JP2002542461A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002542461A5 JP2002542461A5 JP2000612061A JP2000612061A JP2002542461A5 JP 2002542461 A5 JP2002542461 A5 JP 2002542461A5 JP 2000612061 A JP2000612061 A JP 2000612061A JP 2000612061 A JP2000612061 A JP 2000612061A JP 2002542461 A5 JP2002542461 A5 JP 2002542461A5
- Authority
- JP
- Japan
- Prior art keywords
- well
- sample
- module
- inlet
- sample processing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000001514 detection method Methods 0.000 claims description 27
- 230000027455 binding Effects 0.000 claims description 25
- 150000007523 nucleic acids Chemical class 0.000 claims description 17
- 108020004707 nucleic acids Proteins 0.000 claims description 17
- 239000012491 analyte Substances 0.000 claims description 15
- 238000006243 chemical reaction Methods 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 12
- 239000003446 ligand Substances 0.000 claims description 11
- 238000000926 separation method Methods 0.000 claims description 10
- 239000003153 chemical reaction reagent Substances 0.000 claims description 8
- 239000007787 solid Substances 0.000 claims description 7
- 230000009089 cytolysis Effects 0.000 claims description 6
- 230000002934 lysing Effects 0.000 claims description 6
- 239000002094 self assembled monolayer Substances 0.000 claims description 6
- 230000003321 amplification Effects 0.000 claims description 4
- 238000001962 electrophoresis Methods 0.000 claims description 4
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 4
- 239000000523 sample Substances 0.000 description 31
- 241000700605 Viruses Species 0.000 description 11
- 210000004027 cells Anatomy 0.000 description 10
- 241000894007 species Species 0.000 description 10
- 239000000758 substrate Substances 0.000 description 10
- 235000018102 proteins Nutrition 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 102100010813 EGF Human genes 0.000 description 4
- 101700033006 EGF Proteins 0.000 description 4
- 229940116977 Epidermal Growth Factor Drugs 0.000 description 4
- 102000004965 antibodies Human genes 0.000 description 4
- 108090001123 antibodies Proteins 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- KTWOOEGAPBSYNW-UHFFFAOYSA-N Ferrocene Chemical compound [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 description 3
- 102000011923 Thyrotropin Human genes 0.000 description 3
- 108010061174 Thyrotropin Proteins 0.000 description 3
- 238000004132 cross linking Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drugs Drugs 0.000 description 3
- 239000012212 insulator Substances 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 239000003638 reducing agent Substances 0.000 description 3
- 230000027756 respiratory electron transport chain Effects 0.000 description 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N (3β)-Cholest-5-en-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 102100008450 AFP Human genes 0.000 description 2
- 229960003965 ANTIEPILEPTICS Drugs 0.000 description 2
- 239000000275 Adrenocorticotropic Hormone Substances 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N Cortisol Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 102000004594 DNA Polymerase I Human genes 0.000 description 2
- 108010017826 DNA Polymerase I Proteins 0.000 description 2
- 101700011961 DPOM Proteins 0.000 description 2
- 229940110715 ENZYMES FOR TREATMENT OF WOUNDS AND ULCERS Drugs 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000003951 Erythropoietin Human genes 0.000 description 2
- 108090000394 Erythropoietin Proteins 0.000 description 2
- 229940028334 Follicle Stimulating Hormone Drugs 0.000 description 2
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 description 2
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 description 2
- 229940088597 Hormone Drugs 0.000 description 2
- 229940084986 Human Chorionic Gonadotropin Drugs 0.000 description 2
- 229940040129 Luteinizing Hormone Drugs 0.000 description 2
- 102000009151 Luteinizing Hormone Human genes 0.000 description 2
- 108010073521 Luteinizing Hormone Proteins 0.000 description 2
- 101710029649 MDV043 Proteins 0.000 description 2
- 229920000272 Oligonucleotide Polymers 0.000 description 2
- 101700061424 POLB Proteins 0.000 description 2
- 102100008873 POMC Human genes 0.000 description 2
- 108060006375 POMC Proteins 0.000 description 2
- 101700054624 RF1 Proteins 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N Theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
- 108010041111 Thrombopoietin Proteins 0.000 description 2
- 102000036902 Thrombopoietin Human genes 0.000 description 2
- 102000003978 Tissue plasminogen activator Human genes 0.000 description 2
- 108090000373 Tissue plasminogen activator Proteins 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 108010026331 alpha-Fetoproteins Proteins 0.000 description 2
- 230000003556 anti-epileptic Effects 0.000 description 2
- 239000001961 anticonvulsive agent Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 238000010382 chemical cross-linking Methods 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 230000000295 complement Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 229940105423 erythropoietin Drugs 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229940020899 hematological Enzymes Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229960000890 hydrocortisone Drugs 0.000 description 2
- 230000001717 pathogenic Effects 0.000 description 2
- 150000003573 thiols Chemical class 0.000 description 2
- 229960000187 tissue plasminogen activator Drugs 0.000 description 2
- NKCXQMYPWXSLIZ-PSRDDEIFSA-N (2S)-2-[[(2S)-1-[(2S)-5-amino-2-[[2-[[(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]-3-m Chemical compound O=C([C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)[C@@H](C)O)[C@@H](C)O)C(C)C)N1CCC[C@H]1C(=O)N[C@@H](CO)C(O)=O NKCXQMYPWXSLIZ-PSRDDEIFSA-N 0.000 description 1
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- 102100003649 ACP3 Human genes 0.000 description 1
- 102100007877 APOE Human genes 0.000 description 1
- 101700025839 APOE Proteins 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 229940025084 Amphetamine Drugs 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 229940064005 Antibiotic throat preparations Drugs 0.000 description 1
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 description 1
- 229940042052 Antibiotics for systemic use Drugs 0.000 description 1
- 229940042786 Antitubercular Antibiotics Drugs 0.000 description 1
- 102000007592 Apolipoproteins Human genes 0.000 description 1
- 108010071619 Apolipoproteins Proteins 0.000 description 1
- 241000712891 Arenavirus Species 0.000 description 1
- 229960001230 Asparagine Drugs 0.000 description 1
- 241000588807 Bordetella Species 0.000 description 1
- 102100011842 CEACAM5 Human genes 0.000 description 1
- 101710043956 CEACAM5 Proteins 0.000 description 1
- 101710043948 CEACAM7 Proteins 0.000 description 1
- 102100007493 CNTF Human genes 0.000 description 1
- 229960004015 Calcitonin Drugs 0.000 description 1
- 102400000113 Calcitonin Human genes 0.000 description 1
- 108060001064 Calcitonin Proteins 0.000 description 1
- 241000606161 Chlamydia Species 0.000 description 1
- 241000606153 Chlamydia trachomatis Species 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N Chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 229960005091 Chloramphenicol Drugs 0.000 description 1
- 229940107161 Cholesterol Drugs 0.000 description 1
- 108090000322 Cholinesterases Proteins 0.000 description 1
- 102000003914 Cholinesterases Human genes 0.000 description 1
- 108090000317 Chymotrypsin Proteins 0.000 description 1
- 108010005939 Ciliary Neurotrophic Factor Proteins 0.000 description 1
- 241000193163 Clostridioides difficile Species 0.000 description 1
- 241000193403 Clostridium Species 0.000 description 1
- 241000193468 Clostridium perfringens Species 0.000 description 1
- 241000193449 Clostridium tetani Species 0.000 description 1
- 241000711573 Coronaviridae Species 0.000 description 1
- 241000186216 Corynebacterium Species 0.000 description 1
- 241000186227 Corynebacterium diphtheriae Species 0.000 description 1
- 241000700626 Cowpox virus Species 0.000 description 1
- 229960003624 Creatine Drugs 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N Cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 101710008158 D15 Proteins 0.000 description 1
- 102100002445 DNTT Human genes 0.000 description 1
- 101710028159 DNTT Proteins 0.000 description 1
- 206010011985 Decubitus ulcer Diseases 0.000 description 1
- NIJJYAXOARWZEE-UHFFFAOYSA-N Depacane Chemical compound CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 description 1
- 238000005698 Diels-Alder reaction Methods 0.000 description 1
- LTMHDMANZUZIPE-PUGKRICDSA-N Digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 1
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 1
- UVTNFZQICZKOEM-UHFFFAOYSA-N Disopyramide Chemical compound C=1C=CC=NC=1C(C(N)=O)(CCN(C(C)C)C(C)C)C1=CC=CC=C1 UVTNFZQICZKOEM-UHFFFAOYSA-N 0.000 description 1
- 102000001390 EC 4.1.2.13 Human genes 0.000 description 1
- 108010068561 EC 4.1.2.13 Proteins 0.000 description 1
- 241000709661 Enterovirus Species 0.000 description 1
- 241000991587 Enterovirus C Species 0.000 description 1
- CXOFVDLJLONNDW-UHFFFAOYSA-N Epinat Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 description 1
- 241000588722 Escherichia Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 229960005309 Estradiol Drugs 0.000 description 1
- YAGKRVSRTSUGEY-UHFFFAOYSA-N Ferricyanide Chemical compound [Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] YAGKRVSRTSUGEY-UHFFFAOYSA-N 0.000 description 1
- 229940012952 Fibrinogen Drugs 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 229940019698 Fibrinogen containing hemostatics Drugs 0.000 description 1
- 108060003412 GRP Proteins 0.000 description 1
- 241000224467 Giardia intestinalis Species 0.000 description 1
- 229940093922 Gynecological Antibiotics Drugs 0.000 description 1
- 229940093912 Gynecological Sulfonamides Drugs 0.000 description 1
- 102000015779 HDL Lipoproteins Human genes 0.000 description 1
- 102000015787 HIV Protease Human genes 0.000 description 1
- 108010010369 HIV Protease Proteins 0.000 description 1
- 241000606790 Haemophilus Species 0.000 description 1
- 241000606768 Haemophilus influenzae Species 0.000 description 1
- 208000006454 Hepatitis Diseases 0.000 description 1
- 208000009889 Herpes Simplex Diseases 0.000 description 1
- 102000002265 Human Growth Hormone Human genes 0.000 description 1
- 108010000521 Human Growth Hormone Proteins 0.000 description 1
- 239000000854 Human Growth Hormone Substances 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 108091006822 Human Serum Albumin Proteins 0.000 description 1
- 206010020460 Human T-cell lymphotropic virus type I infection Diseases 0.000 description 1
- 241000714260 Human T-lymphotropic virus 1 Species 0.000 description 1
- 241000714259 Human T-lymphotropic virus 2 Species 0.000 description 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 description 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 description 1
- 229940072221 IMMUNOGLOBULINS Drugs 0.000 description 1
- 102000018358 Immunoglobulins Human genes 0.000 description 1
- 108060003951 Immunoglobulins Proteins 0.000 description 1
- 210000003000 Inclusion Bodies Anatomy 0.000 description 1
- 102400000022 Insulin-Like Growth Factor II Human genes 0.000 description 1
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 description 1
- 102000004218 Insulin-like growth factor I Human genes 0.000 description 1
- 108090000723 Insulin-like growth factor I Proteins 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- 229940047122 Interleukins Drugs 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- 102000003855 L-lactate dehydrogenases Human genes 0.000 description 1
- 108091000084 L-lactate dehydrogenases Proteins 0.000 description 1
- XUIIKFGFIJCVMT-LBPRGKRZSA-N L-thyroxine zwitterion Chemical compound IC1=CC(C[C@H]([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-LBPRGKRZSA-N 0.000 description 1
- 102000007330 LDL Lipoproteins Human genes 0.000 description 1
- 108010007622 LDL Lipoproteins Proteins 0.000 description 1
- 102000016267 Leptin Human genes 0.000 description 1
- 108010092277 Leptin Proteins 0.000 description 1
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N Leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 description 1
- 229940040461 Lipase Drugs 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 102100019096 MB Human genes 0.000 description 1
- 101710027747 MT2151 Proteins 0.000 description 1
- 238000006683 Mannich reaction Methods 0.000 description 1
- 238000006751 Mitsunobu reaction Methods 0.000 description 1
- 241000186359 Mycobacterium Species 0.000 description 1
- 241000186362 Mycobacterium leprae Species 0.000 description 1
- 108010062374 Myoglobin Proteins 0.000 description 1
- 241000588653 Neisseria Species 0.000 description 1
- 241000588652 Neisseria gonorrhoeae Species 0.000 description 1
- 241000714209 Norwalk virus Species 0.000 description 1
- 241000150452 Orthohantavirus Species 0.000 description 1
- -1 PDFG Proteins 0.000 description 1
- 101700004495 PSG2 Proteins 0.000 description 1
- 206010033616 Pancreatic disease Diseases 0.000 description 1
- 241001631646 Papillomaviridae Species 0.000 description 1
- 229960002695 Phenobarbital Drugs 0.000 description 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N Phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 1
- 229960002036 Phenytoin Drugs 0.000 description 1
- LLKYUHGUYSLMPA-UHFFFAOYSA-N Phosphoramidite Chemical compound NP([O-])[O-] LLKYUHGUYSLMPA-UHFFFAOYSA-N 0.000 description 1
- 241001505332 Polyomavirus sp. Species 0.000 description 1
- 208000004210 Pressure Ulcer Diseases 0.000 description 1
- REQCZEXYDRLIBE-UHFFFAOYSA-N Procainamide Chemical compound CCN(CC)CCNC(=O)C1=CC=C(N)C=C1 REQCZEXYDRLIBE-UHFFFAOYSA-N 0.000 description 1
- 229940097325 Prolactin Drugs 0.000 description 1
- 102000003946 Prolactin Human genes 0.000 description 1
- 108010057464 Prolactin Proteins 0.000 description 1
- 241000125945 Protoparvovirus Species 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 241000589776 Pseudomonas putida Species 0.000 description 1
- 241000711798 Rabies lyssavirus Species 0.000 description 1
- 241000702263 Reovirus sp. Species 0.000 description 1
- 241000702670 Rotavirus Species 0.000 description 1
- 241000710799 Rubella virus Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 206010039447 Salmonellosis Diseases 0.000 description 1
- 241000607768 Shigella Species 0.000 description 1
- 241000607764 Shigella dysenteriae Species 0.000 description 1
- 206010040550 Shigella infection Diseases 0.000 description 1
- 241000580858 Simian-Human immunodeficiency virus Species 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 102000013275 Somatomedins Human genes 0.000 description 1
- 108010026080 Somatomedins Proteins 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 241000193996 Streptococcus pyogenes Species 0.000 description 1
- 101700038204 TGFA Proteins 0.000 description 1
- 241000718007 Taenionema palladium Species 0.000 description 1
- 229960003604 Testosterone Drugs 0.000 description 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N Tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
- 229960000278 Theophylline Drugs 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 210000001685 Thyroid Gland Anatomy 0.000 description 1
- 229940034208 Thyroxine Drugs 0.000 description 1
- 229940024982 Topical Antifungal Antibiotics Drugs 0.000 description 1
- 102000004338 Transferrin Human genes 0.000 description 1
- 108090000901 Transferrin Proteins 0.000 description 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 1
- 102000009618 Transforming Growth Factors Human genes 0.000 description 1
- 108010009583 Transforming Growth Factors Proteins 0.000 description 1
- 102000006747 Transforming growth factor alpha Human genes 0.000 description 1
- 241000589886 Treponema Species 0.000 description 1
- 102000004987 Troponin T Human genes 0.000 description 1
- 108090001108 Troponin T Proteins 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 102100015249 VEGFA Human genes 0.000 description 1
- 241000700647 Variola virus Species 0.000 description 1
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 1
- 241000607598 Vibrio Species 0.000 description 1
- 241000607626 Vibrio cholerae Species 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Xylocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- 241000607734 Yersinia <bacteria> Species 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000005917 acylation reaction Methods 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 229960002734 amfetamine Drugs 0.000 description 1
- 238000010640 amide synthesis reaction Methods 0.000 description 1
- 150000001412 amines Chemical group 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000038129 antigens Human genes 0.000 description 1
- 108091007172 antigens Proteins 0.000 description 1
- 239000004019 antithrombin Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- BPYKTIZUTYGOLE-IFADSCNNSA-N bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000003115 biocidal Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking Effects 0.000 description 1
- 230000003182 bronchodilatating Effects 0.000 description 1
- 239000000168 bronchodilator agent Substances 0.000 description 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 description 1
- 229930003827 cannabinoid Natural products 0.000 description 1
- 239000003557 cannabinoid Substances 0.000 description 1
- 230000002149 cannabinoid Effects 0.000 description 1
- 229940065144 cannabinoids Drugs 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000003177 cardiotonic Effects 0.000 description 1
- 239000000496 cardiotonic agent Substances 0.000 description 1
- 230000001413 cellular Effects 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229940048961 cholinesterase Drugs 0.000 description 1
- 229960002376 chymotrypsin Drugs 0.000 description 1
- 229960003920 cocaine Drugs 0.000 description 1
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 1
- ZPUCINDJVBIVPJ-BARDWOONSA-N cocaine Natural products O([C@@H]1C[C@H]2CC[C@H](N2C)[C@@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-BARDWOONSA-N 0.000 description 1
- 150000004696 coordination complex Chemical class 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 239000006046 creatine Substances 0.000 description 1
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine zwitterion Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 238000010511 deprotection reaction Methods 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 229960005156 digoxin Drugs 0.000 description 1
- 229960001066 disopyramide Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- ORXDSIPBTFAEKJ-UHFFFAOYSA-N ferrocyanide Chemical compound N#C[Fe-4](C#N)(C#N)(C#N)(C#N)C#N ORXDSIPBTFAEKJ-UHFFFAOYSA-N 0.000 description 1
- 230000001605 fetal Effects 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000002068 genetic Effects 0.000 description 1
- 201000010238 heart disease Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229940079866 intestinal antibiotics Drugs 0.000 description 1
- 229940079867 intestinal antiinfectives Sulfonamides Drugs 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 229940039781 leptin Drugs 0.000 description 1
- 229950008325 levothyroxine Drugs 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 102000004882 lipase Human genes 0.000 description 1
- 108090001060 lipase Proteins 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 229960001252 methamphetamine Drugs 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006011 modification reaction Methods 0.000 description 1
- 238000001668 nucleic acid synthesis Methods 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 125000003835 nucleoside group Chemical group 0.000 description 1
- 229940005935 ophthalmologic Antibiotics Drugs 0.000 description 1
- 229940005938 ophthalmologic antiinfectives Sulfonamides Drugs 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229960000244 procainamide Drugs 0.000 description 1
- 108010043671 prostatic acid phosphatase Proteins 0.000 description 1
- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical compound OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 description 1
- 230000002285 radioactive Effects 0.000 description 1
- 238000006268 reductive amination reaction Methods 0.000 description 1
- 230000000241 respiratory Effects 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 125000004434 sulfur atoms Chemical group 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 210000003369 syncitium Anatomy 0.000 description 1
- 230000001225 therapeutic Effects 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 229940026752 topical Sulfonamides Drugs 0.000 description 1
- 230000001551 toxigenic Effects 0.000 description 1
- 231100000033 toxigenic Toxicity 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 229960001322 trypsin Drugs 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 229960000604 valproic acid Drugs 0.000 description 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/295,691 | 1999-04-21 | ||
US09/295,691 US6942771B1 (en) | 1999-04-21 | 1999-04-21 | Microfluidic systems in the electrochemical detection of target analytes |
PCT/US2000/010903 WO2000062931A1 (en) | 1999-04-21 | 2000-04-21 | The use of microfluidic systems in the electrochemical detection of target analytes |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2002542461A JP2002542461A (ja) | 2002-12-10 |
JP2002542461A5 true JP2002542461A5 (US07534331-20090519-C00005.png) | 2007-03-15 |
Family
ID=23138824
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000612061A Pending JP2002542461A (ja) | 1999-04-21 | 2000-04-21 | 標的被検体の電気化学的検出でのマイクロ流体システムの使用 |
Country Status (11)
Families Citing this family (342)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6048734A (en) | 1995-09-15 | 2000-04-11 | The Regents Of The University Of Michigan | Thermal microvalves in a fluid flow method |
US7560237B2 (en) * | 1997-06-12 | 2009-07-14 | Osmetech Technology Inc. | Electronics method for the detection of analytes |
US6761816B1 (en) | 1998-06-23 | 2004-07-13 | Clinical Micro Systems, Inc. | Printed circuit boards with monolayers and capture ligands |
AU1241000A (en) | 1998-10-27 | 2000-05-15 | Clinical Micro Sensors, Inc. | Detection of target analytes using particles and electrodes |
US20020177135A1 (en) * | 1999-07-27 | 2002-11-28 | Doung Hau H. | Devices and methods for biochip multiplexing |
US7312087B2 (en) * | 2000-01-11 | 2007-12-25 | Clinical Micro Sensors, Inc. | Devices and methods for biochip multiplexing |
US20040053290A1 (en) * | 2000-01-11 | 2004-03-18 | Terbrueggen Robert Henry | Devices and methods for biochip multiplexing |
US6942771B1 (en) * | 1999-04-21 | 2005-09-13 | Clinical Micro Sensors, Inc. | Microfluidic systems in the electrochemical detection of target analytes |
US8080380B2 (en) * | 1999-05-21 | 2011-12-20 | Illumina, Inc. | Use of microfluidic systems in the detection of target analytes using microsphere arrays |
US8481268B2 (en) | 1999-05-21 | 2013-07-09 | Illumina, Inc. | Use of microfluidic systems in the detection of target analytes using microsphere arrays |
US6875619B2 (en) | 1999-11-12 | 2005-04-05 | Motorola, Inc. | Microfluidic devices comprising biochannels |
ES2278757T3 (es) * | 2000-01-11 | 2007-08-16 | Clinical Micro Sensors, Inc. | Cartucho que comprende un biochip. |
US6602400B1 (en) | 2000-06-15 | 2003-08-05 | Motorola, Inc. | Method for enhanced bio-conjugation events |
AU2001288249A1 (en) * | 2000-08-14 | 2002-02-25 | The Regents Of The University Of California | Biosensors and methods for their use |
US6787339B1 (en) | 2000-10-02 | 2004-09-07 | Motorola, Inc. | Microfluidic devices having embedded metal conductors and methods of fabricating said devices |
EP1331999A2 (en) * | 2000-11-03 | 2003-08-06 | Clinical Micro Sensors, Inc. | Devices and methods for biochip multiplexing |
WO2002053290A2 (en) * | 2001-01-08 | 2002-07-11 | President And Fellows Of Harvard College | Valves and pumps for microfluidic systems and method for making microfluidic systems |
US6913697B2 (en) | 2001-02-14 | 2005-07-05 | Science & Technology Corporation @ Unm | Nanostructured separation and analysis devices for biological membranes |
US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
JP4323806B2 (ja) * | 2001-03-19 | 2009-09-02 | ユィロス・パテント・アクチボラグ | 反応可変要素の特徴付け |
US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
US7323140B2 (en) | 2001-03-28 | 2008-01-29 | Handylab, Inc. | Moving microdroplets in a microfluidic device |
US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US6852287B2 (en) | 2001-09-12 | 2005-02-08 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
DE10117772C2 (de) * | 2001-04-09 | 2003-04-03 | Advalytix Ag | Mischvorrichtung und Mischverfahren für die Durchmischung kleiner Flüssigkeitsmengen |
DE10123803C1 (de) * | 2001-05-16 | 2002-10-31 | Roche Diagnostics Gmbh | Elektrochemische Messzelle |
US7338760B2 (en) | 2001-10-26 | 2008-03-04 | Ntu Ventures Private Limited | Sample preparation integrated chip |
US7691244B2 (en) * | 2001-12-18 | 2010-04-06 | Massachusetts Institute Of Technology | Microfluidic pumps and mixers driven by induced-charge electro-osmosis |
US6532997B1 (en) | 2001-12-28 | 2003-03-18 | 3M Innovative Properties Company | Sample processing device with integral electrophoresis channels |
JP3740528B2 (ja) * | 2002-02-05 | 2006-02-01 | 独立行政法人産業技術総合研究所 | 微細粒子製造方法 |
CN1630707A (zh) * | 2002-02-12 | 2005-06-22 | 色雷特康公司 | 用于快速改变传感器周围溶液环境的系统与方法 |
GB0205455D0 (en) | 2002-03-07 | 2002-04-24 | Molecular Sensing Plc | Nucleic acid probes, their synthesis and use |
DE10224567B4 (de) * | 2002-06-03 | 2014-10-23 | Boehringer Ingelheim Vetmedica Gmbh | Sensor-Anordnung und Verfahren zum Betreiben einer Sensor-Anordnung |
JP4106977B2 (ja) | 2002-06-21 | 2008-06-25 | 株式会社日立製作所 | 分析チップ及び分析装置 |
US20040018577A1 (en) | 2002-07-29 | 2004-01-29 | Emerson Campbell John Lewis | Multiple hybrid immunoassay |
US20040099531A1 (en) * | 2002-08-15 | 2004-05-27 | Rengaswamy Srinivasan | Methods and apparatus for electrochemically testing samples for constituents |
US7250602B2 (en) * | 2002-08-26 | 2007-07-31 | Osaka University | Probe device |
WO2004029221A2 (en) | 2002-09-27 | 2004-04-08 | The General Hospital Corporation | Microfluidic device for cell separation and uses thereof |
WO2004036202A1 (en) | 2002-10-16 | 2004-04-29 | Cellectricon Ab | Nanoelectrodes and nanotips for recording transmembrane currents in a plurality of cells |
US20040091850A1 (en) * | 2002-11-08 | 2004-05-13 | Travis Boone | Single cell analysis of membrane molecules |
GB0227765D0 (en) * | 2002-11-28 | 2003-01-08 | Secr Defence | Apparatus for processing a fluid sample |
EP1594798B1 (en) * | 2003-01-30 | 2018-12-19 | Gyros Patent Ab | Inner walls of microfluidic devices |
DE10305050A1 (de) | 2003-02-07 | 2004-08-19 | Roche Diagnostics Gmbh | Analytisches Testelement und Verfahren für Blutuntersuchungen |
WO2005019793A2 (en) | 2003-05-14 | 2005-03-03 | Nantero, Inc. | Sensor platform using a horizontally oriented nanotube element |
US7238269B2 (en) | 2003-07-01 | 2007-07-03 | 3M Innovative Properties Company | Sample processing device with unvented channel |
JP4996248B2 (ja) | 2003-07-31 | 2012-08-08 | ハンディーラブ インコーポレイテッド | 粒子含有サンプルの処理 |
GB2404739B (en) * | 2003-08-05 | 2006-04-12 | E2V Tech Uk Ltd | Sensor |
US7396677B2 (en) * | 2003-11-07 | 2008-07-08 | Nanosphere, Inc. | Method of preparing nucleic acids for detection |
US7250775B1 (en) * | 2003-11-12 | 2007-07-31 | The Regents Of The University Of California | Microfluidic devices and methods based on measurements of electrical admittance |
AU2003284487A1 (en) * | 2003-11-28 | 2005-06-17 | Olympus Corporation | Biosubstance testing apparatus and reaction stage thereof |
US8293471B2 (en) * | 2004-01-28 | 2012-10-23 | Marshall University Research Corporation | Apparatus and method for a continuous rapid thermal cycle system |
GB2416030B (en) * | 2004-01-28 | 2008-07-23 | Norchip As | A diagnostic system for carrying out a nucleic acid sequence amplification and detection process |
US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
ES2572382T3 (es) | 2004-05-03 | 2016-05-31 | Handylab Inc | Un dispositivo microfluídico para el procesamiento de muestras que contienen polinucleótidos |
US7592139B2 (en) | 2004-09-24 | 2009-09-22 | Sandia National Laboratories | High temperature flow-through device for rapid solubilization and analysis |
US7402616B2 (en) | 2004-09-30 | 2008-07-22 | Lifescan, Inc. | Fusible conductive ink for use in manufacturing microfluidic analytical systems |
EP1871527B1 (en) | 2004-12-23 | 2017-09-27 | Abbott Point of Care Inc. | Molecular diagnostics system |
WO2006066977A1 (en) * | 2004-12-24 | 2006-06-29 | Leiden University | Novel use of fluorescence resonance energy transfer |
JP4583937B2 (ja) * | 2005-01-07 | 2010-11-17 | 積水化学工業株式会社 | 砒素イオンの電気化学測定方法 |
US20060166223A1 (en) * | 2005-01-26 | 2006-07-27 | Reed Michael W | DNA purification and analysis on nanoengineered surfaces |
DE102005013762C5 (de) | 2005-03-22 | 2012-12-20 | Sew-Eurodrive Gmbh & Co. Kg | Elektronisches Gerät und Verfahren zur Bestimmung der Temperatur eines Leistungshalbleiters |
US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
GB0508983D0 (en) | 2005-05-03 | 2005-06-08 | Oxford Gene Tech Ip Ltd | Cell analyser |
CA2607579A1 (en) * | 2005-05-06 | 2006-11-23 | The Regents Of The University Of California | Microfluidic system for identifying or sizing individual particles passing through a channel |
CN101535499B (zh) | 2005-05-09 | 2017-04-19 | 赛拉诺斯股份有限公司 | 点护理流体系统及其应用 |
US20070072287A1 (en) * | 2005-05-23 | 2007-03-29 | Biovitesse, Inc. | Biomems cartridges |
US20060275852A1 (en) * | 2005-06-06 | 2006-12-07 | Montagu Jean I | Assays based on liquid flow over arrays |
JP4660662B2 (ja) * | 2005-09-06 | 2011-03-30 | アークレイ株式会社 | カートリッジ |
AU2006267082A1 (en) * | 2005-07-14 | 2007-01-18 | Nano-Ditech Corporation | Microfluidic devices and methods of preparing and using the same |
US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
JP4699840B2 (ja) * | 2005-08-31 | 2011-06-15 | ローム株式会社 | バイオチップ及び免疫分析方法 |
EP1931979B1 (en) | 2005-10-04 | 2015-11-18 | Headway Technologies, Inc. | Microfluidic detection of analytes |
KR100697292B1 (ko) * | 2005-10-04 | 2007-03-20 | 삼성전자주식회사 | 반도체 장치 및 그 형성 방법 |
JP5268175B2 (ja) * | 2006-01-12 | 2013-08-21 | バイオセンス テクノロジーズ インク. | 迅速に細胞の生存テストを実行するための方法及び構成物 |
US20070170056A1 (en) * | 2006-01-26 | 2007-07-26 | Arnold Don W | Microscale electrochemical cell and methods incorporating the cell |
US8088616B2 (en) | 2006-03-24 | 2012-01-03 | Handylab, Inc. | Heater unit for microfluidic diagnostic system |
US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US11287421B2 (en) | 2006-03-24 | 2022-03-29 | Labrador Diagnostics Llc | Systems and methods of sample processing and fluid control in a fluidic system |
DK2001990T3 (en) | 2006-03-24 | 2016-10-03 | Handylab Inc | Integrated microfluidic sample processing system and method for its use |
US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US7909928B2 (en) * | 2006-03-24 | 2011-03-22 | The Regents Of The University Of Michigan | Reactive coatings for regioselective surface modification |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US8741230B2 (en) | 2006-03-24 | 2014-06-03 | Theranos, Inc. | Systems and methods of sample processing and fluid control in a fluidic system |
GB2436616A (en) * | 2006-03-29 | 2007-10-03 | Inverness Medical Switzerland | Assay device and method |
JP4664846B2 (ja) * | 2006-03-29 | 2011-04-06 | 株式会社東芝 | 核酸検出用デバイス |
ITTO20060273A1 (it) * | 2006-04-12 | 2007-10-13 | Silicon Biosystem S P A | Metodi ed apparati per la selezione e/o il processamento di particellle, in particolare per la lisi selettiva e/o ottimizzata di cellule |
JP4167697B2 (ja) * | 2006-04-13 | 2008-10-15 | 株式会社東芝 | 核酸検出用デバイス |
ITTO20060278A1 (it) | 2006-04-13 | 2007-10-14 | Silicon Biosystem S P A | Metodo per la selezione e/o il processamento di particelle, in particolare cellule |
US7851184B2 (en) | 2006-04-18 | 2010-12-14 | Advanced Liquid Logic, Inc. | Droplet-based nucleic acid amplification method and apparatus |
WO2007133703A2 (en) * | 2006-05-10 | 2007-11-22 | Dxterity Diagnostics | Detection of nucleic acid targets using chemically reactive oligonucleotide probes |
US20100216657A1 (en) * | 2006-05-16 | 2010-08-26 | Arcxis Biotechnologies, Inc. | Pcr-free sample preparation and detection systems for high speed biologic analysis and identification |
US10741034B2 (en) | 2006-05-19 | 2020-08-11 | Apdn (B.V.I.) Inc. | Security system and method of marking an inventory item and/or person in the vicinity |
WO2008000060A1 (en) * | 2006-05-19 | 2008-01-03 | The Governors Of The University Of Alberta | Microfluidic methods for nucleic acid monitoring |
US7947148B2 (en) | 2006-06-01 | 2011-05-24 | The Regents Of The University Of Michigan | Dry adhesion bonding |
EP2589668A1 (en) | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Rare cell analysis using sample splitting and DNA tags |
US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
EP2029779A4 (en) | 2006-06-14 | 2010-01-20 | Living Microsystems Inc | HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS |
US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
US20080100279A1 (en) * | 2006-06-15 | 2008-05-01 | University Of South Florida | Nano-Based Device for Detection of Disease Biomarkers and Other Target Molecules |
US8349604B2 (en) * | 2006-06-15 | 2013-01-08 | University Of South Florida | Nano-based device for detection of disease biomarkers and other target molecules |
US8163535B2 (en) * | 2006-06-26 | 2012-04-24 | Blood Cell Storage, Inc. | Devices and processes for nucleic acid extraction |
WO2008002882A2 (en) | 2006-06-26 | 2008-01-03 | Blood Cell Storage, Inc. | Device and method for extraction and analysis of nucleic acids from biological samples |
US20080032311A1 (en) * | 2006-08-04 | 2008-02-07 | Zhenghua Ji | Low volume mixing of sample |
US7516658B2 (en) | 2006-09-29 | 2009-04-14 | Rosemount Inc. | Electro-kinetic pressure/flow sensor |
EP2082061B8 (en) | 2006-10-06 | 2020-10-07 | Applied DNA Sciences, Inc. | Method for a continuous rapid thermal cycle system |
WO2008133640A2 (en) * | 2006-10-11 | 2008-11-06 | Arcxis Biotechnologies, Inc. | Disposable micropurification cards, methods, and systems thereof |
WO2008060604A2 (en) | 2006-11-14 | 2008-05-22 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US8765076B2 (en) | 2006-11-14 | 2014-07-01 | Handylab, Inc. | Microfluidic valve and method of making same |
JP4884180B2 (ja) * | 2006-11-21 | 2012-02-29 | 東京エレクトロン株式会社 | 基板処理装置および基板処理方法 |
ES2422597T3 (es) * | 2006-11-28 | 2013-09-12 | Pictor Ltd | Membrana de ensayo y método de uso de la misma |
US20100112569A1 (en) * | 2007-01-23 | 2010-05-06 | Roy Bar-Ziv | Microfluidic devices and methods of generating and using same |
US20080182136A1 (en) * | 2007-01-26 | 2008-07-31 | Arnold Don W | Microscale Electrochemical Cell And Methods Incorporating The Cell |
US20090107335A1 (en) | 2007-02-27 | 2009-04-30 | Deka Products Limited Partnership | Air trap for a medical infusion device |
US20100168609A1 (en) * | 2007-03-14 | 2010-07-01 | Ogeno Gmbh | Biopsy device for the enrichment of tissue, cells, or analytes |
US8399047B2 (en) * | 2007-03-22 | 2013-03-19 | The Regents Of The Univeristy Of Michigan | Multifunctional CVD coatings |
US20100151465A1 (en) | 2008-03-27 | 2010-06-17 | Jingyue Ju | Selective Capture and Release of Analytes |
US20100233693A1 (en) * | 2007-04-16 | 2010-09-16 | On-O-ity, Inc | Methods for diagnosing, prognosing, or theranosing a condition using rare cells |
CN101038284B (zh) * | 2007-04-25 | 2011-04-27 | 博奥生物有限公司 | 一种提高电阻抗检测装置的电阻抗检测灵敏度的方法 |
EP2803992B1 (en) * | 2007-04-27 | 2021-02-17 | ARKRAY, Inc. | Sample analyzing method by capillary electrophoresis method |
WO2009006456A1 (en) | 2007-06-29 | 2009-01-08 | The Trustees Of Columbia University | Microfluidic device for counting biological particles |
US8921121B2 (en) * | 2007-06-29 | 2014-12-30 | The Trustees Of Columbia University In The City Of New York | Methods, devices, and systems for chemiluminescence-based microfluidic cell counting |
US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
USD621060S1 (en) | 2008-07-14 | 2010-08-03 | Handylab, Inc. | Microfluidic cartridge |
US20090136385A1 (en) | 2007-07-13 | 2009-05-28 | Handylab, Inc. | Reagent Tube |
US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
AU2008276308A1 (en) * | 2007-07-13 | 2009-01-22 | The Board Of Trustees Of The Leland Stanford Junior University | Method and apparatus using electric field for improved biological assays |
US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US8133671B2 (en) | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
AU2008276211B2 (en) | 2007-07-13 | 2015-01-22 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
GB0715170D0 (en) * | 2007-08-03 | 2007-09-12 | Enigma Diagnostics Ltd | Reaction vessel |
WO2009019452A1 (en) * | 2007-08-03 | 2009-02-12 | Enigma Diagnostics Limited | Reaction vessel |
US8308926B2 (en) | 2007-08-20 | 2012-11-13 | Purdue Research Foundation | Microfluidic pumping based on dielectrophoresis |
US8278047B2 (en) | 2007-10-01 | 2012-10-02 | Nabsys, Inc. | Biopolymer sequencing by hybridization of probes to form ternary complexes and variable range alignment |
US8707964B2 (en) * | 2007-10-31 | 2014-04-29 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
US20090105561A1 (en) * | 2007-10-17 | 2009-04-23 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Medical or veterinary digestive tract utilization systems and methods |
US8789536B2 (en) | 2007-10-17 | 2014-07-29 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
WO2009049675A1 (en) * | 2007-10-17 | 2009-04-23 | Agilent Technologies, Inc. | Measurement device with motion-triggered data exchange |
US8303573B2 (en) | 2007-10-17 | 2012-11-06 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
US8808276B2 (en) * | 2007-10-23 | 2014-08-19 | The Invention Science Fund I, Llc | Adaptive dispensation in a digestive tract |
US20090163894A1 (en) * | 2007-10-31 | 2009-06-25 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Medical or veterinary digestive tract utilization systems and methods |
US8109920B2 (en) * | 2007-10-31 | 2012-02-07 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
US8333754B2 (en) * | 2007-10-31 | 2012-12-18 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
US8808271B2 (en) | 2007-10-31 | 2014-08-19 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
US20090137866A1 (en) * | 2007-11-28 | 2009-05-28 | Searete Llc, A Limited Liability Corporation Of The State Delaware | Medical or veterinary digestive tract utilization systems and methods |
JP4516107B2 (ja) * | 2007-12-19 | 2010-08-04 | 株式会社東芝 | 塩基配列判定方法、塩基配列判定システム及び塩基配列判定プログラム |
US20090227476A1 (en) * | 2008-03-07 | 2009-09-10 | Applied Microarrays, Inc. | Amplification and microarray detection apparatus and methods of making |
CN101556273B (zh) * | 2008-04-08 | 2013-03-20 | 博奥生物有限公司 | 利用电阻抗传感技术分析细胞迁移的方法及其专用装置 |
US20090269746A1 (en) * | 2008-04-25 | 2009-10-29 | Gil Atzmon | Microsequencer-whole genome sequencer |
EP3002489B1 (en) | 2008-05-16 | 2017-09-20 | President and Fellows of Harvard College | Valves and other flow control in fluidic systems including microfluidic systems |
US9879360B2 (en) * | 2008-06-20 | 2018-01-30 | International Business Machines Corporation | Microfluidic selection of library elements |
CN101614729B (zh) * | 2008-06-27 | 2013-04-24 | 博奥生物有限公司 | 用于细胞操作及电生理信号检测的微电极阵列器件及专用装置 |
USD618820S1 (en) | 2008-07-11 | 2010-06-29 | Handylab, Inc. | Reagent holder |
USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
CN102203288A (zh) * | 2008-09-03 | 2011-09-28 | 康特姆斯集团有限公司 | 核酸测序的方法和试剂盒 |
WO2010028140A2 (en) | 2008-09-03 | 2010-03-11 | Nabsys, Inc. | Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels |
US8262879B2 (en) | 2008-09-03 | 2012-09-11 | Nabsys, Inc. | Devices and methods for determining the length of biopolymers and distances between probes bound thereto |
US9650668B2 (en) | 2008-09-03 | 2017-05-16 | Nabsys 2.0 Llc | Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels |
PT2562268T (pt) | 2008-09-20 | 2017-03-29 | Univ Leland Stanford Junior | Diagnóstico não invasivo de aneuploidia fetal por sequenciação |
EP2362907A4 (en) * | 2008-11-04 | 2012-08-08 | Blood Cell Storage Inc | NUCLEAR ACID EXTRACTION ON DOVED GLASS SURFACES |
US8608926B2 (en) * | 2008-11-20 | 2013-12-17 | Neroxis Sa | Amperometric in-pipe electrochemical sensing probe |
US20100221726A1 (en) * | 2009-02-09 | 2010-09-02 | Frederic Zenhausern | Relating to devices |
US8357279B2 (en) | 2009-02-23 | 2013-01-22 | Carnegie Mellon University | Methods, apparatus and systems for concentration, separation and removal of particles at/from the surface of drops |
CN102449169B (zh) * | 2009-04-01 | 2016-03-16 | 德克斯特里蒂诊断公司 | 化学连接依赖性的探针扩增(clpa) |
WO2010119396A1 (en) * | 2009-04-15 | 2010-10-21 | Koninklijke Philips Electronics N.V. | Cartridge for an amplification process |
US9090663B2 (en) * | 2009-04-21 | 2015-07-28 | The Trustees Of Columbia University In The City Of New York | Systems and methods for the capture and separation of microparticles |
TW201039872A (en) * | 2009-05-01 | 2010-11-16 | Top Vision Medical Equipment Consultant Co Ltd | Gas delivery mask with features of detection and adjustment of temperature and humidity |
US8673627B2 (en) * | 2009-05-29 | 2014-03-18 | Life Technologies Corporation | Apparatus and methods for performing electrochemical reactions |
TWI425207B (zh) * | 2009-06-11 | 2014-02-01 | Eps Bio Technology Corp | 生化感測試片 |
US9182411B2 (en) * | 2009-07-14 | 2015-11-10 | Colen Innovations, L.L.C. | Methods and apparatus for the detection and differentiation of non-sialated proteins from sialated proteins in a fluid sample |
CA2768779A1 (en) | 2009-07-20 | 2011-01-27 | Siloam Biosciences, Inc. | Microfluidic assay platforms |
US9096909B2 (en) | 2009-07-23 | 2015-08-04 | Chromatin, Inc. | Sorghum centromere sequences and minichromosomes |
JP5352742B2 (ja) | 2009-08-07 | 2013-11-27 | オームクス コーポレーション | 酵素による酸化還元変化化学的脱離(e−trace)免疫学的検定法 |
US9624522B2 (en) | 2009-08-07 | 2017-04-18 | Ohmx Corporation | Single, direct detection of hemoglobin A1c percentage using enzyme triggered redox altering chemical elimination (e-trace) immunoassay |
GB0914762D0 (en) | 2009-08-24 | 2009-09-30 | Univ Glasgow | Fluidics apparatus and fluidics substrate |
WO2011036650A2 (en) | 2009-09-28 | 2011-03-31 | Koninklijke Philips Electronics N.V. | Sensor device with imaging optics |
FR2950699A1 (fr) * | 2009-09-29 | 2011-04-01 | Centre Nat Rech Scient | Dispositif a usage unique pour la detection de particules d'interet, telles que des entites biologiques, systeme de detection comprenant ledit dispositif et procede de mise en oeuvre |
US20110186165A1 (en) * | 2009-10-05 | 2011-08-04 | Borenstein Jeffrey T | Three-dimensional microfluidic platforms and methods of use and manufacture thereof |
US10001476B2 (en) | 2009-10-28 | 2018-06-19 | Genmark Diagnostics, Inc. | Capture ligand controls, blocking probes, masking probes and methods of using the same |
TWI421495B (zh) * | 2009-10-30 | 2014-01-01 | Univ Nat Cheng Kung | 微流體晶片 |
CN102612482A (zh) * | 2009-11-02 | 2012-07-25 | Ffei公司 | 微通道结构方法和设备 |
WO2011062738A1 (en) | 2009-11-23 | 2011-05-26 | Mikhail Briman | Controlled electrochemical activation of carbon-based electrodes |
US20110127034A1 (en) * | 2009-11-30 | 2011-06-02 | Schlumberger Technology Corporation | Preparation of setting slurries |
ES2588703T3 (es) * | 2009-12-07 | 2016-11-04 | Meso Scale Technologies, Llc. | Un cartucho de ensayo |
GB2492268B (en) * | 2010-02-18 | 2019-02-06 | Bima Ltd | Immobilised-bead multiplex assay |
US8596354B2 (en) | 2010-04-02 | 2013-12-03 | Schlumberger Technology Corporation | Detection of tracers used in hydrocarbon wells |
US8452037B2 (en) | 2010-05-05 | 2013-05-28 | Apple Inc. | Speaker clip |
US20120034638A1 (en) | 2010-05-21 | 2012-02-09 | Michael Ahrens | Electrochemical assay for the detection of enzymatically active PSA |
US8715933B2 (en) | 2010-09-27 | 2014-05-06 | Nabsys, Inc. | Assay methods using nicking endonucleases |
TWI495727B (zh) * | 2010-10-08 | 2015-08-11 | Nat Applied Res Laboratories | 微型電化學多重即時定量聚合酶連鎖反應(pcr)系統 |
WO2012058096A1 (en) * | 2010-10-27 | 2012-05-03 | Illumina, Inc. | Microdevices and biosensor cartridges for biological or chemical analysis and systems and methods for the same |
US9387476B2 (en) | 2010-10-27 | 2016-07-12 | Illumina, Inc. | Flow cells for biological or chemical analysis |
DE102010064391A1 (de) * | 2010-10-29 | 2012-05-03 | Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG | Verfahren zur Bestimmung eines Analytgehalts einer Flüssigkeitsprobe mittels eines Bioanalysators |
EP2640849B1 (en) | 2010-11-16 | 2016-04-06 | Nabsys 2.0 LLC | Methods for sequencing a biomolecule by detecting relative positions of hybridized probes |
WO2012075258A2 (en) | 2010-12-03 | 2012-06-07 | Abbott Point Of Care Inc. | Ratiometric immunoassay method and blood testing device |
US9034634B2 (en) * | 2010-12-03 | 2015-05-19 | Abbott Point Of Care Inc. | Sample metering device and assay device with integrated sample dilution |
US9057702B2 (en) * | 2010-12-21 | 2015-06-16 | The Regents Of The University Of California | Compact wide-field fluorescent imaging on a mobile device |
US20120225491A1 (en) * | 2010-12-30 | 2012-09-06 | Ayal Ram | Portable detection devices and methods for detection of biomarkers and other analytes |
WO2012100078A1 (en) | 2011-01-19 | 2012-07-26 | Ohmx Corporation | Enzyme triggered redox altering chemical elimination (e-trace) immmunoassay |
KR101226655B1 (ko) * | 2011-01-28 | 2013-01-25 | 서강대학교산학협력단 | 전기화학적 방법을 기반으로 한 세포 주기 측정 방법 |
WO2012109574A2 (en) | 2011-02-11 | 2012-08-16 | Nabsys, Inc. | Assay methods using dna binding proteins |
US8922860B2 (en) * | 2011-02-22 | 2014-12-30 | Corning Incorporated | Motion control systems and methods for biosensor scanning |
GB201103211D0 (en) | 2011-02-24 | 2011-04-13 | Univ Glasgow | Fluidics apparatus, use of fluidics apparatus and process for the manufacture of fluidics apparatus |
ES2799422T3 (es) * | 2011-03-10 | 2020-12-17 | General Atomics | Dispositivos y métodos de diagnóstico y preparación de muestras |
US8399262B2 (en) | 2011-03-23 | 2013-03-19 | Darrel A. Mazzari | Biosensor |
CN106190806B (zh) | 2011-04-15 | 2018-11-06 | 贝克顿·迪金森公司 | 扫描实时微流体热循环仪和用于同步的热循环和扫描光学检测的方法 |
CN106434871B (zh) | 2011-05-17 | 2020-08-18 | 德克斯特里蒂诊断公司 | 用于检测目标核酸的方法与组合物 |
US8629264B2 (en) | 2011-05-19 | 2014-01-14 | Blood Cell Storage, Inc. | Gravity flow fluidic device for nucleic acid extraction |
US8447443B1 (en) | 2011-06-21 | 2013-05-21 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Systems and methods for peak-seeking control |
US20130087467A1 (en) * | 2011-06-24 | 2013-04-11 | Hongjun Yang | High-performance analytical instrument and method |
WO2013010106A2 (en) * | 2011-07-13 | 2013-01-17 | Lockheed Martin Corporation | Three dimensional microfluidic multiplexed diagnostic system |
US9638663B2 (en) * | 2011-07-25 | 2017-05-02 | Proxim Diagnostics Corporation | Cartridge for diagnostic testing |
WO2013019714A1 (en) | 2011-07-29 | 2013-02-07 | The Trustees Of Columbia University In The City Of New York | Mems affinity sensor for continuous monitoring of analytes |
EP2758552A4 (en) * | 2011-09-23 | 2015-09-09 | Univ Columbia | ISOLATION AND ENRICHMENT OF NUCLEIC ACIDS ON A MICROCHIP |
KR102121853B1 (ko) | 2011-09-30 | 2020-06-12 | 벡톤 디킨슨 앤드 컴퍼니 | 일체화된 시약 스트립 |
USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
JP2014532720A (ja) | 2011-11-04 | 2014-12-08 | オームクス コーポレイション | バイオセンサーにおいて使用される新規化学 |
CN104040238B (zh) | 2011-11-04 | 2017-06-27 | 汉迪拉布公司 | 多核苷酸样品制备装置 |
WO2013102093A1 (en) * | 2011-12-28 | 2013-07-04 | Ibis Biosciences, Inc. | Multiple- analyte assay device and system |
CA2860739A1 (en) | 2012-01-09 | 2013-07-18 | Ohmx Corporation | Enzyme cascade methods for e-trace assay signal amplification |
AU2013214849B2 (en) | 2012-02-03 | 2016-09-01 | Becton, Dickinson And Company | External files for distribution of molecular diagnostic tests and determination of compatibility between tests |
EP2633911B1 (en) * | 2012-02-28 | 2016-09-14 | ARKRAY, Inc. | Mixing apparatus |
US20150047978A1 (en) | 2012-03-13 | 2015-02-19 | Piramal Enterprises Limited | Biosensor having nanostructured electrodes |
CN107099445B (zh) * | 2012-03-16 | 2020-06-16 | 统计诊断与创新有限公司 | 具有集成传送模块的测试盒 |
EP2664933B1 (de) * | 2012-05-15 | 2014-06-25 | Omicron electronics GmbH | Testgerät, Testsystem und Verfahren zum Testen eines energietechnischen Prüflings |
WO2014004563A1 (en) * | 2012-06-25 | 2014-01-03 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Electrokinetic polymerase chain reaction (pcr) devices and methods |
US20140299468A1 (en) * | 2012-06-25 | 2014-10-09 | Hongjun Yang | High-Performance Analytical Instrument and Method |
CA2880104A1 (en) | 2012-07-27 | 2014-01-30 | Ohmx Corporation | Electric measurement of monolayers following pro-cleave detection of presence and activity of enzymes and other target analytes |
EP3121288A1 (en) | 2012-07-27 | 2017-01-25 | Ohmx Corporation | Electronic measurements of monolayers following homogeneous reactions of their components |
US20140200167A1 (en) | 2012-08-01 | 2014-07-17 | Nanomdx, Inc. | Functionally integrated device for multiplex genetic identification |
WO2014022700A2 (en) * | 2012-08-01 | 2014-02-06 | Prakash Ranjit A | Functionally integrated device for multiplex genetic identification and method for separation and detection of dna fragments |
CN107051604B (zh) | 2012-08-30 | 2019-07-05 | 生命技术公司 | 竖直夹具装置 |
US20150226735A1 (en) * | 2012-09-19 | 2015-08-13 | Universal Biosensors Pty Ltd | Systems and methods for enzyme detection |
US9820033B2 (en) | 2012-09-28 | 2017-11-14 | Apple Inc. | Speaker assembly |
US20140322706A1 (en) | 2012-10-24 | 2014-10-30 | Jon Faiz Kayyem | Integrated multipelx target analysis |
EP2965817B1 (en) | 2012-10-24 | 2017-09-27 | Genmark Diagnostics Inc. | Integrated multiplex target analysis |
WO2014078521A1 (en) * | 2012-11-14 | 2014-05-22 | The Trustees Of Columbia University In The City Of New York | Isolation and enrichment of nucleic acids on microchip |
WO2014081460A1 (en) * | 2012-11-20 | 2014-05-30 | Kisner Mark | Chemical sequencing and control to expand and enhance detection capabilities utilizing a colorimetric test |
US20150290639A1 (en) * | 2012-12-03 | 2015-10-15 | Vladimir Evtodienko | Pressure assisted lateral flow diagnostic device |
US8872328B2 (en) * | 2012-12-19 | 2014-10-28 | General Electric Company | Integrated power module package |
US9914966B1 (en) | 2012-12-20 | 2018-03-13 | Nabsys 2.0 Llc | Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation |
CA2896541C (en) | 2013-01-04 | 2020-04-21 | Ian Chamberlin | Assay apparatuses, methods and reagents |
EP2956550B1 (en) | 2013-01-18 | 2020-04-08 | Nabsys 2.0 LLC | Enhanced probe binding |
WO2014127409A1 (en) * | 2013-02-19 | 2014-08-28 | The University Of Queensland | Device and method for the detection of target entities |
US10309947B2 (en) | 2013-02-27 | 2019-06-04 | Trace-Ability, Inc. | System and method for radiosynthesis, quality control and dose dispensing |
US9963740B2 (en) | 2013-03-07 | 2018-05-08 | APDN (B.V.I.), Inc. | Method and device for marking articles |
US9623409B2 (en) | 2013-03-11 | 2017-04-18 | Cue Inc. | Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes |
EP2972333B1 (en) * | 2013-03-11 | 2018-09-19 | The University of Toledo | A biosensor device to target analytes in situ, in vivo, and/or in real time, and methods of making and using the same |
US10545161B2 (en) | 2013-03-11 | 2020-01-28 | Cue Health Inc. | Systems and methods for detection and quantification of analytes |
EP3540444B1 (en) | 2013-03-11 | 2022-10-26 | Cue Health Inc. | Systems and methods for detection and quantification of analytes |
AU2014235532B2 (en) | 2013-03-15 | 2018-08-09 | Genmark Diagnostics, Inc. | Systems, methods, and apparatus for manipulating deformable fluid vessels |
CN105593379A (zh) * | 2013-08-07 | 2016-05-18 | 艾克泽基因公司 | 用辅助寡核苷酸电化学检测的系统、方法和装置 |
WO2015042493A2 (en) | 2013-09-20 | 2015-03-26 | Ohmx Corporation | Psa enzymatic activity: a new biomarker for assessing prostate cancer aggressiveness |
CA2926436A1 (en) | 2013-10-07 | 2015-04-16 | Judith Murrah | Multimode image and spectral reader |
US9498778B2 (en) | 2014-11-11 | 2016-11-22 | Genmark Diagnostics, Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
USD881409S1 (en) | 2013-10-24 | 2020-04-14 | Genmark Diagnostics, Inc. | Biochip cartridge |
KR101562865B1 (ko) * | 2014-01-24 | 2015-10-26 | 한국과학기술연구원 | 신경 영양인자를 감지하기 위한 초소형 센서 시스템 |
KR101618113B1 (ko) * | 2014-02-10 | 2016-05-09 | 나노바이오시스 주식회사 | 일 방향 슬라이딩 구동 수단을 구비하는 pcr 장치 및 이를 이용하는 pcr 방법 |
US10895563B2 (en) | 2014-02-26 | 2021-01-19 | Trace-Ability, Inc. | Palette-based systems for analyte characterization |
US11002717B2 (en) | 2014-02-26 | 2021-05-11 | Trace-Ability, Inc. | Systems and methods for characterizing radioactive analytes |
US10309921B2 (en) * | 2014-03-03 | 2019-06-04 | The Florida International University Board Of Trustees | Label-free electrochemical biosensor |
US10745825B2 (en) | 2014-03-18 | 2020-08-18 | Apdn (B.V.I.) Inc. | Encrypted optical markers for security applications |
EP3119610B1 (en) | 2014-03-18 | 2024-05-22 | APDN (B.V.I.) Inc. | Encrypted optical markers for security applications |
US9451354B2 (en) * | 2014-05-12 | 2016-09-20 | Apple Inc. | Liquid expulsion from an orifice |
USD745423S1 (en) | 2014-05-12 | 2015-12-15 | Cue Inc. | Automated analyzer test cartridge and sample collection device for analyte detection |
CA2951561C (en) | 2014-06-10 | 2023-04-18 | Dxterity Diagnostics Incorporated | Devices and methods for collecting and stabilizing biological samples |
WO2016012870A1 (en) * | 2014-07-22 | 2016-01-28 | Bhat, Shama | System for the characterization of nucleic acid and detection of dna amplification using electrical method |
US10137423B2 (en) * | 2014-07-30 | 2018-11-27 | Schlumberger Technology Corporation | Devices and methods for measuring analyte concentration |
WO2016022696A1 (en) | 2014-08-05 | 2016-02-11 | The Trustees Of Columbia University In The City Of New York | Method of isolating aptamers for minimal residual disease detection |
WO2016020775A1 (en) * | 2014-08-08 | 2016-02-11 | Kimiya Pty. Ltd. | Diagnostic, prognostic, and analytical system |
WO2016019428A1 (en) * | 2014-08-08 | 2016-02-11 | Kimiya Pty. Ltd. | Diagnostic, prognostic, and analytical system |
US20160041118A1 (en) | 2014-08-11 | 2016-02-11 | Ohmx Corporation | Enzyme triggered redox altering chemical elimination (e-trace) assay with multiplexing capabilities |
US10913973B2 (en) | 2014-09-17 | 2021-02-09 | Board Of Regents, The University Texas System | Methods and devices related to toehold-based strand displacement with loop-mediated isothermal amplification |
WO2016049571A1 (en) | 2014-09-27 | 2016-03-31 | Trace-Ability, Inc. | Palette-based systems for analyte characterization |
GB201420061D0 (en) | 2014-11-11 | 2014-12-24 | Univ Glasgow | Nebulisation of liquids |
US10005080B2 (en) | 2014-11-11 | 2018-06-26 | Genmark Diagnostics, Inc. | Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation |
US9598722B2 (en) | 2014-11-11 | 2017-03-21 | Genmark Diagnostics, Inc. | Cartridge for performing assays in a closed sample preparation and reaction system |
AU2015346527A1 (en) | 2014-11-11 | 2017-06-29 | Genmark Diagnostics, Inc. | Instrument and cartridge for performing assays in a closed sample preparation and reaction system |
US20160178562A1 (en) | 2014-12-19 | 2016-06-23 | Ohmx Corporation | Competitive enzymatic assay |
KR102336308B1 (ko) * | 2014-12-26 | 2021-12-09 | 주식회사 미코바이오메드 | 반복 슬라이딩 구동 수단을 구비하는 pcr 장치 및 이를 이용하는 pcr 방법 |
US10589269B2 (en) * | 2015-01-30 | 2020-03-17 | Hewlett-Packard Development Company, L.P. | Microfluidic transport |
TWI534426B (zh) * | 2015-03-27 | 2016-05-21 | 國立清華大學 | 生物檢測方法 |
US10634602B2 (en) | 2015-06-12 | 2020-04-28 | Cytochip Inc. | Fluidic cartridge for cytometry and additional analysis |
CN113791203B (zh) | 2015-06-12 | 2024-05-17 | 芯易诊有限公司 | 用于分析生物样品的方法 |
AU2016277943B2 (en) * | 2015-06-15 | 2022-09-01 | Cepheid | Integrated purification and measurement of DNA methylation and co-measurement of mutations and/or mRNA expression levels in an automated reaction cartridge |
US9900698B2 (en) | 2015-06-30 | 2018-02-20 | Apple Inc. | Graphene composite acoustic diaphragm |
EP3322968B1 (en) | 2015-07-14 | 2024-02-21 | Cytochip Inc. | Volume sensing in a fluidic cartridge |
EP3689466B1 (en) | 2015-07-17 | 2024-06-05 | Cue Health Inc. | System for enhanced detection and quantification of analytes |
JP6466598B2 (ja) | 2015-07-24 | 2019-02-06 | ヒューレット−パッカード デベロップメント カンパニー エル.ピー.Hewlett‐Packard Development Company, L.P. | 流体試験セル用ライトガイド |
KR101691508B1 (ko) * | 2015-09-03 | 2016-12-30 | 한국과학기술연구원 | 유체 전달 채널이 형성된 커버 부재를 포함하는 신경 탐침 구조체 |
EP3138920B1 (en) * | 2015-09-07 | 2018-06-13 | Miltenyi Biotec GmbH | Disposable cartridge for electroporation |
US10859563B2 (en) | 2015-12-01 | 2020-12-08 | General Electric Company | Erythrocyte aggregation and leukocyte isolation |
US10519605B2 (en) | 2016-04-11 | 2019-12-31 | APDN (B.V.I.), Inc. | Method of marking cellulosic products |
DE102016209904A1 (de) * | 2016-06-06 | 2017-12-07 | Robert Bosch Gmbh | Verfahren und mikrofluidische Vorrichtung zum Verarbeiten einer Probe biologischen Materials |
US10604784B2 (en) | 2016-08-05 | 2020-03-31 | Trustees Of Boston University | Method and device for antibiotic susceptibility testing based on fluctuations of electrical resistance in a microchannel |
EP3516401A1 (en) | 2016-09-19 | 2019-07-31 | Genmark Diagnostics Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
WO2018065102A1 (en) | 2016-10-07 | 2018-04-12 | Boehringer Ingelheim Vetmedica Gmbh | Method and analysis system for testing a sample |
CA3037217A1 (en) * | 2016-10-07 | 2018-04-12 | Boehringer Ingelheim Vetmedica Gmbh | Analysis system and method for testing a sample |
DK3523448T3 (da) | 2016-10-07 | 2021-06-28 | Boehringer Ingelheim Vetmedica Gmbh | Fremgangsmåde og analysesystem til at teste en prøve |
US10995371B2 (en) | 2016-10-13 | 2021-05-04 | Apdn (B.V.I.) Inc. | Composition and method of DNA marking elastomeric material |
WO2018140540A1 (en) | 2017-01-25 | 2018-08-02 | Cue Health Inc. | Systems and methods for enhanced detection and quantification of analytes |
US10920274B2 (en) | 2017-02-21 | 2021-02-16 | Apdn (B.V.I.) Inc. | Nucleic acid coated submicron particles for authentication |
US10648955B2 (en) * | 2017-02-24 | 2020-05-12 | The Government Of The United States Of America, As Represented By The Secretary Of The Navy | Online chemical derivatization using a cooled programmed temperature vaporization inlet |
US11299776B2 (en) | 2017-05-10 | 2022-04-12 | Board Of Regents, The University Of Texas System | Methods and devices related to amplifying nucleic acid at a variety of temperatures |
WO2019013825A1 (en) * | 2017-07-14 | 2019-01-17 | Hewlett-Packard Development Company, L.P. | MICROFLUIDIC VALVE |
WO2019018697A1 (en) * | 2017-07-19 | 2019-01-24 | Evanostics, Llc | CARTRIDGES FOR ORAL FLUID ANALYSIS AND METHODS OF USE |
WO2019040769A1 (en) | 2017-08-24 | 2019-02-28 | Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) | ELECTROCHEMICAL DETECTION OF BACTERIAL AND / OR FUNGAL INFECTIONS |
US20190062809A1 (en) | 2017-08-24 | 2019-02-28 | Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) | Electrochemical detection of bacterial and/or fungal infections |
WO2019049944A1 (en) * | 2017-09-07 | 2019-03-14 | Sony Corporation | PARTICLE CAPTURE CHAMBER, PARTICLE CAPTURE CHIP, PARTICLE CAPTURE METHOD, APPARATUS, AND PARTICLE ANALYSIS SYSTEM |
US11307661B2 (en) | 2017-09-25 | 2022-04-19 | Apple Inc. | Electronic device with actuators for producing haptic and audio output along a device housing |
WO2019083844A1 (en) | 2017-10-23 | 2019-05-02 | Cytochip Inc. | DEVICES AND METHOD FOR MEASURING TARGET ANALYTES AND PARTICLES |
US11009480B2 (en) * | 2017-11-07 | 2021-05-18 | Amrita Vishwa Vidyapeetham | Lab on a chip device for multi-analyte detection and a method of fabrication thereof |
US11690566B2 (en) | 2017-11-21 | 2023-07-04 | MX3 Diagnostics, Inc. | Saliva testing system |
EP3724636A4 (en) | 2017-12-15 | 2021-08-18 | Evanostics, LLC | OPTICAL READER FOR ANALYTE TEST |
US10935561B2 (en) | 2018-06-01 | 2021-03-02 | Genmark Diagnostics, Inc. | Integrated diagnostic instrument |
US10757491B1 (en) | 2018-06-11 | 2020-08-25 | Apple Inc. | Wearable interactive audio device |
US10873798B1 (en) | 2018-06-11 | 2020-12-22 | Apple Inc. | Detecting through-body inputs at a wearable audio device |
WO2019237205A1 (en) * | 2018-06-14 | 2019-12-19 | Coastal Genomics Inc. | Device for capturing macromolecules and methods for manufacturing and using same |
US10948450B2 (en) | 2018-07-23 | 2021-03-16 | Genmark Diagnostics, Inc. | Electrochemical measurements of components in coatings |
KR102401909B1 (ko) * | 2018-08-30 | 2022-05-24 | 주식회사 엘지화학 | 반응 최적화를 위한 고속 스크리닝 분석 시스템 |
US11334032B2 (en) | 2018-08-30 | 2022-05-17 | Apple Inc. | Electronic watch with barometric vent |
US11198128B2 (en) | 2018-09-05 | 2021-12-14 | International Business Machines Corporation | Microfluidic device with array of chambers for encoding detectable information |
US11561144B1 (en) | 2018-09-27 | 2023-01-24 | Apple Inc. | Wearable electronic device with fluid-based pressure sensing |
WO2020122922A1 (en) * | 2018-12-13 | 2020-06-18 | Hewlett-Packard Development Company, L.P. | Multiplex nucleic acid detection |
WO2020159545A1 (en) | 2019-02-01 | 2020-08-06 | Hewlett-Packard Development Company, L.P. | Chemical lysis systems |
CN114399015A (zh) | 2019-04-17 | 2022-04-26 | 苹果公司 | 无线可定位标签 |
US20200333286A1 (en) * | 2019-04-18 | 2020-10-22 | University Of Florida Research Foundation, Inc. | Modularized inexpensive detection of cerebral spinal fluid for medical applications |
US11701036B2 (en) * | 2019-07-10 | 2023-07-18 | MX3 Diagnostics, Inc. | Saliva test strip and method |
CN110346579B (zh) * | 2019-07-24 | 2023-07-07 | 中国科学院重庆绿色智能技术研究院 | 基于纳米孔的体外hiv蛋白酶检测仪器及方法 |
JP2023501227A (ja) * | 2019-10-29 | 2023-01-18 | クアンタム-エスアイ インコーポレイテッド | 配列決定のためにカートリッジを使用する方法およびデバイス |
AU2020375809A1 (en) * | 2019-10-29 | 2022-06-02 | Quantum-Si Incorporated | Systems and methods for sample preparation |
CN110975948A (zh) * | 2019-11-06 | 2020-04-10 | 佛山市铬维科技有限公司 | 微流控细胞计数仪 |
WO2021154935A1 (en) * | 2020-01-29 | 2021-08-05 | The Regents Of The University Of Michigan | Analyte detection |
JP2023513053A (ja) | 2020-01-30 | 2023-03-30 | エムエックススリー・ダイアグノスティクス・インコーポレイテッド | 生体液試料の評価 |
WO2022019893A1 (en) * | 2020-07-21 | 2022-01-27 | Hewlett-Packard Development Company, L.P. | Identifying target nucleic acids using immobilized nuclease |
CN116547537A (zh) | 2020-07-29 | 2023-08-04 | 皮克托有限公司 | SARS-CoV-2抗体免疫测定 |
TW202223378A (zh) * | 2020-12-14 | 2022-06-16 | 國立中央大學 | 複合式細胞成像與生化檢測晶片及其使用方法 |
WO2022221618A1 (en) * | 2021-04-16 | 2022-10-20 | New York University | Bone marrow on a chip |
CN113893892B (zh) * | 2021-11-10 | 2023-02-10 | 大连海事大学 | 一种基于微流控芯片的纳米孔及其制备方法 |
US20230302445A1 (en) * | 2022-03-22 | 2023-09-28 | Perkinelmer Health Sciences, Inc. | Microfluidic chip and electrical interface for microchip electrophoresis |
Family Cites Families (180)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57171912A (en) | 1981-04-14 | 1982-10-22 | Sumitomo Chem Co Ltd | Cream |
US4711955A (en) | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
CA1219824A (en) | 1981-04-17 | 1987-03-31 | David C. Ward | Modified nucleotides and methods of preparing and using same |
US5241060A (en) | 1982-06-23 | 1993-08-31 | Enzo Diagnostics, Inc. | Base moiety-labeled detectable nucleatide |
US4994373A (en) | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
US5509410A (en) | 1983-06-06 | 1996-04-23 | Medisense, Inc. | Strip electrode including screen printing of a single layer |
US4840893A (en) | 1983-12-16 | 1989-06-20 | Medisense, Inc. | Electrochemical assay for nucleic acids and nucleic acid probes |
US4849513A (en) | 1983-12-20 | 1989-07-18 | California Institute Of Technology | Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups |
US4707352A (en) | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group |
US4943523A (en) | 1984-01-30 | 1990-07-24 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
US5002885A (en) | 1984-01-30 | 1991-03-26 | Enzo Biochem, Inc. | Detectable molecules, method preparation and use |
US5175269A (en) | 1984-01-30 | 1992-12-29 | Enzo Diagnostics, Inc. | Compound and detectable molecules having an oligo- or polynucleotide with modifiable reactive group |
US4952685A (en) | 1984-01-30 | 1990-08-28 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
US5013831A (en) | 1984-01-30 | 1991-05-07 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
US4707440A (en) | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Nucleic acid hybridization assay and detectable molecules useful in such assay |
CA1260372A (en) | 1984-04-27 | 1989-09-26 | Elazar Rabbani | Hybridization method for the detection of genetic materials |
US4755458A (en) | 1984-08-30 | 1988-07-05 | Enzo Biochem, Inc. | Composition and method for the detection of the presence of a polynucleotide sequence of interest |
US5112974A (en) | 1985-01-18 | 1992-05-12 | The Trustees Of Columbia University In The City Of New York | Mixed ligand complexes and uses thereof as binding agents to DNA |
US4965188A (en) * | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
US5595908A (en) | 1985-09-26 | 1997-01-21 | University Of Southern Mississipi | Piezoelectric device for detection of polynucleotide hybridization |
CA1273552A (en) | 1985-12-23 | 1990-09-04 | Michael J. Heller | Fluorescent stokes shift probes for polynucleotide hybridization assays |
US4868103A (en) | 1986-02-19 | 1989-09-19 | Enzo Biochem, Inc. | Analyte detection by means of energy transfer |
CA1254945A (en) | 1986-02-27 | 1989-05-30 | Marco F. Cardosi | Application of tetrathiafulvalenes in bioelectrochemical processes |
US5114864A (en) | 1986-06-25 | 1992-05-19 | Trustees Of Tufts College | Fiber optic sensors, apparatus, and detection methods using fluid erodible controlled release polymers for delivery of reagent formulations |
US5143853A (en) | 1986-06-25 | 1992-09-01 | Trustees Of Tufts College | Absorbance modulated fluorescence detection methods and sensors |
US4822746A (en) | 1986-06-25 | 1989-04-18 | Trustees Of Tufts College | Radiative and non-radiative energy transfer and absorbance modulated fluorescence detection methods and sensors |
JPS63238166A (ja) | 1987-03-26 | 1988-10-04 | Mitsubishi Electric Corp | 有機電子素子材料 |
US5192507A (en) | 1987-06-05 | 1993-03-09 | Arthur D. Little, Inc. | Receptor-based biosensors |
GB8720470D0 (en) | 1987-08-29 | 1987-10-07 | Emi Plc Thorn | Sensor arrangements |
US5082830A (en) | 1988-02-26 | 1992-01-21 | Enzo Biochem, Inc. | End labeled nucleotide probe |
US4908319A (en) * | 1988-03-16 | 1990-03-13 | Smyczek Peter J | Laboratory apparatus |
US5320808A (en) * | 1988-08-02 | 1994-06-14 | Abbott Laboratories | Reaction cartridge and carousel for biological sample analyzer |
US5106751A (en) * | 1988-09-15 | 1992-04-21 | Biotronic Systems Corporation | Apparatus for supporting a biochemical sensor responsive to bubbles |
SE462454B (sv) * | 1988-11-10 | 1990-06-25 | Pharmacia Ab | Maetyta foer anvaendning i biosensorer |
US5200051A (en) * | 1988-11-14 | 1993-04-06 | I-Stat Corporation | Wholly microfabricated biosensors and process for the manufacture and use thereof |
US5061336A (en) | 1989-05-01 | 1991-10-29 | Soane Technologies, Inc. | Gel casting method and apparatus |
US5071531A (en) | 1989-05-01 | 1991-12-10 | Soane Technologies, Inc. | Casting of gradient gels |
US5110745A (en) | 1989-06-01 | 1992-05-05 | The Trustees Of The University Of Pennsylvania | Methods of detecting glycated proteins |
AU642444B2 (en) * | 1989-11-30 | 1993-10-21 | Mochida Pharmaceutical Co., Ltd. | Reaction vessel |
CA2033692A1 (en) | 1990-01-25 | 1991-07-26 | Wilhelm Bannwarth | Energy transfer systems |
US5770029A (en) | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices |
US5126022A (en) | 1990-02-28 | 1992-06-30 | Soane Tecnologies, Inc. | Method and device for moving molecules by the application of a plurality of electrical fields |
US5750015A (en) | 1990-02-28 | 1998-05-12 | Soane Biosciences | Method and device for moving molecules by the application of a plurality of electrical fields |
GB2244135B (en) * | 1990-05-04 | 1994-07-13 | Gen Electric Co Plc | Sensor devices |
US5108573A (en) * | 1990-06-05 | 1992-04-28 | The United States Of America As Represented By The United States Department Of Energy | Morphology in electrochemically grown conducting polymer films |
US5776672A (en) | 1990-09-28 | 1998-07-07 | Kabushiki Kaisha Toshiba | Gene detection method |
US5135627A (en) | 1990-10-15 | 1992-08-04 | Soane Technologies, Inc. | Mosaic microcolumns, slabs, and separation media for electrophoresis and chromatography |
US5294369A (en) * | 1990-12-05 | 1994-03-15 | Akzo N.V. | Ligand gold bonding |
DE4039677A1 (de) | 1990-12-12 | 1992-06-17 | Boehringer Mannheim Gmbh | Universalbindefilm |
US5244636A (en) | 1991-01-25 | 1993-09-14 | Trustees Of Tufts College | Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample |
RU1794088C (ru) | 1991-03-18 | 1993-02-07 | Институт Молекулярной Биологии Ан@ Ссср | Способ определени нуклеотидной последовательности ДНК и устройство дл его осуществлени |
DK0639269T3 (da) * | 1991-03-27 | 2002-10-07 | Ambri Ltd | Ionreservoir ved elektrodeoverflade |
US5849486A (en) * | 1993-11-01 | 1998-12-15 | Nanogen, Inc. | Methods for hybridization analysis utilizing electrically controlled hybridization |
US5605662A (en) * | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
US5565322A (en) | 1991-11-07 | 1996-10-15 | Nanogen, Inc. | Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to donor energy transfer system |
US5632957A (en) * | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
EP0567635B1 (en) | 1991-11-15 | 2000-05-31 | Igen International, Inc. | Rapid assays for amplification products |
US5846708A (en) | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
IL103674A0 (en) * | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
US5565552A (en) | 1992-01-21 | 1996-10-15 | Pharmacyclics, Inc. | Method of expanded porphyrin-oligonucleotide conjugate synthesis |
US5391272A (en) * | 1992-03-06 | 1995-02-21 | Andcare, Inc. | Electrochemical immunoassay methods |
EP0566751B1 (en) | 1992-03-23 | 1996-01-10 | F. Hoffmann-La Roche Ag | DNA detection method |
US5486335A (en) | 1992-05-01 | 1996-01-23 | Trustees Of The University Of Pennsylvania | Analysis based on flow restriction |
US5637469A (en) | 1992-05-01 | 1997-06-10 | Trustees Of The University Of Pennsylvania | Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems |
US5726026A (en) | 1992-05-01 | 1998-03-10 | Trustees Of The University Of Pennsylvania | Mesoscale sample preparation device and systems for determination and processing of analytes |
US5498392A (en) | 1992-05-01 | 1996-03-12 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method |
US5587128A (en) * | 1992-05-01 | 1996-12-24 | The Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification devices |
US5304487A (en) | 1992-05-01 | 1994-04-19 | Trustees Of The University Of Pennsylvania | Fluid handling in mesoscale analytical devices |
JP3298882B2 (ja) | 1992-05-01 | 2002-07-08 | トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア | 微細加工した検出構造体 |
US5296375A (en) | 1992-05-01 | 1994-03-22 | Trustees Of The University Of Pennsylvania | Mesoscale sperm handling devices |
CA2094785A1 (en) | 1992-05-08 | 1993-11-09 | Jean Gariepy | Metal chelating peptide |
JP3094183B2 (ja) * | 1992-05-11 | 2000-10-03 | セイコーインスツルメンツ株式会社 | 誘電率測定装置 |
JPH0641183A (ja) | 1992-07-23 | 1994-02-15 | Mitsubishi Kasei Corp | オリゴヌクレオチド単分子膜 |
US5312527A (en) | 1992-10-06 | 1994-05-17 | Concordia University | Voltammetric sequence-selective sensor for target polynucleotide sequences |
US5569364A (en) | 1992-11-05 | 1996-10-29 | Soane Biosciences, Inc. | Separation media for electrophoresis |
US5472881A (en) | 1992-11-12 | 1995-12-05 | University Of Utah Research Foundation | Thiol labeling of DNA for attachment to gold surfaces |
EP0599337B1 (en) | 1992-11-27 | 2006-03-08 | Canon Kabushiki Kaisha | Method for detection of nucleic acid and probe therefor |
CH685458A5 (de) | 1993-03-01 | 1995-07-14 | Disetronic Ag | Sensorarray zur selektiven Feststellung oder Messung mindestens einer Stoffkomponente in einer wässerigen Lösung. |
US5403451A (en) | 1993-03-05 | 1995-04-04 | Riviello; John M. | Method and apparatus for pulsed electrochemical detection using polymer electroactive electrodes |
US5785789A (en) * | 1993-03-18 | 1998-07-28 | Digital Equipment Corporation | Low dielectric constant microsphere filled layers for multilayer electrical structures |
RU2041262C1 (ru) | 1993-08-11 | 1995-08-09 | Институт молекулярной биологии им.В.А.Энгельгардта РАН | Способ иммобилизации водорастворимых биоорганических соединений на капиллярно-пористый носитель |
RU2041261C1 (ru) | 1993-08-11 | 1995-08-09 | Институт молекулярной биологии им.В.А.Энгельгардта РАН | Способ изготовления матрицы для детектирования мисматчей |
RU2041263C1 (ru) | 1993-08-11 | 1995-08-09 | Геннадий Моисеевич Ершов | Способ микродозирования водных растворов веществ на носитель и устройство для его осуществления |
JP2948069B2 (ja) | 1993-09-20 | 1999-09-13 | 株式会社日立製作所 | 化学分析装置 |
GB9320286D0 (en) * | 1993-10-01 | 1993-11-17 | Drew Scient Ltd | Electro-chemical detector |
US5512131A (en) * | 1993-10-04 | 1996-04-30 | President And Fellows Of Harvard College | Formation of microstamped patterns on surfaces and derivative articles |
US6225059B1 (en) | 1993-11-01 | 2001-05-01 | Nanogen, Inc. | Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics |
US20040077074A1 (en) * | 1993-11-01 | 2004-04-22 | Nanogen, Inc. | Multi-chambered analysis device |
US6068818A (en) * | 1993-11-01 | 2000-05-30 | Nanogen, Inc. | Multicomponent devices for molecular biological analysis and diagnostics |
US5505321A (en) | 1994-12-05 | 1996-04-09 | Teledyne Industries, Inc. | Fabrication multilayer combined rigid/flex printed circuit board |
US5591578A (en) * | 1993-12-10 | 1997-01-07 | California Institute Of Technology | Nucleic acid mediated electron transfer |
US5952172A (en) * | 1993-12-10 | 1999-09-14 | California Institute Of Technology | Nucleic acid mediated electron transfer |
US6071699A (en) * | 1996-06-07 | 2000-06-06 | California Institute Of Technology | Nucleic acid mediated electron transfer |
US5824473A (en) | 1993-12-10 | 1998-10-20 | California Institute Of Technology | Nucleic acid mediated electron transfer |
US5595712A (en) * | 1994-07-25 | 1997-01-21 | E. I. Du Pont De Nemours And Company | Chemical mixing and reaction apparatus |
JPH10509025A (ja) | 1994-08-26 | 1998-09-08 | アイジェン, インコーポレイテッド | 固体表面に吸着された核酸の電気的に発生した化学ルミネッセンス性検出のためのバイオセンサーおよび方法 |
US5620850A (en) | 1994-09-26 | 1997-04-15 | President And Fellows Of Harvard College | Molecular recognition at surfaces derivatized with self-assembled monolayers |
US5500071A (en) * | 1994-10-19 | 1996-03-19 | Hewlett-Packard Company | Miniaturized planar columns in novel support media for liquid phase analysis |
US5603351A (en) | 1995-06-07 | 1997-02-18 | David Sarnoff Research Center, Inc. | Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device |
EP0791238B1 (en) | 1994-11-10 | 2004-09-22 | Orchid BioSciences, Inc. | Liquid distribution system |
US5632876A (en) | 1995-06-06 | 1997-05-27 | David Sarnoff Research Center, Inc. | Apparatus and methods for controlling fluid flow in microchannels |
US5585069A (en) | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
US5985119A (en) | 1994-11-10 | 1999-11-16 | Sarnoff Corporation | Electrokinetic pumping |
US5601982A (en) | 1995-02-07 | 1997-02-11 | Sargent; Jeannine P. | Method and apparatus for determining the sequence of polynucleotides |
CA2213854C (en) | 1995-03-10 | 2010-08-10 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
US6207369B1 (en) * | 1995-03-10 | 2001-03-27 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
GB9506312D0 (en) * | 1995-03-28 | 1995-05-17 | Medical Res Council | Improvements in or relating to sample processing |
US5741462A (en) | 1995-04-25 | 1998-04-21 | Irori | Remotely programmable matrices with memories |
DE19519015C1 (de) * | 1995-05-24 | 1996-09-05 | Inst Physikalische Hochtech Ev | Miniaturisierter Mehrkammer-Thermocycler |
US5842106A (en) * | 1995-06-06 | 1998-11-24 | Sarnoff Corporation | Method of producing micro-electrical conduits |
EP1193315A1 (en) | 1995-06-27 | 2002-04-03 | University of North Carolina at Chapel Hill et al. | Microelectronic device for electrochemical detection |
US6168948B1 (en) * | 1995-06-29 | 2001-01-02 | Affymetrix, Inc. | Miniaturized genetic analysis systems and methods |
US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
US20020022261A1 (en) * | 1995-06-29 | 2002-02-21 | Anderson Rolfe C. | Miniaturized genetic analysis systems and methods |
US5657208A (en) * | 1995-07-28 | 1997-08-12 | Hewlett-Packard Company | Surface mount attachments of daughterboards to motherboards |
JPH11510601A (ja) * | 1995-08-03 | 1999-09-14 | アクゾ・ノベル・エヌ・ベー | 診断装置 |
JPH0961312A (ja) | 1995-08-30 | 1997-03-07 | Mochida Pharmaceut Co Ltd | 簡易測定装置 |
US5650061A (en) * | 1995-09-18 | 1997-07-22 | The Regents Of The University Of California | Large amplitude sinusoidal voltammetry |
CA2236788A1 (en) | 1995-11-09 | 1997-05-15 | David Sarnoff Research Center, Inc. | Field-assisted sealing |
AU704863B2 (en) * | 1995-11-15 | 1999-05-06 | Arkray, Inc. | Device and method for assaying biological components in sample |
US5631337A (en) | 1996-01-19 | 1997-05-20 | Soane Bioscience | Thermoreversible hydrogels comprising linear copolymers and their use in electrophoresis |
US5863502A (en) | 1996-01-24 | 1999-01-26 | Sarnoff Corporation | Parallel reaction cassette and associated devices |
US5861247A (en) | 1996-01-26 | 1999-01-19 | University Of Chicago | Rapid method to detect duplex formation in sequencing by hybridization methods |
US5851772A (en) | 1996-01-29 | 1998-12-22 | University Of Chicago | Microchip method for the enrichment of specific DNA sequences |
US6114122A (en) | 1996-03-26 | 2000-09-05 | Affymetrix, Inc. | Fluidics station with a mounting system and method of using |
WO1997036681A1 (en) * | 1996-04-03 | 1997-10-09 | The Perkin-Elmer Corporation | Device and method for multiple analyte detection |
WO1997037755A1 (en) | 1996-04-09 | 1997-10-16 | Sarnoff Corporation | Plate for reaction system |
US6399023B1 (en) | 1996-04-16 | 2002-06-04 | Caliper Technologies Corp. | Analytical system and method |
EP0990149A4 (en) | 1996-05-22 | 2003-02-26 | Au Membrane & Biotech Res Inst | NUCLEIC ACID SENSOR |
US5728532A (en) | 1996-05-31 | 1998-03-17 | Ackley; Donald E. | Electrode configuration for matrix addressing of a molecular detection device |
US6020047A (en) * | 1996-09-04 | 2000-02-01 | Kimberly-Clark Worldwide, Inc. | Polymer films having a printed self-assembling monolayer |
US5874046A (en) * | 1996-10-30 | 1999-02-23 | Raytheon Company | Biological warfare agent sensor system employing ruthenium-terminated oligonucleotides complementary to target live agent DNA sequences |
US7381525B1 (en) * | 1997-03-07 | 2008-06-03 | Clinical Micro Sensors, Inc. | AC/DC voltage apparatus for detection of nucleic acids |
US7045285B1 (en) * | 1996-11-05 | 2006-05-16 | Clinical Micro Sensors, Inc. | Electronic transfer moieties attached to peptide nucleic acids |
US6096273A (en) * | 1996-11-05 | 2000-08-01 | Clinical Micro Sensors | Electrodes linked via conductive oligomers to nucleic acids |
US7393645B2 (en) * | 1996-11-05 | 2008-07-01 | Clinical Micro Sensors, Inc. | Compositions for the electronic detection of analytes utilizing monolayers |
US7160678B1 (en) * | 1996-11-05 | 2007-01-09 | Clinical Micro Sensors, Inc. | Compositions for the electronic detection of analytes utilizing monolayers |
EP0939762A2 (en) | 1996-11-05 | 1999-09-08 | Clinical Micro Sensors | Electrodes linked via conductive oligomers to nucleic acids |
US7014992B1 (en) * | 1996-11-05 | 2006-03-21 | Clinical Micro Sensors, Inc. | Conductive oligomers attached to electrodes and nucleoside analogs |
US5971355A (en) * | 1996-11-27 | 1999-10-26 | Xerox Corporation | Microdevice valve structures to fluid control |
US5905024A (en) | 1996-12-17 | 1999-05-18 | University Of Chicago | Method for performing site-specific affinity fractionation for use in DNA sequencing |
EP0951569A2 (en) | 1996-12-23 | 1999-10-27 | University Of Chicago | Customized oligonucleotide microchips as multiple biosensors |
US6306584B1 (en) * | 1997-01-21 | 2001-10-23 | President And Fellows Of Harvard College | Electronic-property probing of biological molecules at surfaces |
NZ336910A (en) | 1997-02-06 | 2001-09-28 | Xanthon Inc | Electrochemical probes for detection of molecular interactions and drug discovery |
AU5301598A (en) | 1997-02-10 | 1998-08-13 | Gist-Brocades B.V. | Detection of analytes using electrochemistry |
TR199902440T2 (xx) | 1997-02-28 | 2000-02-21 | Burstein Laboratories, Inc. | Disk �zerinde laboratuar. |
US6013459A (en) * | 1997-06-12 | 2000-01-11 | Clinical Micro Sensors, Inc. | Detection of analytes using reorganization energy |
US7560237B2 (en) * | 1997-06-12 | 2009-07-14 | Osmetech Technology Inc. | Electronics method for the detection of analytes |
US5932799A (en) * | 1997-07-21 | 1999-08-03 | Ysi Incorporated | Microfluidic analyzer module |
WO1999033559A1 (en) | 1997-12-24 | 1999-07-08 | Cepheid | Integrated fluid manipulation cartridge |
SE9703314D0 (sv) | 1997-09-15 | 1997-09-15 | Sangtec Medical Ab | Capacity affinity sensor |
US6048692A (en) * | 1997-10-07 | 2000-04-11 | Motorola, Inc. | Sensors for electrically sensing binding events for supported molecular receptors |
US5842787A (en) * | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions |
US5945286A (en) * | 1997-10-23 | 1999-08-31 | Motorola, Inc. | Electrochemical-based molecular detection apparatus and method |
US6063573A (en) * | 1998-01-27 | 2000-05-16 | Clinical Micro Sensors, Inc. | Cycling probe technology using electron transfer detection |
US6686150B1 (en) * | 1998-01-27 | 2004-02-03 | Clinical Micro Sensors, Inc. | Amplification of nucleic acids with electronic detection |
US20050053962A1 (en) * | 1998-01-27 | 2005-03-10 | Gary Blackburn | Amplification of nucleic acids with electronic detection |
CA2319170A1 (en) * | 1998-01-27 | 1999-07-29 | Clinical Micro Sensors, Inc. | Amplification of nucleic acids with electronic detection |
EP2316571A3 (en) * | 1998-05-01 | 2011-07-27 | Gen-Probe Incorporated | Automated diagnostic analyzer and method |
DE69939464D1 (de) | 1998-05-06 | 2008-10-16 | Clinical Micro Sensors Inc | Elekronische verfahren zur erkennung von analyten mit hilfe von einfachschichten |
US20030087228A1 (en) * | 1998-05-06 | 2003-05-08 | Cynthia Bamdad | Electronic detection of nucleic acids using monolayers |
US6761816B1 (en) * | 1998-06-23 | 2004-07-13 | Clinical Micro Systems, Inc. | Printed circuit boards with monolayers and capture ligands |
US7087148B1 (en) * | 1998-06-23 | 2006-08-08 | Clinical Micro Sensors, Inc. | Binding acceleration techniques for the detection of analytes |
US6290839B1 (en) | 1998-06-23 | 2001-09-18 | Clinical Micro Sensors, Inc. | Systems for electrophoretic transport and detection of analytes |
AU4833899A (en) * | 1998-06-24 | 2000-01-10 | Therasense, Inc. | Multi-sensor array for electrochemical recognition of nucleotide sequences and methods |
US6132685A (en) * | 1998-08-10 | 2000-10-17 | Caliper Technologies Corporation | High throughput microfluidic systems and methods |
US6740518B1 (en) * | 1998-09-17 | 2004-05-25 | Clinical Micro Sensors, Inc. | Signal detection techniques for the detection of analytes |
AU1241000A (en) | 1998-10-27 | 2000-05-15 | Clinical Micro Sensors, Inc. | Detection of target analytes using particles and electrodes |
US6300141B1 (en) * | 1999-03-02 | 2001-10-09 | Helix Biopharma Corporation | Card-based biosensor device |
US20040053290A1 (en) * | 2000-01-11 | 2004-03-18 | Terbrueggen Robert Henry | Devices and methods for biochip multiplexing |
US6942771B1 (en) * | 1999-04-21 | 2005-09-13 | Clinical Micro Sensors, Inc. | Microfluidic systems in the electrochemical detection of target analytes |
US20020177135A1 (en) * | 1999-07-27 | 2002-11-28 | Doung Hau H. | Devices and methods for biochip multiplexing |
EP1077264B1 (en) * | 1999-06-07 | 2005-04-20 | Fuji Photo Film Co., Ltd. | DNA chip, PNA chip, and their preparation methods |
US6706519B1 (en) * | 1999-06-22 | 2004-03-16 | Tecan Trading Ag | Devices and methods for the performance of miniaturized in vitro amplification assays |
US6258593B1 (en) | 1999-06-30 | 2001-07-10 | Agilent Technologies Inc. | Apparatus for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber |
CA2388780C (en) | 1999-11-12 | 2006-06-06 | Clinical Micro Sensors, Inc. | Binding acceleration techniques for the detection of analytes |
US6361958B1 (en) * | 1999-11-12 | 2002-03-26 | Motorola, Inc. | Biochannel assay for hybridization with biomaterial |
ES2278757T3 (es) | 2000-01-11 | 2007-08-16 | Clinical Micro Sensors, Inc. | Cartucho que comprende un biochip. |
EP1331999A2 (en) | 2000-11-03 | 2003-08-06 | Clinical Micro Sensors, Inc. | Devices and methods for biochip multiplexing |
US20030175947A1 (en) * | 2001-11-05 | 2003-09-18 | Liu Robin Hui | Enhanced mixing in microfluidic devices |
-
1999
- 1999-04-21 US US09/295,691 patent/US6942771B1/en not_active Expired - Lifetime
-
2000
- 2000-04-21 CA CA002370879A patent/CA2370879A1/en not_active Abandoned
- 2000-04-21 AT AT00923580T patent/ATE256500T1/de not_active IP Right Cessation
- 2000-04-21 JP JP2000612061A patent/JP2002542461A/ja active Pending
- 2000-04-21 PT PT00923580T patent/PT1183102E/pt unknown
- 2000-04-21 AU AU43680/00A patent/AU771571B2/en not_active Ceased
- 2000-04-21 DK DK00923580T patent/DK1183102T3/da active
- 2000-04-21 EP EP03022729A patent/EP1391241A1/en not_active Withdrawn
- 2000-04-21 WO PCT/US2000/010903 patent/WO2000062931A1/en active IP Right Grant
- 2000-04-21 EP EP00923580A patent/EP1183102B1/en not_active Expired - Lifetime
- 2000-04-21 ES ES00923580T patent/ES2213009T3/es not_active Expired - Lifetime
- 2000-04-21 DE DE60007306T patent/DE60007306T2/de not_active Expired - Lifetime
-
2005
- 2005-01-25 US US11/043,515 patent/US7534331B2/en not_active Expired - Lifetime
-
2006
- 2006-09-18 US US11/532,872 patent/US20070098600A1/en not_active Abandoned
-
2007
- 2007-10-30 US US11/981,592 patent/US20090166196A1/en not_active Abandoned
- 2007-10-30 US US11/981,541 patent/US8486247B2/en not_active Expired - Lifetime
- 2007-10-31 US US11/982,403 patent/US20090057147A1/en not_active Abandoned
- 2007-10-31 US US11/982,334 patent/US20100285981A1/en not_active Abandoned
- 2007-10-31 US US11/982,408 patent/US20080242553A1/en not_active Abandoned
- 2007-10-31 US US11/982,368 patent/US20110180425A1/en not_active Abandoned
-
2013
- 2013-06-18 US US13/921,117 patent/US9151746B2/en not_active Expired - Fee Related
-
2015
- 2015-08-27 US US14/837,254 patent/US9557295B2/en not_active Expired - Fee Related
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2002542461A5 (US07534331-20090519-C00005.png) | ||
US9557295B2 (en) | Use of microfluidic systems in the electrochemical detection of target analytes | |
US6306590B1 (en) | Microfluidic matrix localization apparatus and methods | |
US20040011650A1 (en) | Method and apparatus for manipulating polarizable analytes via dielectrophoresis | |
US20040018611A1 (en) | Microfluidic devices for high gradient magnetic separation | |
Xu et al. | Solid-phase reversible immobilization in microfluidic chips for the purification of dye-labeled DNA sequencing fragments | |
US20030175947A1 (en) | Enhanced mixing in microfluidic devices | |
Woolley et al. | Functional integration of PCR amplification and capillary electrophoresis in a microfabricated DNA analysis device | |
US6670133B2 (en) | Microfluidic device for sequencing by hybridization | |
US8481268B2 (en) | Use of microfluidic systems in the detection of target analytes using microsphere arrays | |
Selvaganapathy et al. | Recent progress in microfluidic devices for nucleic acid and antibody assays | |
US20100021907A1 (en) | Method of detecting a plurality of nucleic acids | |
AU2004202695A1 (en) | The use of microfluidic systems in the electrochemical detection of target analytes | |
Yeung | Development of electrochemistry-based DNA assay in a silicon/glass bio-device for point-of-care applications | |
Erickson et al. | A DNA Hybridization Chip With Electrokinetically-Based Single Nucleotide Polymorphism (SNP) Discrimination |