JP2005518361A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005518361A5 JP2005518361A5 JP2003546874A JP2003546874A JP2005518361A5 JP 2005518361 A5 JP2005518361 A5 JP 2005518361A5 JP 2003546874 A JP2003546874 A JP 2003546874A JP 2003546874 A JP2003546874 A JP 2003546874A JP 2005518361 A5 JP2005518361 A5 JP 2005518361A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- concentration
- alleviating
- riboflavin
- valine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 29
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 12
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 8
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims 8
- 239000004475 Arginine Substances 0.000 claims 6
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims 6
- 239000004471 Glycine Substances 0.000 claims 6
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 6
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 6
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 6
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 6
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 6
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 6
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 6
- 239000004473 Threonine Substances 0.000 claims 6
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 6
- 235000004279 alanine Nutrition 0.000 claims 6
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 6
- 229960003121 arginine Drugs 0.000 claims 6
- 229960003104 ornithine Drugs 0.000 claims 6
- 229960002477 riboflavin Drugs 0.000 claims 6
- 235000019192 riboflavin Nutrition 0.000 claims 6
- 239000002151 riboflavin Substances 0.000 claims 6
- 239000004474 valine Substances 0.000 claims 6
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 5
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 4
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 4
- 238000002512 chemotherapy Methods 0.000 claims 4
- 239000003085 diluting agent Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 239000012636 effector Substances 0.000 claims 4
- 208000030159 metabolic disease Diseases 0.000 claims 4
- 235000016709 nutrition Nutrition 0.000 claims 4
- 208000030212 nutrition disease Diseases 0.000 claims 4
- 229960003080 taurine Drugs 0.000 claims 4
- 231100000331 toxic Toxicity 0.000 claims 4
- 230000002588 toxic effect Effects 0.000 claims 4
- 230000004143 urea cycle Effects 0.000 claims 4
- 235000001014 amino acid Nutrition 0.000 claims 3
- 229940024606 amino acid Drugs 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims 2
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims 2
- 229960002173 citrulline Drugs 0.000 claims 2
- 235000013477 citrulline Nutrition 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- OQGRFQCUGLKSAV-UHFFFAOYSA-N n-(2,6-dioxopiperidin-3-yl)-2-phenylacetamide Chemical compound C1CC(=O)NC(=O)C1NC(=O)CC1=CC=CC=C1 OQGRFQCUGLKSAV-UHFFFAOYSA-N 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 235000009697 arginine Nutrition 0.000 claims 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/995,010 US20030105104A1 (en) | 2001-11-27 | 2001-11-27 | Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy |
| PCT/US2002/037354 WO2003045372A1 (en) | 2001-11-27 | 2002-11-21 | Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005518361A JP2005518361A (ja) | 2005-06-23 |
| JP2005518361A5 true JP2005518361A5 (https=) | 2006-01-05 |
| JP4614660B2 JP4614660B2 (ja) | 2011-01-19 |
Family
ID=25541300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003546874A Expired - Fee Related JP4614660B2 (ja) | 2001-11-27 | 2002-11-21 | 細胞傷害的化学療法の毒性作用を軽減するために有用な、アミノ酸およびリボフラビンの配合物 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20030105104A1 (https=) |
| EP (1) | EP1450781B1 (https=) |
| JP (1) | JP4614660B2 (https=) |
| KR (1) | KR100953483B1 (https=) |
| CN (1) | CN100358527C (https=) |
| AT (1) | ATE330595T1 (https=) |
| BR (1) | BR0214430A (https=) |
| CA (1) | CA2468133C (https=) |
| DE (1) | DE60212693T2 (https=) |
| EA (1) | EA009516B1 (https=) |
| HU (1) | HU230986B1 (https=) |
| IL (2) | IL162141A0 (https=) |
| MX (1) | MXPA04004994A (https=) |
| NO (1) | NO332858B1 (https=) |
| NZ (1) | NZ532833A (https=) |
| PL (1) | PL353656A1 (https=) |
| RO (1) | RO121173B1 (https=) |
| SI (1) | SI21542A (https=) |
| UA (1) | UA78977C2 (https=) |
| WO (1) | WO2003045372A1 (https=) |
| ZA (1) | ZA200404115B (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004013142A1 (en) * | 2002-08-02 | 2004-02-12 | The Institute Of Radiation Medicine, Academy Of Miilitary Medical Sciences, People's Liberation Army | A riboflavin derivative and its manufacture and uses |
| US20060035981A1 (en) * | 2003-08-02 | 2006-02-16 | Mazzio Elizabeth A | Inhibition of anaerobic glucose metabolism and corresponding composition as a natural non-toxic approach to cancer treatment |
| US20070248693A1 (en) * | 2003-08-02 | 2007-10-25 | Elizabeth Mazzio | Nutraceutical composition and method of use for treatment / prevention of cancer |
| RU2240788C1 (ru) * | 2003-09-09 | 2004-11-27 | Воронежская государственная медицинская академия им. Н.Н. Бурденко | Детоксикационное средство |
| SI2153870T1 (sl) | 2004-11-26 | 2014-05-30 | Ucl Business Plc | Sestavki, ki obsegajo ornitin in fenilacetat ali fenilbutirat, za zdravljenje hepatitične encefalopatije |
| EP2328007B1 (en) * | 2005-09-19 | 2014-12-24 | CDM Optics, Inc. | Task-based imaging systems |
| WO2007119378A1 (ja) * | 2006-03-15 | 2007-10-25 | Suntory Limited | リボフラビンとセサミン類とを含有する組成物 |
| WO2008050836A1 (en) * | 2006-10-25 | 2008-05-02 | Ajinomoto Co., Inc. | Agent for ameliorating adverse side-effect of chemotherapeutic agent |
| JPWO2008105384A1 (ja) * | 2007-02-26 | 2010-06-03 | 協和発酵バイオ株式会社 | シトルリン含有錠剤 |
| AU2008239318B2 (en) | 2007-03-15 | 2013-10-03 | Suntory Holdings Limited | Anti-fatigue agent |
| US9101537B2 (en) | 2008-07-25 | 2015-08-11 | Reven Pharmaceuticals, Inc. | Compositions and methods for the prevention and treatment of cardiovascular diseases |
| AU2014200578B2 (en) * | 2008-09-19 | 2016-08-11 | Société des Produits Nestlé S.A. | Nutritional support to prevent or moderate bone marrow paralysis or neutropenia during anti-cancer treatment |
| RU2011115184A (ru) | 2008-09-19 | 2012-10-27 | Нестек С.А. (Ch) | Питательная поддержка для предупреждения или ослабления паралича костного мозга или нейтропении во время противораковой терапии |
| HUE035921T2 (en) | 2009-04-03 | 2018-05-28 | Ocera Therapeutics Inc | L-ornithine phenyl acetate and methods of making thereof |
| CN104434894A (zh) | 2009-06-08 | 2015-03-25 | Ucl商业有限公司 | 使用l-鸟氨酸苯乙酸盐治疗门静脉高压和恢复肝功能 |
| US8449512B2 (en) | 2010-04-09 | 2013-05-28 | Davinci Biomedical Research Products Inc. | Stoma stabilitating device and method |
| EP2397458A1 (en) * | 2010-06-21 | 2011-12-21 | Lunamed AG | Organic salts and co-crystals of phenylbutyric acid |
| JP2013532661A (ja) | 2010-07-22 | 2013-08-19 | リベン ファーマシューティカルズ インコーポレイテッド | 磁気双極子安定化溶液の使用を含む疾患を処置または改善する方法および行動を向上させる方法 |
| MX350541B (es) * | 2010-09-24 | 2017-09-08 | Univ Florida | Materiales y metodos para mejorar la funcion gastrointestinal. |
| US8946473B2 (en) | 2010-10-06 | 2015-02-03 | Ocera Therapeutics, Inc. | Methods of making L-ornithine phenyl acetate |
| CN103429234B (zh) | 2010-12-10 | 2016-10-05 | 布罗迪健康科学有限公司 | 茉莉酮酸酯治疗膀胱功能障碍的用途 |
| KR101919747B1 (ko) * | 2011-02-17 | 2018-11-20 | 각꼬호우진 구루메 다이가쿠 | 화학요법제의 항종양 활성 증강제 |
| PL2729008T3 (pl) * | 2011-07-07 | 2017-10-31 | Res Cancer Institute Of America | Systemy, sposoby i formulacje do leczenia raka |
| EP2968241B1 (en) | 2013-03-11 | 2018-10-31 | University of Florida Research Foundation, Inc. | Materials and methods for improving lung function and for prevention and/or treatment of radiation-induced lung complications |
| WO2015067759A1 (en) * | 2013-11-08 | 2015-05-14 | Legacy Healthcare Ltd | Method for the management of cancer and treatment of cancer comorbidities |
| JP6598425B2 (ja) * | 2014-02-27 | 2019-10-30 | 花王株式会社 | 疲労の評価方法 |
| ES2769000T3 (es) | 2014-11-24 | 2020-06-24 | Ucl Business Ltd | Tratamiento de enfermedades asociadas con la activación de células estrelladas hepáticas utilizando terapias reductoras de amoníaco |
| WO2017031131A1 (en) | 2015-08-18 | 2017-02-23 | Ocera Therapeutics, Inc. | Treatment and prevention of muscle loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
| US11219611B2 (en) | 2015-11-13 | 2022-01-11 | Ocera Therapeutics, Inc. | Formulations of L-ornithine phenylacetate |
| CN105495582A (zh) * | 2015-12-11 | 2016-04-20 | 北京康比特体育科技股份有限公司 | 一款抗疲劳、促恢复的保健食品氨基酸组合物 |
| MX389665B (es) | 2017-05-11 | 2025-03-20 | Ocera Therapeutics Inc | Procesos para producir fenilacetato de l-ornitina |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5535049A (en) * | 1978-09-04 | 1980-03-11 | Otsuka Pharmaceut Factory Inc | Amino acid transfusion for cancerous patient |
| JPS58126767A (ja) * | 1982-01-22 | 1983-07-28 | Ajinomoto Co Inc | 肝臓病患者用栄養組成物 |
| ATE54826T1 (de) * | 1985-10-23 | 1990-08-15 | Mulli Kurt Nachf Gmbh | Thymusextraktfraktionen enthaltende pharmazeutische zusammensetzung. |
| US5045468A (en) * | 1986-12-12 | 1991-09-03 | Cell Enterprises, Inc. | Protein-free culture medium which promotes hybridoma growth |
| ES2063882T5 (es) * | 1989-10-02 | 2001-12-01 | Novartis Nutrition Ag | Hidrolizados de proteinas. |
| US5292773A (en) * | 1990-02-14 | 1994-03-08 | Hirsch Gerald P | Treating aids and HIV infection with methionine |
| DE69331528T2 (de) * | 1992-12-23 | 2002-10-31 | Abbott Laboratories, Abbott Park | Medizinische nahrungsmittel für die ernährungsergänzung bei metabolischen erkrankungen von säuglingen/kleinkindern |
| US5571783A (en) * | 1993-03-09 | 1996-11-05 | Clintec Nutrition Company | Composition and method for treating patients with hepatic disease |
| FR2705765B1 (fr) * | 1993-04-29 | 1995-08-18 | Eurofours Sa | Porte de four. |
| US5547927A (en) * | 1993-05-28 | 1996-08-20 | Abbott Laboratories | Enteral nutritional product for patients undergoing radiation therapy and/or chemotherapy |
| NZ248605A (en) * | 1993-05-28 | 1994-12-22 | Abbott Lab | Enteral nutritional product comprising protein and fat |
| US5719133A (en) * | 1994-09-21 | 1998-02-17 | Novartis Nutrition Ag | Adolescent dietary composition |
| US5656608B1 (en) * | 1995-02-23 | 2000-09-26 | Novartis Nutrition Ltd | Amino acid compositions and methods of treatment using same |
| US5728678A (en) * | 1995-06-06 | 1998-03-17 | Nestec Ltd. | Method and composition for providing nutrition to a renal failure patient |
| US5776913A (en) * | 1995-10-10 | 1998-07-07 | Colgate Palmolive Company | Therapeutic diet for metabolic abnormalities found in animals with lymphoma |
| ATE310505T1 (de) * | 1996-05-14 | 2005-12-15 | Stanislaw R Burzynski | Liposomale antineoplaston therapie mit bemerkenswert verbesserter antineoplastischer aktivität |
| US5817927A (en) * | 1997-04-11 | 1998-10-06 | Betzdearborn Inc. | Method and apparatus for monitoring water process equipment |
| US5817695A (en) * | 1997-12-24 | 1998-10-06 | Pellico; Michael A. | Nutritional product with high fat, low carbohydrate and amino acid imbalance |
| PT1062879E (pt) | 1999-06-26 | 2003-12-31 | Braun Melsungen Ag | Solucao aquosa para nutricao parenteral |
| GB0009056D0 (en) * | 2000-04-12 | 2000-05-31 | Nestle Sa | Composition comprising free amino acids |
| US6377094B1 (en) * | 2002-03-25 | 2002-04-23 | Oak Technology, Inc. | Arbitrary waveform synthesizer using a free-running ring oscillator |
-
2001
- 2001-11-27 US US09/995,010 patent/US20030105104A1/en not_active Abandoned
-
2002
- 2002-04-26 PL PL02353656A patent/PL353656A1/xx not_active Application Discontinuation
- 2002-11-21 JP JP2003546874A patent/JP4614660B2/ja not_active Expired - Fee Related
- 2002-11-21 DE DE60212693T patent/DE60212693T2/de not_active Expired - Lifetime
- 2002-11-21 WO PCT/US2002/037354 patent/WO2003045372A1/en not_active Ceased
- 2002-11-21 CA CA2468133A patent/CA2468133C/en not_active Expired - Fee Related
- 2002-11-21 RO ROA200400481A patent/RO121173B1/ro unknown
- 2002-11-21 HU HU0402240A patent/HU230986B1/hu not_active IP Right Cessation
- 2002-11-21 UA UA20040605059A patent/UA78977C2/uk unknown
- 2002-11-21 SI SI200220037A patent/SI21542A/sl not_active IP Right Cessation
- 2002-11-21 BR BR0214430-1A patent/BR0214430A/pt not_active Application Discontinuation
- 2002-11-21 KR KR1020047007754A patent/KR100953483B1/ko not_active Expired - Fee Related
- 2002-11-21 CN CNB028236068A patent/CN100358527C/zh not_active Expired - Fee Related
- 2002-11-21 NZ NZ532833A patent/NZ532833A/en not_active IP Right Cessation
- 2002-11-21 EP EP02789801A patent/EP1450781B1/en not_active Expired - Lifetime
- 2002-11-21 AT AT02789801T patent/ATE330595T1/de not_active IP Right Cessation
- 2002-11-21 EA EA200400737A patent/EA009516B1/ru not_active IP Right Cessation
- 2002-11-21 MX MXPA04004994A patent/MXPA04004994A/es active IP Right Grant
- 2002-11-21 IL IL16214102A patent/IL162141A0/xx unknown
-
2004
- 2004-05-24 IL IL162141A patent/IL162141A/en not_active IP Right Cessation
- 2004-05-26 ZA ZA2004/04115A patent/ZA200404115B/en unknown
- 2004-06-07 NO NO20042364A patent/NO332858B1/no not_active IP Right Cessation
-
2005
- 2005-04-18 US US11/108,277 patent/US7427619B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005518361A5 (https=) | ||
| CA2468133A1 (en) | Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy | |
| ES2221385T3 (es) | Preparaciones de gabapentina y pregabalina estabilizadas con aminoacidos y procedimiento para prepararlas. | |
| JP2022159555A (ja) | 神経疾患を治療するための方法 | |
| JP2018012722A5 (https=) | ||
| WO2010051541A3 (en) | Compositions containing delta-9-thc-amino acid esters and process of preparation | |
| MXPA06002344A (es) | Composiciones farmaceuticas y metodo para usar levodopa y carbidopa. | |
| WO2005028516A3 (en) | Albumin-binding derivatives of therapeutic peptides | |
| EP0182356B1 (en) | Nutrient compositions | |
| RU2014121518A (ru) | Растворы на основе мелатонина и порошки для их получения | |
| JP2024520526A5 (https=) | ||
| WO2002074302A1 (en) | Amino acid compositions for ameliorating liver failure | |
| US20060166931A1 (en) | Clathrates of butylphtualide with cyclodextrin or its derivatives, a process for their preparation and the use thereof | |
| JP2006508972A5 (https=) | ||
| EA200501129A1 (ru) | Парентеральные композиции пептида для лечения системной красной волчанки | |
| JP2003504395A5 (https=) | ||
| TW200410681A (en) | Amino acid compound for improving central function | |
| JP2011503142A5 (https=) | ||
| KR950010884A (ko) | 사람 및 동물에서 염증성 반응을 일으키는 공격 또는 패혈증 치료용의 아미노산계 조성물 | |
| KR20050095833A (ko) | 경구 영양 조성물 | |
| JP2006506440A5 (https=) | ||
| ES2360759T3 (es) | Composiciones farmacéuticas y procedimiento de utilización de la levodopa y de la carbidopa. | |
| WO2017024953A1 (zh) | 尼莫地平水溶性衍生物及其制备方法和应用 | |
| YU81101A (sh) | Polimorfni oblici kristalnog citrata azabiciklo (2,2,2) oktan-3-amina i njihovih farmaceutskih kompozicija | |
| JP2008532601A5 (https=) |