JP2002526458A5 - - Google Patents
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- Publication number
- JP2002526458A5 JP2002526458A5 JP2000573771A JP2000573771A JP2002526458A5 JP 2002526458 A5 JP2002526458 A5 JP 2002526458A5 JP 2000573771 A JP2000573771 A JP 2000573771A JP 2000573771 A JP2000573771 A JP 2000573771A JP 2002526458 A5 JP2002526458 A5 JP 2002526458A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- sodium salt
- contrast agent
- substituted
- sulfonic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 159000000000 sodium salts Chemical group 0.000 claims 17
- 239000002872 contrast media Substances 0.000 claims 15
- 125000000542 sulfonic acid group Chemical group 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000004964 sulfoalkyl group Chemical group 0.000 claims 8
- 125000003277 amino group Chemical group 0.000 claims 5
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 2
- 238000002583 angiography Methods 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000005110 aryl thio group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 125000002843 carboxylic acid group Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 230000005284 excitation Effects 0.000 claims 1
- 238000000799 fluorescence microscopy Methods 0.000 claims 1
- 230000001678 irradiating effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10283301A JP2000095758A (ja) | 1998-09-18 | 1998-09-18 | 近赤外蛍光造影剤および蛍光造影方法 |
| JP10-283301 | 1998-09-18 | ||
| PCT/EP1999/007088 WO2000016810A1 (en) | 1998-09-18 | 1999-09-16 | Near infrared fluorescent contrast agent and fluorescence imaging |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002331674A Division JP3507060B2 (ja) | 1998-09-18 | 2002-11-15 | 近赤外蛍光造影剤及び蛍光イメージング |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002526458A JP2002526458A (ja) | 2002-08-20 |
| JP2002526458A5 true JP2002526458A5 (enExample) | 2005-06-30 |
Family
ID=17663691
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10283301A Pending JP2000095758A (ja) | 1998-09-18 | 1998-09-18 | 近赤外蛍光造影剤および蛍光造影方法 |
| JP2000573771A Pending JP2002526458A (ja) | 1998-09-18 | 1999-09-16 | 近赤外蛍光造影剤及び蛍光イメージング |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10283301A Pending JP2000095758A (ja) | 1998-09-18 | 1998-09-18 | 近赤外蛍光造影剤および蛍光造影方法 |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US7488468B1 (enExample) |
| EP (1) | EP1113822B1 (enExample) |
| JP (2) | JP2000095758A (enExample) |
| KR (2) | KR100531708B1 (enExample) |
| CN (2) | CN1515552A (enExample) |
| AT (1) | ATE248608T1 (enExample) |
| AU (1) | AU763991B2 (enExample) |
| BG (3) | BG65172B1 (enExample) |
| BR (1) | BR9913849A (enExample) |
| CA (1) | CA2344315A1 (enExample) |
| DE (1) | DE69911034T2 (enExample) |
| DK (1) | DK1113822T3 (enExample) |
| EA (2) | EA005070B1 (enExample) |
| EE (1) | EE200100162A (enExample) |
| ES (1) | ES2207338T3 (enExample) |
| HK (1) | HK1042855B (enExample) |
| HU (1) | HUP0103503A3 (enExample) |
| ID (1) | ID29455A (enExample) |
| IL (2) | IL141656A0 (enExample) |
| MX (1) | MXPA01002194A (enExample) |
| NO (2) | NO322559B1 (enExample) |
| NZ (1) | NZ510019A (enExample) |
| PL (1) | PL193411B1 (enExample) |
| PT (1) | PT1113822E (enExample) |
| RS (1) | RS50203B (enExample) |
| SK (1) | SK3742001A3 (enExample) |
| TR (1) | TR200100746T2 (enExample) |
| UA (2) | UA67800C2 (enExample) |
| WO (1) | WO2000016810A1 (enExample) |
| YU (1) | YU97502A (enExample) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6593148B1 (en) | 1994-03-01 | 2003-07-15 | Li-Cor, Inc. | Cyanine dye compounds and labeling methods |
| US7547721B1 (en) | 1998-09-18 | 2009-06-16 | Bayer Schering Pharma Ag | Near infrared fluorescent contrast agent and fluorescence imaging |
| JP2000095758A (ja) | 1998-09-18 | 2000-04-04 | Schering Ag | 近赤外蛍光造影剤および蛍光造影方法 |
| AU2097500A (en) * | 1999-12-15 | 2001-06-25 | Fuji Photo Film Co., Ltd. | Near infrared fluorescent contrast agent and fluorescence imaging |
| US7790144B2 (en) * | 2000-01-18 | 2010-09-07 | Mallinckrodt Inc. | Receptor-avid exogenous optical contrast and therapeutic agents |
| US20080233050A1 (en) * | 2000-01-18 | 2008-09-25 | Mallinckrodt Inc. | Diagnostic and therapeutic optical agents |
| WO2002024815A1 (en) * | 2000-09-19 | 2002-03-28 | Li-Cor, Inc. | Cyanine dyes |
| US7597878B2 (en) * | 2000-09-19 | 2009-10-06 | Li-Cor, Inc. | Optical fluorescent imaging |
| US6663847B1 (en) * | 2000-10-13 | 2003-12-16 | Mallinckrodt Inc. | Dynamic organ function monitoring agents |
| US6669926B1 (en) * | 2000-10-16 | 2003-12-30 | Mallinckrodt, Inc. | Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients |
| US6716413B1 (en) * | 2000-10-16 | 2004-04-06 | Mallinckrodt, Inc. | Indole compounds as tissue-specific exogenous optical agents |
| US6733744B1 (en) * | 2000-10-16 | 2004-05-11 | Mallinckrodt Inc. | Indole compounds as minimally invasive physiological function monitoring agents |
| US6673334B1 (en) * | 2000-10-16 | 2004-01-06 | Mallinkcrodt, Inc. | Light sensitive compounds for instant determination of organ function |
| US6656451B1 (en) * | 2000-10-16 | 2003-12-02 | Mallinckrodt, Inc. | Indole compounds as novel dyes for organ function monitoring |
| US7556797B2 (en) | 2000-10-16 | 2009-07-07 | Mallinckrodt Inc. | Minimally invasive physiological function monitoring agents |
| EP1341557A2 (en) | 2000-10-27 | 2003-09-10 | Beth Israel Deaconess Medical Center | Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates |
| WO2004065491A1 (en) * | 2003-01-24 | 2004-08-05 | Schering Ag | Hydrophilic, thiol-reactive cyanine dyes and conjugates thereof with biomolecules for fluorescence diagnosis |
| JP2005145921A (ja) * | 2003-11-19 | 2005-06-09 | Konica Minolta Medical & Graphic Inc | 診断用蛍光造影剤及び蛍光造影診断方法 |
| US7682602B2 (en) * | 2003-12-19 | 2010-03-23 | Konica Minolta Medical & Graphic, Inc. | Near-infrared fluorescent contrast medium |
| JP2005220045A (ja) * | 2004-02-04 | 2005-08-18 | Konica Minolta Medical & Graphic Inc | 蛍光造影剤 |
| DE602005025911D1 (de) * | 2004-11-22 | 2011-02-24 | Ge Healthcare As | Kontrastmittel für eine extrazelluläre matrix |
| EP1679082A1 (en) * | 2005-01-07 | 2006-07-12 | Schering AG | Use of cyanine dyes for the diagnosis of proliferative diseases |
| US8227621B2 (en) | 2005-06-30 | 2012-07-24 | Li-Cor, Inc. | Cyanine dyes and methods of use |
| FR2889700B1 (fr) * | 2005-08-11 | 2012-11-23 | Synthinnove Lab | Marqueurs, leur procede de fabrication et leurs applications |
| US8173819B2 (en) | 2005-09-02 | 2012-05-08 | Visen Medical, Inc. | Nicotinic and picolinic acid derived near-infrared fluorophores |
| JP5106397B2 (ja) | 2005-09-02 | 2012-12-26 | ビセン メディカル, インコーポレイテッド | 生体適合性n,n−二置換スルホンアミド含有蛍光色素標識 |
| US7947256B2 (en) | 2005-09-02 | 2011-05-24 | Visen Medical, Inc. | Biocompatible fluorescent imaging agents |
| US8838210B2 (en) | 2006-06-29 | 2014-09-16 | AccuView, Inc. | Scanned laser vein contrast enhancer using a single laser |
| ITSV20060002A1 (it) | 2006-01-19 | 2007-07-20 | Ferrania Technologies Spa | Colorante fluorescente di tipo cianinico |
| EP1815870A1 (en) * | 2006-02-01 | 2007-08-08 | DKFZ Deutsches Krebsforschungszentrum | Cyanine dye compounds linked to metal chelator for bi-modal diagnostic imaging |
| JP4958461B2 (ja) * | 2006-03-30 | 2012-06-20 | 富士フイルム株式会社 | 近赤外吸収色素含有硬化性組成物 |
| US7745645B2 (en) * | 2007-01-22 | 2010-06-29 | Pierce Biotechnology, Inc. | Sulfonamide derivatives of xanthene compounds |
| US8344158B2 (en) * | 2007-08-15 | 2013-01-01 | Washington University | Fluorescent polymethine cyanine dyes |
| DE102007059752A1 (de) | 2007-12-10 | 2009-06-18 | Bayer Schering Pharma Aktiengesellschaft | Funktionalisierte, feste Polymernanopartikel enthaltend Epothilone |
| US20090214436A1 (en) | 2008-02-18 | 2009-08-27 | Washington University | Dichromic fluorescent compounds |
| JP5500875B2 (ja) * | 2009-01-30 | 2014-05-21 | キヤノン株式会社 | 新規化合物、該新規化合物を用いたプローブ及び該新規化合物もしくは該プローブを用いた蛍光イメージング用造影剤 |
| EP2396318A4 (en) | 2009-02-11 | 2013-06-05 | Life Technologies Corp | COLORANTS WITH HIGH STOKES DERIVATION |
| JP2011046663A (ja) | 2009-08-28 | 2011-03-10 | Fujifilm Corp | 近赤外蛍光造影剤 |
| JP2011046662A (ja) | 2009-08-28 | 2011-03-10 | Fujifilm Corp | 近赤外蛍光造影剤 |
| EP2470887B1 (en) | 2009-08-28 | 2020-03-11 | VisEn Medical, Inc. | Systems for tomographic imaging in diffuse media using a hybrid inversion technique |
| CA2810822C (en) | 2009-09-22 | 2018-03-06 | Visen Medical, Inc. | Systems and methods for virtual index-matching of diffusive media |
| US8273875B2 (en) | 2009-11-16 | 2012-09-25 | University Of Notre Dame Du Lac | High performance luminescent compounds |
| JP5817073B2 (ja) * | 2010-01-28 | 2015-11-18 | 国立大学法人三重大学 | 新規インドシアニン化合物を用いた診断用組成物及び分析方法 |
| PL2530093T3 (pl) * | 2010-01-28 | 2019-06-28 | National University Corporation Mie University | Związek indocyjaninowy, jego metoda syntezy, metoda jego oczyszczania, kompozycja diagnostyczna wykorzystująca związek indocyjaninowy oraz urządzenie do pomiaru biokinetyki in vivo i urządzenie do wizualizacji krążenia wykorzystujące kompozycję diagnostyczną |
| WO2012123916A2 (en) | 2011-03-15 | 2012-09-20 | Ramot At Tel-Aviv University Ltd. | Activatable fluorogenic compounds and uses thereof as near infrared probes |
| EP2764406B1 (en) * | 2011-10-07 | 2018-03-14 | Cedars-Sinai Medical Center | Compositions and methods for tumor imaging and targeting by a class of organic heptamethine cyanine dyes that possess dual nuclear and near-infrared properties |
| EP3553075B1 (en) | 2012-01-23 | 2025-01-08 | Washington University | Goggle imaging systems and methods |
| EP2906106B1 (en) | 2012-10-15 | 2023-06-14 | VisEn Medical, Inc. | Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources |
| US10517483B2 (en) | 2012-12-05 | 2019-12-31 | Accuvein, Inc. | System for detecting fluorescence and projecting a representative image |
| US20170232119A1 (en) | 2013-03-15 | 2017-08-17 | Purdue Research Foundation | Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors |
| JP6192799B2 (ja) | 2013-03-15 | 2017-09-06 | パーデュー・リサーチ・ファウンデーションPurdue Research Foundation | 腫瘍の標的画像化に使用される化合物にコンジュゲートしているアミノ酸連結基の合成および組成物 |
| EP2997353B1 (en) * | 2013-05-15 | 2022-10-12 | The Administrators of The Tulane Educational Fund | Microscopy of a tissue sample using structured illumination |
| US11001562B2 (en) | 2013-10-31 | 2021-05-11 | Beth Israel Deaconess Medical Center | Near-infrared fluorescent nerve contrast agents and methods of use thereof |
| EP4147724A1 (en) | 2013-10-31 | 2023-03-15 | Beth Israel Deaconess Medical Center | Near-infrared fluorescent contrast bioimaging agents and methods of use thereof |
| CN106455979A (zh) | 2013-12-31 | 2017-02-22 | 纪念斯隆-凯特琳癌症中心 | 用于荧光源实时多通道成像的系统、方法和设备 |
| AR102743A1 (es) * | 2014-11-26 | 2017-03-22 | Li Cor Inc | Medios de contraste ir para imágenes por fluorescencia |
| KR20170094268A (ko) | 2014-12-15 | 2017-08-17 | 메모리얼 슬로안-케터링 캔서 센터 | 향상된 신경-결합 선택성을 갖는 고리형 펩티드, 상기 고리형 펩티드와 결합된 나노입자, 및 실시간 생체내 신경 조직 영상화를 위한 이들의 용도 |
| US10251711B2 (en) | 2015-01-07 | 2019-04-09 | Michael Frank Gunter WOOD | Optical probes for corridor surgery |
| KR20160086481A (ko) | 2015-01-09 | 2016-07-20 | 차의과학대학교 산학협력단 | 신규 유기 화합물 및 이를 포함하는 근적외선 형광 조영제, 그리고 조영제의 나노입자화 방법 |
| US10806804B2 (en) | 2015-05-06 | 2020-10-20 | Washington University | Compounds having RD targeting motifs and methods of use thereof |
| RU2720976C2 (ru) * | 2015-06-03 | 2020-05-15 | Сюржимаб С.А.С. | Флуоресцентные конъюгаты и их применение для диагностики опухоли |
| US10405753B2 (en) | 2015-11-10 | 2019-09-10 | Intuitive Surgical Operations, Inc. | Pharmaceutical compositions of near IR closed chain, sulfo-cyanine dyes |
| CA3007062A1 (en) * | 2015-12-01 | 2017-06-08 | Dishman Pharmaceuticals And Chemicals Limited | An improved process for the preparation of indocyanine green |
| KR20180093961A (ko) | 2015-12-15 | 2018-08-22 | 메모리얼 슬로안-케터링 캔서 센터 | 조직 구별, 예를 들어, 수술 중 시각화를 위한 영상화 시스템 및 방법 |
| FR3058148A1 (fr) | 2016-10-31 | 2018-05-04 | Compagnie Generale Des Etablissements Michelin | Composition de caoutchouc comprenant une charge renforcante specifique |
| WO2018102372A1 (en) | 2016-11-30 | 2018-06-07 | Memorial Sloan Kettering Cancer Center | Inhibitor-functionalized ultrasmall nanoparticles and methods thereof |
| US10758631B2 (en) | 2017-04-11 | 2020-09-01 | Li-Cor, Inc. | Solid cyanine dyes |
| WO2018191261A1 (en) * | 2017-04-11 | 2018-10-18 | Li-Cor, Inc. | Solid cyanine dyes |
| KR101980292B1 (ko) * | 2017-08-03 | 2019-05-20 | (주)바이오액츠 | 형광 화합물 및 이의 제조방법 |
| US11549017B2 (en) * | 2017-09-29 | 2023-01-10 | Perkinelmer Health Sciences, Inc. | NIR to SWIR fluorescent compounds for imaging and detection |
| CN111278663B (zh) | 2017-10-30 | 2022-04-26 | 米其林集团总公司 | 设有由至少异戊二烯弹性体、增强树脂和金属盐制成的内层的轮胎 |
| CN109959612A (zh) * | 2017-12-14 | 2019-07-02 | 深圳先进技术研究院 | 一种光声探针在制备ntr光声检测试剂中的应用 |
| EP3773153A4 (en) | 2018-03-30 | 2021-11-17 | Perkinelmer Health Sciences Inc. | SYSTEMS AND PROCEDURES FOR THE 3D RECONSTRUCTION OF ANATOMICAL ORGANS AND INCLUSIONS USING SHORT WAVE INFRARED (SWIR) PROJECTION STOMOGRAPHY |
| IL287989B2 (en) * | 2019-05-13 | 2025-07-01 | Bracco Imaging Spa | Modified cyanine dyes and their conjugates |
| KR102034113B1 (ko) * | 2019-06-13 | 2019-10-18 | 나우비젼 주식회사 | 종양특이성을 증가시킨 신장배출형 형광 조영제 및 이를 이용한 영상화 방법 |
| JP7512577B2 (ja) * | 2019-09-24 | 2024-07-09 | 株式会社ニコン | 撮影方法、眼科装置、およびプログラム |
| EP4072598A4 (en) | 2019-12-13 | 2024-02-21 | Washington University | Near infrared fluorescent dyes, formulations and related methods |
| EP4015004A1 (en) | 2020-12-18 | 2022-06-22 | Phi Pharma SA | Proteoglycan specific branched peptides |
| WO2022163807A1 (ja) * | 2021-01-29 | 2022-08-04 | 国立大学法人北海道大学 | 光音響イメージング剤 |
| WO2022258455A1 (en) | 2021-06-07 | 2022-12-15 | Surgvision Gmbh | Stable liquid phantom for near-infrared fluorescence verification |
| CN113717089B (zh) * | 2021-09-22 | 2023-05-05 | 中国科学院精密测量科学与技术创新研究院 | 一种氟化Cy7化合物及其合成方法和应用 |
| KR102414554B1 (ko) * | 2022-02-27 | 2022-06-30 | (주)바이오액츠 | 생체물질을 검출하기 위한 형광 화합물 및 이의 제조방법 |
| US20250082795A1 (en) | 2023-09-12 | 2025-03-13 | Curadel Surgical Innovations, Inc. | Combinations of imaging agent conjugates and application thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62123454A (ja) * | 1985-08-08 | 1987-06-04 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
| US4871656A (en) | 1987-04-24 | 1989-10-03 | Eastman Kodak Company | Photographic silver halide elements containing infrared filter dyes |
| ATE206395T1 (de) | 1990-05-15 | 2001-10-15 | Hyperion Inc | Fluoreszierende porphyrin- und fluoreszierende phthalocyanin-polyethylenglykol-, polyol- und saccharidderivate als fluoreszierende sonden |
| US5298379A (en) | 1992-06-30 | 1994-03-29 | Eastman Kodak Company | Radiation sensitive element with absorber dye to enhance spectral sensitivity range |
| JP2955803B2 (ja) | 1992-07-22 | 1999-10-04 | 富士写真フイルム株式会社 | ハロゲン化銀写真感光材料 |
| EP0591820A1 (en) * | 1992-10-05 | 1994-04-13 | E.I. Du Pont De Nemours And Company | Near-infrared absorbing dyes prepared from Stenhouse salts |
| JPH06145539A (ja) | 1992-11-04 | 1994-05-24 | Fuji Photo Film Co Ltd | シアニン化合物 |
| US5658751A (en) | 1993-04-13 | 1997-08-19 | Molecular Probes, Inc. | Substituted unsymmetrical cyanine dyes with selected permeability |
| US5440042A (en) | 1993-05-26 | 1995-08-08 | E. I. Du Pont De Nemours And Company | Thioheterocyclic near-infrared dyes |
| DE4426892A1 (de) * | 1994-07-29 | 1996-02-15 | Riedel De Haen Ag | Verwendung von Indolenincyanindisulfonsäure-Derivaten |
| DE4445065A1 (de) * | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
| US5968479A (en) | 1995-01-30 | 1999-10-19 | Daiichi Pure Chemicals Co., Ltd. | Diagnostic marker |
| IT1276833B1 (it) * | 1995-10-09 | 1997-11-03 | Sorin Biomedica Cardio Spa | Coloranti fluorescenti della famiglia della solfo benz e indocianina |
| DE19539409C2 (de) | 1995-10-11 | 1999-02-18 | Diagnostikforschung Inst | Kontrastmittel für die Nahinfrarot-Diagnostik |
| US5723204A (en) | 1995-12-26 | 1998-03-03 | Xerox Corporation | Two-sided electrical paper |
| WO1997040104A1 (en) | 1996-04-19 | 1997-10-30 | Amersham Pharmacia Biotech Uk Limited | Squarate dyes and their use in fluorescent sequencing method |
| US5672332A (en) | 1996-05-13 | 1997-09-30 | Mallinckrodt Medical, Inc. | Delta 1,2 bicyclo 4,4,0! functional dyes for contrast enhancement in optical imaging |
| US5709845A (en) | 1996-05-13 | 1998-01-20 | Rajagopalan; Raghavan | Tricyclic functional dyes for contrast enhancement in optical imaging |
| US5672333A (en) | 1996-05-13 | 1997-09-30 | Mallinckrodt Medical, Inc. | Delta1,6 bicyclo 4,4,0! functional dyes for contrast enhancement in optical imaging |
| DE19649971A1 (de) * | 1996-11-19 | 1998-05-28 | Diagnostikforschung Inst | Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung) |
| DE19717904A1 (de) * | 1997-04-23 | 1998-10-29 | Diagnostikforschung Inst | Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie |
| GB9710049D0 (en) | 1997-05-19 | 1997-07-09 | Nycomed Imaging As | Method |
| US6083486A (en) | 1998-05-14 | 2000-07-04 | The General Hospital Corporation | Intramolecularly-quenched near infrared fluorescent probes |
| JP2000095758A (ja) | 1998-09-18 | 2000-04-04 | Schering Ag | 近赤外蛍光造影剤および蛍光造影方法 |
| US6114350A (en) | 1999-04-19 | 2000-09-05 | Nen Life Science Products, Inc. | Cyanine dyes and synthesis methods thereof |
| US6159657A (en) | 1999-08-31 | 2000-12-12 | Eastman Kodak Company | Thermal imaging composition and member containing sulfonated ir dye and methods of imaging and printing |
| US6663847B1 (en) | 2000-10-13 | 2003-12-16 | Mallinckrodt Inc. | Dynamic organ function monitoring agents |
| US6673334B1 (en) | 2000-10-16 | 2004-01-06 | Mallinkcrodt, Inc. | Light sensitive compounds for instant determination of organ function |
-
1998
- 1998-09-18 JP JP10283301A patent/JP2000095758A/ja active Pending
-
1999
- 1999-09-16 TR TR2001/00746T patent/TR200100746T2/xx unknown
- 1999-09-16 BR BR9913849-2A patent/BR9913849A/pt not_active Application Discontinuation
- 1999-09-16 PT PT99969341T patent/PT1113822E/pt unknown
- 1999-09-16 US US09/787,394 patent/US7488468B1/en not_active Expired - Fee Related
- 1999-09-16 CA CA002344315A patent/CA2344315A1/en not_active Abandoned
- 1999-09-16 ID IDW20010649A patent/ID29455A/id unknown
- 1999-09-16 DE DE69911034T patent/DE69911034T2/de not_active Expired - Lifetime
- 1999-09-16 YU YU97502A patent/YU97502A/sh unknown
- 1999-09-16 RS YU19801A patent/RS50203B/sr unknown
- 1999-09-16 HK HK02104712.7A patent/HK1042855B/zh not_active IP Right Cessation
- 1999-09-16 EE EEP200100162A patent/EE200100162A/xx unknown
- 1999-09-16 CN CNA021548455A patent/CN1515552A/zh active Pending
- 1999-09-16 DK DK99969341T patent/DK1113822T3/da active
- 1999-09-16 SK SK374-2001A patent/SK3742001A3/sk unknown
- 1999-09-16 KR KR1020047013684A patent/KR100531708B1/ko not_active Expired - Fee Related
- 1999-09-16 AT AT99969341T patent/ATE248608T1/de not_active IP Right Cessation
- 1999-09-16 EA EA200201216A patent/EA005070B1/ru not_active IP Right Cessation
- 1999-09-16 IL IL14165699A patent/IL141656A0/xx active IP Right Grant
- 1999-09-16 HU HU0103503A patent/HUP0103503A3/hu unknown
- 1999-09-16 NZ NZ510019A patent/NZ510019A/en not_active IP Right Cessation
- 1999-09-16 PL PL99346709A patent/PL193411B1/pl not_active IP Right Cessation
- 1999-09-16 UA UA2001042578A patent/UA67800C2/uk unknown
- 1999-09-16 EA EA200100318A patent/EA004249B1/ru not_active IP Right Cessation
- 1999-09-16 KR KR1020017003501A patent/KR100585370B1/ko not_active Expired - Fee Related
- 1999-09-16 JP JP2000573771A patent/JP2002526458A/ja active Pending
- 1999-09-16 MX MXPA01002194A patent/MXPA01002194A/es not_active IP Right Cessation
- 1999-09-16 ES ES99969341T patent/ES2207338T3/es not_active Expired - Lifetime
- 1999-09-16 WO PCT/EP1999/007088 patent/WO2000016810A1/en not_active Ceased
- 1999-09-16 AU AU59814/99A patent/AU763991B2/en not_active Ceased
- 1999-09-16 EP EP99969341A patent/EP1113822B1/en not_active Expired - Lifetime
- 1999-09-16 CN CNB998103969A patent/CN1196497C/zh not_active Expired - Fee Related
-
2001
- 2001-02-26 IL IL141656A patent/IL141656A/en not_active IP Right Cessation
- 2001-03-13 BG BG105337A patent/BG65172B1/bg unknown
- 2001-03-13 BG BG107411A patent/BG65173B1/bg unknown
- 2001-03-13 BG BG107411/2002A patent/BG107411A/xx unknown
- 2001-03-16 NO NO20011338A patent/NO322559B1/no not_active IP Right Cessation
-
2002
- 2002-12-04 NO NO20025819A patent/NO20025819D0/no not_active Application Discontinuation
- 2002-12-18 UA UA20021210274A patent/UA75360C2/uk unknown
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