JP2003503477A5 - - Google Patents
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- Publication number
- JP2003503477A5 JP2003503477A5 JP2001507800A JP2001507800A JP2003503477A5 JP 2003503477 A5 JP2003503477 A5 JP 2003503477A5 JP 2001507800 A JP2001507800 A JP 2001507800A JP 2001507800 A JP2001507800 A JP 2001507800A JP 2003503477 A5 JP2003503477 A5 JP 2003503477A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- amlodipine
- methyl
- trityl
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/HU1999/000050 WO2001002360A1 (en) | 1999-07-05 | 1999-07-05 | Process for preparing amlodipine benzenesulphonate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003503477A JP2003503477A (ja) | 2003-01-28 |
| JP2003503477A5 true JP2003503477A5 (https=) | 2006-01-05 |
| JP3764386B2 JP3764386B2 (ja) | 2006-04-05 |
Family
ID=10991279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001507800A Expired - Lifetime JP3764386B2 (ja) | 1999-07-05 | 1999-07-05 | アムロジピンベンゼンスルホン酸塩の製造方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6596874B1 (https=) |
| EP (1) | EP1196383B1 (https=) |
| JP (1) | JP3764386B2 (https=) |
| KR (1) | KR100585442B1 (https=) |
| CN (1) | CN1141297C (https=) |
| AT (1) | ATE283841T1 (https=) |
| AU (1) | AU777565B2 (https=) |
| BG (1) | BG65657B1 (https=) |
| CA (1) | CA2376540C (https=) |
| CZ (1) | CZ300509B6 (https=) |
| DE (1) | DE69922417T2 (https=) |
| DK (1) | DK1196383T3 (https=) |
| EA (1) | EA004208B1 (https=) |
| EE (1) | EE05398B1 (https=) |
| ES (1) | ES2234272T3 (https=) |
| HK (1) | HK1044151B (https=) |
| MX (1) | MXPA01013407A (https=) |
| NO (1) | NO321714B1 (https=) |
| NZ (1) | NZ517013A (https=) |
| PL (1) | PL194193B1 (https=) |
| PT (1) | PT1196383E (https=) |
| SK (1) | SK285611B6 (https=) |
| UA (1) | UA72768C2 (https=) |
| WO (1) | WO2001002360A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100354806B1 (ko) * | 2000-06-21 | 2002-10-05 | 한국유나이티드제약 주식회사 | 암로디핀 베실레이트의 신규 중간체 및 그의 제조방법 |
| KR100452491B1 (ko) * | 2001-03-29 | 2004-10-12 | 한미약품 주식회사 | 신규한 결정형 암로디핀 캠실레이트 염 및 그의 제조방법 |
| US7153970B2 (en) | 2001-07-06 | 2006-12-26 | Lek Pharmaceuticals D.D. | High purity amlodipine benzenesulfonate and a process for its preparation |
| US6680334B2 (en) | 2001-08-28 | 2004-01-20 | Pfizer Inc | Crystalline material |
| US6828339B2 (en) * | 2001-11-21 | 2004-12-07 | Synthon Bv | Amlodipine salt forms and processes for preparing them |
| KR100496436B1 (ko) * | 2002-07-30 | 2005-06-20 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| KR100462304B1 (ko) * | 2002-07-30 | 2004-12-17 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| KR100467669B1 (ko) * | 2002-08-21 | 2005-01-24 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| US6784297B2 (en) | 2002-09-04 | 2004-08-31 | Kopran Limited | Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate |
| JP2008013489A (ja) * | 2006-07-06 | 2008-01-24 | Ohara Yakuhin Kogyo Kk | ベシル酸アムロジピン含有錠剤 |
| EP1975167A1 (en) | 2007-03-30 | 2008-10-01 | Esteve Quimica, S.A. | Acetone solvate of phthaloyl amlodipine |
| CN101812014B (zh) * | 2010-04-28 | 2011-08-24 | 王明 | 一种苯磺酸氨氯地平化合物及其制法 |
| CN102993083A (zh) * | 2012-12-21 | 2013-03-27 | 王学军 | 一种苯磺酸氨氯地平的制备方法 |
| CN104262237A (zh) * | 2014-09-28 | 2015-01-07 | 常州瑞明药业有限公司 | 氨氯地平自由碱的合成方法 |
| US11452690B1 (en) | 2021-01-27 | 2022-09-27 | ECI Pharmaceuticals, LLC | Oral liquid compositions comprising amlodipine besylate and methods of using the same |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK161312C (da) * | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
| GB8608335D0 (en) * | 1986-04-04 | 1986-05-08 | Pfizer Ltd | Pharmaceutically acceptable salts |
| SI9200344B (sl) * | 1992-11-26 | 1998-06-30 | Lek, | Postopek za pripravo amlodipin benzensulfonata |
| HU221810B1 (hu) * | 1997-08-12 | 2003-01-28 | EGIS Gyógyszergyár Rt. | Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei |
| DE19738943B4 (de) | 1997-09-05 | 2008-01-03 | Siemens Ag | Verfahren und Einrichtung zur Bestimmung von Eigenschaften eines Stahls |
-
1999
- 1999-05-07 UA UA2002020897A patent/UA72768C2/uk unknown
- 1999-07-05 HK HK02105733.9A patent/HK1044151B/zh not_active IP Right Cessation
- 1999-07-05 AU AU49237/99A patent/AU777565B2/en not_active Expired
- 1999-07-05 CN CNB998167746A patent/CN1141297C/zh not_active Expired - Lifetime
- 1999-07-05 DK DK99933061T patent/DK1196383T3/da active
- 1999-07-05 KR KR1020027000052A patent/KR100585442B1/ko not_active Expired - Lifetime
- 1999-07-05 EE EEP200100686A patent/EE05398B1/xx unknown
- 1999-07-05 JP JP2001507800A patent/JP3764386B2/ja not_active Expired - Lifetime
- 1999-07-05 EA EA200200125A patent/EA004208B1/ru not_active IP Right Cessation
- 1999-07-05 US US10/019,424 patent/US6596874B1/en not_active Expired - Lifetime
- 1999-07-05 ES ES99933061T patent/ES2234272T3/es not_active Expired - Lifetime
- 1999-07-05 CA CA002376540A patent/CA2376540C/en not_active Expired - Lifetime
- 1999-07-05 NZ NZ517013A patent/NZ517013A/en not_active IP Right Cessation
- 1999-07-05 MX MXPA01013407A patent/MXPA01013407A/es not_active IP Right Cessation
- 1999-07-05 WO PCT/HU1999/000050 patent/WO2001002360A1/en not_active Ceased
- 1999-07-05 PL PL99352493A patent/PL194193B1/pl unknown
- 1999-07-05 EP EP99933061A patent/EP1196383B1/en not_active Expired - Lifetime
- 1999-07-05 PT PT99933061T patent/PT1196383E/pt unknown
- 1999-07-05 SK SK2-2002A patent/SK285611B6/sk not_active IP Right Cessation
- 1999-07-05 DE DE69922417T patent/DE69922417T2/de not_active Expired - Lifetime
- 1999-07-05 CZ CZ20014690A patent/CZ300509B6/cs unknown
- 1999-07-05 AT AT99933061T patent/ATE283841T1/de active
-
2001
- 2001-12-03 BG BG106164A patent/BG65657B1/bg unknown
-
2002
- 2002-01-04 NO NO20020029A patent/NO321714B1/no not_active IP Right Cessation
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