ES2200820T3 - Fosforamidato, y mono-, di- y tri-esteres fosfato de (1r,cis)-4-(6-amino-9h-purin-9-il)-2-ciclopenten-1-metanol en calidad de agentes antivirales. - Google Patents
Fosforamidato, y mono-, di- y tri-esteres fosfato de (1r,cis)-4-(6-amino-9h-purin-9-il)-2-ciclopenten-1-metanol en calidad de agentes antivirales.Info
- Publication number
- ES2200820T3 ES2200820T3 ES00905043T ES00905043T ES2200820T3 ES 2200820 T3 ES2200820 T3 ES 2200820T3 ES 00905043 T ES00905043 T ES 00905043T ES 00905043 T ES00905043 T ES 00905043T ES 2200820 T3 ES2200820 T3 ES 2200820T3
- Authority
- ES
- Spain
- Prior art keywords
- amino
- methanol
- cyclopenten
- purin
- cis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 title claims description 120
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Substances OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 title claims description 54
- 229910019142 PO4 Inorganic materials 0.000 title claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title claims description 4
- 239000010452 phosphate Substances 0.000 title claims description 4
- 239000003443 antiviral agent Substances 0.000 title claims description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 164
- 125000003118 aryl group Chemical group 0.000 claims abstract description 45
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 43
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 30
- 239000001257 hydrogen Substances 0.000 claims abstract description 30
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract description 28
- 150000002148 esters Chemical group 0.000 claims abstract description 23
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims abstract description 22
- 238000011282 treatment Methods 0.000 claims abstract description 18
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 17
- 150000002367 halogens Chemical group 0.000 claims abstract description 17
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 16
- 125000001424 substituent group Chemical group 0.000 claims abstract description 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 125000003342 alkenyl group Chemical group 0.000 claims abstract description 14
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 14
- 125000004181 carboxyalkyl group Chemical group 0.000 claims abstract description 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 12
- 230000009385 viral infection Effects 0.000 claims abstract description 12
- 125000000392 cycloalkenyl group Chemical group 0.000 claims abstract description 10
- 208000036142 Viral infection Diseases 0.000 claims abstract description 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 9
- 125000004103 aminoalkyl group Chemical group 0.000 claims abstract description 8
- 150000007942 carboxylates Chemical class 0.000 claims abstract description 8
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 8
- 125000004001 thioalkyl group Chemical group 0.000 claims abstract description 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 7
- 125000000081 (C5-C8) cycloalkenyl group Chemical group 0.000 claims abstract description 6
- JTXJZBMXQMTSQN-UHFFFAOYSA-N amino hydrogen carbonate Chemical group NOC(O)=O JTXJZBMXQMTSQN-UHFFFAOYSA-N 0.000 claims abstract description 4
- COZAZKCWQGBJDE-JGVFFNPUSA-N [(1r,4s)-4-(6-aminopurin-9-yl)cyclopent-2-en-1-yl]methanol Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1C[C@@H](CO)C=C1 COZAZKCWQGBJDE-JGVFFNPUSA-N 0.000 claims description 160
- 238000000034 method Methods 0.000 claims description 62
- -1 O- (phenylmethoxy-D-alaninyl) phosphoramidate Chemical compound 0.000 claims description 61
- 239000000203 mixture Substances 0.000 claims description 56
- 239000000243 solution Substances 0.000 claims description 37
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 30
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 19
- 239000002775 capsule Substances 0.000 claims description 17
- 241000725303 Human immunodeficiency virus Species 0.000 claims description 14
- 238000002360 preparation method Methods 0.000 claims description 14
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 12
- 230000008569 process Effects 0.000 claims description 12
- 208000015181 infectious disease Diseases 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 11
- 241000700605 Viruses Species 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 10
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- 125000002877 alkyl aryl group Chemical group 0.000 claims description 9
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 8
- 150000002431 hydrogen Chemical class 0.000 claims description 8
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical group ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 claims description 8
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 7
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 7
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- WGZTVIAGBFHWKR-QMMMGPOBSA-N [(2S)-2-amino-3-phenylpropanoyl]oxyphosphonamidic acid Chemical compound NP(=O)(O)OC(=O)[C@@H](N)CC1=CC=CC=C1 WGZTVIAGBFHWKR-QMMMGPOBSA-N 0.000 claims description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
- 239000000725 suspension Substances 0.000 claims description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
- 230000000840 anti-viral effect Effects 0.000 claims description 4
- CQRPUKWAZPZXTO-UHFFFAOYSA-M magnesium;2-methylpropane;chloride Chemical compound [Mg+2].[Cl-].C[C-](C)C CQRPUKWAZPZXTO-UHFFFAOYSA-M 0.000 claims description 4
- CCVKPWUMYBYHCD-UHFFFAOYSA-N oxolane;pyridine Chemical compound C1CCOC1.C1=CC=NC=C1 CCVKPWUMYBYHCD-UHFFFAOYSA-N 0.000 claims description 4
- NUBCYSLFSQITLM-LBPRGKRZSA-N (3S)-4-[amino(hydroxy)phosphoryl]oxy-3-(dimethoxyamino)-4-oxo-3-phenylbutanoic acid Chemical compound NP(=O)(O)OC(=O)[C@@](CC(O)=O)(N(OC)OC)C1=CC=CC=C1 NUBCYSLFSQITLM-LBPRGKRZSA-N 0.000 claims description 3
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims description 3
- PNYFJEJUFGKXPV-LLVKDONJSA-N [(2R)-3-methyl-2-(phenylmethoxyamino)butanoyl]oxyphosphonamidic acid Chemical compound NP(=O)(O)OC(=O)[C@@H](C(C)C)NOCC1=CC=CC=C1 PNYFJEJUFGKXPV-LLVKDONJSA-N 0.000 claims description 3
- GFLWDLJYDXIPMP-OAHLLOKOSA-N [(2R)-3-phenyl-2-(phenylmethoxyamino)propanoyl]oxyphosphonamidic acid Chemical compound C([C@H](C(=O)OP(O)(=O)N)NOCC=1C=CC=CC=1)C1=CC=CC=C1 GFLWDLJYDXIPMP-OAHLLOKOSA-N 0.000 claims description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
- 238000013160 medical therapy Methods 0.000 claims description 3
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims description 3
- 230000000865 phosphorylative effect Effects 0.000 claims description 3
- 238000011321 prophylaxis Methods 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 101100240516 Caenorhabditis elegans nhr-10 gene Proteins 0.000 claims description 2
- 101100240517 Caenorhabditis elegans nhr-11 gene Proteins 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 159000000000 sodium salts Chemical class 0.000 claims description 2
- 125000000848 adenin-9-yl group Chemical group [H]N([H])C1=C2N=C([H])N(*)C2=NC([H])=N1 0.000 claims 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 10
- 125000005915 C6-C14 aryl group Chemical group 0.000 abstract 8
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 description 34
- 238000003786 synthesis reaction Methods 0.000 description 34
- 239000006260 foam Substances 0.000 description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 33
- 238000009472 formulation Methods 0.000 description 29
- 239000004615 ingredient Substances 0.000 description 29
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 27
- 239000004480 active ingredient Substances 0.000 description 25
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 20
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 16
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 15
- 229910001868 water Inorganic materials 0.000 description 15
- 238000001704 evaporation Methods 0.000 description 14
- 230000008020 evaporation Effects 0.000 description 14
- 239000003826 tablet Substances 0.000 description 13
- 239000003039 volatile agent Substances 0.000 description 13
- 208000030507 AIDS Diseases 0.000 description 12
- 125000004432 carbon atom Chemical group C* 0.000 description 12
- 239000008367 deionised water Substances 0.000 description 12
- 229910021641 deionized water Inorganic materials 0.000 description 12
- 239000007787 solid Substances 0.000 description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 11
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 11
- ITVPBBDAZKBMRP-UHFFFAOYSA-N chloro-dioxido-oxo-$l^{5}-phosphane;hydron Chemical compound OP(O)(Cl)=O ITVPBBDAZKBMRP-UHFFFAOYSA-N 0.000 description 11
- 239000007788 liquid Substances 0.000 description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 9
- 208000035475 disorder Diseases 0.000 description 9
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 9
- 238000001819 mass spectrum Methods 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 8
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 description 8
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- 238000003756 stirring Methods 0.000 description 8
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 8
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- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 6
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- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 6
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9903090 | 1999-02-12 | ||
| GBGB9903090.0A GB9903090D0 (en) | 1999-02-12 | 1999-02-12 | Therapeutic compounds |
| US17020599P | 1999-12-10 | 1999-12-10 | |
| US170205P | 1999-12-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2200820T3 true ES2200820T3 (es) | 2004-03-16 |
Family
ID=26315118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00905043T Expired - Lifetime ES2200820T3 (es) | 1999-02-12 | 2000-02-10 | Fosforamidato, y mono-, di- y tri-esteres fosfato de (1r,cis)-4-(6-amino-9h-purin-9-il)-2-ciclopenten-1-metanol en calidad de agentes antivirales. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7115590B1 (https=) |
| EP (1) | EP1150988B1 (https=) |
| JP (1) | JP2002536452A (https=) |
| KR (1) | KR20010102082A (https=) |
| CN (1) | CN1346360A (https=) |
| AR (1) | AR031975A1 (https=) |
| AT (1) | ATE241633T1 (https=) |
| AU (1) | AU772478B2 (https=) |
| BR (1) | BR0008135A (https=) |
| CA (1) | CA2362662A1 (https=) |
| CZ (1) | CZ20012908A3 (https=) |
| DE (1) | DE60002986T2 (https=) |
| DK (1) | DK1150988T3 (https=) |
| DZ (1) | DZ3007A1 (https=) |
| ES (1) | ES2200820T3 (https=) |
| HK (1) | HK1039337B (https=) |
| HU (1) | HUP0105476A3 (https=) |
| IL (1) | IL144647A0 (https=) |
| NO (1) | NO20013910L (https=) |
| NZ (1) | NZ513450A (https=) |
| PL (1) | PL204458B1 (https=) |
| PT (1) | PT1150988E (https=) |
| TR (1) | TR200102313T2 (https=) |
| WO (1) | WO2000047591A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001042255A1 (en) * | 1999-12-10 | 2001-06-14 | Glaxo Group Limited | (1R,CIS)-4-(4-AMINO-7H-PYRROLO'2,3-I(D) ! PYRIMIDINE-7-YL)-2-CYCLOPENTENE-1-METHANOL DERIVATIVES AS ANTIVIRAL |
| PE20010915A1 (es) * | 1999-12-10 | 2001-09-29 | Glaxo Group Ltd | Analogos de (1s, cis)-4-(2-amino-9h-purin-9-il)-2-ciclopenten-1-metanol para uso en el tratamiento de infecciones virales |
| EP1736478B1 (en) | 2000-05-26 | 2015-07-22 | IDENIX Pharmaceuticals, Inc. | Methods and compositions for treating flaviviruses and pestiviruses |
| US20020119443A1 (en) † | 2000-07-21 | 2002-08-29 | Gilead Sciences, Inc. | Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same |
| GB0129945D0 (en) * | 2001-12-13 | 2002-02-06 | Mrc Technology Ltd | Chemical compounds |
| GB0401088D0 (en) | 2004-01-19 | 2004-02-18 | Univ Cardiff | Phosphoramidate derivatives |
| US9243025B2 (en) | 2011-03-31 | 2016-01-26 | Idenix Pharmaceuticals, Llc | Compounds and pharmaceutical compositions for the treatment of viral infections |
| AR088441A1 (es) | 2011-09-12 | 2014-06-11 | Idenix Pharmaceuticals Inc | Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales |
| US8507460B2 (en) | 2011-10-14 | 2013-08-13 | Idenix Pharmaceuticals, Inc. | Substituted 3′,5′-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections |
| US9296778B2 (en) | 2012-05-22 | 2016-03-29 | Idenix Pharmaceuticals, Inc. | 3′,5′-cyclic phosphate prodrugs for HCV infection |
| WO2013177188A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphoramidate prodrugs for hcv infection |
| JP6165848B2 (ja) | 2012-05-22 | 2017-07-19 | イデニク ファーマシューティカルズ エルエルシー | 肝疾患のためのｄ−アミノ酸化合物 |
| MX2014014323A (es) | 2012-05-25 | 2015-02-12 | Janssen R & D Ireland | Nucleosidos de espirooxetano de uracilo. |
| WO2014052638A1 (en) | 2012-09-27 | 2014-04-03 | Idenix Pharmaceuticals, Inc. | Esters and malonates of sate prodrugs |
| EP2906579B1 (en) | 2012-10-08 | 2018-04-18 | Idenix Pharmaceuticals LLC. | 2'-chloro nucleoside analogs for hcv infection |
| US10723754B2 (en) | 2012-10-22 | 2020-07-28 | Idenix Pharmaceuticals Llc | 2′,4′-bridged nucleosides for HCV infection |
| EP2935304A1 (en) | 2012-12-19 | 2015-10-28 | IDENIX Pharmaceuticals, Inc. | 4'-fluoro nucleosides for the treatment of hcv |
| WO2014137926A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | 3'-deoxy nucleosides for the treatment of hcv |
| WO2014137930A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | Thiophosphate nucleosides for the treatment of hcv |
| WO2014160484A1 (en) | 2013-03-13 | 2014-10-02 | Idenix Pharmaceuticals, Inc. | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
| EP2981542B1 (en) | 2013-04-01 | 2021-09-15 | Idenix Pharmaceuticals LLC | 2',4'-fluoro nucleosides for the treatment of hcv |
| US10005779B2 (en) | 2013-06-05 | 2018-06-26 | Idenix Pharmaceuticals Llc | 1′,4′-thio nucleosides for the treatment of HCV |
| WO2015017713A1 (en) | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
| US10202411B2 (en) | 2014-04-16 | 2019-02-12 | Idenix Pharmaceuticals Llc | 3′-substituted methyl or alkynyl nucleosides nucleotides for the treatment of HCV |
| CA3182565A1 (en) | 2015-03-06 | 2016-09-15 | Atea Pharmaceuticals, Inc. | .beta.-d-2'-deoxy-2'-.alpha.-fluoro-2'-.beta.-c-substituted-2-modified-n6-substituted purine nucleotides for hcv treatment |
| WO2018013937A1 (en) | 2016-07-14 | 2018-01-18 | Atea Pharmaceuticals, Inc. | Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
| WO2018048937A1 (en) | 2016-09-07 | 2018-03-15 | Atea Pharmaceuticals, Inc. | 2'-substituted-n6-substituted purine nucleotides for rna virus treatment |
| WO2021173713A1 (en) | 2020-02-27 | 2021-09-02 | Atea Pharmaceuticals, Inc. | Highly active compounds against covid-19 |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| WO2024107859A1 (en) * | 2022-11-15 | 2024-05-23 | Rome Therapeutics, Inc. | Cyclopentene-oxymethylene phosphonamidates and related compounds and their use in treating medical conditions |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5244896A (en) * | 1990-09-14 | 1993-09-14 | Marion Merrell Dow Inc. | Carbocyclic adenosine analogs useful as immunosuppressants |
| GB9505025D0 (en) * | 1995-03-13 | 1995-05-03 | Medical Res Council | Chemical compounds |
| US6887707B2 (en) * | 1996-10-28 | 2005-05-03 | University Of Washington | Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA |
| GB9821058D0 (en) * | 1998-09-28 | 1998-11-18 | Univ Cardiff | Chemical compound |
| WO2001042255A1 (en) * | 1999-12-10 | 2001-06-14 | Glaxo Group Limited | (1R,CIS)-4-(4-AMINO-7H-PYRROLO'2,3-I(D) ! PYRIMIDINE-7-YL)-2-CYCLOPENTENE-1-METHANOL DERIVATIVES AS ANTIVIRAL |
| US20030096833A1 (en) * | 2001-08-31 | 2003-05-22 | Jagtap Prakash G. | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
-
2000
- 2000-02-10 CA CA002362662A patent/CA2362662A1/en not_active Abandoned
- 2000-02-10 PL PL350023A patent/PL204458B1/pl not_active IP Right Cessation
- 2000-02-10 HU HU0105476A patent/HUP0105476A3/hu unknown
- 2000-02-10 DK DK00905043T patent/DK1150988T3/da active
- 2000-02-10 US US09/913,226 patent/US7115590B1/en not_active Expired - Fee Related
- 2000-02-10 CZ CZ20012908A patent/CZ20012908A3/cs unknown
- 2000-02-10 AU AU26713/00A patent/AU772478B2/en not_active Ceased
- 2000-02-10 EP EP00905043A patent/EP1150988B1/en not_active Expired - Lifetime
- 2000-02-10 JP JP2000598510A patent/JP2002536452A/ja active Pending
- 2000-02-10 DE DE60002986T patent/DE60002986T2/de not_active Expired - Fee Related
- 2000-02-10 WO PCT/EP2000/001045 patent/WO2000047591A1/en not_active Ceased
- 2000-02-10 BR BR0008135-3A patent/BR0008135A/pt not_active IP Right Cessation
- 2000-02-10 AR ARP000100596A patent/AR031975A1/es not_active Application Discontinuation
- 2000-02-10 NZ NZ513450A patent/NZ513450A/xx unknown
- 2000-02-10 IL IL14464700A patent/IL144647A0/xx unknown
- 2000-02-10 PT PT00905043T patent/PT1150988E/pt unknown
- 2000-02-10 TR TR2001/02313T patent/TR200102313T2/xx unknown
- 2000-02-10 HK HK02100897.2A patent/HK1039337B/en not_active IP Right Cessation
- 2000-02-10 KR KR1020017010198A patent/KR20010102082A/ko not_active Withdrawn
- 2000-02-10 CN CN00806002A patent/CN1346360A/zh active Pending
- 2000-02-10 ES ES00905043T patent/ES2200820T3/es not_active Expired - Lifetime
- 2000-02-10 AT AT00905043T patent/ATE241633T1/de not_active IP Right Cessation
- 2000-03-09 DZ DZ000019A patent/DZ3007A1/xx active
-
2001
- 2001-08-10 NO NO20013910A patent/NO20013910L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DZ3007A1 (fr) | 2003-03-27 |
| PL350023A1 (en) | 2002-10-21 |
| CN1346360A (zh) | 2002-04-24 |
| AU2671300A (en) | 2000-08-29 |
| DK1150988T3 (da) | 2003-09-29 |
| DE60002986T2 (de) | 2004-05-19 |
| AR031975A1 (es) | 2003-10-22 |
| HUP0105476A2 (en) | 2002-06-29 |
| US7115590B1 (en) | 2006-10-03 |
| NO20013910L (no) | 2001-10-10 |
| ATE241633T1 (de) | 2003-06-15 |
| EP1150988B1 (en) | 2003-05-28 |
| CZ20012908A3 (cs) | 2002-10-16 |
| HK1039337A1 (en) | 2002-04-19 |
| HK1039337B (en) | 2003-11-21 |
| JP2002536452A (ja) | 2002-10-29 |
| IL144647A0 (en) | 2002-05-23 |
| TR200102313T2 (tr) | 2002-03-21 |
| CA2362662A1 (en) | 2000-08-17 |
| KR20010102082A (ko) | 2001-11-15 |
| AU772478B2 (en) | 2004-04-29 |
| NZ513450A (en) | 2004-03-26 |
| PT1150988E (pt) | 2003-10-31 |
| NO20013910D0 (no) | 2001-08-10 |
| PL204458B1 (pl) | 2010-01-29 |
| WO2000047591A1 (en) | 2000-08-17 |
| DE60002986D1 (en) | 2003-07-03 |
| HUP0105476A3 (en) | 2002-08-28 |
| EP1150988A1 (en) | 2001-11-07 |
| BR0008135A (pt) | 2002-02-19 |
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