JP2002538183A5 - - Google Patents
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- Publication number
- JP2002538183A5 JP2002538183A5 JP2000603353A JP2000603353A JP2002538183A5 JP 2002538183 A5 JP2002538183 A5 JP 2002538183A5 JP 2000603353 A JP2000603353 A JP 2000603353A JP 2000603353 A JP2000603353 A JP 2000603353A JP 2002538183 A5 JP2002538183 A5 JP 2002538183A5
- Authority
- JP
- Japan
- Prior art keywords
- gal
- preparation
- another preferred
- glycoforms
- human glycosylated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- NNISLDGFPWIBDF-MPRBLYSKSA-N alpha-D-Gal-(1->3)-beta-D-Gal-(1->4)-D-GlcNAc Chemical class O[C@@H]1[C@@H](NC(=O)C)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@@H](CO)O1 NNISLDGFPWIBDF-MPRBLYSKSA-N 0.000 description 4
- 101000718529 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) Alpha-galactosidase Proteins 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 125000005629 sialic acid group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/266,014 US6458574B1 (en) | 1996-09-12 | 1999-03-11 | Treatment of a α-galactosidase a deficiency |
| US09/266,014 | 1999-03-11 | ||
| PCT/US2000/006118 WO2000053730A2 (en) | 1999-03-11 | 2000-03-09 | Medical preparations for the treatment of alpha-galactosidase a deficiency |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010215000A Division JP5615648B2 (ja) | 1999-03-11 | 2010-09-27 | α−ガラクトシダーゼA欠乏症の治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002538183A JP2002538183A (ja) | 2002-11-12 |
| JP2002538183A5 true JP2002538183A5 (https=) | 2006-03-02 |
Family
ID=23012821
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000603353A Pending JP2002538183A (ja) | 1999-03-11 | 2000-03-09 | α−ガラクトシダーゼA欠乏症の治療 |
| JP2010215000A Expired - Lifetime JP5615648B2 (ja) | 1999-03-11 | 2010-09-27 | α−ガラクトシダーゼA欠乏症の治療 |
| JP2013174418A Expired - Lifetime JP5899169B2 (ja) | 1999-03-11 | 2013-08-26 | α−ガラクトシダーゼA欠乏症の治療 |
| JP2014254079A Expired - Lifetime JP6081980B2 (ja) | 1999-03-11 | 2014-12-16 | α−ガラクトシダーゼA欠乏症の治療 |
| JP2016200833A Expired - Lifetime JP6346236B2 (ja) | 1999-03-11 | 2016-10-12 | α−ガラクトシダーゼA欠乏症の治療 |
| JP2017219734A Expired - Lifetime JP6626071B2 (ja) | 1999-03-11 | 2017-11-15 | α−ガラクトシダーゼA欠乏症の治療 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010215000A Expired - Lifetime JP5615648B2 (ja) | 1999-03-11 | 2010-09-27 | α−ガラクトシダーゼA欠乏症の治療 |
| JP2013174418A Expired - Lifetime JP5899169B2 (ja) | 1999-03-11 | 2013-08-26 | α−ガラクトシダーゼA欠乏症の治療 |
| JP2014254079A Expired - Lifetime JP6081980B2 (ja) | 1999-03-11 | 2014-12-16 | α−ガラクトシダーゼA欠乏症の治療 |
| JP2016200833A Expired - Lifetime JP6346236B2 (ja) | 1999-03-11 | 2016-10-12 | α−ガラクトシダーゼA欠乏症の治療 |
| JP2017219734A Expired - Lifetime JP6626071B2 (ja) | 1999-03-11 | 2017-11-15 | α−ガラクトシダーゼA欠乏症の治療 |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US6458574B1 (https=) |
| EP (6) | EP1163349B1 (https=) |
| JP (6) | JP2002538183A (https=) |
| KR (2) | KR100961740B1 (https=) |
| CN (4) | CN103585621B (https=) |
| AT (1) | ATE386808T1 (https=) |
| AU (1) | AU3519400A (https=) |
| CA (3) | CA3012663A1 (https=) |
| CY (3) | CY1107951T1 (https=) |
| DE (1) | DE60038104T2 (https=) |
| DK (3) | DK2314699T3 (https=) |
| ES (3) | ES2300256T3 (https=) |
| HK (2) | HK1043386B (https=) |
| HU (1) | HU228743B1 (https=) |
| IL (2) | IL145381A0 (https=) |
| MX (1) | MXPA01009222A (https=) |
| NO (2) | NO329689B1 (https=) |
| NZ (1) | NZ514077A (https=) |
| PL (1) | PL210833B1 (https=) |
| PT (3) | PT1163349E (https=) |
| RU (1) | RU2248213C2 (https=) |
| WO (1) | WO2000053730A2 (https=) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6458574B1 (en) * | 1996-09-12 | 2002-10-01 | Transkaryotic Therapies, Inc. | Treatment of a α-galactosidase a deficiency |
| US6083725A (en) * | 1996-09-13 | 2000-07-04 | Transkaryotic Therapies, Inc. | Tranfected human cells expressing human α-galactosidase A protein |
| IL155588A0 (en) * | 2003-04-27 | 2003-11-23 | Metabogal Ltd | Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby |
| US20050032211A1 (en) * | 1996-09-26 | 2005-02-10 | Metabogal Ltd. | Cell/tissue culturing device, system and method |
| US7629309B2 (en) | 2002-05-29 | 2009-12-08 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| US20040005309A1 (en) * | 2002-05-29 | 2004-01-08 | Symbiontics, Inc. | Targeted therapeutic proteins |
| US7560424B2 (en) | 2001-04-30 | 2009-07-14 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| ATE384736T1 (de) * | 2001-04-30 | 2008-02-15 | Zystor Therapeutics Inc | Subzelluläres targeting von therapeutischen proteinen |
| US20030072761A1 (en) | 2001-10-16 | 2003-04-17 | Lebowitz Jonathan | Methods and compositions for targeting proteins across the blood brain barrier |
| EP1503788B1 (en) * | 2002-04-25 | 2011-06-29 | Shire Human Genetic Therapies, Inc. | Treatment of alpha-galactosidase a deficiency |
| PT2441467E (pt) | 2003-01-31 | 2015-10-12 | Sinai School Medicine | Terapia combinada para o tratamento de transtornos associados a uma deficiência proteica |
| US7422310B2 (en) * | 2003-04-25 | 2008-09-09 | Hewlett-Packard Development Company, L.P. | Methods and apparatus for selecting image enhancement techniques |
| US20100196345A1 (en) * | 2003-04-27 | 2010-08-05 | Protalix | Production of high mannose proteins in plant culture |
| US7951557B2 (en) | 2003-04-27 | 2011-05-31 | Protalix Ltd. | Human lysosomal proteins from plant cell culture |
| US7442372B2 (en) † | 2003-08-29 | 2008-10-28 | Biomarin Pharmaceutical Inc. | Delivery of therapeutic compounds to the brain and other tissues |
| CN1922313B (zh) | 2004-02-10 | 2011-10-26 | 生物马林医药公司 | 酸性α-糖苷酶及其片段 |
| US20050208090A1 (en) * | 2004-03-18 | 2005-09-22 | Medtronic, Inc. | Methods and systems for treatment of neurological diseases of the central nervous system |
| JP2008503590A (ja) * | 2004-06-21 | 2008-02-07 | メドトロニック・インコーポレーテッド | 組成物を細胞にデリバリーするための医学用システム及び方法 |
| CN1308444C (zh) * | 2005-04-15 | 2007-04-04 | 中国人民解放军军事医学科学院野战输血研究所 | 基因重组α-半乳糖苷酶大批量发酵液的纯化方法 |
| EP2932982B1 (en) | 2005-05-17 | 2018-10-03 | Amicus Therapeutics, Inc. | A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives |
| BRPI0618583A2 (pt) * | 2005-11-18 | 2011-09-06 | Tokyo Metropolitan Org Med Res | enzima altamente funcional tendo especifidade ao substrato modificada |
| WO2007086067A1 (en) * | 2006-01-30 | 2007-08-02 | Diagnostic Technologies Ltd. | Method for monitoring tocolytic treatment |
| US20090117091A1 (en) * | 2006-11-13 | 2009-05-07 | Lebowitz Jonathan | Methods for treating pompe disease |
| CN101861382B (zh) * | 2007-05-07 | 2015-07-15 | 普罗塔里克斯有限公司 | 大规模一次性生物反应器 |
| EP2185187A1 (en) * | 2007-08-29 | 2010-05-19 | Shire Human Genetic Therapies, Inc. | Subcutaneous administration of alpha-galatosidase a |
| HRP20170698T1 (hr) | 2008-05-07 | 2017-09-22 | Biomarin Pharmaceutical Inc. | Lizosomski usmjereni peptidi i njihove uporabe |
| US9050276B2 (en) | 2009-06-16 | 2015-06-09 | The Trustees Of Columbia University In The City Of New York | Autism-associated biomarkers and uses thereof |
| EP2475376B1 (en) | 2009-06-17 | 2016-03-30 | BioMarin Pharmaceutical Inc. | Formulations for lysosomal enzymes |
| WO2011107990A1 (en) * | 2010-03-02 | 2011-09-09 | Protalix Ltd. | Stabilized alpha-galactosidase and uses thereof |
| US9194011B2 (en) | 2009-11-17 | 2015-11-24 | Protalix Ltd. | Stabilized alpha-galactosidase and uses thereof |
| WO2011133802A1 (en) * | 2010-04-21 | 2011-10-27 | Helix Therapeutics, Inc. | Compositions and methods for treatment of lysosomal storage disorders |
| CA2805557A1 (en) | 2010-07-08 | 2012-01-12 | Baxter International Inc. | Method of producing recombinant high molecular weight vwf in cell culture |
| WO2012051567A2 (en) | 2010-10-15 | 2012-04-19 | The Trustees Of Columbia University In The City Of New York | Obesity-related genes and their proteins and uses thereof |
| ES2746554T3 (es) | 2010-11-02 | 2020-03-06 | Univ Columbia | Métodos para tratar los trastornos de pérdida de cabello |
| BR112013022277B1 (pt) | 2011-03-04 | 2021-08-03 | Glytech, Inc | Método para produção de cadeia de açúcar contendo ácido siálico |
| PL3586861T3 (pl) | 2011-06-08 | 2022-05-23 | Translate Bio, Inc. | Kompozycje nanocząstek lipidowych i sposoby dostarczania mrna |
| KR20200032244A (ko) | 2012-03-07 | 2020-03-25 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 폼페병의 치료를 위한 고농도 알파-글루코시다제 조성물 |
| US10039777B2 (en) | 2012-03-20 | 2018-08-07 | Neuro-Lm Sas | Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders |
| EP3459565A1 (en) | 2012-03-29 | 2019-03-27 | The Trustees of Columbia University in the City of New York | Methods for treating hair loss disorders |
| US10155027B2 (en) | 2012-07-17 | 2018-12-18 | Amicus Therapeutics, Inc. | Alpha-galactosidase A and 1-deoxygalactonojirimycin co-formulation for the treatment of fabry disease |
| HK1209625A1 (en) * | 2012-07-17 | 2016-04-08 | Amicus Therapeutics, Inc. | Alpha-galactosidase a and 1-deoxygalactonojirimycin co-formulation |
| WO2014016873A1 (en) | 2012-07-26 | 2014-01-30 | Jcr Pharmaceuticals Co., Ltd. | Method for production of recombinant human alpha-galactosidase a |
| JP6226435B2 (ja) * | 2012-07-26 | 2017-11-08 | Jcrファーマ株式会社 | 組換えヒトα−ガラクトシダーゼAの製造方法 |
| WO2014120900A1 (en) * | 2013-01-31 | 2014-08-07 | Icahn School Of Medicine At Mount Sinai | Enhanced therapeutic regimens for treating fabry disease |
| DK2971098T3 (en) | 2013-03-14 | 2019-02-18 | Translate Bio Inc | QUANTITATIVE ASSESSMENT FOR CAPE EFFECTIVENESS OF MESSENGER RNA |
| CN105051213A (zh) | 2013-03-14 | 2015-11-11 | 夏尔人类遗传性治疗公司 | 信使rna加帽效率的定量评估 |
| TW202332774A (zh) | 2013-10-23 | 2023-08-16 | 美商健臻公司 | 重組醣蛋白及其用途 |
| US9682123B2 (en) | 2013-12-20 | 2017-06-20 | The Trustees Of Columbia University In The City Of New York | Methods of treating metabolic disease |
| PE20161417A1 (es) | 2014-03-05 | 2017-01-22 | Ultragenyx Pharmaceutical Inc | Composiciones de glicoproteinas sialiladas y uso de estas |
| WO2016054231A1 (en) | 2014-09-30 | 2016-04-07 | Amicus Therapeutics, Inc. | Highly potent acid alpha-glucosidase with enhanced carbohydrates |
| KR20250025516A (ko) | 2014-12-22 | 2025-02-21 | 젠자임 코포레이션 | 포유류 세포의 배양 방법 |
| FI3237621T3 (fi) * | 2014-12-22 | 2023-06-01 | Codexis Inc | Ihmisen alfa-galaktosidaasivariantteja |
| WO2016116966A1 (en) | 2015-01-22 | 2016-07-28 | Jcr Pharmaceuticals Co., Ltd. | Method for purification of recombinant human alpha-galactosidase a from material containing contaminant host cell proteins |
| US9981021B1 (en) | 2015-04-09 | 2018-05-29 | Kinetiq, Inc. | Subcutaneous therapeutic enzyme formulations, uses, and methods for generating thereof |
| GB201508025D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Fabry disease gene therapy |
| CA2997947A1 (en) | 2015-09-09 | 2017-03-16 | The Trustees Of Columbia University In The City Of New York | Reduction of er-mam-localized app-c99 and methods of treating alzheimer's disease |
| KR102510941B1 (ko) | 2015-12-30 | 2023-03-20 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 폼페병 치료용의 강화된 산 알파-글루코시다제 |
| US11136597B2 (en) | 2016-02-16 | 2021-10-05 | Yale University | Compositions for enhancing targeted gene editing and methods of use thereof |
| IL325155A (en) | 2016-03-30 | 2026-02-01 | Amicus Therapeutics Inc | Formulations containing recombinant acid alpha-glucosidase |
| US10227577B2 (en) * | 2016-03-30 | 2019-03-12 | Amicus Therapeutics, Inc. | Method for selection of high M6P recombinant proteins |
| NL2017294B1 (en) | 2016-08-05 | 2018-02-14 | Univ Erasmus Med Ct Rotterdam | Natural cryptic exon removal by pairs of antisense oligonucleotides. |
| WO2018071814A1 (en) | 2016-10-14 | 2018-04-19 | The Trustees Of Columbia University In The City Of New York | Methods of treating alcohol abuse disorder |
| CA3039673A1 (en) * | 2016-10-20 | 2018-04-26 | Sangamo Therapeutics, Inc. | Methods and compositions for the treatment of fabry disease |
| TW201829770A (zh) | 2017-01-10 | 2018-08-16 | 美商阿米庫斯醫療股份有限公司 | 用於治療fabry氏病之重組α-半乳糖苷酶A |
| EA039750B1 (ru) * | 2017-03-30 | 2022-03-10 | Амикус Терапьютикс, Инк. | Способ отбора рекомбинантных белков с высоким содержанием m6p |
| WO2018187493A1 (en) | 2017-04-04 | 2018-10-11 | Yale University | Compositions and methods for in utero delivery |
| EP3624831B1 (en) | 2017-05-15 | 2023-03-29 | Amicus Therapeutics, Inc. | Recombinant human acid alpha-glucosidase |
| WO2020047282A1 (en) * | 2018-08-29 | 2020-03-05 | University Of Copenhagen | Lysosomal enzymes modified by cell based glycoengineering |
| SG11202106348QA (en) * | 2018-12-20 | 2021-07-29 | Codexis Inc | Human alpha-galactosidase variants |
| EP3996696A1 (en) | 2019-07-09 | 2022-05-18 | Genethon | Treatment of glycogen storage disease (gsd) |
| TW202128264A (zh) * | 2019-09-25 | 2021-08-01 | 瑞士商赫孚孟拉羅股份公司 | 使用經預測之溶離緩衝鹽濃度的陽離子層析法 |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5322158B2 (https=) * | 1974-05-02 | 1978-07-06 | ||
| US4407957A (en) | 1981-03-13 | 1983-10-04 | Damon Corporation | Reversible microencapsulation of a core material |
| DE3580384D1 (de) | 1984-04-09 | 1990-12-13 | Toyo Boseki | Praeparat mit verzoegerter freigabe zum aufbringen auf die schleimhaeute der mundhoehle. |
| US4764376A (en) | 1984-06-18 | 1988-08-16 | Eli Lilly And Company | Method of inhibiting aromatase |
| GB8530631D0 (en) * | 1985-12-12 | 1986-01-22 | Ciba Geigy Ag | Thrombin inhibitors |
| US4764378A (en) | 1986-02-10 | 1988-08-16 | Zetachron, Inc. | Buccal drug dosage form |
| US5272066A (en) * | 1986-03-07 | 1993-12-21 | Massachusetts Institute Of Technology | Synthetic method for enhancing glycoprotein stability |
| US5179023A (en) | 1989-03-24 | 1993-01-12 | Research Corporation Technologies, Inc. | Recombinant α-galactosidase a therapy for Fabry disease |
| EP0463109A4 (en) | 1989-03-24 | 1992-11-19 | Research Corporation Technologies, Inc. | Recombinant alpha-galactosidase, a therapy for fabry disease |
| US5382518A (en) * | 1989-07-13 | 1995-01-17 | Sanofi | Urate oxidase activity protein, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells |
| CA2041638C (en) * | 1989-09-05 | 2001-05-15 | Peter L. Whitfeld | Recombinant polynucleotide constructs suitable for providing secretion of pai-2 |
| US5661132A (en) * | 1989-12-14 | 1997-08-26 | Auragen, Inc. | Wound healing |
| US5697901A (en) * | 1989-12-14 | 1997-12-16 | Elof Eriksson | Gene delivery by microneedle injection |
| US5401650A (en) * | 1990-10-24 | 1995-03-28 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of biologically active α-galactosidase A |
| US5356804A (en) | 1990-10-24 | 1994-10-18 | Mount Sinai School Of Medicine Of The City Of New York | Cloning and expression of biologically active human α-galactosidase A |
| CA2109085C (en) | 1991-04-25 | 2003-03-11 | Keith E. Dionne | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products |
| WO1993000951A1 (en) | 1991-07-02 | 1993-01-21 | Inhale, Inc. | Method and device for delivering aerosolized medicaments |
| US5750376A (en) | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
| NZ245015A (en) | 1991-11-05 | 1995-12-21 | Transkaryotic Therapies Inc | Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production |
| US5733761A (en) | 1991-11-05 | 1998-03-31 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US5858751A (en) | 1992-03-09 | 1999-01-12 | The Regents Of The University Of California | Compositions and methods for producing sialyltransferases |
| ES2105262T3 (es) | 1992-05-18 | 1997-10-16 | Minnesota Mining & Mfg | Dispositivo de suministro de farmaco a traves de las mucosas. |
| US5785049A (en) | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5804413A (en) | 1992-07-31 | 1998-09-08 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Herpes simplex virus strains for gene transfer |
| US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
| ES2179831T3 (es) | 1992-09-29 | 2003-02-01 | Inhale Therapeutic Syst | Liberacion en los pulmones de fragmentos activos de hormona paratiroidiana. |
| US5389539A (en) | 1992-11-30 | 1995-02-14 | Massachusetts Institute Of Technology | Purification of heparinase I, II, and III from Flavobacterium heparinum |
| US6329191B1 (en) | 1993-08-30 | 2001-12-11 | Hawaii Biotechnology Group, Inc. | DNA encoding recombinant coffee bean alpha-galactosidase |
| EP0726964A4 (en) * | 1993-09-23 | 1999-01-13 | New England Biolabs Inc | INSULATION AND COMPOSITION OF NEW GLYCOSIDASES |
| DE4339605A1 (de) | 1993-11-20 | 1995-05-24 | Beiersdorf Ag | Desodorierende Wirkstoffkombinationen auf der Basis von alpha, omega-Alkandicarbonsäuren und Fettsäurepartialglyceriden |
| US5843015A (en) | 1993-12-28 | 1998-12-01 | Becton Dickinson And Company | Molecules for iontophoretic delivery |
| US5789247A (en) | 1994-04-01 | 1998-08-04 | Ballay; Annick | Expression in non-tumoral human lymphoblastoid lines with an integrative vector |
| FR2718357B1 (fr) | 1994-04-06 | 1997-10-03 | Defarges Alain Moreau | Perfectionnements apportés à un dispositif d'injection par jet sans aiguille. |
| US5834251A (en) * | 1994-12-30 | 1998-11-10 | Alko Group Ltd. | Methods of modifying carbohydrate moieties |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| JPH10513057A (ja) * | 1995-01-30 | 1998-12-15 | ニューヨーク・ブラッド・センター・インコーポレイテッド | 組換えα−ガラクトシダーゼ酵素 |
| US5780014A (en) | 1995-04-14 | 1998-07-14 | Inhale Therapeutic Systems | Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin |
| US5654007A (en) | 1995-06-07 | 1997-08-05 | Inhale Therapeutic Systems | Methods and system for processing dispersible fine powders |
| US6566089B1 (en) * | 1996-09-04 | 2003-05-20 | Tularik Inc. | Cell-based drug screens for regulators of gene expression |
| US6458574B1 (en) * | 1996-09-12 | 2002-10-01 | Transkaryotic Therapies, Inc. | Treatment of a α-galactosidase a deficiency |
| US6083725A (en) * | 1996-09-13 | 2000-07-04 | Transkaryotic Therapies, Inc. | Tranfected human cells expressing human α-galactosidase A protein |
| JP4001925B2 (ja) | 1996-09-13 | 2007-10-31 | トランスカーヨティック セラピーズ インク. | α―ガラクトシダーゼA欠損症の治療 |
| IL125423A (en) * | 1998-07-20 | 2004-08-31 | Israel State | Alkaline alpha-galactosidase having broad substrate specificity |
| US6749851B2 (en) * | 2001-08-31 | 2004-06-15 | Clearant, Inc. | Methods for sterilizing preparations of digestive enzymes |
-
1999
- 1999-03-11 US US09/266,014 patent/US6458574B1/en not_active Expired - Lifetime
-
2000
- 2000-03-09 MX MXPA01009222A patent/MXPA01009222A/es active IP Right Grant
- 2000-03-09 IL IL14538100A patent/IL145381A0/xx unknown
- 2000-03-09 CN CN201310243356.3A patent/CN103585621B/zh not_active Expired - Lifetime
- 2000-03-09 CN CNA2007101482923A patent/CN101219213A/zh not_active Withdrawn
- 2000-03-09 EP EP00913825A patent/EP1163349B1/en not_active Expired - Lifetime
- 2000-03-09 PL PL350658A patent/PL210833B1/pl unknown
- 2000-03-09 EP EP10180757A patent/EP2287319A1/en not_active Withdrawn
- 2000-03-09 PT PT00913825T patent/PT1163349E/pt unknown
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- 2000-03-09 JP JP2000603353A patent/JP2002538183A/ja active Pending
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- 2000-03-09 EP EP10152432A patent/EP2186902B1/en not_active Revoked
- 2000-03-09 CN CN201610478912.9A patent/CN106110309A/zh active Pending
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- 2000-03-09 AT AT00913825T patent/ATE386808T1/de active
- 2000-03-09 EP EP17169335.1A patent/EP3231871A1/en not_active Withdrawn
- 2000-03-09 DK DK00913825T patent/DK1163349T3/da active
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2001
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2002
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2008
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2010
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2012
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2013
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2014
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2016
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2017
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2018
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