BR0009541A - Emulsão, composição farmacêutica, e, método para preparar uma composição farmacêutica de emulsão óleo-em-água - Google Patents

Emulsão, composição farmacêutica, e, método para preparar uma composição farmacêutica de emulsão óleo-em-água

Info

Publication number
BR0009541A
BR0009541A BR0009541-9A BR0009541A BR0009541A BR 0009541 A BR0009541 A BR 0009541A BR 0009541 A BR0009541 A BR 0009541A BR 0009541 A BR0009541 A BR 0009541A
Authority
BR
Brazil
Prior art keywords
emulsion
pharmaceutical composition
oil
preparing
propofol
Prior art date
Application number
BR0009541-9A
Other languages
English (en)
Inventor
Satish K Pejaver
Rajeshwar Motheram
Barrett E Rabinow
Josben C Dela Rosa
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int filed Critical Baxter Int
Publication of BR0009541A publication Critical patent/BR0009541A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"EMULSãO, COMPOSIçãO FARMACêUTICA, E, MéTODO PARA PREPARAR UMA COMPOSIçãO FARMACêUTICA DE EMULSãO óLEO-EM-áGUA". Proporciona-se formulações de emulsões anestésicas intravenosas de propofol que contêm concentrações suficientemente baixas de óleo de soja para produzir uma emulsão estável e, simultaneamente, proporcionar nutrientes reduzidos que inibem crescimento microbiano, desta forma proporcionando proteção contaminação microbiana acidental durante infusões IV prolongadas. Adicionalmente à inibição de crescimento microbiano devido a uma redução de nutrientes, a formulação apresenta inibição adicional inesperada devido a uma maior disponibilidade de propofol. A baixa concentração de óleo de soja também proporciona uma formulação que reduz as chances de sobrecarga de gordura quando administrada a pacientes cronicamente doentes durante um período prolongado.
BR0009541-9A 1999-04-05 2000-03-29 Emulsão, composição farmacêutica, e, método para preparar uma composição farmacêutica de emulsão óleo-em-água BR0009541A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/286,159 US6100302A (en) 1999-04-05 1999-04-05 Propofol formulation with enhanced microbial characteristics
PCT/US2000/008378 WO2000059471A1 (en) 1999-04-05 2000-03-29 Propofol formulation with enhanced microbial characteristics

Publications (1)

Publication Number Publication Date
BR0009541A true BR0009541A (pt) 2002-01-02

Family

ID=23097354

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0009541-9A BR0009541A (pt) 1999-04-05 2000-03-29 Emulsão, composição farmacêutica, e, método para preparar uma composição farmacêutica de emulsão óleo-em-água

Country Status (9)

Country Link
US (1) US6100302A (pt)
EP (1) EP1165045A1 (pt)
JP (1) JP2002541086A (pt)
KR (2) KR100861820B1 (pt)
AU (1) AU774259B2 (pt)
BR (1) BR0009541A (pt)
CA (1) CA2366793C (pt)
MX (1) MXPA01010064A (pt)
WO (1) WO2000059471A1 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6749868B1 (en) 1993-02-22 2004-06-15 American Bioscience, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US6726919B2 (en) * 2000-06-16 2004-04-27 Rtp Pharma, Inc. Injectable dispersion of propofol
US6399087B1 (en) * 2000-12-20 2002-06-04 Amphastar Pharmaceuticals, Inc. Propofol formulation with enhanced microbial inhibition
US20030054042A1 (en) * 2001-09-14 2003-03-20 Elaine Liversidge Stabilization of chemical compounds using nanoparticulate formulations
EP1429749A2 (en) 2001-09-26 2004-06-23 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
US6815555B2 (en) 2001-09-26 2004-11-09 Theravance, Inc. Substituted phenol compounds useful for anesthesia and sedation
WO2003080027A1 (en) * 2002-03-20 2003-10-02 Elan Pharma International, Ltd. Nanoparticulate compositions of angiogenesis inhibitors
AU2003222491A1 (en) * 2002-05-02 2003-12-31 Fdl, Inc. Novel parenteral composition comprising propofol
KR100459025B1 (ko) * 2002-05-02 2004-12-03 (주) 에프디엘 프로포폴을 함유하는 신규한 주사제용 조성물
US7550155B2 (en) * 2002-07-29 2009-06-23 Transform Pharmaceuticals Inc. Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses
NZ538255A (en) * 2002-07-29 2006-11-30 Transform Pharmaceuticals Inc Aqueous 2,6-diisopropylphenol pharmaceutical compositions
EP1555976A4 (en) * 2002-10-29 2007-11-14 Transform Pharmaceuticals Inc PROPOFOL ASSOCIATED WITH CYSTEINE
AU2003299590B8 (en) 2002-12-09 2010-04-08 Abraxis Bioscience, Llc Compositions and methods of delivery of pharmacological agents
US20040225022A1 (en) * 2003-05-09 2004-11-11 Desai Neil P. Propofol formulation containing reduced oil and surfactants
US8476010B2 (en) 2003-07-10 2013-07-02 App Pharmaceuticals Llc Propofol formulations with non-reactive container closures
US8546453B2 (en) 2003-08-14 2013-10-01 Rensheng Zhang Propofol compositions and methods for reducing pain associated with propofol injection
WO2006030450A2 (en) * 2004-09-13 2006-03-23 Bharat Serums & Vaccines Ltd. Stable emulsion compositions for intravenous administration having antimicrobial preservative efficacy
DE602006004887D1 (de) * 2005-08-05 2009-03-05 Bharat Serums & Vaccines Ltd Intravenöse propofol-emulsionszusammensetzungen mit konservierendem effekt
AU2006310044A1 (en) * 2005-08-12 2007-05-10 Bharat Serums & Vaccines Ltd. Aqueous anaesthetic compositions comprising propofol
BRPI0615265A8 (pt) * 2005-08-31 2018-03-06 Abraxis Bioscience Llc composições compreendendo agentes farmacêuticos pouco hidrossoluíveis e agentes antimicrobianos
JP5368093B2 (ja) * 2005-08-31 2013-12-18 アブラクシス バイオサイエンス， エルエルシー 増大した安定性を有する難水溶性薬剤の組成物および調製の方法
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
JP2013001700A (ja) * 2011-06-21 2013-01-07 Fujifilm Corp プロポフォール含有水中油型エマルション組成物
JP5759804B2 (ja) * 2011-06-27 2015-08-05 富士フイルム株式会社 容器詰製剤
AU2013263292B2 (en) 2012-05-16 2018-03-08 Maninder SANDHU Pharmaceutical compositions for the delivery of substantially water-insoluble drugs
CN104490780B (zh) * 2015-01-16 2017-04-19 河北一品制药有限公司 一种丙泊酚脂肪乳注射液的制备方法
WO2017031261A1 (en) 2015-08-20 2017-02-23 Mewa Singh Polyphenolic polymer to make water-insoluble molecules become water-soluble
CN110478366A (zh) * 2019-08-23 2019-11-22 宜昌人福药业有限责任公司 含非水溶性镇痛药的局部用组合物及其制备方法和用途
US11992483B2 (en) 2021-03-31 2024-05-28 Cali Biosciences Us, Llc Emulsions for local anesthetics

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1472793A (en) 1974-03-28 1977-05-04 Ici Ltd Pharmaceutical compositions
MY112798A (en) * 1994-02-04 2001-09-29 Karlshamns Lipidteknik Ab Oil-in-water emulsions
GB9405593D0 (en) * 1994-03-22 1994-05-11 Zeneca Ltd Pharmaceutical compositions
US5637625A (en) * 1996-03-19 1997-06-10 Research Triangle Pharmaceuticals Ltd. Propofol microdroplet formulations
DE69912441T2 (de) * 1998-08-19 2004-08-19 Skyepharma Canada Inc., Verdun Injizierbare wässerige propofoldispersionen
US6140374A (en) * 1998-10-23 2000-10-31 Abbott Laboratories Propofol composition

Also Published As

Publication number Publication date
AU4046300A (en) 2000-10-23
MXPA01010064A (es) 2002-06-21
KR100741604B1 (ko) 2007-07-20
JP2002541086A (ja) 2002-12-03
CA2366793A1 (en) 2000-10-12
KR100861820B1 (ko) 2008-10-07
CA2366793C (en) 2009-06-02
KR20070058012A (ko) 2007-06-07
US6100302A (en) 2000-08-08
EP1165045A1 (en) 2002-01-02
AU774259B2 (en) 2004-06-24
WO2000059471A1 (en) 2000-10-12
KR20010112400A (ko) 2001-12-20

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Legal Events

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O, 11,13 E 25 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.