KR20010102082A - 항바이러스제로서의 포스포르아미데이트, 및 (1ｒ, 시스)-4-(6-아미노-9ｈ-푸린-9-일)-2-시클로펜텐-1-메탄올의 모노-, 디-, 및 트리-포스페이트 에스테르 - Google Patents

항바이러스제로서의 포스포르아미데이트, 및 (1ｒ, 시스)-4-(6-아미노-9ｈ-푸린-9-일)-2-시클로펜텐-1-메탄올의 모노-, 디-, 및 트리-포스페이트 에스테르 Download PDF

Info

Publication number
KR20010102082A
KR20010102082A KR1020017010198A KR20017010198A KR20010102082A KR 20010102082 A KR20010102082 A KR 20010102082A KR 1020017010198 A KR1020017010198 A KR 1020017010198A KR 20017010198 A KR20017010198 A KR 20017010198A KR 20010102082 A KR20010102082 A KR 20010102082A
Authority
KR
South Korea
Prior art keywords
amino
methanol
purin
cis
phosphoramidate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020017010198A
Other languages
English (en)
Korean (ko)
Inventor
수잔 메리 달루지
크리스토퍼 맥구이간
Original Assignee
그레이엄 브레레톤, 레슬리 에드워즈
글락소 그룹 리미티드
추후보정
유니버시티 칼리지 카디프 컨설턴츠 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9903090.0A external-priority patent/GB9903090D0/en
Application filed by 그레이엄 브레레톤, 레슬리 에드워즈, 글락소 그룹 리미티드, 추후보정, 유니버시티 칼리지 카디프 컨설턴츠 리미티드 filed Critical 그레이엄 브레레톤, 레슬리 에드워즈
Publication of KR20010102082A publication Critical patent/KR20010102082A/ko
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020017010198A 1999-02-12 2000-02-10 항바이러스제로서의 포스포르아미데이트, 및 (1ｒ, 시스)-4-(6-아미노-9ｈ-푸린-9-일)-2-시클로펜텐-1-메탄올의 모노-, 디-, 및 트리-포스페이트 에스테르 Withdrawn KR20010102082A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9903090.0 1999-02-12
GBGB9903090.0A GB9903090D0 (en) 1999-02-12 1999-02-12 Therapeutic compounds
US17020599P 1999-12-10 1999-12-10
US60/170,205 1999-12-10
PCT/EP2000/001045 WO2000047591A1 (en) 1999-02-12 2000-02-10 Phosphoramidate, and mono-, di-, and tri-phosphate esters of (1r, cis)-4-(6-amino-9h-purin-9-yl)-2-cyclopentene-1-methanol as antiviral agents

Publications (1)

Publication Number Publication Date
KR20010102082A true KR20010102082A (ko) 2001-11-15

Family

ID=26315118

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017010198A Withdrawn KR20010102082A (ko) 1999-02-12 2000-02-10 항바이러스제로서의 포스포르아미데이트, 및 (1ｒ, 시스)-4-(6-아미노-9ｈ-푸린-9-일)-2-시클로펜텐-1-메탄올의 모노-, 디-, 및 트리-포스페이트 에스테르

Country Status (24)

Country Link
US (1) US7115590B1 (https=)
EP (1) EP1150988B1 (https=)
JP (1) JP2002536452A (https=)
KR (1) KR20010102082A (https=)
CN (1) CN1346360A (https=)
AR (1) AR031975A1 (https=)
AT (1) ATE241633T1 (https=)
AU (1) AU772478B2 (https=)
BR (1) BR0008135A (https=)
CA (1) CA2362662A1 (https=)
CZ (1) CZ20012908A3 (https=)
DE (1) DE60002986T2 (https=)
DK (1) DK1150988T3 (https=)
DZ (1) DZ3007A1 (https=)
ES (1) ES2200820T3 (https=)
HK (1) HK1039337B (https=)
HU (1) HUP0105476A3 (https=)
IL (1) IL144647A0 (https=)
NO (1) NO20013910L (https=)
NZ (1) NZ513450A (https=)
PL (1) PL204458B1 (https=)
PT (1) PT1150988E (https=)
TR (1) TR200102313T2 (https=)
WO (1) WO2000047591A1 (https=)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001042255A1 (en) * 1999-12-10 2001-06-14 Glaxo Group Limited (1R,CIS)-4-(4-AMINO-7H-PYRROLO'2,3-I(D) ! PYRIMIDINE-7-YL)-2-CYCLOPENTENE-1-METHANOL DERIVATIVES AS ANTIVIRAL
PE20010915A1 (es) * 1999-12-10 2001-09-29 Glaxo Group Ltd Analogos de (1s, cis)-4-(2-amino-9h-purin-9-il)-2-ciclopenten-1-metanol para uso en el tratamiento de infecciones virales
EP1736478B1 (en) 2000-05-26 2015-07-22 IDENIX Pharmaceuticals, Inc. Methods and compositions for treating flaviviruses and pestiviruses
US20020119443A1 (en) † 2000-07-21 2002-08-29 Gilead Sciences, Inc. Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
GB0129945D0 (en) * 2001-12-13 2002-02-06 Mrc Technology Ltd Chemical compounds
GB0401088D0 (en) 2004-01-19 2004-02-18 Univ Cardiff Phosphoramidate derivatives
US9243025B2 (en) 2011-03-31 2016-01-26 Idenix Pharmaceuticals, Llc Compounds and pharmaceutical compositions for the treatment of viral infections
AR088441A1 (es) 2011-09-12 2014-06-11 Idenix Pharmaceuticals Inc Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales
US8507460B2 (en) 2011-10-14 2013-08-13 Idenix Pharmaceuticals, Inc. Substituted 3′,5′-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections
US9296778B2 (en) 2012-05-22 2016-03-29 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphate prodrugs for HCV infection
WO2013177188A1 (en) 2012-05-22 2013-11-28 Idenix Pharmaceuticals, Inc. 3',5'-cyclic phosphoramidate prodrugs for hcv infection
JP6165848B2 (ja) 2012-05-22 2017-07-19 イデニク ファーマシューティカルズ エルエルシー 肝疾患のためのｄ−アミノ酸化合物
MX2014014323A (es) 2012-05-25 2015-02-12 Janssen R & D Ireland Nucleosidos de espirooxetano de uracilo.
WO2014052638A1 (en) 2012-09-27 2014-04-03 Idenix Pharmaceuticals, Inc. Esters and malonates of sate prodrugs
EP2906579B1 (en) 2012-10-08 2018-04-18 Idenix Pharmaceuticals LLC. 2'-chloro nucleoside analogs for hcv infection
US10723754B2 (en) 2012-10-22 2020-07-28 Idenix Pharmaceuticals Llc 2′,4′-bridged nucleosides for HCV infection
EP2935304A1 (en) 2012-12-19 2015-10-28 IDENIX Pharmaceuticals, Inc. 4'-fluoro nucleosides for the treatment of hcv
WO2014137926A1 (en) 2013-03-04 2014-09-12 Idenix Pharmaceuticals, Inc. 3'-deoxy nucleosides for the treatment of hcv
WO2014137930A1 (en) 2013-03-04 2014-09-12 Idenix Pharmaceuticals, Inc. Thiophosphate nucleosides for the treatment of hcv
WO2014160484A1 (en) 2013-03-13 2014-10-02 Idenix Pharmaceuticals, Inc. Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv
EP2981542B1 (en) 2013-04-01 2021-09-15 Idenix Pharmaceuticals LLC 2',4'-fluoro nucleosides for the treatment of hcv
US10005779B2 (en) 2013-06-05 2018-06-26 Idenix Pharmaceuticals Llc 1′,4′-thio nucleosides for the treatment of HCV
WO2015017713A1 (en) 2013-08-01 2015-02-05 Idenix Pharmaceuticals, Inc. D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease
US10202411B2 (en) 2014-04-16 2019-02-12 Idenix Pharmaceuticals Llc 3′-substituted methyl or alkynyl nucleosides nucleotides for the treatment of HCV
CA3182565A1 (en) 2015-03-06 2016-09-15 Atea Pharmaceuticals, Inc. .beta.-d-2'-deoxy-2'-.alpha.-fluoro-2'-.beta.-c-substituted-2-modified-n6-substituted purine nucleotides for hcv treatment
WO2018013937A1 (en) 2016-07-14 2018-01-18 Atea Pharmaceuticals, Inc. Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection
WO2018048937A1 (en) 2016-09-07 2018-03-15 Atea Pharmaceuticals, Inc. 2'-substituted-n6-substituted purine nucleotides for rna virus treatment
WO2021173713A1 (en) 2020-02-27 2021-09-02 Atea Pharmaceuticals, Inc. Highly active compounds against covid-19
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
WO2024107859A1 (en) * 2022-11-15 2024-05-23 Rome Therapeutics, Inc. Cyclopentene-oxymethylene phosphonamidates and related compounds and their use in treating medical conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5244896A (en) * 1990-09-14 1993-09-14 Marion Merrell Dow Inc. Carbocyclic adenosine analogs useful as immunosuppressants
GB9505025D0 (en) * 1995-03-13 1995-05-03 Medical Res Council Chemical compounds
US6887707B2 (en) * 1996-10-28 2005-05-03 University Of Washington Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA
GB9821058D0 (en) * 1998-09-28 1998-11-18 Univ Cardiff Chemical compound
WO2001042255A1 (en) * 1999-12-10 2001-06-14 Glaxo Group Limited (1R,CIS)-4-(4-AMINO-7H-PYRROLO'2,3-I(D) ! PYRIMIDINE-7-YL)-2-CYCLOPENTENE-1-METHANOL DERIVATIVES AS ANTIVIRAL
US20030096833A1 (en) * 2001-08-31 2003-05-22 Jagtap Prakash G. Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof

Also Published As

Publication number Publication date
DZ3007A1 (fr) 2003-03-27
PL350023A1 (en) 2002-10-21
CN1346360A (zh) 2002-04-24
AU2671300A (en) 2000-08-29
DK1150988T3 (da) 2003-09-29
DE60002986T2 (de) 2004-05-19
AR031975A1 (es) 2003-10-22
ES2200820T3 (es) 2004-03-16
HUP0105476A2 (en) 2002-06-29
US7115590B1 (en) 2006-10-03
NO20013910L (no) 2001-10-10
ATE241633T1 (de) 2003-06-15
EP1150988B1 (en) 2003-05-28
CZ20012908A3 (cs) 2002-10-16
HK1039337A1 (en) 2002-04-19
HK1039337B (en) 2003-11-21
JP2002536452A (ja) 2002-10-29
IL144647A0 (en) 2002-05-23
TR200102313T2 (tr) 2002-03-21
CA2362662A1 (en) 2000-08-17
AU772478B2 (en) 2004-04-29
NZ513450A (en) 2004-03-26
PT1150988E (pt) 2003-10-31
NO20013910D0 (no) 2001-08-10
PL204458B1 (pl) 2010-01-29
WO2000047591A1 (en) 2000-08-17
DE60002986D1 (en) 2003-07-03
HUP0105476A3 (en) 2002-08-28
EP1150988A1 (en) 2001-11-07
BR0008135A (pt) 2002-02-19

Similar Documents

Publication Publication Date Title
KR20010102082A (ko) 항바이러스제로서의 포스포르아미데이트, 및 (1ｒ, 시스)-4-(6-아미노-9ｈ-푸린-9-일)-2-시클로펜텐-1-메탄올의 모노-, 디-, 및 트리-포스페이트 에스테르
US10695357B2 (en) Methods for treating filoviridae virus infections
MX2013013570A (es) Profarmacos de monofosfato de purina para el tratamiento de infecciones virales.
JPH07116042B2 (ja) ヌクレオシド化合物
CN104151360A (zh) 磷酸/膦酸衍生物及其医药用途
US20240226131A1 (en) 2'-chloro-2'-fluoro-n2-amino-n6-methylamino purine nucleotides for flavivirus treatment
ES2213061T3 (es) Analogos de (1s,cis)-4-(2-amino-9h-purin-9-il)-2-ciclopenten-1-metanol como agente antiviral.
US20030045508A1 (en) (1r,cis)-4-(4-amino-7h-pyrrolo'2,3-i(d) pyrimidine-7-yl)-2-cyclopentene-1-methanol derivatives as antiviral
KR20100087241A (ko) 아데포비어 디피복실 오로트산 염 및 이의 제조방법
MXPA01008129A (es) Esteres de fosforamidato, y mono-, di-, y tri-fosfato de (1r, cis)-4-(6-amino-9h-purin-9-il)-2- ciclopenteno-1-metanol como agentes antivirales.
US20030040506A1 (en) Analogs of (1s,cis)-4-(2-amino-9h-purin -9-yl) -2-Cyclopentene-1-methanol as antiviral
WO2023034617A1 (en) 2'-chloro-2'-fluoro-n2-amino-n6-methylamino purine nucleotides for flavivirus treatment
HK1195317A (en) Purine monophosphate prodrugs for treatment of viral infections

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

PC1203 Withdrawal of no request for examination

St.27 status event code: N-1-6-B10-B12-nap-PC1203

WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid
R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

R18 Changes to party contact information recorded

Free format text: ST27 STATUS EVENT CODE: A-3-3-R10-R18-OTH-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000