|
CA2265460A1
(en)
|
1996-09-11 |
1998-03-19 |
The Government Of The United States Of America, Represented By The Secre Tary, Department Of Health And Human Services |
Aav4 vector and uses thereof
|
|
US6436392B1
(en)
*
|
1998-05-20 |
2002-08-20 |
University Of Iowa Research Foundation |
Adeno-associated virus vectors
|
|
US6797505B2
(en)
*
|
1998-05-27 |
2004-09-28 |
Cell Genesys, Inc. |
Recombinant AAV vectors for gene therapy of hemophilia A
|
|
EP1082413B1
(en)
*
|
1998-05-28 |
2008-07-23 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
Aav5 vector and uses thereof
|
|
US6200560B1
(en)
*
|
1998-10-20 |
2001-03-13 |
Avigen, Inc. |
Adeno-associated virus vectors for expression of factor VIII by target cells
|
|
US7122335B1
(en)
|
1999-06-08 |
2006-10-17 |
University Of Iowa Research Foundation |
Compounds and methods to enhance rAAV transduction
|
|
JP4969002B2
(ja)
*
|
1999-06-08 |
2012-07-04 |
ユニバーシテイ・オブ・アイオワ・リサーチ・フアウンデーシヨン |
rAAV形質導入を増加するための化合物および方法
|
|
US7241447B1
(en)
*
|
1999-10-07 |
2007-07-10 |
University Of Iowa Research Foundation |
Adeno-associated virus vectors and uses thereof
|
|
AU7879000A
(en)
*
|
1999-10-12 |
2001-04-23 |
University Of North Carolina At Chapel Hill, The |
Adeno-associated virus vectors encoding factor viii and methods of using the same
|
|
AU1775901A
(en)
*
|
1999-11-17 |
2001-05-30 |
Avigen, Inc. |
Recombinant adeno-associated virus virions for the treatment of lysosomal disorders
|
|
CA2400634A1
(en)
*
|
2000-02-17 |
2001-08-23 |
Chester Li |
Genetic modification of the lung as a portal for gene delivery
|
|
US6855314B1
(en)
*
|
2000-03-22 |
2005-02-15 |
The United States Of America As Represented By The Department Of Health And Human Services |
AAV5 vector for transducing brain cells and lung cells
|
|
US6593123B1
(en)
*
|
2000-08-07 |
2003-07-15 |
Avigen, Inc. |
Large-scale recombinant adeno-associated virus (rAAV) production and purification
|
|
WO2002055110A2
(en)
*
|
2000-10-25 |
2002-07-18 |
Genzyme Corp |
Methods for treating blood coagulation disorders
|
|
US20020159978A1
(en)
*
|
2001-02-06 |
2002-10-31 |
James Allen |
Muscle-directed gene transfer by use of recombinant AAV-1 and AAV-6 virions
|
|
WO2002071843A1
(en)
*
|
2001-03-14 |
2002-09-19 |
Genteric, Inc. |
Recombinant adeno-assocaited virus-mediated gene transfer via retroductal infusion of virions
|
|
CN1520259A
(zh)
*
|
2001-04-25 |
2004-08-11 |
���ݴ�ѧУ��ίԱ�� |
利用球状载体将第八因子/第九因子进行肝脏基因转移治疗血友病的方法
|
|
ATE437221T1
(de)
*
|
2001-05-14 |
2009-08-15 |
Gbp Ip Llc |
Lentivirale vektoren kodierend für gerinnungsfaktoren für die gentherapie
|
|
US8241622B2
(en)
*
|
2001-07-13 |
2012-08-14 |
University Of Iowa Research Foundation |
Adeno-associated virus vectors with intravector heterologous terminal palindromic sequences
|
|
EP1418810A4
(en)
*
|
2001-08-03 |
2006-08-02 |
Us Gov Health & Human Serv |
TREATMENT OF HEMOPHILIA ORAL
|
|
PT1567641E
(pt)
|
2001-08-24 |
2012-08-21 |
Uvic Industry Partnerships Inc |
Proaerolisina contendo sequência de activação de proteases e métodos de uso para o tratamento do cancro da próstata
|
|
US20030235555A1
(en)
*
|
2002-04-05 |
2003-12-25 |
David Shealey |
Asthma-related anti-IL-13 immunoglobulin derived proteins, compositions, methods and uses
|
|
US7419817B2
(en)
*
|
2002-05-17 |
2008-09-02 |
The United States Of America As Represented By The Secretary Department Of Health And Human Services, Nih. |
Scalable purification of AAV2, AAV4 or AAV5 using ion-exchange chromatography
|
|
KR100535325B1
(ko)
*
|
2002-09-24 |
2005-12-09 |
한국생명공학연구원 |
Aav 유전자 전달체 제조용 헬퍼 플라스미드
|
|
US20040092008A1
(en)
*
|
2002-11-12 |
2004-05-13 |
Snyder Richard O. |
Recombinant AAV vectors for gene therapy of hemophilia A
|
|
JP2007524379A
(ja)
*
|
2003-03-31 |
2007-08-30 |
ユニバーシテイ・オブ・アイオワ・リサーチ・フアウンデーシヨン |
上皮ナトリウムチャンネル関連障害のPharmico−遺伝子治療
|
|
US7963956B2
(en)
*
|
2003-04-22 |
2011-06-21 |
Antisense Pharma Gmbh |
Portable equipment for administration of fluids into tissues and tumors by convection enhanced delivery technique
|
|
WO2005017101A2
(en)
|
2003-05-19 |
2005-02-24 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH |
Avian adenoassociated virus (aaav) and uses thereof
|
|
WO2005017149A1
(en)
*
|
2003-06-03 |
2005-02-24 |
Cell Genesys, Inc. |
Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site
|
|
US7485291B2
(en)
*
|
2003-06-03 |
2009-02-03 |
Cell Genesys, Inc. |
Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
|
|
WO2004111246A1
(en)
*
|
2003-06-19 |
2004-12-23 |
Peter Bromley |
Protein production system
|
|
CN1856576B
(zh)
|
2003-09-30 |
2011-05-04 |
宾夕法尼亚州立大学托管会 |
腺伴随病毒(aav)进化支、序列、含有这些序列的载体及它们的应用
|
|
WO2005056807A2
(en)
|
2003-12-04 |
2005-06-23 |
The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, National Institutes Of Health |
Bovine adeno-associated viral (baav) vector and uses thereof
|
|
WO2006029196A1
(en)
*
|
2004-09-08 |
2006-03-16 |
The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, National Institutes Of H Ealth |
Transcytosis of adeno-associated viruses
|
|
WO2006110689A2
(en)
|
2005-04-07 |
2006-10-19 |
The Trustees Of The University Of Pennsylvania |
Method of increasing the function of an aav vector
|
|
CA2604299A1
(en)
*
|
2005-04-14 |
2006-10-19 |
Csl Behring Gmbh |
Modified coagulation factor viii with enhanced stability and its derivates
|
|
US8283151B2
(en)
*
|
2005-04-29 |
2012-10-09 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Isolation, cloning and characterization of new adeno-associated virus (AAV) serotypes
|
|
EP4154903A1
(en)
*
|
2008-04-22 |
2023-03-29 |
Vib Vzw |
Liver-specific nucleic acid regulatory elements and methods and use thereof
|
|
US9315825B2
(en)
|
2010-03-29 |
2016-04-19 |
The Trustees Of The University Of Pennsylvania |
Pharmacologically induced transgene ablation system
|
|
DK2675902T3
(da)
|
2011-02-17 |
2019-06-03 |
Univ Pennsylvania |
Sammensætninger og fremgangsmåder til at ændre vævsspecificitet og forbedre aav9-medieret genoverførsel
|
|
GB201210357D0
(en)
|
2012-06-12 |
2012-07-25 |
Ucl Business Plc |
Factor VIII sequences
|
|
CN103215308B
(zh)
*
|
2013-02-01 |
2015-12-23 |
中国科学院苏州生物医学工程技术研究所 |
表达重组人fviii的整合质粒、细胞株及其构建方法和应用
|
|
US9719106B2
(en)
|
2013-04-29 |
2017-08-01 |
The Trustees Of The University Of Pennsylvania |
Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof
|
|
RS61039B1
(sr)
|
2013-09-12 |
2020-12-31 |
Biomarin Pharm Inc |
Aav vektori koji sadrže gen koji kodira faktor viii
|
|
CN104087613B
(zh)
*
|
2014-06-30 |
2017-08-29 |
中国科学院苏州生物医学工程技术研究所 |
基于aav‑itr的基因表达微载体及其构建方法和应用
|
|
DK3193911T5
(da)
*
|
2014-07-25 |
2024-10-14 |
Csl Behring Gmbh |
Forbedrede faktor VII-præparater til brug ved behandling af hæmofili A
|
|
CA3237630A1
(en)
*
|
2014-08-13 |
2016-02-18 |
The Children's Hospital Of Philadelphia |
An improved expression cassette for packaging and expression of variant factor viii for the treatment of hemostasis disorders
|
|
SG11201703148TA
(en)
*
|
2014-11-05 |
2017-05-30 |
Voyager Therapeutics Inc |
Aadc polynucleotides for the treatment of parkinson's disease
|
|
CN115074366A
(zh)
*
|
2015-04-16 |
2022-09-20 |
埃默里大学 |
用于肝脏中蛋白质表达的重组启动子和载体及其用途
|
|
EP3332012A4
(en)
*
|
2015-08-06 |
2019-01-16 |
The Trustees of The University of Pennsylvania |
GLP-1 AND USE THEREOF IN COMPOSITIONS FOR THE TREATMENT OF METABOLISM DISEASES
|
|
RU2742352C2
(ru)
|
2015-09-24 |
2021-02-05 |
Байомарин Фармасьютикал Инк. |
Векторы фактора fviii на основе аденоассоциированных вирусов, соответствующие вирусные частицы и содержащие их терапевтические композиции
|
|
CA3002524A1
(en)
|
2015-10-28 |
2017-05-04 |
Sangamo Therapeutics, Inc. |
Liver-specific constructs, factor viii expression cassettes and methods of use thereof
|
|
EA202092049A1
(ru)
*
|
2015-11-13 |
2020-11-10 |
Баксалта Инкорпорейтед |
Вирусные векторы, кодирующие рекомбинантные варианты fviii с повышенной экспрессией для генной терапии гемофилии a
|
|
EP3374387A1
(en)
*
|
2015-11-13 |
2018-09-19 |
Baxalta Incorporated |
Viral vectors encoding recombinant fviii variants with increased expression for gene therapy of hemophilia a
|
|
US10385320B2
(en)
|
2015-12-02 |
2019-08-20 |
The Board Of Trustees Of The Leland Stanford Junior University |
Recombinant adeno-associated virus capsids with enhanced human skeletal muscle tropism
|
|
WO2017139381A1
(en)
|
2016-02-08 |
2017-08-17 |
University Of Iowa Research Foundation |
Methods to produce chimeric adeno-associated virus/bocavirus parvovirus
|
|
US10179176B2
(en)
|
2016-02-16 |
2019-01-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Recombinant adeno-associated virus capsids resistant to pre-existing human neutralizing antibodies
|
|
EP3210632B1
(en)
*
|
2016-02-23 |
2022-09-28 |
EyeServ GmbH |
Gene therapy for the treatment of a retinal degeneration disease
|
|
CA3198936A1
(en)
|
2016-03-07 |
2017-09-14 |
University Of Iowa Research Foundation |
Aav-mediated expression using a synthetic promoter and enhancer
|
|
KR102450833B1
(ko)
|
2016-04-15 |
2022-10-05 |
더 트러스티스 오브 더 유니버시티 오브 펜실베니아 |
혈우병 a 치료용 유전자 요법
|
|
US12173305B2
(en)
|
2016-05-26 |
2024-12-24 |
University Of Iowa Research Foundation |
cis and trans requirements for terminal resolution of human bocavirus 1
|
|
WO2018044933A1
(en)
|
2016-08-30 |
2018-03-08 |
The Regents Of The University Of California |
Methods for biomedical targeting and delivery and devices and systems for practicing the same
|
|
US11142775B2
(en)
|
2017-01-13 |
2021-10-12 |
University Of Iowa Research Foundation |
Bocaparvovirus small noncoding RNA and uses thereof
|
|
JOP20190200A1
(ar)
|
2017-02-28 |
2019-08-27 |
Univ Pennsylvania |
تركيبات نافعة في معالجة ضمور العضل النخاعي
|
|
JP7455579B2
(ja)
|
2017-02-28 |
2024-03-26 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
新規アデノ随伴ウイルス(aav)クレードfベクター及びその用途
|
|
JOP20190269A1
(ar)
*
|
2017-06-15 |
2019-11-20 |
Voyager Therapeutics Inc |
بولي نوكليوتيدات aadc لعلاج مرض باركنسون
|
|
JP7229989B2
(ja)
|
2017-07-17 |
2023-02-28 |
ボイジャー セラピューティクス インコーポレイテッド |
軌道アレイガイドシステム
|
|
TW202545984A
(zh)
*
|
2017-08-09 |
2025-12-01 |
美商生物化學醫療公司 |
核酸分子及其用途
|
|
MX2020008932A
(es)
|
2018-02-27 |
2020-10-01 |
Univ Pennsylvania |
Novedosos vectores de virus adenoasociado (aav), vectores de aav que tienen una desamidacion reducida de la capside y usos de estos.
|
|
US11608510B2
(en)
|
2018-03-30 |
2023-03-21 |
The Board Of Trustees Of The Leland Stanford Junior University |
Recombinant adeno-associated virus capsids with enhanced human pancreatic tropism
|
|
TW202005978A
(zh)
|
2018-05-14 |
2020-02-01 |
美商拜奧馬林製藥公司 |
新穎肝靶向腺相關病毒載體
|
|
SG11202011296VA
(en)
|
2018-05-15 |
2020-12-30 |
Voyager Therapeutics Inc |
Compositions and methods for the treatment of parkinson's disease
|
|
CN118638832A
(zh)
*
|
2018-05-15 |
2024-09-13 |
杜克大学 |
用于对阿克曼菌进行基因操纵的系统和方法
|
|
WO2020033863A1
(en)
|
2018-08-09 |
2020-02-13 |
Bioverativ Therapeutics Inc. |
Nucleic acid molecules and uses thereof for non-viral gene therapy
|
|
JP7603013B2
(ja)
*
|
2019-02-20 |
2024-12-19 |
リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル |
がんを標的とする、ウイルスによってコードされる、調節可能なt(catvert)またはnk細胞(catvern)リンカー
|
|
PE20220014A1
(es)
|
2019-04-29 |
2022-01-11 |
Univ Pennsylvania |
Nuevas capsides de aav y composiciones que las contienen
|
|
AR118928A1
(es)
*
|
2019-05-14 |
2021-11-10 |
Biomarin Pharm Inc |
Métodos de redosificación de vectores de terapia génica
|
|
KR20220031000A
(ko)
*
|
2019-07-03 |
2022-03-11 |
각꼬호우징 닛뽄 이까다이가꾸 |
핵산 봉입aav 중공입자의 제조방법
|
|
CN111876400B
(zh)
*
|
2020-08-06 |
2022-05-24 |
昆明理工大学 |
一种常温裂解酶Sly和编码此酶的多核苷酸
|
|
JP2023537070A
(ja)
|
2020-08-07 |
2023-08-30 |
アミカス セラピューティックス インコーポレイテッド |
小胞を標的とするタンパク質及びその使用
|
|
IL300410A
(en)
|
2020-08-14 |
2023-04-01 |
Univ Pennsylvania |
Novel AAV capsids and compositions containing them
|
|
IL302127A
(en)
|
2020-10-18 |
2023-06-01 |
Univ Pennsylvania |
An improved adeno-associated virus (AAV) vector and its uses
|
|
AU2021369793A1
(en)
|
2020-10-29 |
2023-06-08 |
The Trustees Of The University Of Pennsylvania |
Aav capsids and compositions containing same
|
|
TW202309066A
(zh)
|
2021-04-27 |
2023-03-01 |
賓州大學委員會 |
衍生自豬的腺相關病毒衣殼及其用途
|
|
JP2024524270A
(ja)
|
2021-06-23 |
2024-07-05 |
アスクバイオ・ユーケー・リミテッド |
調節性核酸配列
|
|
WO2024015966A2
(en)
|
2022-07-15 |
2024-01-18 |
The Trustees Of The University Of Pennsylvania |
Recombinant aav having aav clade d and clade e capsids and compositions containing same
|
|
JP2025542309A
(ja)
|
2022-12-20 |
2025-12-25 |
ナノセル セラピューティクス ホールディングス ビー.ブイ. |
組み込み型ウイルスベクターおよび自己不活性化ウイルスベクターならびにその構築物および使用
|
|
EP4389899A1
(en)
|
2022-12-22 |
2024-06-26 |
Synpromics Ltd. |
Regulatory nucleic acid sequences
|
|
WO2025239324A1
(ja)
*
|
2024-05-13 |
2025-11-20 |
中外製薬株式会社 |
遺伝子改変非ヒト動物
|