JP2006506440A5 - - Google Patents
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- Publication number
- JP2006506440A5 JP2006506440A5 JP2004553902A JP2004553902A JP2006506440A5 JP 2006506440 A5 JP2006506440 A5 JP 2006506440A5 JP 2004553902 A JP2004553902 A JP 2004553902A JP 2004553902 A JP2004553902 A JP 2004553902A JP 2006506440 A5 JP2006506440 A5 JP 2006506440A5
- Authority
- JP
- Japan
- Prior art keywords
- tin mesoporphyrin
- amino acid
- mesoporphyrin
- water
- tin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- LLDZJTIZVZFNCM-UHFFFAOYSA-J 3-[18-(2-carboxyethyl)-8,13-diethyl-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;dichlorotin(2+) Chemical compound [H+].[H+].[Cl-].[Cl-].[Sn+4].[N-]1C(C=C2C(=C(C)C(=CC=3C(=C(C)C(=C4)N=3)CC)[N-]2)CCC([O-])=O)=C(CCC([O-])=O)C(C)=C1C=C1C(C)=C(CC)C4=N1 LLDZJTIZVZFNCM-UHFFFAOYSA-J 0.000 claims 17
- 238000000034 method Methods 0.000 claims 12
- 235000001014 amino acid Nutrition 0.000 claims 11
- 150000001413 amino acids Chemical class 0.000 claims 11
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 8
- -1 tin mesoporphyrin compound Chemical class 0.000 claims 8
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 4
- 239000004475 Arginine Substances 0.000 claims 4
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 claims 4
- 239000004471 Glycine Substances 0.000 claims 4
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 4
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 4
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 4
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 4
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 4
- 239000004472 Lysine Substances 0.000 claims 4
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 4
- 235000004279 alanine Nutrition 0.000 claims 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 4
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 239000003637 basic solution Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 150000004820 halides Chemical class 0.000 claims 2
- 238000002156 mixing Methods 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 208000027119 bilirubin metabolic disease Diseases 0.000 claims 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- BTIJJDXEELBZFS-QDUVMHSLSA-K hemin Chemical compound CC1=C(CCC(O)=O)C(C=C2C(CCC(O)=O)=C(C)\C(N2[Fe](Cl)N23)=C\4)=N\C1=C/C2=C(C)C(C=C)=C3\C=C/1C(C)=C(C=C)C/4=N\1 BTIJJDXEELBZFS-QDUVMHSLSA-K 0.000 claims 1
- 229940025294 hemin Drugs 0.000 claims 1
- 208000036796 hyperbilirubinemia Diseases 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910001507 metal halide Inorganic materials 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 239000012265 solid product Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000001291 vacuum drying Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42785102P | 2002-11-20 | 2002-11-20 | |
| PCT/US2003/036885 WO2004045546A2 (en) | 2002-11-20 | 2003-11-18 | Water-soluble mesoporphyrin compounds and methods of preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006506440A JP2006506440A (ja) | 2006-02-23 |
| JP2006506440A5 true JP2006506440A5 (https=) | 2007-01-11 |
Family
ID=32326603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004553902A Pending JP2006506440A (ja) | 2002-11-20 | 2003-11-18 | 水溶性メソポルフィリン化合物および製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20040097481A1 (https=) |
| EP (1) | EP1567165A4 (https=) |
| JP (1) | JP2006506440A (https=) |
| AU (1) | AU2003295618A1 (https=) |
| CA (1) | CA2506081C (https=) |
| WO (1) | WO2004045546A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7375216B2 (en) * | 2002-06-04 | 2008-05-20 | Infacare Pharmaceutical Corporation | Preparation of metal mesoporphyrin compounds |
| AU2003237349B2 (en) * | 2002-06-04 | 2010-06-03 | Infacare Pharmaceutical Corporation | Preparation of metal mesoporphyrin halide compounds |
| US20060222668A1 (en) * | 2005-04-01 | 2006-10-05 | Wellspring Pharmaceutical Corporation | Stannsoporfin compositions, drug products and methods of manufacture |
| EP1865777A4 (en) * | 2005-04-01 | 2008-07-16 | Infacare Pharmaceutical Corp | STANNSOPORFIN COMPOSITIONS AND ADMINISTRATION |
| US20080113955A1 (en) * | 2006-10-04 | 2008-05-15 | Benjamin Levinson | Treatment of infant hyperbilirubinemia using low dosages of stannsoporfin |
| AU2012202684B2 (en) * | 2006-10-04 | 2014-04-10 | Mallinckrodt Hospital Products IP Limited | High-purity large-scale preparation of stannsoporfin |
| US7960371B2 (en) * | 2006-10-04 | 2011-06-14 | Infacare Pharmaceutical Corporation | High-purity large-scale preparation of stannsoporfin |
| CN110522905A (zh) * | 2008-01-21 | 2019-12-03 | 德莫迪斯公司 | 丝氨酸蛋白酶抑制剂在治疗皮肤病中的用途 |
| PL2691398T3 (pl) | 2011-03-30 | 2017-07-31 | Infacare Pharmaceutical Corporation | Sposoby syntezy mezoporfiryn metali |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US225264A (en) * | 1880-03-09 | Alpbed akeb | ||
| US4708964A (en) * | 1984-02-09 | 1987-11-24 | Chemex Pharmaceuticals | Lipoxygenase inhibitors |
| US4692440A (en) * | 1985-03-25 | 1987-09-08 | The Rockefeller University | Therapeutic use of tin mesoporphyrin |
| US4657902A (en) * | 1985-03-25 | 1987-04-14 | The Rockefeller University | Therapeutic use of tin mesoporphyrin |
| US4782049A (en) * | 1986-12-08 | 1988-11-01 | The Rockefeller University | Tin protoporphyrin and tin mesoporphyrin in the treatment of psoriasis |
| DE3827940A1 (de) * | 1988-08-13 | 1990-03-01 | Schering Ag | 13,17-propionsaeure- und propionsaeurederivat- substituierte porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| US5912341A (en) * | 1995-03-14 | 1999-06-15 | Hoffman/Barrett, L.L.C. | Heteroatom-functionalized porphyrazines and multimetallic complexes and polymers derived therefrom |
| WO1997005152A1 (en) * | 1995-08-02 | 1997-02-13 | Warner-Lambert Company | Amino acid complexes of cobalt (iii) mesoporphyrin ix and cobalt (iii) protoporphyrin ix |
| JP2003526668A (ja) * | 2000-03-10 | 2003-09-09 | ザ ロックフェラー ユニバーシティー | 心臓血管損傷の調節 |
| CA2448570A1 (en) * | 2001-05-31 | 2002-12-05 | Miravant Pharmaceuticals, Inc. | Substituted porphyrin and azaporphyrin derivatives and their use in photodynamic therapy, radioimaging and mri diagnosis |
| AU2003237349B2 (en) * | 2002-06-04 | 2010-06-03 | Infacare Pharmaceutical Corporation | Preparation of metal mesoporphyrin halide compounds |
-
2003
- 2003-11-14 US US10/713,889 patent/US20040097481A1/en not_active Abandoned
- 2003-11-18 WO PCT/US2003/036885 patent/WO2004045546A2/en not_active Ceased
- 2003-11-18 EP EP03786815A patent/EP1567165A4/en not_active Withdrawn
- 2003-11-18 JP JP2004553902A patent/JP2006506440A/ja active Pending
- 2003-11-18 AU AU2003295618A patent/AU2003295618A1/en not_active Abandoned
- 2003-11-18 CA CA002506081A patent/CA2506081C/en not_active Expired - Fee Related
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