JP2004053596A5 - - Google Patents

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JP2004053596A5
JP2004053596A5 JP2003183409A JP2003183409A JP2004053596A5 JP 2004053596 A5 JP2004053596 A5 JP 2004053596A5 JP 2003183409 A JP2003183409 A JP 2003183409A JP 2003183409 A JP2003183409 A JP 2003183409A JP 2004053596 A5 JP2004053596 A5 JP 2004053596A5
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adsorbent
method described
desorption
substrate
spectrometry
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JP4079223B2 (ja
JP2004053596A (ja
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Claims (22)

  1. 試料中の少なくとも1つの被分析物を検出するための基材を調製する方法であって、
    a)少なくとも2つの異なる選択条件に該試料を曝露する工程であって、各選択条件は、該吸着体と溶離物との組み合わせによって規定されて、該吸着体による該被分析物の保持を可能にする、工程;
    b)脱離スペクトロメトリーによって、該被分析物が保持される少なくとも1つの選択条件を決定する工程;および
    c)決定された選択条件の少なくとも1つの吸着体を含む基材を調製する工程、
    を包含する、方法。
  2. 疾患の診断マーカーを複数検出する方法であって、
    a)基材に付着した少なくとも一つの吸着体と、被験体由来の生物学的試料を接触させて、少なくとも一つの吸着体を診断マーカーに結合させる工程;
    b)少なくとも一つの溶離物で少なくとも一つの吸着体を洗浄して、結合していない材料を除去し、かつ少なくとも一つの吸着体による診断マーカーの保持を可能にする工程;
    c)脱離スペクトロメトリーによって、保持された診断マーカーを検出する工程;および
    d)複数の診断マーカーの検出データを提供する工程であって、データが、複数の診断マーカーの示差的な存在を示す工程
    を包含する、方法。
  3. 複数の吸着体が少なくとも一つの基材に付着し、各吸着体が、アドレス可能な位置において付着している、請求項 2 記載の方法。
  4. 疾患が、ガン、心臓病、自己免疫疾患、ウイルス感染、アルツハイマー病、および糖尿病から選択される、請求項 2 記載の方法。
  5. 生物学的試料が、組織、血液、尿、大便、リンパ液、脳脊髄液、および関節内液から選択される、請求項 2 記載の方法。
  6. 生物学的試料が病理細胞に由来する、請求項 2 記載の方法。
  7. 少なくとも一つの吸着体が疎水性吸着体である、請求項 2 記載の方法。
  8. 少なくとも一つの吸着体がチオフィリック( thiophilic )吸着体である、請求項 2 記載の方法。
  9. 少なくとも一つの吸着体が正常相吸着体である、請求項 2 記載の方法。
  10. 少なくとも一つの吸着体がアニオン交換吸着体である、請求項 2 記載の方法。
  11. 少なくとも一つの吸着体がカチオン交換吸着体である、請求項 2 記載の方法。
  12. 少なくとも一つの吸着体が金属イオン吸着体である、請求項 2 記載の方法。
  13. 少なくとも一つの吸着体が糖タンパク質相互作用吸着体である、請求項 2 記載の方法。
  14. 少なくとも一つの吸着体が核酸を含む、請求項 2 記載の方法。
  15. 少なくとも一つの吸着体が、診断マーカーに結合する複数の抗体を含む、請求項 2 記載 の方法。
  16. 同一のアドレス可能な位置において、抗体が基材に付着する、請求項 15 記載の方法。
  17. 異なるアドレス可能な位置において、診断マーカーが抗体に結合する、請求項 15 記載の方法。
  18. 一つまたは複数のマーカーがポリペプチドを含む、請求項 2 17 のいずれか一項記載の方法。
  19. 一つまたは複数のマーカーが核酸を含む、請求項 2 17 のいずれか一項記載の方法。
  20. 脱離スペクトロメトリーが、レーザー脱離/イオン化質量スペクトロメトリーである、請求項 2 17 のいずれか一項記載の方法。
  21. 脱離スペクトロメトリーが、レーザー脱離/イオン化質量スペクトロメトリーである、請求項 18 記載の方法。
  22. 脱離スペクトロメトリーが、レーザー脱離/イオン化質量スペクトロメトリーである、請求項 19 記載の方法。
JP2003183409A 1997-06-20 2003-06-26 生物学および医学に応用される被保持物クロマトグラフィーおよびタンパク質チップアレイ Expired - Fee Related JP4079223B2 (ja)

Applications Claiming Priority (2)

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US5433397P 1997-06-20 1997-06-20
US6748497P 1997-12-01 1997-12-01

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JP2001395462A Division JP4079210B2 (ja) 1997-06-20 2001-12-26 生物学および医学に応用される被保持物クロマトグラフィーおよびタンパク質チップアレイ

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JP2004053596A JP2004053596A (ja) 2004-02-19
JP2004053596A5 true JP2004053596A5 (ja) 2005-10-20
JP4079223B2 JP4079223B2 (ja) 2008-04-23

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JP50491899A Expired - Fee Related JP3287578B2 (ja) 1997-06-20 1998-06-19 生物学および医学に応用される被保持物クロマトグラフィーおよびタンパク質チップアレイ
JP50487699A Expired - Fee Related JP4017193B2 (ja) 1997-06-20 1998-06-19 生物学および医学に応用される被保持物クロマトグラフィーおよびタンパク質チップアレイ
JP50491799A Withdrawn JP2002511145A (ja) 1997-06-20 1998-06-19 生物学および医学に応用される被保持物クロマトグラフィーおよびタンパク質チップアレイ
JP2001395462A Expired - Fee Related JP4079210B2 (ja) 1997-06-20 2001-12-26 生物学および医学に応用される被保持物クロマトグラフィーおよびタンパク質チップアレイ
JP2003183409A Expired - Fee Related JP4079223B2 (ja) 1997-06-20 2003-06-26 生物学および医学に応用される被保持物クロマトグラフィーおよびタンパク質チップアレイ
JP2006278224A Expired - Fee Related JP4129540B2 (ja) 1997-06-20 2006-10-12 生物学および医学に応用される被保持物クロマトグラフィーおよびタンパク質チップアレイ
JP2007201176A Withdrawn JP2008039781A (ja) 1997-06-20 2007-08-01 生物学および医学に応用される被保持物クロマトグラフィーおよびタンパク質チップアレイ

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JP50487699A Expired - Fee Related JP4017193B2 (ja) 1997-06-20 1998-06-19 生物学および医学に応用される被保持物クロマトグラフィーおよびタンパク質チップアレイ
JP50491799A Withdrawn JP2002511145A (ja) 1997-06-20 1998-06-19 生物学および医学に応用される被保持物クロマトグラフィーおよびタンパク質チップアレイ
JP2001395462A Expired - Fee Related JP4079210B2 (ja) 1997-06-20 2001-12-26 生物学および医学に応用される被保持物クロマトグラフィーおよびタンパク質チップアレイ

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JP2007201176A Withdrawn JP2008039781A (ja) 1997-06-20 2007-08-01 生物学および医学に応用される被保持物クロマトグラフィーおよびタンパク質チップアレイ

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US (16) US6818411B2 (ja)
EP (3) EP0990257A1 (ja)
JP (7) JP3287578B2 (ja)
KR (3) KR100629699B1 (ja)
CN (3) CN100369181C (ja)
AT (1) ATE423391T1 (ja)
AU (3) AU754145B2 (ja)
CA (3) CA2294416A1 (ja)
DE (1) DE69840584D1 (ja)
IL (6) IL133609A0 (ja)
NO (1) NO996243L (ja)
NZ (6) NZ516848A (ja)
WO (3) WO1998059360A1 (ja)

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