JP2002536452A5 - - Google Patents
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- Publication number
- JP2002536452A5 JP2002536452A5 JP2000598510A JP2000598510A JP2002536452A5 JP 2002536452 A5 JP2002536452 A5 JP 2002536452A5 JP 2000598510 A JP2000598510 A JP 2000598510A JP 2000598510 A JP2000598510 A JP 2000598510A JP 2002536452 A5 JP2002536452 A5 JP 2002536452A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- purin
- cyclopentene
- methanol
- cis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *C(C(*)=O)(N)NCCP(CC[C@](C1)C=C[C@]1[n]1c2ncnc(N)c2nc1)(O*)=O Chemical compound *C(C(*)=O)(N)NCCP(CC[C@](C1)C=C[C@]1[n]1c2ncnc(N)c2nc1)(O*)=O 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9903090.0A GB9903090D0 (en) | 1999-02-12 | 1999-02-12 | Therapeutic compounds |
| US17020599P | 1999-12-10 | 1999-12-10 | |
| US9903090.0 | 1999-12-10 | ||
| US60/170,205 | 1999-12-10 | ||
| PCT/EP2000/001045 WO2000047591A1 (en) | 1999-02-12 | 2000-02-10 | Phosphoramidate, and mono-, di-, and tri-phosphate esters of (1r, cis)-4-(6-amino-9h-purin-9-yl)-2-cyclopentene-1-methanol as antiviral agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002536452A JP2002536452A (ja) | 2002-10-29 |
| JP2002536452A5 true JP2002536452A5 (https=) | 2007-04-05 |
Family
ID=26315118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000598510A Pending JP2002536452A (ja) | 1999-02-12 | 2000-02-10 | 抗ウイルス剤としての（１Ｒ，ｃｉｓ）−４−（６−アミノ−９Ｈ−プリン−９−イル）−２−シクロペンテン−１−メタノールのホスホルアミダート、ならびに一、二および三リン酸エステル |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7115590B1 (https=) |
| EP (1) | EP1150988B1 (https=) |
| JP (1) | JP2002536452A (https=) |
| KR (1) | KR20010102082A (https=) |
| CN (1) | CN1346360A (https=) |
| AR (1) | AR031975A1 (https=) |
| AT (1) | ATE241633T1 (https=) |
| AU (1) | AU772478B2 (https=) |
| BR (1) | BR0008135A (https=) |
| CA (1) | CA2362662A1 (https=) |
| CZ (1) | CZ20012908A3 (https=) |
| DE (1) | DE60002986T2 (https=) |
| DK (1) | DK1150988T3 (https=) |
| DZ (1) | DZ3007A1 (https=) |
| ES (1) | ES2200820T3 (https=) |
| HK (1) | HK1039337B (https=) |
| HU (1) | HUP0105476A3 (https=) |
| IL (1) | IL144647A0 (https=) |
| NO (1) | NO20013910L (https=) |
| NZ (1) | NZ513450A (https=) |
| PL (1) | PL204458B1 (https=) |
| PT (1) | PT1150988E (https=) |
| TR (1) | TR200102313T2 (https=) |
| WO (1) | WO2000047591A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001042255A1 (en) * | 1999-12-10 | 2001-06-14 | Glaxo Group Limited | (1R,CIS)-4-(4-AMINO-7H-PYRROLO'2,3-I(D) ! PYRIMIDINE-7-YL)-2-CYCLOPENTENE-1-METHANOL DERIVATIVES AS ANTIVIRAL |
| PE20010915A1 (es) * | 1999-12-10 | 2001-09-29 | Glaxo Group Ltd | Analogos de (1s, cis)-4-(2-amino-9h-purin-9-il)-2-ciclopenten-1-metanol para uso en el tratamiento de infecciones virales |
| EP1736478B1 (en) | 2000-05-26 | 2015-07-22 | IDENIX Pharmaceuticals, Inc. | Methods and compositions for treating flaviviruses and pestiviruses |
| US20020119443A1 (en) † | 2000-07-21 | 2002-08-29 | Gilead Sciences, Inc. | Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same |
| GB0129945D0 (en) * | 2001-12-13 | 2002-02-06 | Mrc Technology Ltd | Chemical compounds |
| GB0401088D0 (en) | 2004-01-19 | 2004-02-18 | Univ Cardiff | Phosphoramidate derivatives |
| US9243025B2 (en) | 2011-03-31 | 2016-01-26 | Idenix Pharmaceuticals, Llc | Compounds and pharmaceutical compositions for the treatment of viral infections |
| AR088441A1 (es) | 2011-09-12 | 2014-06-11 | Idenix Pharmaceuticals Inc | Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales |
| US8507460B2 (en) | 2011-10-14 | 2013-08-13 | Idenix Pharmaceuticals, Inc. | Substituted 3′,5′-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections |
| US9296778B2 (en) | 2012-05-22 | 2016-03-29 | Idenix Pharmaceuticals, Inc. | 3′,5′-cyclic phosphate prodrugs for HCV infection |
| WO2013177188A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphoramidate prodrugs for hcv infection |
| JP6165848B2 (ja) | 2012-05-22 | 2017-07-19 | イデニク ファーマシューティカルズ エルエルシー | 肝疾患のためのｄ−アミノ酸化合物 |
| MX2014014323A (es) | 2012-05-25 | 2015-02-12 | Janssen R & D Ireland | Nucleosidos de espirooxetano de uracilo. |
| WO2014052638A1 (en) | 2012-09-27 | 2014-04-03 | Idenix Pharmaceuticals, Inc. | Esters and malonates of sate prodrugs |
| EP2906579B1 (en) | 2012-10-08 | 2018-04-18 | Idenix Pharmaceuticals LLC. | 2'-chloro nucleoside analogs for hcv infection |
| US10723754B2 (en) | 2012-10-22 | 2020-07-28 | Idenix Pharmaceuticals Llc | 2′,4′-bridged nucleosides for HCV infection |
| EP2935304A1 (en) | 2012-12-19 | 2015-10-28 | IDENIX Pharmaceuticals, Inc. | 4'-fluoro nucleosides for the treatment of hcv |
| WO2014137926A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | 3'-deoxy nucleosides for the treatment of hcv |
| WO2014137930A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | Thiophosphate nucleosides for the treatment of hcv |
| WO2014160484A1 (en) | 2013-03-13 | 2014-10-02 | Idenix Pharmaceuticals, Inc. | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
| EP2981542B1 (en) | 2013-04-01 | 2021-09-15 | Idenix Pharmaceuticals LLC | 2',4'-fluoro nucleosides for the treatment of hcv |
| US10005779B2 (en) | 2013-06-05 | 2018-06-26 | Idenix Pharmaceuticals Llc | 1′,4′-thio nucleosides for the treatment of HCV |
| WO2015017713A1 (en) | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
| US10202411B2 (en) | 2014-04-16 | 2019-02-12 | Idenix Pharmaceuticals Llc | 3′-substituted methyl or alkynyl nucleosides nucleotides for the treatment of HCV |
| CA3182565A1 (en) | 2015-03-06 | 2016-09-15 | Atea Pharmaceuticals, Inc. | .beta.-d-2'-deoxy-2'-.alpha.-fluoro-2'-.beta.-c-substituted-2-modified-n6-substituted purine nucleotides for hcv treatment |
| WO2018013937A1 (en) | 2016-07-14 | 2018-01-18 | Atea Pharmaceuticals, Inc. | Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
| WO2018048937A1 (en) | 2016-09-07 | 2018-03-15 | Atea Pharmaceuticals, Inc. | 2'-substituted-n6-substituted purine nucleotides for rna virus treatment |
| WO2021173713A1 (en) | 2020-02-27 | 2021-09-02 | Atea Pharmaceuticals, Inc. | Highly active compounds against covid-19 |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| WO2024107859A1 (en) * | 2022-11-15 | 2024-05-23 | Rome Therapeutics, Inc. | Cyclopentene-oxymethylene phosphonamidates and related compounds and their use in treating medical conditions |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5244896A (en) * | 1990-09-14 | 1993-09-14 | Marion Merrell Dow Inc. | Carbocyclic adenosine analogs useful as immunosuppressants |
| GB9505025D0 (en) * | 1995-03-13 | 1995-05-03 | Medical Res Council | Chemical compounds |
| US6887707B2 (en) * | 1996-10-28 | 2005-05-03 | University Of Washington | Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA |
| GB9821058D0 (en) * | 1998-09-28 | 1998-11-18 | Univ Cardiff | Chemical compound |
| WO2001042255A1 (en) * | 1999-12-10 | 2001-06-14 | Glaxo Group Limited | (1R,CIS)-4-(4-AMINO-7H-PYRROLO'2,3-I(D) ! PYRIMIDINE-7-YL)-2-CYCLOPENTENE-1-METHANOL DERIVATIVES AS ANTIVIRAL |
| US20030096833A1 (en) * | 2001-08-31 | 2003-05-22 | Jagtap Prakash G. | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
-
2000
- 2000-02-10 CA CA002362662A patent/CA2362662A1/en not_active Abandoned
- 2000-02-10 PL PL350023A patent/PL204458B1/pl not_active IP Right Cessation
- 2000-02-10 HU HU0105476A patent/HUP0105476A3/hu unknown
- 2000-02-10 DK DK00905043T patent/DK1150988T3/da active
- 2000-02-10 US US09/913,226 patent/US7115590B1/en not_active Expired - Fee Related
- 2000-02-10 CZ CZ20012908A patent/CZ20012908A3/cs unknown
- 2000-02-10 AU AU26713/00A patent/AU772478B2/en not_active Ceased
- 2000-02-10 EP EP00905043A patent/EP1150988B1/en not_active Expired - Lifetime
- 2000-02-10 JP JP2000598510A patent/JP2002536452A/ja active Pending
- 2000-02-10 DE DE60002986T patent/DE60002986T2/de not_active Expired - Fee Related
- 2000-02-10 WO PCT/EP2000/001045 patent/WO2000047591A1/en not_active Ceased
- 2000-02-10 BR BR0008135-3A patent/BR0008135A/pt not_active IP Right Cessation
- 2000-02-10 AR ARP000100596A patent/AR031975A1/es not_active Application Discontinuation
- 2000-02-10 NZ NZ513450A patent/NZ513450A/xx unknown
- 2000-02-10 IL IL14464700A patent/IL144647A0/xx unknown
- 2000-02-10 PT PT00905043T patent/PT1150988E/pt unknown
- 2000-02-10 TR TR2001/02313T patent/TR200102313T2/xx unknown
- 2000-02-10 HK HK02100897.2A patent/HK1039337B/en not_active IP Right Cessation
- 2000-02-10 KR KR1020017010198A patent/KR20010102082A/ko not_active Withdrawn
- 2000-02-10 CN CN00806002A patent/CN1346360A/zh active Pending
- 2000-02-10 ES ES00905043T patent/ES2200820T3/es not_active Expired - Lifetime
- 2000-02-10 AT AT00905043T patent/ATE241633T1/de not_active IP Right Cessation
- 2000-03-09 DZ DZ000019A patent/DZ3007A1/xx active
-
2001
- 2001-08-10 NO NO20013910A patent/NO20013910L/no not_active Application Discontinuation
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