CA2414705A1 - Thienopyrrolidinones - Google Patents

Thienopyrrolidinones Download PDF

Info

Publication number
CA2414705A1
CA2414705A1 CA002414705A CA2414705A CA2414705A1 CA 2414705 A1 CA2414705 A1 CA 2414705A1 CA 002414705 A CA002414705 A CA 002414705A CA 2414705 A CA2414705 A CA 2414705A CA 2414705 A1 CA2414705 A1 CA 2414705A1
Authority
CA
Canada
Prior art keywords
optionally substituted
pyrrol
thieno
dihydro
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002414705A
Other languages
English (en)
French (fr)
Inventor
Adrian Liam Gill
William Harris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2414705A1 publication Critical patent/CA2414705A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA002414705A 2000-07-04 2001-06-28 Thienopyrrolidinones Abandoned CA2414705A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0016454.1 2000-07-04
GBGB0016454.1A GB0016454D0 (en) 2000-07-04 2000-07-04 Thienopyrrolidinones
PCT/EP2001/007423 WO2002002567A1 (en) 2000-07-04 2001-06-28 Thienopyrrolidinones

Publications (1)

Publication Number Publication Date
CA2414705A1 true CA2414705A1 (en) 2002-01-10

Family

ID=9895032

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002414705A Abandoned CA2414705A1 (en) 2000-07-04 2001-06-28 Thienopyrrolidinones

Country Status (16)

Country Link
US (1) US6528653B2 (enExample)
EP (1) EP1301517B1 (enExample)
JP (1) JP3878128B2 (enExample)
KR (1) KR100519831B1 (enExample)
CN (1) CN1186346C (enExample)
AR (1) AR030241A1 (enExample)
AT (1) ATE284887T1 (enExample)
AU (2) AU2001287568B2 (enExample)
BR (1) BR0112147A (enExample)
CA (1) CA2414705A1 (enExample)
DE (1) DE60107852T2 (enExample)
ES (1) ES2233677T3 (enExample)
GB (1) GB0016454D0 (enExample)
MX (1) MXPA02012595A (enExample)
PT (1) PT1301517E (enExample)
WO (1) WO2002002567A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004035507A (ja) * 2002-07-05 2004-02-05 Nippon Soda Co Ltd ピロール誘導体及びその製造方法
WO2005012311A1 (en) * 2003-07-31 2005-02-10 Wyeth N-sulfonylheterocyclopyrrolylalkylamine compounds as 5-hydroxytryptamine-6 ligands
CN1939922B (zh) * 2005-09-27 2010-10-13 天津和美生物技术有限公司 可抑制细胞释放肿瘤坏死因子的5H-噻吩[3，4-c]吡咯-4，6-二酮衍生物
US20070185929A1 (en) * 2006-02-01 2007-08-09 Sap Portals Isreal Ltd. Method and apparatus for processing monitoring
TWI873092B (zh) 2018-04-06 2025-02-21 美商百歐克斯製藥公司 取代的苯并呋喃、苯并吡咯、苯并噻吩及結構相關的補體抑制劑

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797413A (en) 1986-05-14 1989-01-10 Merck & Co., Inc. Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
US4863092A (en) 1988-09-01 1989-09-05 Robertshaw Controls Company Apparatus for making a diaphragm assembly and method of making the apparatus
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
GB9610964D0 (en) 1996-05-24 1996-07-31 Pharmacia & Upjohn Spa Substituted tetralylmethylen-oxindole analogues as tyrosine kinase inhibitors
EP0929520B1 (en) 1996-08-23 2005-11-02 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
AU7622698A (en) 1996-12-05 1998-06-29 Sugen, Inc. Use of indolinone compounds as modulators of protein kinases
CA2289102A1 (en) 1997-05-07 1998-11-12 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
GB9716557D0 (en) 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
FR2770215B1 (fr) 1997-10-28 2000-01-14 Pf Medicament Derives d'aminomethyl-benzo[a]quinolizidine, leur preparation et leur application en therapeutique pour les maladies neurodegeneratives
US6153634A (en) 1998-12-17 2000-11-28 Hoffmann-La Roche Inc. 4,5-azolo-oxindoles
ES2301255T3 (es) 1998-12-17 2008-06-16 F. Hoffmann-La Roche Ag 4,5-pirazinaxindoles como inhibidores de proteinoquinasas.

Also Published As

Publication number Publication date
CN1440412A (zh) 2003-09-03
US6528653B2 (en) 2003-03-04
DE60107852T2 (de) 2005-12-08
EP1301517B1 (en) 2004-12-15
ES2233677T3 (es) 2005-06-16
ATE284887T1 (de) 2005-01-15
BR0112147A (pt) 2003-07-01
GB0016454D0 (en) 2000-08-23
WO2002002567A1 (en) 2002-01-10
JP3878128B2 (ja) 2007-02-07
EP1301517A1 (en) 2003-04-16
AU8756801A (en) 2002-01-14
JP2004502694A (ja) 2004-01-29
CN1186346C (zh) 2005-01-26
MXPA02012595A (es) 2003-04-10
US20020028841A1 (en) 2002-03-07
KR100519831B1 (ko) 2005-10-06
KR20030013522A (ko) 2003-02-14
AU2001287568B2 (en) 2007-01-11
DE60107852D1 (en) 2005-01-20
AR030241A1 (es) 2003-08-13
PT1301517E (pt) 2005-04-29

Similar Documents

Publication Publication Date Title
CA2291065C (en) Raf kinase inhibitors
EP1664059B1 (en) Thienopyrroles as antiviral agents
US4239769A (en) Pharmacologically active compounds
WO2010151317A1 (en) Substituted hydroxamic acids and uses thereof
KR102318498B1 (ko) Fshr의 조절인자로서의 피라졸 화합물 및 이의 용도
SK180699A3 (en) HYDRAZINE DERIVATIVES, PREAPARATION PROCESS THEREOF, ITS USE ANDì (54) PHARMACEUTICAL COMPOSITION COMTAINING IT
MX2007000668A (es) Derivados de hidantoina para el tratamiento de trastornos inflamatorios.
WO2008038841A1 (en) Thiadiazolone derivative and use thereof
AU2004230220A1 (en) Substituted 3-cyanothiophene acetamides as glucagon receptor antagonists
EP1828169A2 (en) Urea inhibitors of map kinases
FI79319C (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara tricykliska oxindolkarboxamidderivat.
AU2001287568B2 (en) Thienopyrrolidinones
AU2001287568A1 (en) Thienopyrrolidinones
US9776991B2 (en) Thienomethylpiperazine derivatives as inhibitors of soluble epoxide hydrolase
US3997539A (en) 3-(4-Acylaminopiperazin-1-yl alkyl)indoles, precursors and processes for the preparation thereof
ZA200209971B (en) Thienopyrrolidinones.
CN110627860B (zh) 一类特异性去sumo化蛋白酶1抑制剂及其制备方法和应用
AU770168B2 (en) New metalloprotease inhibitors, a process for their preparation and pharmaceutical compositions containing them
Martín et al. A novel one‐step synthesis of 4H‐furo [3, 4‐b] pyrans and a transformation into a difuro [3, 4‐b: 3′, 4′‐e] pyridine
Guccione et al. Synthesis of 3‐methyl‐substituted pyrazolotriazolopyrimidin‐4‐one and pyrazolothiazolopyrimidin‐4‐one derivatives
Sun et al. A novel four-component reaction involving ring-opening/recyclization of 1, 3-thiazolidinedione
Wei et al. Synthesis of substituted thieno [2, 3‐bpyrroles
CN114573567A (zh) 一种吲唑环联三氮唑类化合物及其制备方法和应用
KR101315788B1 (ko) 매트릭스 메탈로프로테이나제의 억제제로서 사용하기 위한테트라하이드로푸란 유도체
KR100371122B1 (ko) 하이드라진 유도체

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued