KR100861820B1 - 미생물 특성이 증진된 프로포폴 제제 - Google Patents

미생물 특성이 증진된 프로포폴 제제 Download PDF

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KR100861820B1
KR100861820B1 KR1020077010526A KR20077010526A KR100861820B1 KR 100861820 B1 KR100861820 B1 KR 100861820B1 KR 1020077010526 A KR1020077010526 A KR 1020077010526A KR 20077010526 A KR20077010526 A KR 20077010526A KR 100861820 B1 KR100861820 B1 KR 100861820B1
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South Korea
Prior art keywords
propofol
oil
emulsion
water
immiscible solvent
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Expired - Fee Related
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KR1020077010526A
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English (en)
Korean (ko)
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KR20070058012A (ko
Inventor
사티쉬 케이. 페자버
라제쉬워 마더람
바렛 이. 라비노우
조스벤 씨 델라 로사
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백스터 인터내셔널 인코포레이티드
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Publication of KR20070058012A publication Critical patent/KR20070058012A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020077010526A 1999-04-05 2000-03-29 미생물 특성이 증진된 프로포폴 제제 Expired - Fee Related KR100861820B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/286,159 1999-04-05
US09/286,159 US6100302A (en) 1999-04-05 1999-04-05 Propofol formulation with enhanced microbial characteristics

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020017012652A Division KR100741604B1 (ko) 1999-04-05 2000-03-29 미생물 특성이 증진된 프로포폴 제제

Publications (2)

Publication Number Publication Date
KR20070058012A KR20070058012A (ko) 2007-06-07
KR100861820B1 true KR100861820B1 (ko) 2008-10-07

Family

ID=23097354

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020077010526A Expired - Fee Related KR100861820B1 (ko) 1999-04-05 2000-03-29 미생물 특성이 증진된 프로포폴 제제
KR1020017012652A Expired - Fee Related KR100741604B1 (ko) 1999-04-05 2000-03-29 미생물 특성이 증진된 프로포폴 제제

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020017012652A Expired - Fee Related KR100741604B1 (ko) 1999-04-05 2000-03-29 미생물 특성이 증진된 프로포폴 제제

Country Status (9)

Country Link
US (1) US6100302A (https=)
EP (1) EP1165045A1 (https=)
JP (1) JP2002541086A (https=)
KR (2) KR100861820B1 (https=)
AU (1) AU774259B2 (https=)
BR (1) BR0009541A (https=)
CA (1) CA2366793C (https=)
MX (1) MXPA01010064A (https=)
WO (1) WO2000059471A1 (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6749868B1 (en) 1993-02-22 2004-06-15 American Bioscience, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
ES2211151T3 (es) 1998-08-19 2004-07-01 Skyepharma Canada Inc. Dispersiones acuosas inyectables de propofol.
EP2036540A3 (en) * 2000-06-16 2009-12-16 Jagotec AG Improved injectable dispersions of propofol
US6399087B1 (en) * 2000-12-20 2002-06-04 Amphastar Pharmaceuticals, Inc. Propofol formulation with enhanced microbial inhibition
US20030054042A1 (en) * 2001-09-14 2003-03-20 Elaine Liversidge Stabilization of chemical compounds using nanoparticulate formulations
JP2005504090A (ja) 2001-09-26 2005-02-10 バクスター・インターナショナル・インコーポレイテッド 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製
EP1430017A2 (en) 2001-09-26 2004-06-23 Theravance, Inc. Substituted phenol compounds useful for anesthesia and sedation
EP1490030B2 (en) * 2002-03-20 2010-07-14 Elan Pharma International Limited Nanoparticulate compositions of angiogenesis inhibitors
WO2003105817A1 (en) * 2002-05-02 2003-12-24 Fdl, Inc. Novel parenteral composition comprising propofol
KR100459025B1 (ko) * 2002-05-02 2004-12-03 (주) 에프디엘 프로포폴을 함유하는 신규한 주사제용 조성물
CN100438861C (zh) * 2002-07-29 2008-12-03 变换药品公司 含水2,6-二异丙基苯酚药物组合物
US7550155B2 (en) * 2002-07-29 2009-06-23 Transform Pharmaceuticals Inc. Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses
US20040171691A1 (en) * 2002-10-29 2004-09-02 Transform Pharmaceuticals, Inc. Propofol with cysteine
CN103405405A (zh) * 2002-12-09 2013-11-27 阿布拉西斯生物科学有限责任公司 组合物和传递药剂的方法
US20040225022A1 (en) * 2003-05-09 2004-11-11 Desai Neil P. Propofol formulation containing reduced oil and surfactants
US8476010B2 (en) 2003-07-10 2013-07-02 App Pharmaceuticals Llc Propofol formulations with non-reactive container closures
US8546453B2 (en) 2003-08-14 2013-10-01 Rensheng Zhang Propofol compositions and methods for reducing pain associated with propofol injection
AU2005283726A1 (en) * 2004-09-13 2006-03-23 Bharat Serums & Vaccines Ltd. Stable emulsion compositions for intravenous administration having antimicrobial preservative efficacy
KR20080043793A (ko) * 2005-08-05 2008-05-19 바라트 쎄럼스 앤드 백신스 리미티드 방부 효능을 갖는 정맥 프로포폴 에멀젼 조성물
CN101287447B (zh) * 2005-08-12 2012-10-24 印度血清及疫苗有限公司 包含丙泊酚的水性麻醉剂组合物
KR101420445B1 (ko) 2005-08-31 2014-07-16 아브락시스 바이오사이언스, 엘엘씨 수 난용성 제약학적 약제 및 항균제를 포함하는 조성물
AU2006284657B2 (en) * 2005-08-31 2012-07-19 Abraxis Bioscience, Llc Compositions and methods for preparation of poorly water soluble drugs with increased stability
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
JP2013001700A (ja) * 2011-06-21 2013-01-07 Fujifilm Corp プロポフォール含有水中油型エマルション組成物
JP5759804B2 (ja) * 2011-06-27 2015-08-05 富士フイルム株式会社 容器詰製剤
JP6247685B2 (ja) 2012-05-16 2017-12-13 メワ・シン 実質的に水不溶性の薬物の送達のための医薬組成物
CN104490780B (zh) * 2015-01-16 2017-04-19 河北一品制药有限公司 一种丙泊酚脂肪乳注射液的制备方法
US11622937B2 (en) 2015-08-20 2023-04-11 Mewa Singh Polyphenolic polymer to make water-insoluble molecules become water-soluble
CN110478366A (zh) * 2019-08-23 2019-11-22 宜昌人福药业有限责任公司 含非水溶性镇痛药的局部用组合物及其制备方法和用途
US11992483B2 (en) 2021-03-31 2024-05-28 Cali Biosciences Us, Llc Emulsions for local anesthetics

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4056635A (en) 1974-03-28 1977-11-01 Imperial Chemical Industries Limited 2,6-Diisopropylphenol as an anaesthetic agent

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9506681A (pt) * 1994-02-04 1997-11-18 Scotia Lipidteknik Ab Emulsão oleo em água e composição farmacêutica
GB9405593D0 (en) * 1994-03-22 1994-05-11 Zeneca Ltd Pharmaceutical compositions
US5637625A (en) * 1996-03-19 1997-06-10 Research Triangle Pharmaceuticals Ltd. Propofol microdroplet formulations
ES2211151T3 (es) * 1998-08-19 2004-07-01 Skyepharma Canada Inc. Dispersiones acuosas inyectables de propofol.
US6140374A (en) * 1998-10-23 2000-10-31 Abbott Laboratories Propofol composition

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4056635A (en) 1974-03-28 1977-11-01 Imperial Chemical Industries Limited 2,6-Diisopropylphenol as an anaesthetic agent

Also Published As

Publication number Publication date
WO2000059471A1 (en) 2000-10-12
CA2366793A1 (en) 2000-10-12
KR20010112400A (ko) 2001-12-20
BR0009541A (pt) 2002-01-02
KR100741604B1 (ko) 2007-07-20
KR20070058012A (ko) 2007-06-07
AU774259B2 (en) 2004-06-24
CA2366793C (en) 2009-06-02
JP2002541086A (ja) 2002-12-03
AU4046300A (en) 2000-10-23
US6100302A (en) 2000-08-08
MXPA01010064A (es) 2002-06-21
EP1165045A1 (en) 2002-01-02

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