JP2021500373A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2021500373A5 JP2021500373A5 JP2020523010A JP2020523010A JP2021500373A5 JP 2021500373 A5 JP2021500373 A5 JP 2021500373A5 JP 2020523010 A JP2020523010 A JP 2020523010A JP 2020523010 A JP2020523010 A JP 2020523010A JP 2021500373 A5 JP2021500373 A5 JP 2021500373A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- compound according
- independently
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CS(C)N(CCNCC(O)=O)CCN(CCNCC(*)=O)CC(O)=O Chemical compound CS(C)N(CCNCC(O)=O)CCN(CCNCC(*)=O)CC(O)=O 0.000 description 2
- IXUWMUYNSXVWAS-UHFFFAOYSA-N NC(CCC(C(O)=O)NCCN(CCN(CCNCC(O)=O)CC(O)=O)CC(O)=O)=O Chemical compound NC(CCC(C(O)=O)NCCN(CCN(CCNCC(O)=O)CC(O)=O)CC(O)=O)=O IXUWMUYNSXVWAS-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024078640A JP2024109682A (ja) | 2017-10-23 | 2024-05-14 | 線維芽細胞活性化タンパク質α（ＦＡＰ－α）を標的とする撮像剤および放射線療法用薬剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762575607P | 2017-10-23 | 2017-10-23 | |
| US62/575,607 | 2017-10-23 | ||
| PCT/US2018/057086 WO2019083990A2 (en) | 2017-10-23 | 2018-10-23 | IMAGING AND RADIATION THERAPY AGENTS TARGETING α-FIBROBLAST ACTIVATION PROTEIN α (FAP-α) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024078640A Division JP2024109682A (ja) | 2017-10-23 | 2024-05-14 | 線維芽細胞活性化タンパク質α（ＦＡＰ－α）を標的とする撮像剤および放射線療法用薬剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021500373A JP2021500373A (ja) | 2021-01-07 |
| JP2021500373A5 true JP2021500373A5 (enExample) | 2021-12-02 |
Family
ID=66247306
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020523010A Pending JP2021500373A (ja) | 2017-10-23 | 2018-10-23 | 線維芽細胞活性化タンパク質α（ＦＡＰ−α）を標的とする撮像剤および放射線療法用薬剤 |
| JP2024078640A Pending JP2024109682A (ja) | 2017-10-23 | 2024-05-14 | 線維芽細胞活性化タンパク質α（ＦＡＰ－α）を標的とする撮像剤および放射線療法用薬剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024078640A Pending JP2024109682A (ja) | 2017-10-23 | 2024-05-14 | 線維芽細胞活性化タンパク質α（ＦＡＰ－α）を標的とする撮像剤および放射線療法用薬剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US20200330624A1 (enExample) |
| EP (1) | EP3700580A4 (enExample) |
| JP (2) | JP2021500373A (enExample) |
| KR (2) | KR102764076B1 (enExample) |
| CN (2) | CN116617420A (enExample) |
| AU (2) | AU2018355222B2 (enExample) |
| BR (1) | BR112020008011A2 (enExample) |
| CA (1) | CA3088138A1 (enExample) |
| EA (1) | EA202090776A1 (enExample) |
| IL (1) | IL274088A (enExample) |
| MX (2) | MX2020004807A (enExample) |
| WO (1) | WO2019083990A2 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018111989A1 (en) * | 2016-12-14 | 2018-06-21 | Purdue Research Foundation | Fibroblast activation protein (fap)-targeted imaging and therapy |
| EP3723753A4 (en) * | 2017-12-15 | 2022-01-26 | Praxis Biotech LLC | FIBROBLAST ACTIVATION PROTEIN INHIBITORS |
| CA3088326A1 (en) * | 2018-02-06 | 2019-08-15 | Universitat Heidelberg | Fap inhibitor |
| JP7161044B2 (ja) | 2018-10-17 | 2022-10-25 | パーデュー・リサーチ・ファウンデーション | 線維症における線維芽細胞活性化タンパク質（ｆａｐ）を標的とする撮像法および治療法 |
| CN113811529A (zh) | 2018-12-21 | 2021-12-17 | 普拉西斯生物技术有限责任公司 | 成纤维细胞激活蛋白抑制剂 |
| HUE070009T2 (hu) | 2019-07-08 | 2025-05-28 | 3B Pharmaceuticals Gmbh | Fibroblaszt aktiváló protein ligandumot tartalmazó vegyületek és alkalmazásuk |
| EP3763726A1 (en) | 2019-07-08 | 2021-01-13 | 3B Pharmaceuticals GmbH | Compounds comprising a fibroblast activation protein ligand and use thereof |
| BR112022000144A2 (pt) * | 2019-07-08 | 2022-02-22 | 3B Pharmaceuticals Gmbh | Compostos que compreendem um ligante de proteína de ativação de fibroblastos e uso dos mesmos |
| CA3150890A1 (en) * | 2019-09-17 | 2021-03-25 | Philip Stewart Low | Fibroblast activation protein (fap)-targeted imaging and therapy of cancers and other fibrotic and inflammatory diseases |
| WO2021155292A1 (en) * | 2020-01-31 | 2021-08-05 | Philip Stewart Low | Fibroblast activation protein (fap) - targeted antifibrotic therapy |
| EP3891138B1 (en) | 2020-02-12 | 2022-01-12 | Philochem AG | Fibroblast activation protein ligands for targeted delivery applications |
| JP2023525082A (ja) | 2020-05-07 | 2023-06-14 | アンスティテュ・クリー | 免疫抑制線維芽細胞集団のバイオマーカーとしてのａｎｔｘｒ１及び免疫療法に対する応答を予測するためのその使用 |
| WO2021234181A1 (en) * | 2020-05-22 | 2021-11-25 | Universität Heidelberg | Use of fap inhibitor in a method of diagnosis |
| CN112138175A (zh) * | 2020-09-01 | 2020-12-29 | 上海市质子重离子临床技术研发中心 | 一种放射性核素99mTc标记FAPI的化合物的制备方法 |
| CN114790194B (zh) * | 2020-12-21 | 2024-03-26 | 苏州药明博锐生物科技有限公司 | 成纤维细胞活化蛋白抑制剂 |
| EP4050018A1 (en) | 2021-01-07 | 2022-08-31 | 3B Pharmaceuticals GmbH | Compounds comprising a fibroblast activation protein ligand and use thereof |
| WO2022148843A1 (en) | 2021-01-07 | 2022-07-14 | 3B Pharmaceuticals Gmbh | Compounds comprising a fibroblast activation protein ligand and use thereof |
| CN114369084B (zh) * | 2021-02-10 | 2023-02-03 | 烟台蓝纳成生物技术有限公司 | 一种截短型伊文思蓝修饰的成纤维细胞活化蛋白抑制剂及其制备方法和应用 |
| US11975079B2 (en) * | 2021-02-10 | 2024-05-07 | Yantai Lannacheng Biotechnology Co., Ltd. | Truncated Evans Blue modified fibroblast activation protein inhibitor, preparation method and application thereof |
| WO2022171811A1 (en) | 2021-02-12 | 2022-08-18 | Philochem Ag | Bivalent fibroblast activation protein ligands for targeted delivery applications |
| EP4043452A1 (en) | 2021-02-12 | 2022-08-17 | Philochem AG | Bivalent fibroblast activation protein ligands for targeted delivery applications |
| CN113105432B (zh) * | 2021-03-30 | 2022-03-04 | 上海交通大学医学院附属仁济医院 | 一种碳-11（11c）放射性药物及其制备方法和应用 |
| WO2022212958A1 (en) * | 2021-04-02 | 2022-10-06 | The Johns Hopkins University | Heterobivalent and homobivalent agents targeting fibroblast activation protein alpha and/or prostate-specific membrane antigen |
| CN113277989B (zh) * | 2021-04-27 | 2022-05-31 | 中南大学湘雅医院 | 一种68Ga标记的分子探针、制备方法及其应用 |
| KR102811593B1 (ko) * | 2021-05-19 | 2025-05-22 | 페로노바 피티와이 리미티드 | 나노입자 매핑 |
| CN113527266A (zh) * | 2021-06-23 | 2021-10-22 | 上海健康医学院 | 一种靶向fap的双氧水响应的前药及其制备方法与应用 |
| GB202109922D0 (en) | 2021-07-09 | 2021-08-25 | Blue Earth Diagnostics Ltd | Radiotracers and therapeutics binding to fibroblast activation protein (fap) |
| EP4122499A1 (en) * | 2021-07-23 | 2023-01-25 | 3B Pharmaceuticals GmbH | Fibroblast activation protein inhibitors and use thereof |
| TW202320805A (zh) * | 2021-08-18 | 2023-06-01 | 美商杜夫特學院信託管理公司 | 用於pet造影之選擇性靶向纖維母細胞活化蛋白之放射性氟標誌試劑 |
| CN113880810B (zh) * | 2021-09-24 | 2023-02-28 | 厦门大学 | 一种核素标记的配合物及其制备方法和应用 |
| MX2024004077A (es) | 2021-10-04 | 2024-04-18 | Philochem Ag | Ligandos de proteina de activacion de fibroblastos radioetiquetados. |
| TW202317541A (zh) | 2021-10-28 | 2023-05-01 | 行政院原子能委員會核能研究所 | 一種靶向成纖維細胞活化蛋白之化合物或其鹽，其製備方法及其用途 |
| WO2023081301A1 (en) * | 2021-11-05 | 2023-05-11 | On Target Laboratories, LLC | Fibroblast activation protein targeted dyes their related uses |
| US20250177582A1 (en) | 2022-01-30 | 2025-06-05 | Philochem Ag | High-affinity ligands of fibroblast activation protein for targeted delivery applications |
| JPWO2023162946A1 (enExample) * | 2022-02-22 | 2023-08-31 | ||
| CA3245347A1 (en) * | 2022-04-21 | 2023-10-26 | Shanghai Sinotau Biotech Co Ltd | DPF INHIBITORS |
| WO2023222558A1 (en) | 2022-05-14 | 2023-11-23 | Zounek Alexis Nikolai | Precursor and theranostic radiotracer with improved tumor retention |
| CN115304582B (zh) * | 2022-07-20 | 2023-05-12 | 北京法伯新天医药科技有限公司 | FAP-α特异性肿瘤诊断显像剂 |
| CN119866334A (zh) * | 2022-07-28 | 2025-04-22 | 拉迪欧制药公司 | 靶向成纤维细胞活化蛋白的组合物及其使用方法 |
| CN115368342B (zh) * | 2022-08-24 | 2024-01-23 | 西南医科大学附属医院 | 成纤维细胞活性蛋白抑制剂、其放射性核素标记物及制备方法和应用 |
| WO2024052333A1 (en) | 2022-09-06 | 2024-03-14 | Philochem Ag | Multivalent fibroblast activation protein ligands for targeted delivery applications |
| EP4342890A1 (en) * | 2022-09-21 | 2024-03-27 | Erasmus University Rotterdam Medical Center | Platform and scaffold for fap targeting agents |
| CA3268257A1 (en) * | 2022-09-23 | 2024-03-28 | Nuclidium Ag | HIGH-PURITY COPPER RADIOPHARMACEUTICAL COMPOSITIONS AND THEIR DIAGNOSTIC AND THERAPEUTIC USES |
| TW202426433A (zh) | 2022-09-23 | 2024-07-01 | 瑞士商紐利迪姆股份公司 | 成纖維細胞活化蛋白（ｆａｐ）抑制劑、ｆａｐ結合物及其診斷與治療用途 |
| WO2024078592A1 (zh) * | 2022-10-14 | 2024-04-18 | 无锡诺宇医药科技有限公司 | 靶向成纤维细胞活化蛋白的药物及其应用 |
| WO2024165072A1 (zh) * | 2023-02-10 | 2024-08-15 | 成都纽瑞特医疗科技股份有限公司 | 一种多肽化合物及其应用 |
| TW202444713A (zh) * | 2023-05-08 | 2024-11-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 靶向成纖維細胞活化蛋白的配體 |
| WO2025029608A1 (en) * | 2023-07-28 | 2025-02-06 | Ratio Therapeutics, Inc. | Fibroblast activation protein-targeted compositions and methods of use thereof |
| WO2025046043A1 (en) | 2023-08-31 | 2025-03-06 | Stichting Radboud Universitair Medisch Centrum | Endometriosis tracer |
| WO2025063849A2 (en) | 2023-09-21 | 2025-03-27 | Erasmus University Medical Center Rotterdam | Dimeric fap targeting agents |
| WO2025125335A1 (en) | 2023-12-13 | 2025-06-19 | Radiovaxx Gmbh | Cytotoxic or radiopharmaceutical compound with sulfur fluoride exchange group |
| WO2025125621A1 (en) | 2023-12-14 | 2025-06-19 | Radiovaxx Gmbh | Cancer-associated protein-targeted strong or covalently binding precursor compounds and radiotracers |
| WO2025146433A1 (en) | 2024-01-05 | 2025-07-10 | Radiovaxx Gmbh | Precursor and theranostic radiotracer with prolonged tumor retention |
| CN118063689B (zh) * | 2024-01-26 | 2025-01-28 | 锐康九域(厦门)医药科技有限公司 | 成纤维细胞激活蛋白-α响应水解致电荷翻转的聚合物-药物偶联物及其制备方法和应用 |
| CN118271393B (zh) * | 2024-05-31 | 2024-09-03 | 中国药科大学 | 一种靶向fap的二聚化合物及其探针和应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2606785A1 (en) * | 2005-05-19 | 2006-11-23 | Genentech, Inc. | Fibroblast activation protein inhibitor compounds and methods |
| EP2921482B1 (en) * | 2007-06-26 | 2018-09-05 | The Johns Hopkins University | Labeled inhibitors of prostate-specific membrane antigen (psma), biological evaluation, and use as imaging agents |
| PL2318366T3 (pl) | 2008-08-01 | 2017-10-31 | Univ Johns Hopkins | Środki wiążące PSMA i ich zastosowania |
| RU2011116223A (ru) * | 2008-09-25 | 2012-10-27 | Моликьюлар Инсайт Фармасьютикалз, Инк. (Us) | Селективные ингибиторы сепразы |
| WO2016149188A1 (en) * | 2015-03-13 | 2016-09-22 | The Johns Hopkins University | 68Ga-LABELED NOTA-CHELATED PSMA-TARGETED IMAGING AND THERAPEUTIC AGENTS |
| EP3222617B1 (en) * | 2009-03-19 | 2022-07-06 | The Johns Hopkins University | Psma-targeting compounds and uses thereof |
| WO2013107820A1 (en) * | 2012-01-17 | 2013-07-25 | Universiteit Antwerpen | Novel fap inhibitors |
| EP2866842A1 (en) * | 2012-06-29 | 2015-05-06 | GE Healthcare UK Limited | Imaging fibrosis |
| AU2013303233C1 (en) * | 2012-08-15 | 2018-08-23 | Visen Medical, Inc. | Prostate specific antigen agents and methods of using same for prostate cancer imaging |
| EP3102242A2 (en) * | 2014-02-03 | 2016-12-14 | Philochem AG | Targeted drug conjugates |
| WO2016065142A2 (en) * | 2014-10-22 | 2016-04-28 | The Johns Hopkins University | New scaffolds and multifunctional intermediates for imaging psma and cancer therapy |
| US10857246B2 (en) * | 2015-06-01 | 2020-12-08 | The Johns Hopkins University | Nuclear imaging and radiotherapeutics agents targeting carbonic anhydrase IX and uses thereof |
| WO2018111989A1 (en) | 2016-12-14 | 2018-06-21 | Purdue Research Foundation | Fibroblast activation protein (fap)-targeted imaging and therapy |
| CA3088326A1 (en) | 2018-02-06 | 2019-08-15 | Universitat Heidelberg | Fap inhibitor |
-
2018
- 2018-10-23 KR KR1020207013693A patent/KR102764076B1/ko active Active
- 2018-10-23 BR BR112020008011-0A patent/BR112020008011A2/pt unknown
- 2018-10-23 KR KR1020247035948A patent/KR20240162157A/ko active Pending
- 2018-10-23 AU AU2018355222A patent/AU2018355222B2/en active Active
- 2018-10-23 MX MX2020004807A patent/MX2020004807A/es unknown
- 2018-10-23 CN CN202310498227.2A patent/CN116617420A/zh active Pending
- 2018-10-23 CN CN201880083520.XA patent/CN111511408A/zh active Pending
- 2018-10-23 EP EP18871298.8A patent/EP3700580A4/en active Pending
- 2018-10-23 JP JP2020523010A patent/JP2021500373A/ja active Pending
- 2018-10-23 CA CA3088138A patent/CA3088138A1/en active Pending
- 2018-10-23 WO PCT/US2018/057086 patent/WO2019083990A2/en not_active Ceased
- 2018-10-23 US US16/758,182 patent/US20200330624A1/en active Pending
- 2018-10-23 EA EA202090776A patent/EA202090776A1/ru unknown
-
2020
- 2020-04-20 IL IL274088A patent/IL274088A/en unknown
- 2020-07-13 MX MX2023013164A patent/MX2023013164A/es unknown
-
2023
- 2023-07-18 US US18/354,282 patent/US11938201B2/en active Active
-
2024
- 2024-02-23 US US18/585,905 patent/US12115233B2/en active Active
- 2024-05-14 JP JP2024078640A patent/JP2024109682A/ja active Pending
- 2024-05-16 AU AU2024203249A patent/AU2024203249A1/en active Pending
- 2024-12-20 US US18/990,863 patent/US20250186628A1/en active Pending
-
2025
- 2025-04-07 US US19/172,114 patent/US20250235565A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021500373A5 (enExample) | ||
| Butte et al. | Near-infrared imaging of brain tumors using the Tumor Paint BLZ-100 to achieve near-complete resection of brain tumors | |
| RU2350355C9 (ru) | Флюоресцентный контрастирующий агент ближней инфракрасной области спектра и способ флуоресцентной томографии | |
| DE60133626T2 (de) | Hydrophile zyaninfarbstoffe | |
| JP5416970B2 (ja) | ニコチン酸及びピコリン酸誘導近赤外線蛍光団 | |
| EP2764406B1 (en) | Compositions and methods for tumor imaging and targeting by a class of organic heptamethine cyanine dyes that possess dual nuclear and near-infrared properties | |
| Cai et al. | Near‐infrared fluorescence imaging of gastrin releasing peptide receptor targeting in prostate cancer lymph node metastases | |
| AU2016208387A1 (en) | Charge-balanced imaging agents | |
| JP2002526458A5 (enExample) | ||
| JP2000095758A (ja) | 近赤外蛍光造影剤および蛍光造影方法 | |
| DE60106389T2 (de) | Vielseitige hydrophile farbstoffe | |
| JP2019512500A (ja) | Ｃａ ｉｘ標的ｎｉｒ色素及びそれらの使用 | |
| Zhou et al. | Targeting tumor hypoxia: a third generation 2-nitroimidazole-indocyanine dye-conjugate with improved fluorescent yield | |
| Zhang et al. | Visualizing tumors in real time: a highly sensitive PSMA probe for NIR-II imaging and intraoperative tumor resection | |
| EP1937676A1 (en) | Biocompatible fluorescent imaging agents | |
| Xu et al. | Design, synthesis, and in vitro and in vivo evaluation of high affinity and specificity near-infrared fluorescent bombesin antagonists for tumor imaging | |
| Yang et al. | Structurally symmetric near-infrared fluorophore IRDye78-protein complex enables multimodal cancer imaging | |
| CN111989324A (zh) | 靶向化合物及其生产方法 | |
| CN106008374B (zh) | 吡嗪类化合物及其在医药上的用途 | |
| US20110280806A1 (en) | Dye conjugate imaging agents | |
| CN112969689A (zh) | 一种含磺酰氟的对parp受体具有高亲和力的化合物及其制备和用途 | |
| WO2024145492A9 (en) | cRGD -CONJUGATED IMAGING AGENT | |
| JP2003510294A (ja) | 手術中に腫瘍の周縁を視覚化するための、血管新生の標的構造物に対する抗体−色素結合物 | |
| US20220387632A1 (en) | Renal clearable fluorescent contrast agent with increased tumor specificity, and imaging method using same | |
| US7326403B2 (en) | Radioactive iodine-labeled compound |