JP2006506440A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006506440A5 JP2006506440A5 JP2004553902A JP2004553902A JP2006506440A5 JP 2006506440 A5 JP2006506440 A5 JP 2006506440A5 JP 2004553902 A JP2004553902 A JP 2004553902A JP 2004553902 A JP2004553902 A JP 2004553902A JP 2006506440 A5 JP2006506440 A5 JP 2006506440A5
- Authority
- JP
- Japan
- Prior art keywords
- tin mesoporphyrin
- amino acid
- mesoporphyrin
- water
- tin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- LLDZJTIZVZFNCM-UHFFFAOYSA-J 3-[18-(2-carboxyethyl)-8,13-diethyl-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;dichlorotin(2+) Chemical compound [H+].[H+].[Cl-].[Cl-].[Sn+4].[N-]1C(C=C2C(=C(C)C(=CC=3C(=C(C)C(=C4)N=3)CC)[N-]2)CCC([O-])=O)=C(CCC([O-])=O)C(C)=C1C=C1C(C)=C(CC)C4=N1 LLDZJTIZVZFNCM-UHFFFAOYSA-J 0.000 claims 17
- 238000000034 method Methods 0.000 claims 12
- 235000001014 amino acid Nutrition 0.000 claims 11
- 150000001413 amino acids Chemical class 0.000 claims 11
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 8
- -1 tin mesoporphyrin compound Chemical class 0.000 claims 8
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 4
- 239000004475 Arginine Substances 0.000 claims 4
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 claims 4
- 239000004471 Glycine Substances 0.000 claims 4
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 4
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 4
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 4
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 4
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 4
- 239000004472 Lysine Substances 0.000 claims 4
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 4
- 235000004279 alanine Nutrition 0.000 claims 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 4
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 239000003637 basic solution Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 150000004820 halides Chemical class 0.000 claims 2
- 238000002156 mixing Methods 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 208000027119 bilirubin metabolic disease Diseases 0.000 claims 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- BTIJJDXEELBZFS-QDUVMHSLSA-K hemin Chemical compound CC1=C(CCC(O)=O)C(C=C2C(CCC(O)=O)=C(C)\C(N2[Fe](Cl)N23)=C\4)=N\C1=C/C2=C(C)C(C=C)=C3\C=C/1C(C)=C(C=C)C/4=N\1 BTIJJDXEELBZFS-QDUVMHSLSA-K 0.000 claims 1
- 229940025294 hemin Drugs 0.000 claims 1
- 208000036796 hyperbilirubinemia Diseases 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910001507 metal halide Inorganic materials 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 239000012265 solid product Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000001291 vacuum drying Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42785102P | 2002-11-20 | 2002-11-20 | |
| PCT/US2003/036885 WO2004045546A2 (en) | 2002-11-20 | 2003-11-18 | Water-soluble mesoporphyrin compounds and methods of preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006506440A JP2006506440A (ja) | 2006-02-23 |
| JP2006506440A5 true JP2006506440A5 (https=) | 2007-01-11 |
Family
ID=32326603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004553902A Pending JP2006506440A (ja) | 2002-11-20 | 2003-11-18 | 水溶性メソポルフィリン化合物および製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20040097481A1 (https=) |
| EP (1) | EP1567165A4 (https=) |
| JP (1) | JP2006506440A (https=) |
| AU (1) | AU2003295618A1 (https=) |
| CA (1) | CA2506081C (https=) |
| WO (1) | WO2004045546A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1509527B1 (en) * | 2002-06-04 | 2014-05-07 | InfaCare Pharmaceutical Corporation | Preparation of metal mesoporphyrin halide compounds |
| US7375216B2 (en) | 2002-06-04 | 2008-05-20 | Infacare Pharmaceutical Corporation | Preparation of metal mesoporphyrin compounds |
| US20060222668A1 (en) * | 2005-04-01 | 2006-10-05 | Wellspring Pharmaceutical Corporation | Stannsoporfin compositions, drug products and methods of manufacture |
| AU2006232330A1 (en) * | 2005-04-01 | 2006-10-12 | Infacare Pharmaceutical Corporation | Stannsoporfin compositions and administration |
| KR20140023447A (ko) * | 2006-10-04 | 2014-02-26 | 인파케어 파마슈티칼 코포레이션 | 스탄소포르핀의 고순도 대규모 제조법 |
| CA2664934A1 (en) * | 2006-10-04 | 2008-04-17 | Infacare Pharmaceutical Corporation | Treatment of infant hyperbilirubinemia using low dosages of stannsoporfin |
| AU2012202684B2 (en) * | 2006-10-04 | 2014-04-10 | Mallinckrodt Hospital Products IP Limited | High-purity large-scale preparation of stannsoporfin |
| CN101977626A (zh) * | 2008-01-21 | 2011-02-16 | 德莫迪斯公司 | 丝氨酸蛋白酶抑制剂在治疗皮肤病中的用途 |
| ES2609110T3 (es) | 2011-03-30 | 2017-04-18 | Infacare Pharmaceutical Corporation | Procedimientos de síntesis de mesoporfirinas metálicas |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US225264A (en) * | 1880-03-09 | Alpbed akeb | ||
| US4708964A (en) * | 1984-02-09 | 1987-11-24 | Chemex Pharmaceuticals | Lipoxygenase inhibitors |
| US4657902A (en) * | 1985-03-25 | 1987-04-14 | The Rockefeller University | Therapeutic use of tin mesoporphyrin |
| US4692440A (en) * | 1985-03-25 | 1987-09-08 | The Rockefeller University | Therapeutic use of tin mesoporphyrin |
| US4782049A (en) * | 1986-12-08 | 1988-11-01 | The Rockefeller University | Tin protoporphyrin and tin mesoporphyrin in the treatment of psoriasis |
| DE3827940A1 (de) * | 1988-08-13 | 1990-03-01 | Schering Ag | 13,17-propionsaeure- und propionsaeurederivat- substituierte porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| US5912341A (en) * | 1995-03-14 | 1999-06-15 | Hoffman/Barrett, L.L.C. | Heteroatom-functionalized porphyrazines and multimetallic complexes and polymers derived therefrom |
| AU6497996A (en) * | 1995-08-02 | 1997-02-26 | Warner-Lambert Company | Amino acid complexes of cobalt (iii) mesoporphyrin ix and cobalt (iii) protoporphyrin ix |
| EP1261346A4 (en) * | 2000-03-10 | 2004-10-13 | Univ Rockefeller | REGULATING A CARDIOVASCULAR INJURY |
| CA2448570A1 (en) * | 2001-05-31 | 2002-12-05 | Miravant Pharmaceuticals, Inc. | Substituted porphyrin and azaporphyrin derivatives and their use in photodynamic therapy, radioimaging and mri diagnosis |
| EP1509527B1 (en) * | 2002-06-04 | 2014-05-07 | InfaCare Pharmaceutical Corporation | Preparation of metal mesoporphyrin halide compounds |
-
2003
- 2003-11-14 US US10/713,889 patent/US20040097481A1/en not_active Abandoned
- 2003-11-18 EP EP03786815A patent/EP1567165A4/en not_active Withdrawn
- 2003-11-18 WO PCT/US2003/036885 patent/WO2004045546A2/en not_active Ceased
- 2003-11-18 JP JP2004553902A patent/JP2006506440A/ja active Pending
- 2003-11-18 CA CA002506081A patent/CA2506081C/en not_active Expired - Fee Related
- 2003-11-18 AU AU2003295618A patent/AU2003295618A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1262198B1 (en) | Composition with sustained release of levodopa and carbidopa | |
| CN1138535C (zh) | 含有泡腾酸碱对的药物组合物 | |
| AU2006279333C1 (en) | Pharmaceutical-grade ferric organic compounds, uses thereof and methods of making same | |
| JP5671560B2 (ja) | 固体投与形中のテトラサイクリン金属錯体 | |
| EP3164155B1 (en) | Treprostinil formulations | |
| WO2005028516A3 (en) | Albumin-binding derivatives of therapeutic peptides | |
| JP2006506440A5 (https=) | ||
| JP2005518361A5 (https=) | ||
| JPH02178223A (ja) | イブプロフエン沸騰製剤 | |
| CN114768780B (zh) | 一种Zn-Fe普鲁士蓝类似物复合材料的制备方法及应用 | |
| CN1328450A (zh) | 粒状结晶布洛芬的包衣颗粒 | |
| JP2006500367A (ja) | ブチルフタリドとシクロデキストリンまたはその誘導体との包接複合体、それらの調製のためのプロセスおよびその使用 | |
| AU2013249197B2 (en) | Methods of producing anamorelin hydrochloride having controlled chloride content | |
| CN1795014A (zh) | 分子络合物的制备方法 | |
| CN100393302C (zh) | 难溶性药物组合物渗透泵控释制剂 | |
| WO2013096596A1 (en) | Sustained drug release and improved product stability using non-covalent particle coating methods | |
| CN1278785A (zh) | 单异羟肟酯酯的钒络合物和含其的药用组合物 | |
| JP4891478B2 (ja) | シクロホスファミド被覆錠剤 | |
| JP2006506440A (ja) | 水溶性メソポルフィリン化合物および製造方法 | |
| CN112547019A (zh) | 一种拆分外消旋克唑替尼的方法 | |
| CN104069073B (zh) | 一种含布洛芬的碳酸钙/磷酸八钙颗粒的制备方法 | |
| RU2006143081A (ru) | Водорастворимая лекарственная композиция и способ ее получения | |
| CN101043908B (zh) | 含有美喹他嗪、环糊精和相互作用试剂的络合物 | |
| JP2720079B2 (ja) | 酸性非ステロイド性抗炎症薬含有薬剤 | |
| JPH0228190A (ja) | 新規な亜セレン酸白金錯体および該錯体を有効成分とする抗腫瘍剤 |