HUP0300573A2 - Amid-típusú triazolszármazékok és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Amid-típusú triazolszármazékok és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0300573A2 HUP0300573A2 HU0300573A HUP0300573A HUP0300573A2 HU P0300573 A2 HUP0300573 A2 HU P0300573A2 HU 0300573 A HU0300573 A HU 0300573A HU P0300573 A HUP0300573 A HU P0300573A HU P0300573 A2 HUP0300573 A2 HU P0300573A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- substituted
- substituents
- alkyl group
- groups
- Prior art date
Links
- -1 Triazole compounds Chemical class 0.000 title 1
- 150000001408 amides Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000001424 substituent group Chemical group 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000005843 halogen group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 230000000843 anti-fungal effect Effects 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000000571 coke Substances 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 125000004957 naphthylene group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005650 substituted phenylene group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
Abstract
A találmány új, kiváló antifungális aktivitású, amidtípusútriazolszármazékokra, ezek gyógyászatilag elfogadható prodrugjaira,valamint mindezen vegyületek sóira; továbbá hatóanyagként ilyenvegyületeket tartalmazó (elsősorban antifungális hatású) gyógyászatikészítményekre; valamint a találmány szerinti vegyületek gombásfertőzések kezelésére alkalmas gyógyászati készítmények előállításáratörténő alkalmazására vonatkozik. A találmány szerinti vegyületek (I)általános képletében Ar1 jelentése adott esetben helyettesítettfenilcsoport; Ar2 jelentése adott esetben helyettesített fenilén- vagynaftiléncsoport; X jelentése kénatom vagy metiléncsoport; R1 és R2jelentése hidrogénatom vagy alkilcsoport; R3 jelentése adott esetbenaz alábbiakban definiált A-szubsztituenscsoportból megválasztott 1-5szubsztituenssel helyettesített aril-, heteroaril- vagyaralkilcsoport; az A-szubsztituens-csoportba tartozó szubsztituensek akövetkezők: alkilcsoport, 1-5 szubsztituenssel, éspedig halogénatomok,hidroxililcsoportok, cianocsoportok és alkoxicsoportok közülmegválasztott szubsztituenssel helyettesített alkilcsoport,alkoxicsoport, 1-5 szubsztituenssel, éspedig halogénatomok,hidroxilcsoportok, cianocsoportok és alkoxicsoportok közülmegválasztott szubsztituenssel helyettesített alkoxicsoport,alkanoilcsoport, 1-5 szubsztituenssel, éspedig halogénatomok,hidroxilcsoportok, cianocsoportok és alkoxicsoportok közülmegválasztott szubsztituenssel helyettesített alkanoilcsoport,alkanoiloxicsoport, 1-5 szubsztituensek, éspedig halogénatomok,hidroxilcsoportok, cianocsoportok és alkoxicsoportok közülmegválasztott szubsztituenssel helyettesített alkanoiloxicsoport,halogénatom, hidroxilcsoport, aminocsoport, merkaptocsoport,karbamoilcsoport, nitrocsoport, cianocsoport, karboxilcsoport, -S(O)nR4 általános képletű csoport (ebben a képletben R4 jelentésealkilcsoport vagy 1-5 szubsztituenssel, éspedig halogénatomok közülmegválasztott szubsztituenssel helyettesített alkilcsoport, és nértéke 0, 1 vagy 2), alkenilcsoport, alkinilcsoport, cikloalkilcsoportés cikloalkilalkilcsoport. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000086943 | 2000-03-27 | ||
| PCT/JP2001/002443 WO2001072743A1 (fr) | 2000-03-27 | 2001-03-27 | Composes triazoles possedant une liaison amide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0300573A2 true HUP0300573A2 (hu) | 2003-08-28 |
Family
ID=18603035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0300573A HUP0300573A2 (hu) | 2000-03-27 | 2001-03-27 | Amid-típusú triazolszármazékok és ezeket tartalmazó gyógyszerkészítmények |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6653330B2 (hu) |
| EP (1) | EP1284267B1 (hu) |
| KR (1) | KR20020083530A (hu) |
| CN (1) | CN1432014A (hu) |
| AT (1) | ATE284884T1 (hu) |
| AU (2) | AU4279801A (hu) |
| BR (1) | BR0109573A (hu) |
| CA (1) | CA2404701A1 (hu) |
| CZ (1) | CZ20023209A3 (hu) |
| DE (1) | DE60107836D1 (hu) |
| DK (1) | DK1284267T3 (hu) |
| HU (1) | HUP0300573A2 (hu) |
| IL (1) | IL151880A0 (hu) |
| MX (1) | MXPA02009673A (hu) |
| NO (1) | NO20024615L (hu) |
| NZ (1) | NZ521603A (hu) |
| PL (1) | PL357306A1 (hu) |
| PT (1) | PT1284267E (hu) |
| RU (1) | RU2232761C2 (hu) |
| TW (1) | TW591024B (hu) |
| WO (1) | WO2001072743A1 (hu) |
| ZA (1) | ZA200207710B (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002040472A1 (fr) * | 2000-11-16 | 2002-05-23 | Sankyo Company, Limited | Fongicides à base de carbamoyl-triazoles |
| HUP0303249A3 (en) | 2001-02-22 | 2007-03-28 | Sankyo Co | Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them |
| AU2003223100A1 (en) * | 2002-02-12 | 2003-09-04 | Fdc Limited | 1,2,4-triazol-1-yl-propan-2-ol derivatives as anti-fungal agents |
| AU2003264533A1 (en) * | 2002-09-20 | 2004-04-08 | Sankyo Company, Limited | Water-soluble triazole compound |
| BRPI0411043A (pt) * | 2003-06-06 | 2006-07-11 | Sankyo Co | composição medicinal |
| DE102006039589A1 (de) * | 2006-08-24 | 2008-03-06 | Bayer Healthcare Ag | Aminoacyl-Prodrugs II |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100367327B1 (ko) * | 1995-04-06 | 2003-03-03 | 상꾜 가부시키가이샤 | 트리아졸항진균제 |
| JP3622882B2 (ja) * | 1996-10-04 | 2005-02-23 | 三共株式会社 | トリアゾール誘導体を含有する医薬 |
| JPH10279567A (ja) | 1997-02-04 | 1998-10-20 | Sankyo Co Ltd | トリアゾール誘導体 |
| AU7937998A (en) * | 1997-07-08 | 1999-02-08 | Sankyo Company Limited | Antifungal triazole compounds |
| JPH1180135A (ja) | 1997-07-08 | 1999-03-26 | Sankyo Co Ltd | 抗真菌トリアゾール化合物 |
-
2001
- 2001-03-23 TW TW090106942A patent/TW591024B/zh not_active IP Right Cessation
- 2001-03-27 CA CA002404701A patent/CA2404701A1/en not_active Abandoned
- 2001-03-27 AT AT01915807T patent/ATE284884T1/de not_active IP Right Cessation
- 2001-03-27 AU AU4279801A patent/AU4279801A/xx active Pending
- 2001-03-27 WO PCT/JP2001/002443 patent/WO2001072743A1/ja active IP Right Grant
- 2001-03-27 PT PT01915807T patent/PT1284267E/pt unknown
- 2001-03-27 AU AU2001242798A patent/AU2001242798B2/en not_active Ceased
- 2001-03-27 NZ NZ521603A patent/NZ521603A/en unknown
- 2001-03-27 HU HU0300573A patent/HUP0300573A2/hu unknown
- 2001-03-27 EP EP01915807A patent/EP1284267B1/en not_active Expired - Lifetime
- 2001-03-27 PL PL01357306A patent/PL357306A1/xx not_active Application Discontinuation
- 2001-03-27 BR BR0109573-0A patent/BR0109573A/pt not_active IP Right Cessation
- 2001-03-27 MX MXPA02009673A patent/MXPA02009673A/es not_active Application Discontinuation
- 2001-03-27 DK DK01915807T patent/DK1284267T3/da active
- 2001-03-27 RU RU2002125872/04A patent/RU2232761C2/ru not_active IP Right Cessation
- 2001-03-27 CZ CZ20023209A patent/CZ20023209A3/cs unknown
- 2001-03-27 DE DE60107836T patent/DE60107836D1/de not_active Expired - Lifetime
- 2001-03-27 CN CN01810246A patent/CN1432014A/zh active Pending
- 2001-03-27 IL IL15188001A patent/IL151880A0/xx unknown
- 2001-03-27 KR KR1020027012730A patent/KR20020083530A/ko not_active Application Discontinuation
-
2002
- 2002-09-25 ZA ZA200207710A patent/ZA200207710B/en unknown
- 2002-09-26 NO NO20024615A patent/NO20024615L/no not_active Application Discontinuation
- 2002-09-27 US US10/259,944 patent/US6653330B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20023209A3 (cs) | 2003-01-15 |
| AU2001242798B2 (en) | 2004-02-26 |
| NZ521603A (en) | 2003-10-31 |
| ZA200207710B (en) | 2004-01-02 |
| ATE284884T1 (de) | 2005-01-15 |
| CN1432014A (zh) | 2003-07-23 |
| DK1284267T3 (da) | 2005-01-24 |
| KR20020083530A (ko) | 2002-11-02 |
| WO2001072743A1 (fr) | 2001-10-04 |
| BR0109573A (pt) | 2003-01-28 |
| DE60107836D1 (de) | 2005-01-20 |
| PT1284267E (pt) | 2005-02-28 |
| US20030176480A1 (en) | 2003-09-18 |
| EP1284267A4 (en) | 2004-02-11 |
| EP1284267A1 (en) | 2003-02-19 |
| RU2232761C2 (ru) | 2004-07-20 |
| RU2002125872A (ru) | 2004-01-10 |
| MXPA02009673A (es) | 2003-03-10 |
| TW591024B (en) | 2004-06-11 |
| NO20024615D0 (no) | 2002-09-26 |
| IL151880A0 (en) | 2003-04-10 |
| EP1284267B1 (en) | 2004-12-15 |
| AU4279801A (en) | 2001-10-08 |
| PL357306A1 (en) | 2004-07-26 |
| US6653330B2 (en) | 2003-11-25 |
| CA2404701A1 (en) | 2002-09-26 |
| NO20024615L (no) | 2002-11-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0201646A2 (hu) | Új alfa-aminosav vegyületek, eljárás ezek előállítására, és ezeket tartalmazó gyógyászati készítmények | |
| EA200300792A1 (ru) | Хиназолины в качестве ингибиторов ммр-13 | |
| CY1106522T1 (el) | Ετepοκυκλικη ενωση και αντικαρκινικο μεσο που πepιεχει την ιδια ως δραστικο συστατικο | |
| TR199800720T2 (xx) | Farnesil transferaz inhibe eden 2-kinolon t�revleri. | |
| TW200420542A (en) | A compound having TGF β inhibition activity and a medicinal composition containing the same | |
| HUP0301607A2 (hu) | Szelektív neurokinin antagonista hatású nitrogéntartalmú heterociklusos vegyületek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| HUP0103884A2 (hu) | Arilszulfonanilidkarbamid-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| BG104853A (en) | Thienylazolylalcoxyethanamines, their preparation and their application as medicaments | |
| HUP0000762A2 (hu) | 2-Amino-6-(2-szubsztituált-4-fenoxi)piridin-származékok, valamint a vegyületeket tartalmazó gyógyászati készítmények | |
| RU94046018A (ru) | 3-арилпиразольные производные, способ их получения и фунгицидная композиция на их основе | |
| HUP0100732A2 (hu) | Amidvegyületet és azolszármazékot tartalmazó szinergetikus hatású fungicid kompozíció és alkalmazása | |
| EP0765865A4 (en) | 2-ACYLAMINOPROPANOL COMPOUND AND MEDICINAL COMPOSITION | |
| TR200103349T2 (tr) | Purin türevleri, hazırlama usulü ve bunları içeren ispençiyari bileşimleri. | |
| KR970706275A (ko) | 피리미디닐피라졸 유도체(Pyrimidinylpyrazole derivative) | |
| BG104717A (en) | Water soluble azoles as broad-spectrum antifungals | |
| HUP0300573A2 (hu) | Amid-típusú triazolszármazékok és ezeket tartalmazó gyógyszerkészítmények | |
| BG106847A (en) | Substituted piperazine derivatives as mtp inhibitors | |
| PT1015449E (pt) | Derivados de (hetero)aril-sulfonamida, sua preparacao e sua utilizacao como inibidores do factor xa | |
| HUP0204501A2 (hu) | Gyűrűs vegyületek, ezeket tartalmazó gyógyászati készítmények, valamint eljárás a vegyületek előállítására és alkalmazásuk | |
| HUP9904210A2 (hu) | Kamptotecin-analógok, alkalmazásuk gyógyszerként és ilyen vegyületeket tartalmazó gyógyászati készítmények | |
| DK0982305T3 (da) | Indan-1-ol-derivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende derivaterne | |
| HUP0103166A2 (hu) | Karbamát- és karbamidtartalmú készítmények, és neurotróf alkalmazásuk | |
| ATE195517T1 (de) | Chinolinonderivate und diese enthaltende antiallergische zusammensetzungen | |
| HUP0303137A2 (hu) | Kettős hatású antioxidáns és antiaritmiás szerek | |
| HUP0301000A2 (hu) | 2-Aminotiazolin-származékok, eljárás előállításukra, a vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk NO-szintáz inhibitorokként |