JP2021500373A5 - - Google Patents
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- JP2021500373A5 JP2021500373A5 JP2020523010A JP2020523010A JP2021500373A5 JP 2021500373 A5 JP2021500373 A5 JP 2021500373A5 JP 2020523010 A JP2020523010 A JP 2020523010A JP 2020523010 A JP2020523010 A JP 2020523010A JP 2021500373 A5 JP2021500373 A5 JP 2021500373A5
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- 0 CS(C)N(CCNCC(O)=O)CCN(CCNCC(*)=O)CC(O)=O Chemical compound CS(C)N(CCNCC(O)=O)CCN(CCNCC(*)=O)CC(O)=O 0.000 description 2
- IXUWMUYNSXVWAS-UHFFFAOYSA-N NC(CCC(C(O)=O)NCCN(CCN(CCNCC(O)=O)CC(O)=O)CC(O)=O)=O Chemical compound NC(CCC(C(O)=O)NCCN(CCN(CCNCC(O)=O)CC(O)=O)CC(O)=O)=O IXUWMUYNSXVWAS-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024078640A JP2024109682A (ja) | 2017-10-23 | 2024-05-14 | 線維芽細胞活性化タンパク質α（ＦＡＰ－α）を標的とする撮像剤および放射線療法用薬剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762575607P | 2017-10-23 | 2017-10-23 | |
| US62/575,607 | 2017-10-23 | ||
| PCT/US2018/057086 WO2019083990A2 (en) | 2017-10-23 | 2018-10-23 | IMAGING AND RADIATION THERAPY AGENTS TARGETING α-FIBROBLAST ACTIVATION PROTEIN α (FAP-α) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024078640A Division JP2024109682A (ja) | 2017-10-23 | 2024-05-14 | 線維芽細胞活性化タンパク質α（ＦＡＰ－α）を標的とする撮像剤および放射線療法用薬剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021500373A JP2021500373A (ja) | 2021-01-07 |
| JP2021500373A5 true JP2021500373A5 (enExample) | 2021-12-02 |
Family
ID=66247306
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020523010A Pending JP2021500373A (ja) | 2017-10-23 | 2018-10-23 | 線維芽細胞活性化タンパク質α（ＦＡＰ−α）を標的とする撮像剤および放射線療法用薬剤 |
| JP2024078640A Pending JP2024109682A (ja) | 2017-10-23 | 2024-05-14 | 線維芽細胞活性化タンパク質α（ＦＡＰ－α）を標的とする撮像剤および放射線療法用薬剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024078640A Pending JP2024109682A (ja) | 2017-10-23 | 2024-05-14 | 線維芽細胞活性化タンパク質α（ＦＡＰ－α）を標的とする撮像剤および放射線療法用薬剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US20200330624A1 (enExample) |
| EP (1) | EP3700580A4 (enExample) |
| JP (2) | JP2021500373A (enExample) |
| KR (2) | KR102764076B1 (enExample) |
| CN (2) | CN111511408A (enExample) |
| AU (2) | AU2018355222B2 (enExample) |
| BR (1) | BR112020008011A2 (enExample) |
| CA (1) | CA3088138A1 (enExample) |
| EA (1) | EA202090776A1 (enExample) |
| IL (1) | IL274088A (enExample) |
| MX (2) | MX2020004807A (enExample) |
| WO (1) | WO2019083990A2 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116474108A (zh) | 2016-12-14 | 2023-07-25 | 普渡研究基金会 | 成纤维细胞活化蛋白(fap)-靶向成像和治疗 |
| EA202090776A1 (ru) * | 2017-10-23 | 2020-07-27 | Дзе Джонс Хопкинс Юниверсити | Визуализирующие и радиотерапевтические агенты, нацеленные на фибробласт-активирующий белок-альфа (fapalpha) |
| MX2020006128A (es) * | 2017-12-15 | 2020-09-21 | Praxis Biotech LLC | Inhibidores de la proteina de activacion de fibroblastos. |
| AU2019219057B2 (en) * | 2018-02-06 | 2022-11-24 | Universität Heidelberg | FAP inhibitor |
| CA3116313A1 (en) | 2018-10-17 | 2020-04-23 | Purdue Research Foundation | Fibroblast activation protein (fap) targeted imaging and therapy in fibrosis |
| EP3898654A4 (en) | 2018-12-21 | 2022-10-26 | Praxis Biotech LLC | FIBROBLAST ACTIVATION PROTEIN INHIBITORS |
| SI3997103T1 (sl) | 2019-07-08 | 2025-04-30 | 3B Pharmaceuticals Gmbh | Spojine, ki obsegajo ligand proteina za aktiviranje fibroblastov in uporaba le teh |
| EP3763726A1 (en) | 2019-07-08 | 2021-01-13 | 3B Pharmaceuticals GmbH | Compounds comprising a fibroblast activation protein ligand and use thereof |
| CN118930608A (zh) | 2019-07-08 | 2024-11-12 | 3B制药有限公司 | 包含成纤维细胞活化蛋白配体的化合物及其用途 |
| MX2022003215A (es) * | 2019-09-17 | 2022-04-25 | Purdue Research Foundation | Formacion de imagenes especificas para proteina de activacion de fibroblastos (fap) y terapia contra tipos de cancer y otras enfermedades fibroticas e inflamatorias. |
| EP4096676A4 (en) * | 2020-01-31 | 2024-04-10 | Purdue Research Foundation | FIBROBLAST ACTIVATION PROTEIN (FAP) - TARGETED ANTIFIBROTIC THERAPY |
| EP3891138B1 (en) | 2020-02-12 | 2022-01-12 | Philochem AG | Fibroblast activation protein ligands for targeted delivery applications |
| CN115943312A (zh) | 2020-05-07 | 2023-04-07 | 法国居里学院 | 免疫抑制性成纤维细胞群体的生物标志物antxr1及其在预测对免疫疗法的反应中的用途 |
| WO2021234181A1 (en) * | 2020-05-22 | 2021-11-25 | Universität Heidelberg | Use of fap inhibitor in a method of diagnosis |
| CN112138175A (zh) * | 2020-09-01 | 2020-12-29 | 上海市质子重离子临床技术研发中心 | 一种放射性核素99mTc标记FAPI的化合物的制备方法 |
| CN114790194B (zh) * | 2020-12-21 | 2024-03-26 | 苏州药明博锐生物科技有限公司 | 成纤维细胞活化蛋白抑制剂 |
| EP4050018A1 (en) | 2021-01-07 | 2022-08-31 | 3B Pharmaceuticals GmbH | Compounds comprising a fibroblast activation protein ligand and use thereof |
| CA3206863A1 (en) * | 2021-01-07 | 2022-07-14 | 3B Pharmaceuticals Gmbh | Compounds comprising a fibroblast activation protein ligand and use thereof |
| CN114369084B (zh) * | 2021-02-10 | 2023-02-03 | 烟台蓝纳成生物技术有限公司 | 一种截短型伊文思蓝修饰的成纤维细胞活化蛋白抑制剂及其制备方法和应用 |
| CA3210863C (en) * | 2021-02-10 | 2024-06-04 | Yantai Lannacheng Biotechnology Co., Ltd. | Truncated evans blue modified fibroblast activation protein inhibitor, preparation method and application thereof |
| MX2023009486A (es) | 2021-02-12 | 2023-10-16 | Philochem Ag | Ligandos bivalentes de la proteína de activación de fibroblastos para aplicaciones de entrega dirigida. |
| EP4043452A1 (en) | 2021-02-12 | 2022-08-17 | Philochem AG | Bivalent fibroblast activation protein ligands for targeted delivery applications |
| CN113105432B (zh) * | 2021-03-30 | 2022-03-04 | 上海交通大学医学院附属仁济医院 | 一种碳-11（11c）放射性药物及其制备方法和应用 |
| CA3214070A1 (en) * | 2021-04-02 | 2022-10-06 | Sangeeta Banerjee RAY | Heterobivalent and homobivalent agents targeting fibroblast activation protein alpha and/or prostate-specific membrane antigen |
| CN113277989B (zh) * | 2021-04-27 | 2022-05-31 | 中南大学湘雅医院 | 一种68Ga标记的分子探针、制备方法及其应用 |
| AU2022275579C1 (en) * | 2021-05-19 | 2024-08-22 | Ferronova Pty Ltd | Mapping nanoparticles |
| CN113527266A (zh) * | 2021-06-23 | 2021-10-22 | 上海健康医学院 | 一种靶向fap的双氧水响应的前药及其制备方法与应用 |
| GB202109922D0 (en) | 2021-07-09 | 2021-08-25 | Blue Earth Diagnostics Ltd | Radiotracers and therapeutics binding to fibroblast activation protein (fap) |
| EP4122499A1 (en) * | 2021-07-23 | 2023-01-25 | 3B Pharmaceuticals GmbH | Fibroblast activation protein inhibitors and use thereof |
| TW202320805A (zh) * | 2021-08-18 | 2023-06-01 | 美商杜夫特學院信託管理公司 | 用於pet造影之選擇性靶向纖維母細胞活化蛋白之放射性氟標誌試劑 |
| CN113880810B (zh) * | 2021-09-24 | 2023-02-28 | 厦门大学 | 一种核素标记的配合物及其制备方法和应用 |
| CA3234394A1 (en) | 2021-10-04 | 2023-04-13 | Philochem Ag | Radiolabelled fibroblast activation protein ligands |
| TW202317541A (zh) | 2021-10-28 | 2023-05-01 | 行政院原子能委員會核能研究所 | 一種靶向成纖維細胞活化蛋白之化合物或其鹽，其製備方法及其用途 |
| WO2023081301A1 (en) * | 2021-11-05 | 2023-05-11 | On Target Laboratories, LLC | Fibroblast activation protein targeted dyes their related uses |
| US20250177582A1 (en) | 2022-01-30 | 2025-06-05 | Philochem Ag | High-affinity ligands of fibroblast activation protein for targeted delivery applications |
| AU2023223808A1 (en) | 2022-02-22 | 2024-09-19 | Osaka University | RADIOLABELED FAPα-AFFINITY COMPOUND AND USE THEREOF |
| JP2025513317A (ja) * | 2022-04-21 | 2025-04-24 | シャンハイ シノタウ バイオテック． シーオー．， エルティーディー | Ｆａｐ阻害剤 |
| WO2023222558A1 (en) | 2022-05-14 | 2023-11-23 | Zounek Alexis Nikolai | Precursor and theranostic radiotracer with improved tumor retention |
| CN115304582B (zh) * | 2022-07-20 | 2023-05-12 | 北京法伯新天医药科技有限公司 | FAP-α特异性肿瘤诊断显像剂 |
| CA3262480A1 (en) * | 2022-07-28 | 2024-02-01 | Ratio Therapeutics, Inc. | Compositions targeting fibroblast-activating proteins and their methods of use |
| CN115368342B (zh) * | 2022-08-24 | 2024-01-23 | 西南医科大学附属医院 | 成纤维细胞活性蛋白抑制剂、其放射性核素标记物及制备方法和应用 |
| JP2025529319A (ja) | 2022-09-06 | 2025-09-04 | フィロケム・アーゲー | 標的送達用途のための多価線維芽細胞活性化タンパク質リガンド |
| EP4342890A1 (en) | 2022-09-21 | 2024-03-27 | Erasmus University Rotterdam Medical Center | Platform and scaffold for fap targeting agents |
| EP4590345A2 (en) * | 2022-09-23 | 2025-07-30 | Nuclidium AG | High-purity copper radiopharmaceutical compositions and diagnostic and therapeutic uses thereof |
| TW202426433A (zh) | 2022-09-23 | 2024-07-01 | 瑞士商紐利迪姆股份公司 | 成纖維細胞活化蛋白（ｆａｐ）抑制劑、ｆａｐ結合物及其診斷與治療用途 |
| WO2024078592A1 (zh) * | 2022-10-14 | 2024-04-18 | 无锡诺宇医药科技有限公司 | 靶向成纤维细胞活化蛋白的药物及其应用 |
| WO2024165072A1 (zh) * | 2023-02-10 | 2024-08-15 | 成都纽瑞特医疗科技股份有限公司 | 一种多肽化合物及其应用 |
| CN120957982A (zh) | 2023-05-08 | 2025-11-14 | 江苏恒瑞医药股份有限公司 | 靶向成纤维细胞活化蛋白的配体 |
| WO2025029608A1 (en) * | 2023-07-28 | 2025-02-06 | Ratio Therapeutics, Inc. | Fibroblast activation protein-targeted compositions and methods of use thereof |
| WO2025046043A1 (en) | 2023-08-31 | 2025-03-06 | Stichting Radboud Universitair Medisch Centrum | Endometriosis tracer |
| WO2025063849A2 (en) | 2023-09-21 | 2025-03-27 | Erasmus University Medical Center Rotterdam | Dimeric fap targeting agents |
| WO2025125335A1 (en) | 2023-12-13 | 2025-06-19 | Radiovaxx Gmbh | Cytotoxic or radiopharmaceutical compound with sulfur fluoride exchange group |
| WO2025125621A1 (en) | 2023-12-14 | 2025-06-19 | Radiovaxx Gmbh | Cancer-associated protein-targeted strong or covalently binding precursor compounds and radiotracers |
| WO2025146433A1 (en) | 2024-01-05 | 2025-07-10 | Radiovaxx Gmbh | Precursor and theranostic radiotracer with prolonged tumor retention |
| CN118063689B (zh) * | 2024-01-26 | 2025-01-28 | 锐康九域(厦门)医药科技有限公司 | 成纤维细胞激活蛋白-α响应水解致电荷翻转的聚合物-药物偶联物及其制备方法和应用 |
| CN118271393B (zh) * | 2024-05-31 | 2024-09-03 | 中国药科大学 | 一种靶向fap的二聚化合物及其探针和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7399869B2 (en) * | 2005-05-19 | 2008-07-15 | Genentech, Inc. | Fibroblast activation protein inhibitor compounds and methods |
| EP2921482B1 (en) * | 2007-06-26 | 2018-09-05 | The Johns Hopkins University | Labeled inhibitors of prostate-specific membrane antigen (psma), biological evaluation, and use as imaging agents |
| HUE034027T2 (en) | 2008-08-01 | 2018-01-29 | Univ Johns Hopkins | Psma-binding agents and uses thereof |
| EP2349995A1 (en) * | 2008-09-25 | 2011-08-03 | Molecular Insight Pharmaceuticals, Inc. | Selective seprase inhibitors |
| CA2755965C (en) | 2009-03-19 | 2019-04-16 | The Johns Hopkins University | Psma-targeting compounds and uses thereof |
| WO2016149188A1 (en) * | 2015-03-13 | 2016-09-22 | The Johns Hopkins University | 68Ga-LABELED NOTA-CHELATED PSMA-TARGETED IMAGING AND THERAPEUTIC AGENTS |
| WO2013107820A1 (en) * | 2012-01-17 | 2013-07-25 | Universiteit Antwerpen | Novel fap inhibitors |
| US20150320892A1 (en) * | 2012-06-29 | 2015-11-12 | Ge Healthcare Limited | Imaging fibrosis |
| US9371362B2 (en) * | 2012-08-15 | 2016-06-21 | Visen Medical, Inc. | Prostate specific antigen agents and methods of using same for prostate cancer imaging |
| GB2538023A (en) * | 2014-02-03 | 2016-11-02 | Philochem Ag | Targeted drug conjugates |
| US10736974B2 (en) * | 2014-10-22 | 2020-08-11 | The Johns Hopkins University | Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy |
| US10857246B2 (en) * | 2015-06-01 | 2020-12-08 | The Johns Hopkins University | Nuclear imaging and radiotherapeutics agents targeting carbonic anhydrase IX and uses thereof |
| CN116474108A (zh) | 2016-12-14 | 2023-07-25 | 普渡研究基金会 | 成纤维细胞活化蛋白(fap)-靶向成像和治疗 |
| EA202090776A1 (ru) * | 2017-10-23 | 2020-07-27 | Дзе Джонс Хопкинс Юниверсити | Визуализирующие и радиотерапевтические агенты, нацеленные на фибробласт-активирующий белок-альфа (fapalpha) |
| AU2019219057B2 (en) | 2018-02-06 | 2022-11-24 | Universität Heidelberg | FAP inhibitor |
-
2018
- 2018-10-23 EA EA202090776A patent/EA202090776A1/ru unknown
- 2018-10-23 US US16/758,182 patent/US20200330624A1/en active Pending
- 2018-10-23 EP EP18871298.8A patent/EP3700580A4/en active Pending
- 2018-10-23 CN CN201880083520.XA patent/CN111511408A/zh active Pending
- 2018-10-23 KR KR1020207013693A patent/KR102764076B1/ko active Active
- 2018-10-23 CN CN202310498227.2A patent/CN116617420A/zh active Pending
- 2018-10-23 JP JP2020523010A patent/JP2021500373A/ja active Pending
- 2018-10-23 MX MX2020004807A patent/MX2020004807A/es unknown
- 2018-10-23 KR KR1020247035948A patent/KR20240162157A/ko active Pending
- 2018-10-23 CA CA3088138A patent/CA3088138A1/en active Pending
- 2018-10-23 WO PCT/US2018/057086 patent/WO2019083990A2/en not_active Ceased
- 2018-10-23 AU AU2018355222A patent/AU2018355222B2/en active Active
- 2018-10-23 BR BR112020008011-0A patent/BR112020008011A2/pt unknown
-
2020
- 2020-04-20 IL IL274088A patent/IL274088A/en unknown
- 2020-07-13 MX MX2023013164A patent/MX2023013164A/es unknown
-
2023
- 2023-07-18 US US18/354,282 patent/US11938201B2/en active Active
-
2024
- 2024-02-23 US US18/585,905 patent/US12115233B2/en active Active
- 2024-05-14 JP JP2024078640A patent/JP2024109682A/ja active Pending
- 2024-05-16 AU AU2024203249A patent/AU2024203249A1/en active Pending
- 2024-12-20 US US18/990,863 patent/US20250186628A1/en active Pending
-
2025
- 2025-04-07 US US19/172,114 patent/US20250235565A1/en active Pending
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