JP2002514611A5 - - Google Patents
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- JP2002514611A5 JP2002514611A5 JP2000548013A JP2000548013A JP2002514611A5 JP 2002514611 A5 JP2002514611 A5 JP 2002514611A5 JP 2000548013 A JP2000548013 A JP 2000548013A JP 2000548013 A JP2000548013 A JP 2000548013A JP 2002514611 A5 JP2002514611 A5 JP 2002514611A5
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8015098P | 1998-03-31 | 1998-03-31 | |
| US60/080,150 | 1998-03-31 | ||
| US11271598P | 1998-12-18 | 1998-12-18 | |
| US60/112,715 | 1998-12-18 | ||
| PCT/US1999/006826 WO1999058162A2 (en) | 1998-03-31 | 1999-03-29 | Pharmaceuticals for the imaging of angiogenic disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002514611A JP2002514611A (ja) | 2002-05-21 |
| JP2002514611A5 true JP2002514611A5 (enExample) | 2009-06-25 |
| JP4487019B2 JP4487019B2 (ja) | 2010-06-23 |
Family
ID=26763137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000548013A Expired - Fee Related JP4487019B2 (ja) | 1998-03-31 | 1999-03-29 | 血管新生疾患を画像化するための薬剤 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20020001566A1 (enExample) |
| EP (1) | EP1068224B1 (enExample) |
| JP (1) | JP4487019B2 (enExample) |
| KR (1) | KR20010042288A (enExample) |
| CN (1) | CN1295578A (enExample) |
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| BR (1) | BR9909420A (enExample) |
| CA (1) | CA2324555A1 (enExample) |
| DE (1) | DE69925262T2 (enExample) |
| EA (1) | EA200001007A1 (enExample) |
| EE (1) | EE200000574A (enExample) |
| ES (1) | ES2241313T3 (enExample) |
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| PL (1) | PL343804A1 (enExample) |
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Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6749853B1 (en) * | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
| US5965132A (en) * | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US6537520B1 (en) | 1998-03-31 | 2003-03-25 | Bristol-Myers Squibb Pharma Company | Pharmaceuticals for the imaging of angiogenic disorders |
| US6794518B1 (en) * | 1998-12-18 | 2004-09-21 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
| US6989139B2 (en) * | 2000-02-15 | 2006-01-24 | Bristol-Myers Squibb Pharma Company | Matrix metalloproteinase inhibitors |
| EP1281068B1 (en) * | 2000-05-08 | 2008-03-26 | TTP LabTech Ltd | Microphysiometer |
| EP1289565B1 (en) | 2000-06-02 | 2015-04-22 | Bracco Suisse SA | Compounds for targeting endothelial cells |
| US8263739B2 (en) | 2000-06-02 | 2012-09-11 | Bracco Suisse Sa | Compounds for targeting endothelial cells, compositions containing the same and methods for their use |
| AU2001268710A1 (en) * | 2000-06-21 | 2002-01-02 | Bristol-Myers Squibb Pharma Company | Pharmaceuticals for the imaging of angiogenic disorders for use in combination therapy |
| AU2001270025B2 (en) * | 2000-06-21 | 2005-08-18 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals for use in combination therapy |
| US20020122768A1 (en) * | 2000-07-06 | 2002-09-05 | Shuang Liu | Stable radiopharmaceutical compositions and methods for preparation thereof |
| JP2005506952A (ja) * | 2000-11-27 | 2005-03-10 | ブリストル−マイヤーズ・スクイブ・メディカル・イメージング・インコーポレイテッド | 心臓潅流およびビトロネクチンレセプター標的造影剤の同時造影 |
| TW593278B (en) | 2001-01-23 | 2004-06-21 | Wyeth Corp | 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands |
| US7271180B2 (en) * | 2001-01-23 | 2007-09-18 | Wyeth | 1-Aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands |
| DE60231801D1 (de) | 2001-04-23 | 2009-05-14 | Mallinckrodt Inc | Tc und re markierte radioaktive glycosylierte octreotid-derivate |
| JP2004537573A (ja) * | 2001-08-08 | 2004-12-16 | ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー | 心臓灌流およびビトロネクチン受容体を標的とするイメージング剤の同時イメージング |
| KR101159061B1 (ko) | 2001-10-22 | 2012-06-22 | 더 스크립스 리서치 인스티튜트 | 항체 표적화 화합물 |
| US7279150B2 (en) | 2002-01-24 | 2007-10-09 | Barnes-Jewish Hospital | Chelating agents with lipophilic carriers |
| JP4731117B2 (ja) | 2002-01-24 | 2011-07-20 | バーンズ−ジューイッシュ ホスピタル | インテグリン標的イメージング剤 |
| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| ES2506142T3 (es) * | 2002-03-01 | 2014-10-13 | Dyax Corp. | Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico |
| US20050250700A1 (en) * | 2002-03-01 | 2005-11-10 | Sato Aaron K | KDR and VEGF/KDR binding peptides |
| US7211240B2 (en) | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
| US7985402B2 (en) | 2002-03-01 | 2011-07-26 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
| US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| US7666979B2 (en) * | 2002-03-01 | 2010-02-23 | Bracco International B.V. | Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same |
| US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| US20050100963A1 (en) | 2002-03-01 | 2005-05-12 | Dyax Corporation | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| AU2003235489A1 (en) * | 2002-05-08 | 2003-11-11 | Tom Mcneil | High efficiency solid-state light source and methods of use and manufacture |
| US6961607B2 (en) * | 2002-07-31 | 2005-11-01 | Uzgiris Egidijus E | Method for assessing myocardial angiogenesis |
| US20040224986A1 (en) | 2002-08-16 | 2004-11-11 | Bart De Corte | Piperidinyl targeting compounds that selectively bind integrins |
| US20040122354A1 (en) * | 2002-09-05 | 2004-06-24 | Semba Charles P. | Infusion catheter having an integrated doppler transducer |
| US20040047917A1 (en) * | 2002-09-06 | 2004-03-11 | Stephen Wilson | Drug delivery and targeting with vitamin B12 conjugates |
| CA2499496C (fr) * | 2002-09-19 | 2012-04-24 | Centre National De La Recherche Scientifique - Cnrs | Synthese et caracterisation de nouveaux systemes de guidage et de vectorisation de molecules d'interet therapeutique vers des cellules cibles |
| WO2004069281A1 (en) * | 2003-01-30 | 2004-08-19 | The General Hospital Corporation | Bifunctional molecules comprising at least one integrin-binding and their use in imaging and therapy of angiogenesis and related disorders |
| EP2949658B1 (en) | 2003-03-03 | 2018-08-08 | Dyax Corp. | Peptides that specifically bind HGF receptor (cMet) and uses thereof |
| MXPA05012109A (es) * | 2003-05-12 | 2006-02-08 | Bristol Myers Squibb Pharma Co | Compuestos antagonistas del receptor de vitronectina y su uso en la preparacion de radiofarmaceuticos. |
| AU2004263136A1 (en) * | 2003-08-08 | 2005-02-17 | Barnes-Jewish Hospital | Emulsion particles for imaging and therapy and methods of use thereof |
| US20050112064A1 (en) * | 2003-08-12 | 2005-05-26 | Sonya Franklin | DNA-dependent MRI contrast agents |
| EP1711203A4 (en) * | 2004-01-16 | 2007-06-13 | Barnes Jewish Hospital | TARGETED ATHEROSCLEROSIS TREATMENT |
| WO2005082912A1 (en) * | 2004-02-23 | 2005-09-09 | Dow Global Technologies Inc | Aqueous-based adhesive for bonding low surface energy substrates |
| US7504088B2 (en) | 2004-06-09 | 2009-03-17 | Kereos, Inc. | Lipophilic derivatives of chelate monoamides |
| DE602005000853D1 (de) * | 2004-07-02 | 2007-05-24 | Vivactis Nv | Messung der Wärme erzeugt durch einen chemischen oder biologischen Prozess. |
| EP1861127A1 (en) * | 2005-03-10 | 2007-12-05 | Bayer Schering Pharma Aktiengesellschaft | Chelators for radioactively labeled conjugates comprising a stabilizing sidechain |
| US20090131327A1 (en) * | 2005-04-29 | 2009-05-21 | Patrick Doherty | Nogo receptor functional motifs and peptide mimetics related thereto and methods of using the same |
| JP2009512443A (ja) * | 2005-10-20 | 2009-03-26 | ザ スクリップス リサーチ インスチチュート | 免疫染色及び免疫標的化のためのFc標識化 |
| US20070140973A1 (en) * | 2005-12-15 | 2007-06-21 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardium perfusion imaging |
| EP2019667A4 (en) * | 2006-04-27 | 2012-08-22 | Barnes Jewish Hospital | DETECTION AND IMAGING OF TARGET TISSUE |
| US20080138288A1 (en) * | 2006-09-29 | 2008-06-12 | Washington University | Combinations for treatment of neovasculature |
| EP2107887A1 (en) * | 2006-12-08 | 2009-10-14 | Molecular Image Inc. | Methods for diagnosis and monitoring of neurologic diseases using magnetic resonance methods |
| US8194963B2 (en) * | 2008-03-10 | 2012-06-05 | Siemens Medical Solutions Usa, Inc. | Efficient estimator of pharmacokinetic parameters in breast MRI |
| CA2727803C (en) | 2008-05-13 | 2013-03-12 | University Of Kansas | Metal abstraction peptide (map) tag and associated methods |
| US20100178245A1 (en) * | 2009-01-13 | 2010-07-15 | Arnsdorf Morton F | Biocompatible Microbubbles to Deliver Radioactive Compounds to Tumors, Atherosclerotic Plaques, Joints and Other Targeted Sites |
| EP2395992A2 (en) | 2009-02-10 | 2011-12-21 | The Scripps Research Institute | Chemically programmed vaccination |
| CN101659694B (zh) * | 2009-05-06 | 2012-12-12 | 河北科技大学 | 抗肿瘤环五肽化合物及其制备方法 |
| WO2013181461A2 (en) | 2012-06-01 | 2013-12-05 | University Of Kansas | Metal abstraction peptide with superoxide dismutase activity |
| AU2014241182A1 (en) * | 2013-03-27 | 2015-09-24 | Theranos Ip Company, Llc | Biological sample processing |
| JP6542197B2 (ja) * | 2013-04-12 | 2019-07-10 | エヴォックス・セラピューティクス・リミテッド | 治療的送達小胞 |
| DE102013113156A1 (de) * | 2013-11-28 | 2015-05-28 | Freie Universität Berlin | Verbindung und Verfahren zur selektiven Radiomarkierung von Polypeptiden mittels Festphasensynthese |
| KR102548998B1 (ko) * | 2020-03-31 | 2023-06-29 | 재단법인 아산사회복지재단 | 혈전영상을 위한 방사성의약품 및 조성물 |
| US12377166B2 (en) * | 2021-08-26 | 2025-08-05 | University Of Washington | Iron oxide nanoparticle for targeted chemo-immunotherapy |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4957939A (en) | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
| DE3360633D1 (en) | 1982-02-12 | 1985-10-03 | Unitika Ltd | Anti-cancer device |
| US4472509A (en) | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
| US5135736A (en) | 1988-08-15 | 1992-08-04 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
| IL91933A (en) | 1988-10-11 | 1994-12-29 | Univ Southern California | Their immuno-bracelet and isophiles which are beneficial in increasing vascular permeability or blood supply to tumor or otherwise damaged tissue |
| ATE142505T1 (de) | 1988-11-14 | 1996-09-15 | Brigham & Womens Hospital | Antikörper, spezifisch gegen elam-1 sowie deren verwendung |
| US5376356A (en) | 1989-03-14 | 1994-12-27 | Neorx Corporation | Imaging tissue sites of inflammation |
| JPH04502769A (ja) | 1989-04-10 | 1992-05-21 | オンコーゲン リミテッド パートナーシップ | オンコスタチンmを使用したヒト内皮細胞増殖およびエフェクター機能の制御法 |
| US5395609A (en) | 1989-06-19 | 1995-03-07 | Antisoma Limited | Synthetic peptides for use in tumor detection |
| DE69018226T2 (de) | 1989-07-20 | 1995-09-21 | Sandoz-Patent-Gmbh, 79539 Loerrach | Markierte polypeptidderivate. |
| IN172208B (enExample) | 1990-04-02 | 1993-05-01 | Sint Sa | |
| WO1993008210A1 (en) | 1991-10-18 | 1993-04-29 | Beth Israel Hospital Association | Vascular permeability factor targeted compounds |
| US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US5660827A (en) | 1992-03-05 | 1997-08-26 | Board Of Regents, The University Of Texas System | Antibodies that bind to endoglin |
| WO1993017715A1 (en) | 1992-03-05 | 1993-09-16 | Board Of Regents, The University Of Texas System | Diagnostic and/or therapeutic agents, targeted to neovascular endothelial cells |
| CN1701814A (zh) | 1992-11-13 | 2005-11-30 | 马克斯普朗克科学促进协会 | 作为血管内皮生长因子受体的f1k-1 |
| US5342757A (en) | 1992-11-13 | 1994-08-30 | Ludwig Institute For Cancer Research | Monoclonal antibodies which specifically binds to endosialin, a 165 Kd glycoprotein found on tumor vascular endothelium, and uses thereof |
| DE4301871A1 (de) | 1993-01-13 | 1994-07-14 | Diagnostikforschung Inst | Neue Mittel zur Diagnose von Gefäßerkrankungen |
| US5744120A (en) | 1993-03-30 | 1998-04-28 | The Dupont Merick Pharmaceutical Company | Ternary radiopharmaceutical complexes |
| DE4311023C2 (de) | 1993-03-31 | 1996-05-02 | Diagnostikforschung Inst | Bifunktionelle chalkogenatom-unterbrochene Chelatbildner von Typ XN¶1¶S¶1¶O¶1¶ für radioaktive Isotope, deren Metallkomplexe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Mittel |
| JPH09500140A (ja) | 1993-07-19 | 1997-01-07 | レゾリューション・ファーマスーティカルズ・インコーポレーテッド | N▲下3▼s立体配置を有するヒドラジノ型放射性核種キレート形成剤 |
| US5753230A (en) | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
| JPH10504807A (ja) | 1994-06-29 | 1998-05-12 | スミスクライン・ビーチャム・コーポレイション | ビトロネクチン受容体拮抗剤 |
| HU220347B (hu) | 1994-07-11 | 2001-12-28 | Board Of Regents The University Of Texas System | Készítmény az érrendszer specifikus koagulálásához |
| AU702487B2 (en) | 1995-08-30 | 1999-02-25 | G.D. Searle & Co. | Meta-guanidine, urea, thiourea or azacyclic amino benzoic acid derivatives as integrin antagonists |
| DE19536785A1 (de) | 1995-09-21 | 1997-03-27 | Diagnostikforschung Inst | Bifunktionelle sulfidhaltige Sulfonamid-Chelatbildner vom Typ S¶2¶NY für radioaktive Isotope |
| DE19536781A1 (de) | 1995-09-21 | 1997-03-27 | Diagnostikforschung Inst | Bifunktionelle sulfidhaltige Sulfonamid-Chelatbildner vom Typ XSNS für radioaktive Isotope |
| DE69628731T3 (de) * | 1995-11-01 | 2012-09-20 | Bracco Suisse S.A. | Gezielte magnetisch markierte molekularmarkersysteme als nmr-bilderzeugungsmittel |
| CN1202161A (zh) | 1995-11-14 | 1998-12-16 | 杜邦麦克药品公司 | 作为金属蛋白酶抑制剂的新的大环化合物 |
| US6331285B1 (en) * | 1996-06-05 | 2001-12-18 | Palatin Technologies, Inc. | Structurally determined cyclic metallo-constructs and applications |
| ZA978758B (en) * | 1996-10-02 | 1999-03-30 | Du Pont Merck Pharma | Technetium-99m-labeled chelator incorporated cyclic peptides that bind to the GPIIb/IIIa receptor as imaging agents |
| US6056973A (en) | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| WO1998016256A1 (en) * | 1996-10-16 | 1998-04-23 | The Burnham Institute | Magnetic resonance imaging of thrombi |
| WO1998018497A2 (en) | 1996-10-28 | 1998-05-07 | Nycomed Imaging As | Contrast agents |
| GB9708265D0 (en) | 1997-04-24 | 1997-06-18 | Nycomed Imaging As | Contrast agents |
| DE19725368A1 (de) * | 1997-06-16 | 1998-12-17 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren und deren Verwendung für bildgebende Verfahren |
| AU9477398A (en) * | 1997-09-10 | 1999-03-29 | Burnham Institute, The | Methods of identifying molecules that home to angiogenic vasculature in tumors |
| WO1999040947A2 (en) * | 1998-02-11 | 1999-08-19 | Resolution Pharmaceuticals Inc. | Angiogenesis targeting molecules |
| WO2000006169A1 (en) | 1998-07-29 | 2000-02-10 | Merck & Co., Inc. | Integrin receptor antagonists |
-
1999
- 1999-03-29 KR KR1020007010831A patent/KR20010042288A/ko not_active Withdrawn
- 1999-03-29 EP EP99941944A patent/EP1068224B1/en not_active Expired - Lifetime
- 1999-03-29 HU HU0101468A patent/HUP0101468A2/hu unknown
- 1999-03-29 CN CN99804710A patent/CN1295578A/zh active Pending
- 1999-03-29 PL PL99343804A patent/PL343804A1/xx unknown
- 1999-03-29 AU AU55417/99A patent/AU5541799A/en not_active Abandoned
- 1999-03-29 WO PCT/US1999/006826 patent/WO1999058162A2/en not_active Ceased
- 1999-03-29 EE EEP200000574A patent/EE200000574A/xx unknown
- 1999-03-29 CA CA002324555A patent/CA2324555A1/en not_active Abandoned
- 1999-03-29 SK SK1395-2000A patent/SK13952000A3/sk unknown
- 1999-03-29 EA EA200001007A patent/EA200001007A1/ru unknown
- 1999-03-29 AT AT99941944T patent/ATE295369T1/de not_active IP Right Cessation
- 1999-03-29 ES ES99941944T patent/ES2241313T3/es not_active Expired - Lifetime
- 1999-03-29 JP JP2000548013A patent/JP4487019B2/ja not_active Expired - Fee Related
- 1999-03-29 BR BR9909420-7A patent/BR9909420A/pt not_active IP Right Cessation
- 1999-03-29 DE DE69925262T patent/DE69925262T2/de not_active Expired - Lifetime
- 1999-03-29 IL IL13809399A patent/IL138093A0/xx unknown
- 1999-03-30 AR ARP990101448A patent/AR020586A1/es not_active Application Discontinuation
- 1999-03-30 US US09/281,474 patent/US20020001566A1/en not_active Abandoned
- 1999-03-30 US US09/281,207 patent/US6322770B1/en not_active Expired - Fee Related
-
2000
- 2000-09-29 NO NO20004917A patent/NO20004917L/no not_active Application Discontinuation
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