JP2008520658A5 - - Google Patents
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- Publication number
- JP2008520658A5 JP2008520658A5 JP2007542955A JP2007542955A JP2008520658A5 JP 2008520658 A5 JP2008520658 A5 JP 2008520658A5 JP 2007542955 A JP2007542955 A JP 2007542955A JP 2007542955 A JP2007542955 A JP 2007542955A JP 2008520658 A5 JP2008520658 A5 JP 2008520658A5
- Authority
- JP
- Japan
- Prior art keywords
- contrast agent
- amino acid
- formula
- agent according
- units
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 2
- 150000003973 alkyl amines Chemical class 0.000 claims description 2
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 125000002837 carbocyclic group Chemical group 0.000 claims description 2
- 125000003709 fluoroalkyl group Chemical group 0.000 claims description 2
- 125000000623 heterocyclic group Chemical group 0.000 claims description 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- 239000002872 contrast media Substances 0.000 claims 11
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 239000012217 radiopharmaceutical Substances 0.000 claims 4
- 229940121896 radiopharmaceutical Drugs 0.000 claims 4
- 230000002799 radiopharmaceutical effect Effects 0.000 claims 4
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 3
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical group OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 claims 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 3
- 239000004472 Lysine Substances 0.000 claims 3
- 239000002738 chelating agent Substances 0.000 claims 3
- 235000018417 cysteine Nutrition 0.000 claims 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 2
- 235000003704 aspartic acid Nutrition 0.000 claims 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 2
- 239000013522 chelant Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- IYKLZBIWFXPUCS-VIFPVBQESA-N (2s)-2-(naphthalen-1-ylamino)propanoic acid Chemical group C1=CC=C2C(N[C@@H](C)C(O)=O)=CC=CC2=C1 IYKLZBIWFXPUCS-VIFPVBQESA-N 0.000 claims 1
- BLCJBICVQSYOIF-UHFFFAOYSA-N 2,2-diaminobutanoic acid Chemical compound CCC(N)(N)C(O)=O BLCJBICVQSYOIF-UHFFFAOYSA-N 0.000 claims 1
- GNTIRRQEPHPUCI-UHFFFAOYSA-N 2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethylamino]-2-oxoethoxy]acetic acid Chemical compound NCCOCCOCCOCCNC(=O)COCC(O)=O GNTIRRQEPHPUCI-UHFFFAOYSA-N 0.000 claims 1
- PECYZEOJVXMISF-UHFFFAOYSA-N 3-aminoalanine Chemical compound [NH3+]CC(N)C([O-])=O PECYZEOJVXMISF-UHFFFAOYSA-N 0.000 claims 1
- 125000004080 3-carboxypropanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C(O[H])=O 0.000 claims 1
- UQTZMGFTRHFAAM-ZETCQYMHSA-N 3-iodo-L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(I)=C1 UQTZMGFTRHFAAM-ZETCQYMHSA-N 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- NTWVQPHTOUKMDI-YFKPBYRVSA-N N-Methyl-arginine Chemical compound CN[C@H](C(O)=O)CCCN=C(N)N NTWVQPHTOUKMDI-YFKPBYRVSA-N 0.000 claims 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 229940009098 aspartate Drugs 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000001142 dicarboxylic acid group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229930195712 glutamate Natural products 0.000 claims 1
- 229940049906 glutamate Drugs 0.000 claims 1
- 125000000350 glycoloyl group Chemical group O=C([*])C([H])([H])O[H] 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 238000011503 in vivo imaging Methods 0.000 claims 1
- 229960003646 lysine Drugs 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229960003104 ornithine Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- 125000000542 sulfonic acid group Chemical group 0.000 claims 1
- 239000013589 supplement Substances 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20045081 | 2004-11-22 | ||
| NO20045081 | 2004-11-22 | ||
| PCT/NO2005/000435 WO2006054904A2 (en) | 2004-11-22 | 2005-11-21 | Contrast agents to target extracellular matrix |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012144870A Division JP2012207027A (ja) | 2004-11-22 | 2012-06-28 | 造影剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008520658A JP2008520658A (ja) | 2008-06-19 |
| JP2008520658A5 true JP2008520658A5 (https=) | 2012-02-23 |
| JP5116480B2 JP5116480B2 (ja) | 2013-01-09 |
Family
ID=36182407
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007542955A Expired - Fee Related JP5116480B2 (ja) | 2004-11-22 | 2005-11-21 | 造影剤 |
| JP2012144870A Pending JP2012207027A (ja) | 2004-11-22 | 2012-06-28 | 造影剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012144870A Pending JP2012207027A (ja) | 2004-11-22 | 2012-06-28 | 造影剤 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8182790B2 (https=) |
| EP (2) | EP2243496A3 (https=) |
| JP (2) | JP5116480B2 (https=) |
| KR (1) | KR20070091609A (https=) |
| CN (1) | CN101107016B (https=) |
| AT (1) | ATE494913T1 (https=) |
| AU (1) | AU2005307195A1 (https=) |
| BR (1) | BRPI0518328A2 (https=) |
| CA (1) | CA2586621A1 (https=) |
| DE (1) | DE602005025911D1 (https=) |
| ES (1) | ES2358745T3 (https=) |
| IL (1) | IL182898A0 (https=) |
| MX (1) | MX2007006050A (https=) |
| NO (1) | NO20073039L (https=) |
| RU (1) | RU2007118385A (https=) |
| WO (1) | WO2006054904A2 (https=) |
| ZA (1) | ZA200705043B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0610395D0 (en) * | 2006-05-25 | 2006-07-05 | Ge Healthcare Ltd | Novel imaging agents |
| EP2056886A2 (en) * | 2006-08-28 | 2009-05-13 | GE Healthcare Limited | 68ga-labeled peptide-based radiopharmaceuticals |
| JP2008266194A (ja) * | 2007-04-19 | 2008-11-06 | Hiroshi Tanaka | 分子プローブの原料として有用な新規有機化合物 |
| GB0722650D0 (en) * | 2007-11-19 | 2007-12-27 | Ge Healthcare Ltd | Novel imaging method |
| JP5604305B2 (ja) | 2007-12-13 | 2014-10-08 | アンセルム（アンスチチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル） | 線維症の非侵襲性の特異的イメージングのための、ポリペプチド、環状ポリペプチドおよびそれを含む医薬 |
| US8815214B2 (en) * | 2008-01-18 | 2014-08-26 | Visen Medical, Inc. | Fluorescent imaging agents |
| CN102088991A (zh) | 2008-05-13 | 2011-06-08 | 堪萨斯大学 | 金属提取肽标签和相关方法 |
| GB0814722D0 (en) * | 2008-08-12 | 2008-09-17 | Ge Healthcare Ltd | Treatment monitoring |
| GB0910013D0 (en) * | 2009-06-10 | 2009-07-22 | Ge Healthcare Ltd | PET imaging of fibogenesis |
| KR100991716B1 (ko) * | 2009-10-22 | 2010-11-04 | 경북대학교 산학협력단 | 광학영상 조영제, 그 용도 및 장치 |
| CN102504603B (zh) * | 2011-10-20 | 2014-01-29 | 中国海洋大学 | 一种多聚物与生物染色剂的偶合物及其制备方法和用途 |
| US9187735B2 (en) | 2012-06-01 | 2015-11-17 | University Of Kansas | Metal abstraction peptide with superoxide dismutase activity |
| WO2015085005A1 (en) * | 2013-12-03 | 2015-06-11 | The General Hospital Corporation | Molecular imaging probes |
| CN117623996B (zh) * | 2022-08-10 | 2025-07-22 | 中国药科大学 | 一种二价keap1-nrf2抑制剂、制备方法及其医药用途 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4647447A (en) | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| US4615876A (en) * | 1983-04-25 | 1986-10-07 | Curators Of The University Of Missouri | Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides |
| US4687659A (en) | 1984-11-13 | 1987-08-18 | Salutar, Inc. | Diamide-DTPA-paramagnetic contrast agents for MR imaging |
| US5268486A (en) | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
| US6048982A (en) | 1986-04-18 | 2000-04-11 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
| ATE145337T1 (de) | 1988-05-02 | 1996-12-15 | Phanos Tech Inc | Verbindungen, zusammensetzungen und verfahren zum binden von bio-affektions-substanzen an oberflächenmembranen von bioteilchen |
| GB8903022D0 (en) * | 1989-02-10 | 1989-03-30 | Celltech Ltd | Chemical compounds |
| EP0643706A1 (en) | 1991-11-27 | 1995-03-22 | Zynaxis Inc. | Compounds, compositions and methods for binding bio-affecting substances to surface membranes of bio-particles |
| DE69735901T2 (de) | 1996-10-28 | 2007-05-10 | Ge Healthcare As | Verbesseringen an oder in verbindung mit diagnostischen/therapeutischen mitteln |
| ATE314097T1 (de) | 1996-10-28 | 2006-01-15 | Amersham Health As | Kontrastmittel |
| JP2001509796A (ja) * | 1997-01-29 | 2001-07-24 | ニユコメド・イメージング・アクシエセルカペト | 重合体 |
| EP1037947B1 (en) | 1997-07-28 | 2003-09-10 | Amersham plc | Cyanine dyes |
| US5942637A (en) * | 1998-03-30 | 1999-08-24 | North Dakota State University Research Foundation | Compounds containing tetradecachlorocyclohexasilane dianion |
| US6852318B1 (en) * | 1998-05-08 | 2005-02-08 | The Regents Of The University Of California | Methods for detecting and inhibiting angiogenesis |
| WO1999058139A2 (en) * | 1998-05-08 | 1999-11-18 | The Regents Of The University Of California | Methods for detecting and inhibiting angiogenesis |
| JP2000095758A (ja) * | 1998-09-18 | 2000-04-04 | Schering Ag | 近赤外蛍光造影剤および蛍光造影方法 |
| US6230777B1 (en) | 1999-02-04 | 2001-05-15 | Midmac Systems, Inc. | Filter forming and joining apparatus |
| CA2405469C (en) * | 2000-04-12 | 2012-03-20 | Amersham Health As | Integrin binding peptide derivatives |
| NO20004795D0 (no) * | 2000-09-26 | 2000-09-26 | Nycomed Imaging As | Peptidbaserte forbindelser |
| EP1337278A2 (en) * | 2000-11-27 | 2003-08-27 | Bristol-Myers Squibb Medical Imaging, Inc. | Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent |
| BRPI0210886B8 (pt) * | 2001-07-10 | 2021-05-25 | Amersham Health As | composto, composição farmacêutica, uso de um composto, e, métodos de geração de imagens, de monitoração do efeito do tratamento de um corpo humano ou animal com uma droga para combater uma condição associada com câncer e de tratamento de câncer ou de uma doença relacionada em um corpo humano ou animal |
| GB0116815D0 (en) | 2001-07-10 | 2001-08-29 | Nycomed Amersham Plc | Improved chelator conjugates |
| GB0206750D0 (en) | 2002-03-22 | 2002-05-01 | Amersham Plc | Radiofluorination methods |
| JP2006510576A (ja) | 2002-06-17 | 2006-03-30 | カルテラ、アクチボラグ | アテローム性動脈硬化症のプラーク形成の進行を防止するためのインテグリンα１０鎖の方法および使用 |
| US7063158B2 (en) | 2003-06-16 | 2006-06-20 | Deepwater Technologies, Inc. | Bottom tensioned offshore oil well production riser |
| NO20033115D0 (no) * | 2003-07-08 | 2003-07-08 | Amersham Health As | Peptid-baserte forbindelser |
| GB0317815D0 (en) | 2003-07-30 | 2003-09-03 | Amersham Health As | Imaging agents |
| WO2005019247A2 (en) | 2003-08-15 | 2005-03-03 | Board Of Regents, The University Of Texas System | Cyclic peptide and imaging compound compositions and uses for targeted imaging and therapy |
| JP2007512321A (ja) * | 2003-11-24 | 2007-05-17 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
| ATE447417T1 (de) * | 2004-03-04 | 2009-11-15 | Ge Healthcare As | Konjugate von angiotensin-peptid analoga und chelatbildner für diagnose und therapie |
| RU2393167C2 (ru) * | 2004-06-16 | 2010-06-27 | Джи-И Хелткер АС | Пептидные соединения |
| JP5280682B2 (ja) * | 2004-06-16 | 2013-09-04 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | ペプチド系化合物 |
-
2005
- 2005-11-21 DE DE602005025911T patent/DE602005025911D1/de not_active Expired - Lifetime
- 2005-11-21 WO PCT/NO2005/000435 patent/WO2006054904A2/en not_active Ceased
- 2005-11-21 ES ES05817391T patent/ES2358745T3/es not_active Expired - Lifetime
- 2005-11-21 BR BRPI0518328-6A patent/BRPI0518328A2/pt not_active Application Discontinuation
- 2005-11-21 EP EP10169506A patent/EP2243496A3/en not_active Withdrawn
- 2005-11-21 MX MX2007006050A patent/MX2007006050A/es not_active Application Discontinuation
- 2005-11-21 CN CN2005800470720A patent/CN101107016B/zh not_active Expired - Fee Related
- 2005-11-21 RU RU2007118385/04A patent/RU2007118385A/ru not_active Application Discontinuation
- 2005-11-21 EP EP05817391A patent/EP1814598B1/en not_active Expired - Lifetime
- 2005-11-21 US US11/719,662 patent/US8182790B2/en not_active Expired - Fee Related
- 2005-11-21 CA CA002586621A patent/CA2586621A1/en not_active Abandoned
- 2005-11-21 AU AU2005307195A patent/AU2005307195A1/en not_active Abandoned
- 2005-11-21 AT AT05817391T patent/ATE494913T1/de not_active IP Right Cessation
- 2005-11-21 KR KR1020077011496A patent/KR20070091609A/ko not_active Withdrawn
- 2005-11-21 JP JP2007542955A patent/JP5116480B2/ja not_active Expired - Fee Related
-
2007
- 2007-05-01 IL IL182898A patent/IL182898A0/en unknown
- 2007-06-07 ZA ZA200705043A patent/ZA200705043B/xx unknown
- 2007-06-14 NO NO20073039A patent/NO20073039L/no not_active Application Discontinuation
-
2012
- 2012-06-28 JP JP2012144870A patent/JP2012207027A/ja active Pending
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