JP2002501945A5 - - Google Patents
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- JP2002501945A5 JP2002501945A5 JP2000530082A JP2000530082A JP2002501945A5 JP 2002501945 A5 JP2002501945 A5 JP 2002501945A5 JP 2000530082 A JP2000530082 A JP 2000530082A JP 2000530082 A JP2000530082 A JP 2000530082A JP 2002501945 A5 JP2002501945 A5 JP 2002501945A5
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- Prior art keywords
- alkyl
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- compound
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- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 description 76
- 125000000217 alkyl group Chemical group 0.000 description 38
- 125000003118 aryl group Chemical group 0.000 description 37
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 33
- 125000003710 aryl alkyl group Chemical group 0.000 description 28
- 239000008194 pharmaceutical composition Substances 0.000 description 26
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 description 19
- 125000004404 heteroalkyl group Chemical group 0.000 description 18
- 125000004433 nitrogen atom Chemical group N* 0.000 description 18
- 125000004429 atom Chemical group 0.000 description 12
- 229910052736 halogen Inorganic materials 0.000 description 12
- 125000001072 heteroaryl group Chemical group 0.000 description 12
- 150000002367 halogens Chemical class 0.000 description 9
- 125000002950 monocyclic group Chemical group 0.000 description 9
- 229910052757 nitrogen Inorganic materials 0.000 description 9
- 125000001424 substituent group Chemical group 0.000 description 9
- 0 C*C(C(C=C1)Oc2cc(C=Cl)cnc2)C=C1NS(c1ccc(C2(C)*C(*)*2)cc1)(=O)=O Chemical compound C*C(C(C=C1)Oc2cc(C=Cl)cnc2)C=C1NS(c1ccc(C2(C)*C(*)*2)cc1)(=O)=O 0.000 description 8
- PIGFYZPCRLYGLF-UHFFFAOYSA-N Aluminum nitride Chemical compound [Al]#N PIGFYZPCRLYGLF-UHFFFAOYSA-N 0.000 description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 7
- 125000005843 halogen group Chemical group 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- -1 5-chloro-3-pyridyloxy Chemical group 0.000 description 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 3
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 description 3
- 125000002947 alkylene group Chemical group 0.000 description 3
- 125000005529 alkyleneoxy group Chemical group 0.000 description 3
- 125000002619 bicyclic group Chemical group 0.000 description 3
- 125000004122 cyclic group Chemical group 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 125000005842 heteroatom Chemical group 0.000 description 3
- 125000001624 naphthyl group Chemical group 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 102000000536 PPAR gamma Human genes 0.000 description 2
- 108010016731 PPAR gamma Proteins 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 208000016097 disease of metabolism Diseases 0.000 description 2
- 208000027866 inflammatory disease Diseases 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 208000030159 metabolic disease Diseases 0.000 description 2
- 208000008589 Obesity Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7304298P | 1998-01-29 | 1998-01-29 | |
| US60/073,042 | 1998-01-29 | ||
| PCT/US1999/001147 WO1999038845A1 (en) | 1998-01-29 | 1999-01-20 | Ppar-gamma modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002501945A JP2002501945A (ja) | 2002-01-22 |
| JP2002501945A5 true JP2002501945A5 (https=) | 2006-01-05 |
| JP4253126B2 JP4253126B2 (ja) | 2009-04-08 |
Family
ID=22111361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000530082A Expired - Fee Related JP4253126B2 (ja) | 1998-01-29 | 1999-01-20 | Ｐｐａｒ−ガンマ調節剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6200995B1 (https=) |
| EP (1) | EP1053227B1 (https=) |
| JP (1) | JP4253126B2 (https=) |
| AT (1) | ATE413386T1 (https=) |
| AU (1) | AU759255B2 (https=) |
| CA (1) | CA2318731C (https=) |
| DE (1) | DE69939864D1 (https=) |
| ES (1) | ES2317688T3 (https=) |
| WO (1) | WO1999038845A1 (https=) |
Families Citing this family (144)
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1999
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- 1999-01-20 JP JP2000530082A patent/JP4253126B2/ja not_active Expired - Fee Related
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- 1999-01-20 AU AU21176/99A patent/AU759255B2/en not_active Ceased
- 1999-01-20 WO PCT/US1999/001147 patent/WO1999038845A1/en not_active Ceased
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- 1999-01-20 EP EP99901492A patent/EP1053227B1/en not_active Expired - Lifetime
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2000
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