JP2004502694A5 - - Google Patents
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- Publication number
- JP2004502694A5 JP2004502694A5 JP2002507819A JP2002507819A JP2004502694A5 JP 2004502694 A5 JP2004502694 A5 JP 2004502694A5 JP 2002507819 A JP2002507819 A JP 2002507819A JP 2002507819 A JP2002507819 A JP 2002507819A JP 2004502694 A5 JP2004502694 A5 JP 2004502694A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- lower alkyl
- compound
- substituted aryl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 25
- 125000000217 alkyl group Chemical group 0.000 claims 21
- 125000003107 substituted aryl group Chemical group 0.000 claims 13
- 125000000623 heterocyclic group Chemical group 0.000 claims 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000002950 monocyclic group Chemical group 0.000 claims 7
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 208000024172 Cardiovascular disease Diseases 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 201000011529 cardiovascular cancer Diseases 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 230000004770 neurodegeneration Effects 0.000 claims 4
- 208000015122 neurodegenerative disease Diseases 0.000 claims 4
- -1 nitro, hydroxyl Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 239000012876 carrier material Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
- OHKAEFOIJCVKDE-TWGQIWQCSA-N (4z)-4-(1h-pyrrol-2-ylmethylidene)-6h-thieno[2,3-b]pyrrol-5-one Chemical compound O=C1NC=2SC=CC=2\C1=C\C1=CC=CN1 OHKAEFOIJCVKDE-TWGQIWQCSA-N 0.000 claims 1
- YMOYTSSMKXZCFR-VURMDHGXSA-N (4z)-4-[(3-methoxy-1h-pyrrol-2-yl)methylidene]-6h-thieno[2,3-b]pyrrol-5-one Chemical compound C1=CNC(\C=C/2C=3C=CSC=3NC\2=O)=C1OC YMOYTSSMKXZCFR-VURMDHGXSA-N 0.000 claims 1
- CSYFNTWWAJGUAC-WTKPLQERSA-N (4z)-4-[(5-methyl-1h-pyrazol-4-yl)methylidene]-6h-thieno[2,3-b]pyrrol-5-one Chemical compound CC1=NNC=C1\C=C/1C(C=CS2)=C2NC\1=O CSYFNTWWAJGUAC-WTKPLQERSA-N 0.000 claims 1
- HFSWOJWBTQMQBS-JYRVWZFOSA-N (4z)-4-[(5-phenyl-1h-pyrazol-4-yl)methylidene]-6h-thieno[2,3-b]pyrrol-5-one Chemical compound O=C1NC=2SC=CC=2\C1=C\C1=CNN=C1C1=CC=CC=C1 HFSWOJWBTQMQBS-JYRVWZFOSA-N 0.000 claims 1
- YJSXBANKTHBJQW-WTKPLQERSA-N (4z)-5-oxo-4-(1h-pyrrol-2-ylmethylidene)-6h-thieno[2,3-b]pyrrole-2-carbonitrile Chemical compound O=C1NC=2SC(C#N)=CC=2\C1=C\C1=CC=CN1 YJSXBANKTHBJQW-WTKPLQERSA-N 0.000 claims 1
- WATMOKNWTZMNQP-DAXSKMNVSA-N (4z)-5-oxo-4-(1h-pyrrol-2-ylmethylidene)-6h-thieno[2,3-b]pyrrole-2-carboxamide Chemical compound O=C1NC=2SC(C(=O)N)=CC=2\C1=C\C1=CC=CN1 WATMOKNWTZMNQP-DAXSKMNVSA-N 0.000 claims 1
- 125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 claims 1
- 125000001376 1,2,4-triazolyl group Chemical group N1N=C(N=C1)* 0.000 claims 1
- 125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- CEVSJBPJNQKMSH-UHFFFAOYSA-N thieno[2,3-b]pyrrol-5-one Chemical compound C1=CSC2=NC(=O)C=C21 CEVSJBPJNQKMSH-UHFFFAOYSA-N 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0016454.1A GB0016454D0 (en) | 2000-07-04 | 2000-07-04 | Thienopyrrolidinones |
| PCT/EP2001/007423 WO2002002567A1 (en) | 2000-07-04 | 2001-06-28 | Thienopyrrolidinones |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004502694A JP2004502694A (ja) | 2004-01-29 |
| JP2004502694A5 true JP2004502694A5 (enExample) | 2005-02-17 |
| JP3878128B2 JP3878128B2 (ja) | 2007-02-07 |
Family
ID=9895032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002507819A Expired - Fee Related JP3878128B2 (ja) | 2000-07-04 | 2001-06-28 | チエノピロリジノン |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6528653B2 (enExample) |
| EP (1) | EP1301517B1 (enExample) |
| JP (1) | JP3878128B2 (enExample) |
| KR (1) | KR100519831B1 (enExample) |
| CN (1) | CN1186346C (enExample) |
| AR (1) | AR030241A1 (enExample) |
| AT (1) | ATE284887T1 (enExample) |
| AU (2) | AU2001287568B2 (enExample) |
| BR (1) | BR0112147A (enExample) |
| CA (1) | CA2414705A1 (enExample) |
| DE (1) | DE60107852T2 (enExample) |
| ES (1) | ES2233677T3 (enExample) |
| GB (1) | GB0016454D0 (enExample) |
| MX (1) | MXPA02012595A (enExample) |
| PT (1) | PT1301517E (enExample) |
| WO (1) | WO2002002567A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004035507A (ja) * | 2002-07-05 | 2004-02-05 | Nippon Soda Co Ltd | ピロール誘導体及びその製造方法 |
| WO2005012311A1 (en) * | 2003-07-31 | 2005-02-10 | Wyeth | N-sulfonylheterocyclopyrrolylalkylamine compounds as 5-hydroxytryptamine-6 ligands |
| CN1939922B (zh) * | 2005-09-27 | 2010-10-13 | 天津和美生物技术有限公司 | 可抑制细胞释放肿瘤坏死因子的5H-噻吩[3，4-c]吡咯-4，6-二酮衍生物 |
| US20070185929A1 (en) * | 2006-02-01 | 2007-08-09 | Sap Portals Isreal Ltd. | Method and apparatus for processing monitoring |
| TWI873092B (zh) | 2018-04-06 | 2025-02-21 | 美商百歐克斯製藥公司 | 取代的苯并呋喃、苯并吡咯、苯并噻吩及結構相關的補體抑制劑 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4797413A (en) | 1986-05-14 | 1989-01-10 | Merck & Co., Inc. | Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use |
| US4863092A (en) | 1988-09-01 | 1989-09-05 | Robertshaw Controls Company | Apparatus for making a diaphragm assembly and method of making the apparatus |
| US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| GB9610964D0 (en) | 1996-05-24 | 1996-07-31 | Pharmacia & Upjohn Spa | Substituted tetralylmethylen-oxindole analogues as tyrosine kinase inhibitors |
| EP0929520B1 (en) | 1996-08-23 | 2005-11-02 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| AU7622698A (en) | 1996-12-05 | 1998-06-29 | Sugen, Inc. | Use of indolinone compounds as modulators of protein kinases |
| CA2289102A1 (en) | 1997-05-07 | 1998-11-12 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| GB9716557D0 (en) | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| FR2770215B1 (fr) | 1997-10-28 | 2000-01-14 | Pf Medicament | Derives d'aminomethyl-benzo[a]quinolizidine, leur preparation et leur application en therapeutique pour les maladies neurodegeneratives |
| US6153634A (en) | 1998-12-17 | 2000-11-28 | Hoffmann-La Roche Inc. | 4,5-azolo-oxindoles |
| ES2301255T3 (es) | 1998-12-17 | 2008-06-16 | F. Hoffmann-La Roche Ag | 4,5-pirazinaxindoles como inhibidores de proteinoquinasas. |
-
2000
- 2000-07-04 GB GBGB0016454.1A patent/GB0016454D0/en not_active Ceased
-
2001
- 2001-06-26 US US09/891,588 patent/US6528653B2/en not_active Expired - Fee Related
- 2001-06-28 AT AT01967106T patent/ATE284887T1/de not_active IP Right Cessation
- 2001-06-28 KR KR10-2003-7000084A patent/KR100519831B1/ko not_active Expired - Fee Related
- 2001-06-28 ES ES01967106T patent/ES2233677T3/es not_active Expired - Lifetime
- 2001-06-28 EP EP01967106A patent/EP1301517B1/en not_active Expired - Lifetime
- 2001-06-28 DE DE60107852T patent/DE60107852T2/de not_active Expired - Fee Related
- 2001-06-28 JP JP2002507819A patent/JP3878128B2/ja not_active Expired - Fee Related
- 2001-06-28 WO PCT/EP2001/007423 patent/WO2002002567A1/en not_active Ceased
- 2001-06-28 AU AU2001287568A patent/AU2001287568B2/en not_active Ceased
- 2001-06-28 MX MXPA02012595A patent/MXPA02012595A/es active IP Right Grant
- 2001-06-28 PT PT01967106T patent/PT1301517E/pt unknown
- 2001-06-28 AU AU8756801A patent/AU8756801A/xx active Pending
- 2001-06-28 CA CA002414705A patent/CA2414705A1/en not_active Abandoned
- 2001-06-28 BR BR0112147-2A patent/BR0112147A/pt not_active IP Right Cessation
- 2001-06-28 CN CNB01812349XA patent/CN1186346C/zh not_active Expired - Fee Related
- 2001-07-03 AR ARP010103167A patent/AR030241A1/es not_active Application Discontinuation
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