that delays release of the compound.
  • a gelling agent such as hydroxypropylmethylcellulose or hydroxylpropylcellulose
  • release properties can be regulated by selection of specific gelling agents, as is known in the art (see, for example, U.S. Pat. No. 5,948,437; European patent EP20040765928, U.S. Pat. No. 7,807,195).
  • cellulose ethylcellulose
  • gelatin hypromellose
  • iron oxide titanium oxide
  • drug release is controlled mainly by diffusion through matrix pores and not by the erosion of the polymers.
  • Drug delivery can also be controlled by use of reservoir type systems in which release is controlled by osmotic gradient across the coating membrane.
  • Capsules can be manufactured which contain granules with different microencapsulation properties which can be blended to achieve a composition that has a desired release rate.
  • D-cycloserine is microencapsulated along with quetiapine or a pharmaceutically acceptable salt thereof using a gelling agent such as hydroxypropyl methylcellulose, together with one or more pharmaceutically acceptable excipients.
  • the sustained release formulation comprises a hydrophilic matrix comprising a gelling agent, preferably hydroxypropyl methylcellulose, D-cycloserine, quetiapine and pharmaceutically acceptable salts thereof, together with one or more pharmaceutically acceptable excipients.
  • the methods of treatment provided herein include administering to a subject at least two active ingredients for the treatment of depression and other neuropsychiatric conditions.
  • NMDAR mediate a process termed long-term potentiation that may be excessive in disorders such as depression, obsessive compulsive personality disorder (OCD), post-traumatic stress disorder (PTSD) or other stress-related disorders (SD) and anxiety disorders such as adjustment disorders with depressive, anxious or mixed features.
  • NMDAR excess disorders may be identified by objective biological markers such as reduced brain glutamate+glutamate (Glx) levels as detected using magnetic resonance spectroscopy (MRS) (e.g. Milak et al., Mol Psychiatry. 2016; 21(3):320-7; Kantrowitz et al. Am J Psychiatry. 2016; 173(12):1241-2).
  • MRS magnetic resonance spectroscopy
  • Major depression is a clinical syndrome that includes a persistent sad mood or loss of interest in activities, which persists for at least two weeks in the absence of treatment. Symptoms of major depression are typically measured using rating scales such as the Hamilton Depression Rating Scale (HAM-D) or the Beck Depression Inventory (BDI). In addition to including symptoms relevant to depressed mood, the HAM-D also contains symptoms sensitive to psychosis, including items for guilt, depersonalization/derealization and paranoia.
  • HAM-D Hamilton Depression Rating Scale
  • BDI Beck Depression Inventory
  • Major depression may also be associated with symptoms of anxiety, which may be measured with rating scales such as the Hamilton Rating Scale for Anxiety (HAM-A).
  • Depressive disorders are divided in major depression (MDD) and bipolar depression (BPD), which may be diagnosed using criteria set forth in the Diagnostic and Statistical Manual, 5th edition, published by the American Psychiatric Association (DSM-5), which provides as well additional description of mental disorders.
  • Major depression may also occur with and without melancholic features.
  • depressive symptoms may occur in the context of anxiety disorders such as generalized anxiety disorder, dissociative disorders, personality disorders or adjustment disorders with depressed mood (DSM-5).
  • Bipolar depression may be divided into Bipolar I and Bipolar II subtypes based upon presence or absence of manic episodes.
  • depressive symptoms can occur in the context of either a depressive episode, or a mixed state in which symptoms of mania and depression occur simultaneously or in rapid sequence. Rapid cycling between mania and depressive episodes may also occur in some individuals.
  • the first therapeutic agent in the described methods includes an NMDAR antagonist, such as DCS provided at the net antagonist dose described herein.
  • the method further comprises administering a second therapeutic agent for the treatment of depression to said subject.
  • the second therapeutic agent is administered in the same composition as the NMDAR antagonist. In other embodiments, it is administered separately.
  • the method is not limited in terms of the timing of the administration of the second therapeutic agent, such that the methods of this invention contemplate a subject already treated with a second therapeutic agent, or a naive subject concomitantly treated with D-cycloserine and the second therapeutic agent, or in some embodiments, the subject initially treated with D-cycloserine is then administered a second therapeutic agent, and each of these scenarios represents an embodiment of this invention.
  • Such second therapeutic agent will be any such agent as herein described, including a tetracyclic antidepressant (TeCA), selective serotonin reuptake inhibitor (SSRI), a serotonin/norephinephrine reuptake inhibitor (SNRI), an atypical antidepressant, an antipsychotic approved for treatment of depression or a combination thereof.
  • TeCA tetracyclic antidepressant
  • SSRI selective serotonin reuptake inhibitor
  • SNRI serotonin/norephinephrine reuptake inhibitor
  • an antidepressant an antipsychotic approved for treatment of depression or a combination thereof.
  • the regimen comprises administering a second therapeutic agent at a dosage which is considered to be suboptimal for treating depression in said subject when treating said subject with said second therapeutic agent alone.
  • the methods of treatment are directed to reducing the incidence or treating suicide or suicide ideation in a subject or population.
  • the medicaments in accordance with the described uses of this invention further comprises a second therapeutic agent for reducing the incidence or treating suicide or suicide ideation in a subject or population.
  • the method is not limited in terms of the timing of the administration of the second therapeutic agent, such that the methods of this invention contemplate a subject or population already treated with a second therapeutic agent, or a naive subject or population concomitantly treated with D-cycloserine and the second therapeutic agent, or in some embodiments, the subject or population is initially treated with D-cycloserine and then administered a second therapeutic agent, and each of these scenarios represents an embodiment of this invention.
  • Such second therapeutic agent will be any such agent as herein described, including a tetracyclic antidepressant (TeCA), selective serotonin reuptake inhibitor (SSRI), a serotonin/norephinephrine reuptake inhibitor (SNRI), an atypical antidepressant or an antipsychotic approved for reducing the incidence or treating suicide or suicide ideation in a subject or population or a combination thereof.
  • TeCA tetracyclic antidepressant
  • SSRI selective serotonin reuptake inhibitor
  • SNRI serotonin/norephinephrine reuptake inhibitor
  • an atypical antidepressant or an antipsychotic approved for reducing the incidence or treating suicide or suicide ideation in a subject or population or a combination thereof atypical antidepressant or an antipsychotic approved for reducing the incidence or treating suicide or suicide ideation in a subject or population or a combination thereof.
  • the regimen comprises administering a second therapeutic agent at a dosage which is considered to be suboptimal for reducing the incidence or treating suicide or suicide ideation in a subject or population when treating said subject with said second therapeutic agent alone.
  • depression can occur throughout life and is at least twice as common in women as in men. Patients often present without the subjective sense of being depressed but complaining of somatic symptoms of depression, most commonly fatigue, sleep disturbances, or impotence. Patients may describe feeling sad, blue, low, irritable, or anxious, as well as being depressed.
  • Diagnosis of major depression is based either on a distinct change of mood that is prominent, generally persists throughout the day, and occurs each day for at least 2 weeks or on markedly diminished interest or pleasure in most activities over a similar period.
  • the diagnosis requires that at least four of the following symptoms be present nearly every day for a period of 2 weeks: significant weight loss (or weight gain in some younger patients), prominent sleep disturbance, agitation or retardation with slow speech, fatigue, feelings of worthlessness and guilt, slowed thinking, and hopelessness.
  • Depression can likewise be associated with the symptoms of disease (e.g., systemic lupus erythematosus) or as a side effect of the treatment of disease (e.g., with antihypertensive therapy).
  • symptoms of disease e.g., systemic lupus erythematosus
  • side effect of the treatment of disease e.g., with antihypertensive therapy.
  • One form of depression, postpartum depression has been commonly found in women during the period following childbirth.
  • the methods and materials of this invention are therefore suitable for treatment of depression or symptoms of depression associated with other diseases, as herein described.
  • the subject has previously been administered or is concurrently administered a second therapeutic agent for the treatment of depression.
  • the second therapeutic agent comprises any such agent as herein described, for example, a tetracyclic antidepressant (TeCA), selective serotonin reuptake inhibitor (SSRI), a serotonin/norephinephrine reuptake inhibitor (SNRI), a or atypical antidepressant with reduced serotonergic effects, an antipsychotic approved for use in treatment of depression or a combination thereof.
  • TeCA tetracyclic antidepressant
  • SSRI selective serotonin reuptake inhibitor
  • SNRI serotonin/norephinephrine reuptake inhibitor
  • a or atypical antidepressant with reduced serotonergic effects an antipsychotic approved for use in treatment of depression or a combination thereof.
  • the second therapeutic agent is administered at a dosage, which is considered to be suboptimal for treating depression in said subject when treating said subject with said second therapeutic agent alone.
  • the invention further provides for the use of D-cycloserine in the preparation of a medicament formulated for oral administration at a dosage of >500 to ⁇ 1000 mg/day for the treatment of depression in a subject in need thereof, wherein the dose is formulated to produce sustained plasma levels of between 25-35 microgram/mL.
  • the invention further provides for the use of D-cycloserine in the preparation of a medicament formulated for oral administration at a dosage of 10-25 mg/kg/day for the treatment of depression in a subject in need thereof, wherein the dose is formulated to produce sustained plasma levels of between 25-35 microgram/mL.
  • DCS dosages are applicable to all of the compositions and methods described herein.
  • plasma levels produced by D-cycloserine administration are sustained from 30 minutes to 2 hours following administration.
  • plasma levels produced by D-cycloserine administration are sustained from 30 minutes to 12 hours following administration.
  • a subject undergoing treatment with the methods of the invention can experience significant improvements in depression. Relative to subjects treated with alternative treatments for depression, subjects treated according to the methods of the invention will experience, in some embodiments, greater improvement, or more long-lasting improvement, as measured by any clinically recognized assessment method for depression (e.g., the 21-item Hamilton Depression Rating Scale). It should be noted that not every subject will benefit from the methods of the invention, just as other pharmaceutical agents do not typically benefit every patient.
  • mice Male C57BL/6J mice (8 weeks old) from Jackson Laboratories (Bar Harbor, Me.) were used. Upon receipt, mice were assigned unique identification numbers (tail marked) and were group housed in OPTImice cages. All animals were acclimated to the colony room for 1 week prior to testing. During the period of acclimation, animals were examined on a regular basis, handled, and weighed to assure adequate health and suitability. Animals were maintained on a 12/12 light/dark cycle. The room temperature was maintained between 20 and 23° C. with a relative humidity maintained between 30% and 70%. Chow and water were provided ad libitum for the duration of the study. All testing was performed during the animal's light cycle phase.
  • the open field (OF) test was performed using Plexiglas square chambers (27.3 ⁇ 27.3 ⁇ 20.3 cm; Med Associates Inc., St Albans, Vt.) surrounded by infrared photobeams (16 ⁇ 16 ⁇ 16) to measure horizontal and vertical activities. Mice were brought to the activity experimental room for at least 1 hr acclimation to the experimental room conditions prior to testing. Animals were administered with vehicle, or test compound and placed in the OF. For assessment of D-cycloserine effects, mice were injected with DCS prior to entry into the test chamber, and activity was monitored for 60 min.
  • vehicle or D-cycloserine was administered 30-min prior to challenge with amphetamine (4 mg/kg) or phencyclidine (5 mg/kg), and activity was summed for 60 min following vehicle or D-cycloserine administration.
  • animals were treated with vehicle or antidepressant agents, following which baseline activity was recorded for 30 minutes. Mice then received DCS injections and were placed back into OF chambers for a 60 minute session. At the end of each OF test session the OF chambers were thoroughly cleaned.
  • NDRIs buproprion
  • tricyclic anti-depressants desipramine, imipramine
  • SSRIs/SNRIs associated with high serotonergic transport (SERT) inhibition activity sertraline, venlafaxine, duloxetine, fluoxetine, citalopram
  • newer agents associated with low serotonergic transport inhibition activity relative to other targets such as norepinephrine transporters or 5-HT1A receptors (levomilnacipran, milnacipran, vilazodone, vortioxetine), unexpected differences among the drug classes were observed (Table 2).
  • antidepressants show differential effects on locomotor hyperactivity in the presence of D-cycloserine, with preferential effect noted for agents such as TCAs or the newer antidepressants vilazodone, vortioxetine, milnacipran and levomilnacipran, relative to traditional SSRI/SNRIs or bupropion, a dopamine-norepinephrine reuptake inhibitor.
  • Newer SNRIs and atypical antidepressants differ from traditional medications in that they have higher specificity for targets other than the serotonin transporter, and thus are relatively more similar to TCAs.
  • NMDAR antagonists were assessed using the rodent forced swim tests. NMDAR antagonists were studied alone and in combination with specific antidepression agents.
  • mice Male BalbC/J mice (8 weeks old) from Jackson Laboratories (Bar Harbor, Me.) were used. Upon receipt, mice were assigned unique identification numbers (tail marked) and were group housed in OPTImice cages. All animals were acclimated to the colony room for 1 week prior to testing. During the period of acclimation, animals were examined on a regular basis, handled, and weighed to assure adequate health and suitability. Animals were maintained on a 12/12 light/dark cycle. The room temperature was maintained between 20 and 23° C. with a relative humidity maintained between 30% and 70%. Chow and water were provided ad libitum for the duration of the study. All testing was performed during the animal's light cycle phase.
  • the forced swimming test consisted of one 6-minute session of forced swimming in individual opaque cylinders (15 cm tall ⁇ 10 cm wide, 1000 ml beakers) containing fresh tap water at a temperature of 23 ⁇ 2° C. and a depth of 12 cm (approximately 800 ml) for each test animal. The time the animal spent immobile was recorded over the 6 min trial. Every 1 min the cumulative immobility time was recorded from the start of the session and noted on the study data record sheet Immobility was defined as the postural position of floating in the water. The animals were generally observed with the back slightly hunched and the head above water with no movements or with small stabilizing movements of the limbs. After the swim test, each animal was placed in a pre-heated cage with a heating pad and allowed to dry.
  • the main variable used to represent immobility in this test was the total time immobile during the 6-min test period. Statistics were performed by analysis of variance (ANOVA) with Dunnett post-hoc testing vs. the control condition or by t-test as appropriate.
  • NRIs, SSRIs, SNRIs, TeCAs, atypical and multimodal antidepressants are all indicated for the treatment of depression.
  • potential for additive effect was evaluated across a range of anti-depressants.
  • the forced swim test was used as described in Example 1. Compounds tested were as follows:
  • Results are shown in FIG. 2 . Effects of DCS 300 mg/kg were highly significant across all agents tested. Particular beneficial effects were observed for bupropion, sertraline, and duloxetine where effects of combined antidepressant and DCS 300 mg/kg were significantly larger than with either agent alone.
  • DCS D-cycloserine
  • results for combined DCS and antidepression agents are shown in FIG. 2 .
  • effects of DCS were maintained in the presence of specified agents, as reflected in the difference between combined treatment and the control, no DCS condition.
  • Specific addition beneficial effects were observed in combination with bupropion, TCAs, sertraline, venlafaxine, duloxetine, fluoxetine, vortioxetine and mirtazapine.
  • Combinations with bupropion, sertraline, and duloxetine produced effects greater than DCS alone.
  • mice Male C57BL/6J mice (8 weeks old) from Jackson Laboratories (Bar Harbor, Me.) were used. D-cycloserine (30, 100, 300, 500 and 1000 mg/kg) was dissolved in PTS vehicle (5% PEG200: 5% Tween80: 90% NaCl) and administered IP at a dose volume of 10 mL/kg.
  • PTS vehicle 5% PEG200: 5% Tween80: 90% NaCl
  • mice For each treatment group a total of 12 mice were dosed: 4 mice were collected at 30, 60 and 120 min. Mean plasma level was computed over the 30-60 min time period.
  • results of the experiment are shown in Table 1.
  • peripheral D-cycloserine administration was associated with a dose-dependent increase in plasma D-cycloserine over the 30-60 min time period (p ⁇ 0.0001).
  • Plasma levels associated with 30 mg/kg DCS treatment were associated with a mean plasma level below 25 microgram/mL.
  • Plasma levels associated with the 100 mg/kg dose or higher were all significantly different from 25 ⁇ g/mL (p ⁇ 0.001).
  • the maximum tolerated dose was 500-1000 mg/kg, suggesting a maximum tolerated blood level of approximately 500 ug/mL.
  • Mirtazapine is a racemic compound consisting of 2 stereoisomers: R-ketamine and S-ketamine.
  • R-ketamine 2 stereoisomers
  • S-ketamine 2 stereoisomers
  • Test compounds included DCS formulated as described above, and Mirtazapine, R-Mirtazapine and S-Mirtazapine (5 mg/kg) which were dissolved in PTS vehicle and administered IP at a dose volume of 10 mL/kg 30 minutes prior to test.
  • Results are shown in Table 4: As shown, highly significant beneficial effects were observed with all combinations as shown by highly significant p-values vs. control. In all combinations, DCS also added significantly to anti-depressant effects of mirtazapine or its isomers as shown by significant p values for DCS vs. no DCS. Finally, significantly greater beneficial improvement was noted with combined DCS+R-mirtazapine vs. DCS+S-mirtazapine as shown by the significant values between the two compounds. Although R-mirtazapine and racemic mirtazapine did not differ statistically, reduction in immobility was numerically greater in the presence of R- vs. racemic mirtazapine in both the absence and presence of DCS.
  • Mirtazapine is a racemic mix of separate R( ⁇ ) and S(+) isomers. A follow-up study evaluated the relative effects of the two isomers independently. Methods are the same as for Example 3. Test compounds are as follows:
  • paroxetine The effects of paroxetine, mirtazapine, S-mirtazapine, R-mirtazapine and D-cycloserine on marble-burying behavior are presented in FIG. 4 .
  • One-Way ANOVA found a significant treatment effect.
  • Post-hoc comparisons demonstrated that paroxetine (5 mg/kg), mirtazapine (1, 2.5, 5, and 10 mg/kg), S-mirtazapine (1, 2.5, 5, 10 mg/kg), as well as R-mirtazapine (10 mg/kg) significantly reduced the number of marbles buried compared to vehicle.
  • R-mirtazapine (1, 2.5, and 5 mg/kg) did not affect this measure.

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