JP4614660B2 - 細胞傷害的化学療法の毒性作用を軽減するために有用な、アミノ酸およびリボフラビンの配合物 - Google Patents

細胞傷害的化学療法の毒性作用を軽減するために有用な、アミノ酸およびリボフラビンの配合物 Download PDF

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JP4614660B2
JP4614660B2 JP2003546874A JP2003546874A JP4614660B2 JP 4614660 B2 JP4614660 B2 JP 4614660B2 JP 2003546874 A JP2003546874 A JP 2003546874A JP 2003546874 A JP2003546874 A JP 2003546874A JP 4614660 B2 JP4614660 B2 JP 4614660B2
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cancer
composition
riboflavin
amino acids
concentration
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Japanese (ja)
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JP2005518361A (ja
JP2005518361A5 (https=
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ブルジンスキー，スタニスロー・アール
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2003546874A 2001-11-27 2002-11-21 細胞傷害的化学療法の毒性作用を軽減するために有用な、アミノ酸およびリボフラビンの配合物 Expired - Fee Related JP4614660B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/995,010 US20030105104A1 (en) 2001-11-27 2001-11-27 Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy
PCT/US2002/037354 WO2003045372A1 (en) 2001-11-27 2002-11-21 Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy

Publications (3)

Publication Number Publication Date
JP2005518361A JP2005518361A (ja) 2005-06-23
JP2005518361A5 JP2005518361A5 (https=) 2006-01-05
JP4614660B2 true JP4614660B2 (ja) 2011-01-19

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JP2003546874A Expired - Fee Related JP4614660B2 (ja) 2001-11-27 2002-11-21 細胞傷害的化学療法の毒性作用を軽減するために有用な、アミノ酸およびリボフラビンの配合物

Country Status (21)

Country Link
US (2) US20030105104A1 (https=)
EP (1) EP1450781B1 (https=)
JP (1) JP4614660B2 (https=)
KR (1) KR100953483B1 (https=)
CN (1) CN100358527C (https=)
AT (1) ATE330595T1 (https=)
BR (1) BR0214430A (https=)
CA (1) CA2468133C (https=)
DE (1) DE60212693T2 (https=)
EA (1) EA009516B1 (https=)
HU (1) HU230986B1 (https=)
IL (2) IL162141A0 (https=)
MX (1) MXPA04004994A (https=)
NO (1) NO332858B1 (https=)
NZ (1) NZ532833A (https=)
PL (1) PL353656A1 (https=)
RO (1) RO121173B1 (https=)
SI (1) SI21542A (https=)
UA (1) UA78977C2 (https=)
WO (1) WO2003045372A1 (https=)
ZA (1) ZA200404115B (https=)

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CA2757373C (en) 2009-04-03 2018-05-08 Ocera Therapeutics, Inc. L-ornithine phenyl acetate and methods of making thereof
EA201691430A1 (ru) 2009-06-08 2017-02-28 ЮСиЭл БИЗНЕС ПиЭлСи Лечение портальной гипертензии и восстановление функции печени с помощью l-орнитинфенилацетата
US8449512B2 (en) 2010-04-09 2013-05-28 Davinci Biomedical Research Products Inc. Stoma stabilitating device and method
EP2397458A1 (en) * 2010-06-21 2011-12-21 Lunamed AG Organic salts and co-crystals of phenylbutyric acid
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KR101758424B1 (ko) 2010-09-24 2017-07-14 유니버시티 오브 플로리다 리서치 파운데이션, 인크. 위장 기능을 증진시키기 위한 물질 및 방법
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JP6090836B2 (ja) * 2011-02-17 2017-03-08 Ｅａファーマ株式会社 化学療法剤の抗腫瘍活性増強剤
AU2012278813B2 (en) * 2011-07-07 2016-09-08 Research Cancer Institute Of America Systems, methods, and formulations for treating cancer
KR101969199B1 (ko) 2013-03-11 2019-04-15 유니버시티 오브 플로리다 리서치 파운데이션, 인크. 폐 기능의 개선 및 방사선 유발된 폐 합병증의 예방 및/또는 치료를 위한 물질 및 방법
JP6742904B2 (ja) * 2013-11-08 2020-08-19 レガシー ヘルスケア リミテッド ガンおよびガン共存症の治療に使用するための組成物
JP6598425B2 (ja) * 2014-02-27 2019-10-30 花王株式会社 疲労の評価方法
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Also Published As

Publication number Publication date
EA200400737A1 (ru) 2004-12-30
HU230986B1 (hu) 2019-08-28
KR20040065565A (ko) 2004-07-22
SI21542A (sl) 2005-02-28
US7427619B2 (en) 2008-09-23
MXPA04004994A (es) 2005-04-08
DE60212693T2 (de) 2007-07-05
DE60212693D1 (de) 2006-08-03
EP1450781A1 (en) 2004-09-01
PL353656A1 (en) 2003-06-02
NZ532833A (en) 2006-12-22
KR100953483B1 (ko) 2010-04-16
CN1596109A (zh) 2005-03-16
JP2005518361A (ja) 2005-06-23
RO121173B1 (ro) 2007-01-30
BR0214430A (pt) 2004-11-03
CN100358527C (zh) 2008-01-02
CA2468133C (en) 2011-02-22
ATE330595T1 (de) 2006-07-15
CA2468133A1 (en) 2003-06-05
IL162141A (en) 2009-05-04
ZA200404115B (en) 2005-11-30
EA009516B1 (ru) 2008-02-28
IL162141A0 (en) 2005-11-20
US20050182064A1 (en) 2005-08-18
HUP0402240A2 (hu) 2005-02-28
UA78977C2 (en) 2007-05-10
AU2002352843A1 (en) 2003-06-10
EP1450781B1 (en) 2006-06-21
NO332858B1 (no) 2013-01-21
HUP0402240A3 (en) 2012-09-28
US20030105104A1 (en) 2003-06-05
NO20042364L (no) 2004-06-07
WO2003045372A1 (en) 2003-06-05

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