JP2002541086A5 - - Google Patents
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- Publication number
- JP2002541086A5 JP2002541086A5 JP2000609035A JP2000609035A JP2002541086A5 JP 2002541086 A5 JP2002541086 A5 JP 2002541086A5 JP 2000609035 A JP2000609035 A JP 2000609035A JP 2000609035 A JP2000609035 A JP 2000609035A JP 2002541086 A5 JP2002541086 A5 JP 2002541086A5
- Authority
- JP
- Japan
- Prior art keywords
- emulsion
- water
- propofol
- oil
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000839 emulsion Substances 0.000 description 13
- OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 description 7
- 229960004134 propofol Drugs 0.000 description 7
- 239000008194 pharmaceutical composition Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 235000012424 soybean oil Nutrition 0.000 description 4
- 239000003549 soybean oil Substances 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 239000008346 aqueous phase Substances 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 239000007764 o/w emulsion Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- 150000003904 phospholipids Chemical class 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000003134 recirculating effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000012929 tonicity agent Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/286,159 | 1999-04-05 | ||
| US09/286,159 US6100302A (en) | 1999-04-05 | 1999-04-05 | Propofol formulation with enhanced microbial characteristics |
| PCT/US2000/008378 WO2000059471A1 (en) | 1999-04-05 | 2000-03-29 | Propofol formulation with enhanced microbial characteristics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002541086A JP2002541086A (ja) | 2002-12-03 |
| JP2002541086A5 true JP2002541086A5 (https=) | 2007-05-24 |
Family
ID=23097354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000609035A Pending JP2002541086A (ja) | 1999-04-05 | 2000-03-29 | 強化された微生物的特徴を有するプロポフォール処方物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6100302A (https=) |
| EP (1) | EP1165045A1 (https=) |
| JP (1) | JP2002541086A (https=) |
| KR (2) | KR100861820B1 (https=) |
| AU (1) | AU774259B2 (https=) |
| BR (1) | BR0009541A (https=) |
| CA (1) | CA2366793C (https=) |
| MX (1) | MXPA01010064A (https=) |
| WO (1) | WO2000059471A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6749868B1 (en) | 1993-02-22 | 2004-06-15 | American Bioscience, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
| US6979456B1 (en) | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
| ES2211151T3 (es) | 1998-08-19 | 2004-07-01 | Skyepharma Canada Inc. | Dispersiones acuosas inyectables de propofol. |
| EP2036540A3 (en) * | 2000-06-16 | 2009-12-16 | Jagotec AG | Improved injectable dispersions of propofol |
| US6399087B1 (en) * | 2000-12-20 | 2002-06-04 | Amphastar Pharmaceuticals, Inc. | Propofol formulation with enhanced microbial inhibition |
| US20030054042A1 (en) * | 2001-09-14 | 2003-03-20 | Elaine Liversidge | Stabilization of chemical compounds using nanoparticulate formulations |
| JP2005504090A (ja) | 2001-09-26 | 2005-02-10 | バクスター・インターナショナル・インコーポレイテッド | 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製 |
| EP1430017A2 (en) | 2001-09-26 | 2004-06-23 | Theravance, Inc. | Substituted phenol compounds useful for anesthesia and sedation |
| EP1490030B2 (en) * | 2002-03-20 | 2010-07-14 | Elan Pharma International Limited | Nanoparticulate compositions of angiogenesis inhibitors |
| WO2003105817A1 (en) * | 2002-05-02 | 2003-12-24 | Fdl, Inc. | Novel parenteral composition comprising propofol |
| KR100459025B1 (ko) * | 2002-05-02 | 2004-12-03 | (주) 에프디엘 | 프로포폴을 함유하는 신규한 주사제용 조성물 |
| CN100438861C (zh) * | 2002-07-29 | 2008-12-03 | 变换药品公司 | 含水2,6-二异丙基苯酚药物组合物 |
| US7550155B2 (en) * | 2002-07-29 | 2009-06-23 | Transform Pharmaceuticals Inc. | Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses |
| US20040171691A1 (en) * | 2002-10-29 | 2004-09-02 | Transform Pharmaceuticals, Inc. | Propofol with cysteine |
| CN103405405A (zh) * | 2002-12-09 | 2013-11-27 | 阿布拉西斯生物科学有限责任公司 | 组合物和传递药剂的方法 |
| US20040225022A1 (en) * | 2003-05-09 | 2004-11-11 | Desai Neil P. | Propofol formulation containing reduced oil and surfactants |
| US8476010B2 (en) | 2003-07-10 | 2013-07-02 | App Pharmaceuticals Llc | Propofol formulations with non-reactive container closures |
| US8546453B2 (en) | 2003-08-14 | 2013-10-01 | Rensheng Zhang | Propofol compositions and methods for reducing pain associated with propofol injection |
| AU2005283726A1 (en) * | 2004-09-13 | 2006-03-23 | Bharat Serums & Vaccines Ltd. | Stable emulsion compositions for intravenous administration having antimicrobial preservative efficacy |
| KR20080043793A (ko) * | 2005-08-05 | 2008-05-19 | 바라트 쎄럼스 앤드 백신스 리미티드 | 방부 효능을 갖는 정맥 프로포폴 에멀젼 조성물 |
| CN101287447B (zh) * | 2005-08-12 | 2012-10-24 | 印度血清及疫苗有限公司 | 包含丙泊酚的水性麻醉剂组合物 |
| KR101420445B1 (ko) | 2005-08-31 | 2014-07-16 | 아브락시스 바이오사이언스, 엘엘씨 | 수 난용성 제약학적 약제 및 항균제를 포함하는 조성물 |
| AU2006284657B2 (en) * | 2005-08-31 | 2012-07-19 | Abraxis Bioscience, Llc | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
| US8426467B2 (en) | 2007-05-22 | 2013-04-23 | Baxter International Inc. | Colored esmolol concentrate |
| US8722736B2 (en) | 2007-05-22 | 2014-05-13 | Baxter International Inc. | Multi-dose concentrate esmolol with benzyl alcohol |
| JP2013001700A (ja) * | 2011-06-21 | 2013-01-07 | Fujifilm Corp | プロポフォール含有水中油型エマルション組成物 |
| JP5759804B2 (ja) * | 2011-06-27 | 2015-08-05 | 富士フイルム株式会社 | 容器詰製剤 |
| JP6247685B2 (ja) | 2012-05-16 | 2017-12-13 | メワ・シン | 実質的に水不溶性の薬物の送達のための医薬組成物 |
| CN104490780B (zh) * | 2015-01-16 | 2017-04-19 | 河北一品制药有限公司 | 一种丙泊酚脂肪乳注射液的制备方法 |
| US11622937B2 (en) | 2015-08-20 | 2023-04-11 | Mewa Singh | Polyphenolic polymer to make water-insoluble molecules become water-soluble |
| CN110478366A (zh) * | 2019-08-23 | 2019-11-22 | 宜昌人福药业有限责任公司 | 含非水溶性镇痛药的局部用组合物及其制备方法和用途 |
| US11992483B2 (en) | 2021-03-31 | 2024-05-28 | Cali Biosciences Us, Llc | Emulsions for local anesthetics |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1472793A (en) * | 1974-03-28 | 1977-05-04 | Ici Ltd | Pharmaceutical compositions |
| BR9506681A (pt) * | 1994-02-04 | 1997-11-18 | Scotia Lipidteknik Ab | Emulsão oleo em água e composição farmacêutica |
| GB9405593D0 (en) * | 1994-03-22 | 1994-05-11 | Zeneca Ltd | Pharmaceutical compositions |
| US5637625A (en) * | 1996-03-19 | 1997-06-10 | Research Triangle Pharmaceuticals Ltd. | Propofol microdroplet formulations |
| ES2211151T3 (es) * | 1998-08-19 | 2004-07-01 | Skyepharma Canada Inc. | Dispersiones acuosas inyectables de propofol. |
| US6140374A (en) * | 1998-10-23 | 2000-10-31 | Abbott Laboratories | Propofol composition |
-
1999
- 1999-04-05 US US09/286,159 patent/US6100302A/en not_active Expired - Fee Related
-
2000
- 2000-03-29 AU AU40463/00A patent/AU774259B2/en not_active Ceased
- 2000-03-29 WO PCT/US2000/008378 patent/WO2000059471A1/en not_active Ceased
- 2000-03-29 CA CA002366793A patent/CA2366793C/en not_active Expired - Fee Related
- 2000-03-29 JP JP2000609035A patent/JP2002541086A/ja active Pending
- 2000-03-29 KR KR1020077010526A patent/KR100861820B1/ko not_active Expired - Fee Related
- 2000-03-29 BR BR0009541-9A patent/BR0009541A/pt not_active Application Discontinuation
- 2000-03-29 KR KR1020017012652A patent/KR100741604B1/ko not_active Expired - Fee Related
- 2000-03-29 MX MXPA01010064A patent/MXPA01010064A/es active IP Right Grant
- 2000-03-29 EP EP00919842A patent/EP1165045A1/en not_active Withdrawn
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