AU774259B2 - Propofol formulation with enhanced microbial characteristics - Google Patents

Propofol formulation with enhanced microbial characteristics Download PDF

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Publication number
AU774259B2
AU774259B2 AU40463/00A AU4046300A AU774259B2 AU 774259 B2 AU774259 B2 AU 774259B2 AU 40463/00 A AU40463/00 A AU 40463/00A AU 4046300 A AU4046300 A AU 4046300A AU 774259 B2 AU774259 B2 AU 774259B2
Authority
AU
Australia
Prior art keywords
emulsion
propofol
oil
water
soybean oil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU40463/00A
Other languages
English (en)
Other versions
AU4046300A (en
Inventor
Josben C. Dela Rosa
Rajeshwar Motheram
Satish K. Pejaver
Barrett E. Rabinow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter International Inc filed Critical Baxter International Inc
Publication of AU4046300A publication Critical patent/AU4046300A/en
Application granted granted Critical
Publication of AU774259B2 publication Critical patent/AU774259B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU40463/00A 1999-04-05 2000-03-29 Propofol formulation with enhanced microbial characteristics Ceased AU774259B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/286,159 US6100302A (en) 1999-04-05 1999-04-05 Propofol formulation with enhanced microbial characteristics
US09/286159 1999-04-05
PCT/US2000/008378 WO2000059471A1 (en) 1999-04-05 2000-03-29 Propofol formulation with enhanced microbial characteristics

Publications (2)

Publication Number Publication Date
AU4046300A AU4046300A (en) 2000-10-23
AU774259B2 true AU774259B2 (en) 2004-06-24

Family

ID=23097354

Family Applications (1)

Application Number Title Priority Date Filing Date
AU40463/00A Ceased AU774259B2 (en) 1999-04-05 2000-03-29 Propofol formulation with enhanced microbial characteristics

Country Status (9)

Country Link
US (1) US6100302A (https=)
EP (1) EP1165045A1 (https=)
JP (1) JP2002541086A (https=)
KR (2) KR100861820B1 (https=)
AU (1) AU774259B2 (https=)
BR (1) BR0009541A (https=)
CA (1) CA2366793C (https=)
MX (1) MXPA01010064A (https=)
WO (1) WO2000059471A1 (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6749868B1 (en) 1993-02-22 2004-06-15 American Bioscience, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
DE69912441T2 (de) 1998-08-19 2004-08-19 Skyepharma Canada Inc., Verdun Injizierbare wässerige propofoldispersionen
EP1292282A2 (en) * 2000-06-16 2003-03-19 RTP Pharma Inc. Improved injectable dispersions of propofol
US6399087B1 (en) * 2000-12-20 2002-06-04 Amphastar Pharmaceuticals, Inc. Propofol formulation with enhanced microbial inhibition
US20030054042A1 (en) * 2001-09-14 2003-03-20 Elaine Liversidge Stabilization of chemical compounds using nanoparticulate formulations
BR0212833A (pt) 2001-09-26 2004-10-13 Baxter Int Preparação de nanopartìculas de tamanho submìcron através de dispersão e de remoção de solvente ou de fase lìquida
CA2459125A1 (en) 2001-09-26 2003-04-03 Theravance, Inc. Substituted phenol compounds useful for anesthesia and sedation
WO2003080027A1 (en) * 2002-03-20 2003-10-02 Elan Pharma International, Ltd. Nanoparticulate compositions of angiogenesis inhibitors
KR100459025B1 (ko) * 2002-05-02 2004-12-03 (주) 에프디엘 프로포폴을 함유하는 신규한 주사제용 조성물
AU2003222491A1 (en) * 2002-05-02 2003-12-31 Fdl, Inc. Novel parenteral composition comprising propofol
BR0313060A (pt) * 2002-07-29 2005-06-28 Transform Pharmaceuticals Inc Composições farmacêuticas aquosas de 2,6-diisopropilfenol
US7550155B2 (en) * 2002-07-29 2009-06-23 Transform Pharmaceuticals Inc. Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses
AU2003286725B2 (en) * 2002-10-29 2007-07-12 Transform Pharmaceuticals, Inc. Propofol with cysteine
CA2509365C (en) 2002-12-09 2012-08-07 American Bioscience, Inc. Compositions and methods of delivery of pharmacological agents
US20040225022A1 (en) * 2003-05-09 2004-11-11 Desai Neil P. Propofol formulation containing reduced oil and surfactants
US8476010B2 (en) 2003-07-10 2013-07-02 App Pharmaceuticals Llc Propofol formulations with non-reactive container closures
US8546453B2 (en) * 2003-08-14 2013-10-01 Rensheng Zhang Propofol compositions and methods for reducing pain associated with propofol injection
EP1799266A2 (en) * 2004-09-13 2007-06-27 Bharat Serums & Vaccines Ltd. Stable emulsion compositions for intravenous administration having antimicrobial preservative efficacy
ATE420625T1 (de) * 2005-08-05 2009-01-15 Bharat Serums & Vaccines Ltd Intravenöse propofol-emulsionszusammensetzungen mit konservierendem effekt
CA2618799C (en) * 2005-08-12 2013-06-04 Bharat Serums & Vaccines Ltd. Aqueous anaesthetic compositions comprising propofol
EP3527202A1 (en) * 2005-08-31 2019-08-21 Abraxis BioScience, LLC Compositions and methods for preparation of poorly water soluble drugs with increased stability
LT3311805T (lt) * 2005-08-31 2020-04-27 Abraxis Bioscience, Llc Kompozicijos, apimančios silpnai vandenyje tirpius farmacinius agentus ir priešmikrobinius agentus
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
JP2013001700A (ja) * 2011-06-21 2013-01-07 Fujifilm Corp プロポフォール含有水中油型エマルション組成物
JP5759804B2 (ja) * 2011-06-27 2015-08-05 富士フイルム株式会社 容器詰製剤
WO2013172999A1 (en) 2012-05-16 2013-11-21 Mewa Singh Pharmaceutical compositions for the delivery of substantially water-insoluble drugs
CN104490780B (zh) * 2015-01-16 2017-04-19 河北一品制药有限公司 一种丙泊酚脂肪乳注射液的制备方法
WO2017031261A1 (en) 2015-08-20 2017-02-23 Mewa Singh Polyphenolic polymer to make water-insoluble molecules become water-soluble
CN110478366A (zh) * 2019-08-23 2019-11-22 宜昌人福药业有限责任公司 含非水溶性镇痛药的局部用组合物及其制备方法和用途
US11992483B2 (en) 2021-03-31 2024-05-28 Cali Biosciences Us, Llc Emulsions for local anesthetics

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4056635A (en) * 1974-03-28 1977-11-01 Imperial Chemical Industries Limited 2,6-Diisopropylphenol as an anaesthetic agent
AU5570599A (en) * 1998-08-19 2000-03-14 Skyepharma Canada Inc. Injectable aqueous dispersions of propofol

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995020943A1 (en) * 1994-02-04 1995-08-10 Scotia Lipidteknik Ab Oil-in-water emulsions
GB9405593D0 (en) * 1994-03-22 1994-05-11 Zeneca Ltd Pharmaceutical compositions
US5637625A (en) * 1996-03-19 1997-06-10 Research Triangle Pharmaceuticals Ltd. Propofol microdroplet formulations
US6140374A (en) * 1998-10-23 2000-10-31 Abbott Laboratories Propofol composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4056635A (en) * 1974-03-28 1977-11-01 Imperial Chemical Industries Limited 2,6-Diisopropylphenol as an anaesthetic agent
US4452817A (en) * 1974-03-28 1984-06-05 Imperial Chemical Industries Plc Anaesthetic compositions containing 2,6-diisopropylphenol
AU5570599A (en) * 1998-08-19 2000-03-14 Skyepharma Canada Inc. Injectable aqueous dispersions of propofol

Also Published As

Publication number Publication date
WO2000059471A1 (en) 2000-10-12
US6100302A (en) 2000-08-08
EP1165045A1 (en) 2002-01-02
CA2366793C (en) 2009-06-02
CA2366793A1 (en) 2000-10-12
KR20070058012A (ko) 2007-06-07
BR0009541A (pt) 2002-01-02
KR100741604B1 (ko) 2007-07-20
KR20010112400A (ko) 2001-12-20
KR100861820B1 (ko) 2008-10-07
AU4046300A (en) 2000-10-23
MXPA01010064A (es) 2002-06-21
JP2002541086A (ja) 2002-12-03

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FGA Letters patent sealed or granted (standard patent)