JP2002514611A5 - - Google Patents

Download PDF

Info

Publication number
JP2002514611A5
JP2002514611A5 JP2000548013A JP2000548013A JP2002514611A5 JP 2002514611 A5 JP2002514611 A5 JP 2002514611A5 JP 2000548013 A JP2000548013 A JP 2000548013A JP 2000548013 A JP2000548013 A JP 2000548013A JP 2002514611 A5 JP2002514611 A5 JP 2002514611A5
Authority
JP
Japan
Prior art keywords
substituted
group
independently selected
acid
twenty
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2000548013A
Other languages
English (en)
Japanese (ja)
Other versions
JP4487019B2 (ja
JP2002514611A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1999/006826 external-priority patent/WO1999058162A2/en
Publication of JP2002514611A publication Critical patent/JP2002514611A/ja
Publication of JP2002514611A5 publication Critical patent/JP2002514611A5/ja
Application granted granted Critical
Publication of JP4487019B2 publication Critical patent/JP4487019B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2000548013A 1998-03-31 1999-03-29 血管新生疾患を画像化するための薬剤 Expired - Fee Related JP4487019B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8015098P 1998-03-31 1998-03-31
US60/080,150 1998-03-31
US11271598P 1998-12-18 1998-12-18
US60/112,715 1998-12-18
PCT/US1999/006826 WO1999058162A2 (en) 1998-03-31 1999-03-29 Pharmaceuticals for the imaging of angiogenic disorders

Publications (3)

Publication Number Publication Date
JP2002514611A JP2002514611A (ja) 2002-05-21
JP2002514611A5 true JP2002514611A5 (https=) 2009-06-25
JP4487019B2 JP4487019B2 (ja) 2010-06-23

Family

ID=26763137

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000548013A Expired - Fee Related JP4487019B2 (ja) 1998-03-31 1999-03-29 血管新生疾患を画像化するための薬剤

Country Status (20)

Country Link
US (2) US6322770B1 (https=)
EP (1) EP1068224B1 (https=)
JP (1) JP4487019B2 (https=)
KR (1) KR20010042288A (https=)
CN (1) CN1295578A (https=)
AR (1) AR020586A1 (https=)
AT (1) ATE295369T1 (https=)
AU (1) AU5541799A (https=)
BR (1) BR9909420A (https=)
CA (1) CA2324555A1 (https=)
DE (1) DE69925262T2 (https=)
EA (1) EA200001007A1 (https=)
EE (1) EE200000574A (https=)
ES (1) ES2241313T3 (https=)
HU (1) HUP0101468A2 (https=)
IL (1) IL138093A0 (https=)
NO (1) NO20004917L (https=)
PL (1) PL343804A1 (https=)
SK (1) SK13952000A3 (https=)
WO (1) WO1999058162A2 (https=)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965132A (en) * 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
US6749853B1 (en) * 1992-03-05 2004-06-15 Board Of Regents, The University Of Texas System Combined methods and compositions for coagulation and tumor treatment
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
US6794518B1 (en) 1998-12-18 2004-09-21 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
US6989139B2 (en) 2000-02-15 2006-01-24 Bristol-Myers Squibb Pharma Company Matrix metalloproteinase inhibitors
AU2001259961A1 (en) * 2000-05-08 2001-11-20 Interuniversitair Micro-Elektronica Centrum Method and technology for high-throughput lead profiling
US7109167B2 (en) 2000-06-02 2006-09-19 Bracco International B.V. Compounds for targeting endothelial cells, compositions containing the same and methods for their use
US8263739B2 (en) 2000-06-02 2012-09-11 Bracco Suisse Sa Compounds for targeting endothelial cells, compositions containing the same and methods for their use
CA2413957A1 (en) * 2000-06-21 2001-12-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals for use in combination therapy
JP2005538030A (ja) * 2000-06-21 2005-12-15 デュポン ファーマシューティカルズ カンパニー 組み合わせ療法での使用のための血管新生障害の画像診断用医薬
CA2413538A1 (en) * 2000-07-06 2002-01-17 Bristol-Myers Squibb Pharma Company Stable radiopharmaceutical compositions and methods for preparation thereof
EP1337278A2 (en) * 2000-11-27 2003-08-27 Bristol-Myers Squibb Medical Imaging, Inc. Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
TW593278B (en) 2001-01-23 2004-06-21 Wyeth Corp 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
US7271180B2 (en) * 2001-01-23 2007-09-18 Wyeth 1-Aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
DE60231801D1 (de) 2001-04-23 2009-05-14 Mallinckrodt Inc Tc und re markierte radioaktive glycosylierte octreotid-derivate
US7138104B2 (en) * 2001-08-08 2006-11-21 Bristol-Myers Squibb Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
EP1443963B1 (en) 2001-10-22 2014-05-21 The Scripps Research Institute Antibody targeting compounds
EP1572639A4 (en) * 2002-01-24 2006-08-09 Barnes Jewish Hospital ON INTEGRIN TARGET MEDIUM FOR IMAGE PRESENTATION
US7279150B2 (en) 2002-01-24 2007-10-09 Barnes-Jewish Hospital Chelating agents with lipophilic carriers
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
AU2003278807A1 (en) 2002-03-01 2004-08-13 Bracco International B.V. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7985402B2 (en) 2002-03-01 2011-07-26 Bracco Suisse Sa Targeting vector-phospholipid conjugates
US7666979B2 (en) * 2002-03-01 2010-02-23 Bracco International B.V. Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US20050250700A1 (en) * 2002-03-01 2005-11-10 Sato Aaron K KDR and VEGF/KDR binding peptides
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
ES2398393T3 (es) * 2002-03-01 2013-03-15 Dyax Corp. Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico y terapia
EP2009676B8 (en) * 2002-05-08 2012-11-21 Phoseon Technology, Inc. A semiconductor materials inspection system
US6961607B2 (en) * 2002-07-31 2005-11-01 Uzgiris Egidijus E Method for assessing myocardial angiogenesis
US20040224986A1 (en) 2002-08-16 2004-11-11 Bart De Corte Piperidinyl targeting compounds that selectively bind integrins
AU2003265898A1 (en) * 2002-09-05 2004-03-29 Genentech, Inc. Infusion catheter having an integrated doppler transducer
US20040047917A1 (en) * 2002-09-06 2004-03-11 Stephen Wilson Drug delivery and targeting with vitamin B12 conjugates
EP1539804B1 (fr) * 2002-09-19 2007-01-03 Centre National De La Recherche Scientifique (Cnrs) Synthese et caracterisation de nouveaux systemes de guidage et de vectorisation de molecules d'interet therapeutique vers des cellules cibles.
WO2004069281A1 (en) * 2003-01-30 2004-08-19 The General Hospital Corporation Bifunctional molecules comprising at least one integrin-binding and their use in imaging and therapy of angiogenesis and related disorders
ES2396368T3 (es) 2003-03-03 2013-02-21 Dyax Corporation Péptidos que se unen específicamente al receptor del HGF (CMET) y usos de los mismos
DE602004024299D1 (de) * 2003-05-12 2010-01-07 Lantheus Medical Imaging Inc Vitronectin rezeptorantagonisten und ihre verwendung als radiopharmazeutika
CA2534426A1 (en) * 2003-08-08 2005-02-17 Barnes-Jewish Hospital Emulsion particles for imaging and therapy and methods of use thereof
US20050112064A1 (en) * 2003-08-12 2005-05-26 Sonya Franklin DNA-dependent MRI contrast agents
WO2005077407A1 (en) * 2004-01-16 2005-08-25 Barnes-Jewish Hospital Targeted atherosclerosis treatment
US20070141267A1 (en) * 2004-02-23 2007-06-21 Sonnenschein Mark F Aqueous-based adhesive for bonding low surface energy substrates
AU2005253962A1 (en) 2004-06-09 2005-12-29 Kereos, Inc. Lipophilic derivatives of chelate monoamides
DE602005000853D1 (de) * 2004-07-02 2007-05-24 Vivactis Nv Messung der Wärme erzeugt durch einen chemischen oder biologischen Prozess.
WO2006094725A1 (en) * 2005-03-10 2006-09-14 Bayer Schering Pharma Aktiengesellschaft Chelators for radioactively labeled conjugates comprising a stabilizing sidechain
JP2008540339A (ja) * 2005-04-29 2008-11-20 ワイス Nogoレセプター機能モチーフおよびそれに関するペプチド模倣物、ならびにそれらを使用する方法
US20070122408A1 (en) * 2005-10-20 2007-05-31 The Scripps Research Institute Fc Labeling for Immunostaining and Immunotargeting
US20070140973A1 (en) * 2005-12-15 2007-06-21 Bristol-Myers Squibb Pharma Company Contrast agents for myocardium perfusion imaging
CA2650574A1 (en) * 2006-04-27 2007-11-08 Barnes-Jewish Hospital Detection and imaging of target tissue
EP2076120A1 (en) * 2006-09-29 2009-07-08 Washington University Combinations for treatment of neovasculature
WO2008073842A1 (en) * 2006-12-08 2008-06-19 Molecular Image Inc. Methods for diagnosis and monitoring of neurologic diseases using magnetic resonance methods
US8194963B2 (en) * 2008-03-10 2012-06-05 Siemens Medical Solutions Usa, Inc. Efficient estimator of pharmacokinetic parameters in breast MRI
CN102088991A (zh) 2008-05-13 2011-06-08 堪萨斯大学 金属提取肽标签和相关方法
US20100178245A1 (en) * 2009-01-13 2010-07-15 Arnsdorf Morton F Biocompatible Microbubbles to Deliver Radioactive Compounds to Tumors, Atherosclerotic Plaques, Joints and Other Targeted Sites
JP2012517447A (ja) 2009-02-10 2012-08-02 ザ スクリプス リサーチ インスティチュート 化学的にプログラムされたワクチン接種法
CN101659694B (zh) * 2009-05-06 2012-12-12 河北科技大学 抗肿瘤环五肽化合物及其制备方法
US9187735B2 (en) 2012-06-01 2015-11-17 University Of Kansas Metal abstraction peptide with superoxide dismutase activity
AU2014241182A1 (en) * 2013-03-27 2015-09-24 Theranos Ip Company, Llc Biological sample processing
CA2910802A1 (en) * 2013-04-12 2014-10-16 Samir El Andaloussi Therapeutic delivery vesicles
DE102013113156A1 (de) * 2013-11-28 2015-05-28 Freie Universität Berlin Verbindung und Verfahren zur selektiven Radiomarkierung von Polypeptiden mittels Festphasensynthese
KR102548998B1 (ko) * 2020-03-31 2023-06-29 재단법인 아산사회복지재단 혈전영상을 위한 방사성의약품 및 조성물
US12377166B2 (en) * 2021-08-26 2025-08-05 University Of Washington Iron oxide nanoparticle for targeted chemo-immunotherapy

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957939A (en) 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
DE3360633D1 (en) 1982-02-12 1985-10-03 Unitika Ltd Anti-cancer device
US4472509A (en) 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
US5135736A (en) 1988-08-15 1992-08-04 Neorx Corporation Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
IL91933A (en) 1988-10-11 1994-12-29 Univ Southern California Vasoactive immunoconjugates useful for increasing the vascular permeability or the blood supply to neoplastic or otherwise diseased tissues
WO1990005539A1 (en) 1988-11-14 1990-05-31 Brigham And Women's Hospital Antibodies specific for elam-1 and the use thereof
US5376356A (en) 1989-03-14 1994-12-27 Neorx Corporation Imaging tissue sites of inflammation
IL112768A (en) 1989-04-10 1998-06-15 Oncogen Pharmaceutical compositions containing oncostatin m for inhibiting angiogenesis
US5395609A (en) 1989-06-19 1995-03-07 Antisoma Limited Synthetic peptides for use in tumor detection
DK0436005T3 (da) 1989-07-20 1995-07-03 Sandoz Ltd Mærkede polypeptidderivater
IN172208B (https=) 1990-04-02 1993-05-01 Sint Sa
WO1993008210A1 (en) 1991-10-18 1993-04-29 Beth Israel Hospital Association Vascular permeability factor targeted compounds
US5776427A (en) 1992-03-05 1998-07-07 Board Of Regents, The University Of Texas System Methods for targeting the vasculature of solid tumors
PT627940E (pt) 1992-03-05 2003-07-31 Univ Texas Utilizacao de imunoconjugados para o diagnostico e/ou terapia de tumores vascularizados
US5965132A (en) 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
CN1701814A (zh) 1992-11-13 2005-11-30 马克斯普朗克科学促进协会 作为血管内皮生长因子受体的f1k-1
US5342757A (en) 1992-11-13 1994-08-30 Ludwig Institute For Cancer Research Monoclonal antibodies which specifically binds to endosialin, a 165 Kd glycoprotein found on tumor vascular endothelium, and uses thereof
DE4301871A1 (de) 1993-01-13 1994-07-14 Diagnostikforschung Inst Neue Mittel zur Diagnose von Gefäßerkrankungen
US5744120A (en) 1993-03-30 1998-04-28 The Dupont Merick Pharmaceutical Company Ternary radiopharmaceutical complexes
DE4311023C2 (de) 1993-03-31 1996-05-02 Diagnostikforschung Inst Bifunktionelle chalkogenatom-unterbrochene Chelatbildner von Typ XN¶1¶S¶1¶O¶1¶ für radioaktive Isotope, deren Metallkomplexe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Mittel
ES2114209T3 (es) 1993-07-19 1998-05-16 Resolution Pharm Inc Queladores de radionuclidos de tipo hidrazino que tienen una configuracion n3s.
US5753230A (en) 1994-03-18 1998-05-19 The Scripps Research Institute Methods and compositions useful for inhibition of angiogenesis
ZA955391B (en) 1994-06-29 1996-02-09 Smithkline Beecham Corp Vitronectin receptor antagonists
DE69519929T2 (de) 1994-07-11 2001-05-23 Board Of Regents, The University Of Texas System Verfahren und zusammensetzungen für die spezifische koagulation von tumorgefässen
IL123164A (en) 1995-08-30 2001-03-19 Searle & Co Meta-guanidine urea thiourea or azacyclic amino benzoic acid derivatives and pharmaceutical compositions containing them
DE19536781A1 (de) 1995-09-21 1997-03-27 Diagnostikforschung Inst Bifunktionelle sulfidhaltige Sulfonamid-Chelatbildner vom Typ XSNS für radioaktive Isotope
DE19536785A1 (de) 1995-09-21 1997-03-27 Diagnostikforschung Inst Bifunktionelle sulfidhaltige Sulfonamid-Chelatbildner vom Typ S¶2¶NY für radioaktive Isotope
US5910300A (en) * 1995-11-01 1999-06-08 Bracco Research S.A. Amphiphilic linkers for coupling administrable diagnostically or physiologically active agents and bioselective targeting compounds
CA2237524A1 (en) 1995-11-14 1997-05-22 Du Pont Pharmaceuticals Company Novel macrocyclic compounds as metalloprotease inhibitors
US6331285B1 (en) * 1996-06-05 2001-12-18 Palatin Technologies, Inc. Structurally determined cyclic metallo-constructs and applications
ZA978758B (en) * 1996-10-02 1999-03-30 Du Pont Merck Pharma Technetium-99m-labeled chelator incorporated cyclic peptides that bind to the GPIIb/IIIa receptor as imaging agents
US6056973A (en) 1996-10-11 2000-05-02 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method of preparation
AU4753997A (en) * 1996-10-16 1998-05-11 Burnham Institute, The Magnetic resonance imaging of thrombi
GB9708265D0 (en) 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
ES2206689T3 (es) 1996-10-28 2004-05-16 Amersham Health As Agentes de contraste.
DE19725368A1 (de) * 1997-06-16 1998-12-17 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren und deren Verwendung für bildgebende Verfahren
JP2001516055A (ja) * 1997-09-10 2001-09-25 ザ バーナム インスティチュート 腫瘍中の血管形成血管系にホーミングする分子を同定する方法
CA2320339A1 (en) * 1998-02-11 1999-08-19 Resolution Pharmaceuticals Inc. Angiogenesis targeting molecules
WO2000006169A1 (en) 1998-07-29 2000-02-10 Merck & Co., Inc. Integrin receptor antagonists

Similar Documents

Publication Publication Date Title
JP2002514611A5 (https=)
TWI776821B (zh) α-V β-6整合素配位子
JPH09512806A (ja) 新規なアミノ酸誘導体、その製造方法及びこれらの化合物を含む医薬組成物(ii)
JP2013533864A5 (https=)
FI76558B (fi) Foerfarande foer framstaellning av en vid blodtrycksjukdom anvaendbar inhibition foer angiotensinomvandlande enzym.
JP2008518978A5 (https=)
RU2001127246A (ru) Соединения-модуляторы пептида β-амилоида (варианты), фармацевтическая композиция, способ предотвращения агрегации природных пептидов β-амилоида, способ обнаружения присутствия или отсутствия природных пептидов β-амилоида в биологическом образце и способ лечения заболевания у субъекта, ассоциированного с β-амилоидозом
RU96101161A (ru) Новые пептидные производные
JP2007537989A (ja) 安定化ペプチド
JP2007504144A5 (https=)
JP2016515999A5 (https=)
JP2002530430A (ja) C型肝炎ウイルスns3プロテアーゼ阻害用の医薬組成物
RU2005138717A (ru) Способ получения дипептида (варианты)
WO2009003284A8 (en) Novel peptides, use thereof in cosmetic and cosmeceutic applications, and compositions comprising same
AU2001264679A1 (en) Synthesis of n-(n-(3,3-dimethylbutyl)-l-alpha-aspartyl)-l-phenylalanine 1-methylester using oxazolidinone derivatives
JP2017518363A5 (https=)
JP3810083B2 (ja) 成長因子の放出を促進し得る2−アルキルトリプトファン含有ペプチド化合物
JPS6136297A (ja) カルボキシアルキルジペプチドを製造する方法
JP2006505555A5 (https=)
JP2006505621A5 (https=)
JP2008520658A5 (https=)
JP2006528208A5 (https=)
JP2003522184A5 (https=)
EP3347369B1 (en) Novel compounds with dual activity
Friedman et al. Characterization of the intestinal transport parameters for small peptide drugs