JP2002525099A5 - - Google Patents

Info

Publication number

JP2002525099A5

JP2002525099A5 JP2000572253A JP2000572253A JP2002525099A5 JP 2002525099 A5 JP2002525099 A5 JP 2002525099A5 JP 2000572253 A JP2000572253 A JP 2000572253A JP 2000572253 A JP2000572253 A JP 2000572253A JP 2002525099 A5 JP2002525099 A5 JP 2002525099A5

Authority

JP

Japan

Prior art keywords

polypeptide

seq

variant

native

immune response

Prior art date

1999-09-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 229920001184 polypeptide Polymers 0.000 claims 36
• 108090000765 processed proteins & peptides Proteins 0.000 claims 36
• 102000004196 processed proteins & peptides Human genes 0.000 claims 36
• 230000002163 immunogen Effects 0.000 claims 10
• 210000001744 T-lymphocyte Anatomy 0.000 claims 6
• 239000002671 adjuvant Substances 0.000 claims 6
• 238000012217 deletion Methods 0.000 claims 6
• 230000037430 deletion Effects 0.000 claims 6
• 239000003623 enhancer Substances 0.000 claims 6
• 238000003780 insertion Methods 0.000 claims 6
• 230000037431 insertion Effects 0.000 claims 6
• 238000006467 substitution reaction Methods 0.000 claims 6
• 238000007792 addition Methods 0.000 claims 5
• 238000012986 modification Methods 0.000 claims 5
• 230000004048 modification Effects 0.000 claims 5
• 229960005486 vaccine Drugs 0.000 claims 5
• 239000000427 antigen Substances 0.000 claims 4
• 108091007433 antigens Proteins 0.000 claims 4
• 102000036639 antigens Human genes 0.000 claims 4
• 230000015788 innate immune response Effects 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 3
• 239000003937 drug carrier Substances 0.000 claims 3
• 230000028993 immune response Effects 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 239000000546 pharmaceutical excipient Substances 0.000 claims 3
• 102000040430 polynucleotide Human genes 0.000 claims 3
• 108091033319 polynucleotide Proteins 0.000 claims 3
• 239000002157 polynucleotide Substances 0.000 claims 3
• 108010081208 RMFPNAPYL Proteins 0.000 claims 2
• 230000005867 T cell response Effects 0.000 claims 2
• 125000000539 amino acid group Chemical group 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 2
• PSLWZOIUBRXAQW-UHFFFAOYSA-M dimethyl(dioctadecyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC PSLWZOIUBRXAQW-UHFFFAOYSA-M 0.000 claims 2
• 239000013598 vector Substances 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 102000004127 Cytokines Human genes 0.000 claims 1
• 108090000695 Cytokines Proteins 0.000 claims 1
• 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
• 102000008949 Histocompatibility Antigens Class I Human genes 0.000 claims 1
• 108010088652 Histocompatibility Antigens Class I Proteins 0.000 claims 1
• 102000018713 Histocompatibility Antigens Class II Human genes 0.000 claims 1
• 108010027412 Histocompatibility Antigens Class II Proteins 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 108010073443 Ribi adjuvant Proteins 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 230000003292 diminished effect Effects 0.000 claims 1
• 230000002708 enhancing effect Effects 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• BWHLPLXXIDYSNW-UHFFFAOYSA-N ketorolac tromethamine Chemical compound OCC(N)(CO)CO.OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 BWHLPLXXIDYSNW-UHFFFAOYSA-N 0.000 claims 1
• 208000032839 leukemia Diseases 0.000 claims 1
• 239000003446 ligand Substances 0.000 claims 1
• 239000004005 microsphere Substances 0.000 claims 1
• 239000001397 quillaja saponaria molina bark Substances 0.000 claims 1
• 229930182490 saponin Natural products 0.000 claims 1
• 150000007949 saponins Chemical class 0.000 claims 1
• 230000004936 stimulating effect Effects 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 239000003053 toxin Substances 0.000 claims 1
• 231100000765 toxin Toxicity 0.000 claims 1
• 108700012359 toxins Proteins 0.000 claims 1