JP2001515859A5 - - Google Patents
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- Publication number
- JP2001515859A5 JP2001515859A5 JP2000510435A JP2000510435A JP2001515859A5 JP 2001515859 A5 JP2001515859 A5 JP 2001515859A5 JP 2000510435 A JP2000510435 A JP 2000510435A JP 2000510435 A JP2000510435 A JP 2000510435A JP 2001515859 A5 JP2001515859 A5 JP 2001515859A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- effective amount
- combination according
- combination
- antiepileptic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 17
- 230000003556 anti-epileptic effect Effects 0.000 description 15
- 239000001961 anticonvulsive agent Substances 0.000 description 15
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 description 10
- 229960002870 gabapentin Drugs 0.000 description 5
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 description 4
- 229960001233 pregabalin Drugs 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 3
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- 239000004084 narcotic analgesic agent Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229940127523 NMDA Receptor Antagonists Drugs 0.000 description 1
- 229940099433 NMDA receptor antagonist Drugs 0.000 description 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 description 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
- 229960002009 naproxen Drugs 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5820797P | 1997-09-08 | 1997-09-08 | |
| US60/058,207 | 1997-09-08 | ||
| PCT/US1998/017083 WO1999012537A1 (en) | 1997-09-08 | 1998-08-18 | Analgesic compositions comprising anti-epileptic compounds and methods of using same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001515859A JP2001515859A (ja) | 2001-09-25 |
| JP2001515859A5 true JP2001515859A5 (https=) | 2006-01-05 |
| JP3782935B2 JP3782935B2 (ja) | 2006-06-07 |
Family
ID=22015361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000510435A Expired - Fee Related JP3782935B2 (ja) | 1997-09-08 | 1998-08-18 | 抗癲癇化合物を含有する鎮痛剤組成物およびその使用方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US6593368B2 (https=) |
| EP (1) | EP1011658B1 (https=) |
| JP (1) | JP3782935B2 (https=) |
| KR (1) | KR100537707B1 (https=) |
| AT (1) | ATE311867T1 (https=) |
| AU (1) | AU750578B2 (https=) |
| BR (1) | BR9812162A (https=) |
| CA (1) | CA2296336C (https=) |
| CU (1) | CU23226B7 (https=) |
| DE (1) | DE69832712T2 (https=) |
| DK (1) | DK1011658T3 (https=) |
| ES (1) | ES2253825T3 (https=) |
| HU (1) | HU226165B1 (https=) |
| IL (2) | IL134165A0 (https=) |
| IS (1) | IS5362A (https=) |
| NO (1) | NO324122B1 (https=) |
| NZ (1) | NZ502671A (https=) |
| PL (1) | PL339142A1 (https=) |
| WO (1) | WO1999012537A1 (https=) |
| ZA (1) | ZA988159B (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL126999A (en) | 1996-07-24 | 2002-03-10 | Warner Lambert Co | Pharmaceutical preparations containing isobutylgaba and its history for use in the treatment of pain |
| WO1999012537A1 (en) * | 1997-09-08 | 1999-03-18 | Warner-Lambert Company | Analgesic compositions comprising anti-epileptic compounds and methods of using same |
| EP1094817A1 (en) * | 1998-07-09 | 2001-05-02 | Warner-Lambert Company | Compositions comprising gaba analogs and caffeine |
| US6451857B1 (en) | 1999-03-10 | 2002-09-17 | Warner-Lambert Company | Analgesic compositions comprising anti-epileptic compounds and methods of using same |
| DE60022333T2 (de) | 1999-04-09 | 2006-07-06 | Euro-Celtique S.A. | Natrium kanalblocker zusammensetzungen und deren verwendung |
| AU5824800A (en) * | 1999-06-23 | 2001-01-31 | Warner-Lambert Company | Use of fosphenytoin for the treatment of acute neuropathic pain |
| HUP0203198A3 (en) * | 1999-08-20 | 2005-07-28 | Ortho Mcneil Pharm Inc | Pharmaceutical composition comprising a tramadol material and an anticonvulsant drug, process for its preparation and its use |
| IL160523A0 (en) | 2001-09-03 | 2004-07-25 | Newron Pharm Spa | PHARMACEUTICAL COMPOSITION COMPRISING GABAPENTIN OR AN ANALOGUE THEREOF AND AN alpha-AMINOAMIDE AND ITS ANALGESIC USE |
| US20070184104A1 (en) * | 2001-10-25 | 2007-08-09 | Depomed, Inc. | Gastric retentive gabapentin dosage forms and methods for using same |
| US7612112B2 (en) * | 2001-10-25 | 2009-11-03 | Depomed, Inc. | Methods of treatment using a gastric retained gabapentin dosage |
| TWI312285B (en) | 2001-10-25 | 2009-07-21 | Depomed Inc | Methods of treatment using a gastric retained gabapentin dosage |
| US20060159743A1 (en) * | 2001-10-25 | 2006-07-20 | Depomed, Inc. | Methods of treating non-nociceptive pain states with gastric retentive gabapentin |
| US6730667B2 (en) * | 2001-11-26 | 2004-05-04 | William R. Deagle | Iontophoresis disc pain blocker |
| WO2003066040A1 (en) | 2002-02-05 | 2003-08-14 | Ajinomoto Co.,Inc. | Medicinal compositions containing gabapentin or pregabalin and n-type calcium channel antagonist |
| RU2286151C2 (ru) * | 2002-02-22 | 2006-10-27 | Уорнер-Ламберт Компани Ллс | Комбинации альфа-2-дельта-лиганда с селективным ингибитором циклооксигеназы-2 |
| WO2004054560A1 (en) * | 2002-12-13 | 2004-07-01 | Warner-Lambert Company Llc | Alpha-2-delta ligand to treat lower urinary tract symptoms |
| FR2862875B1 (fr) * | 2003-12-02 | 2006-04-07 | Mathey Acoustique Service | Preparation pharmaceutique pour le traitement des acouphenes |
| KR20070086334A (ko) * | 2004-11-16 | 2007-08-27 | 리머릭 뉴로사이언스즈, 인크. | 통증을 치료하기 위한 방법 및 조성물 |
| US20070087977A1 (en) * | 2004-11-16 | 2007-04-19 | Wendye Robbins | Methods and compositions for treating pain |
| KR20070087596A (ko) | 2005-09-19 | 2007-08-28 | 테바 파마슈티컬 인더스트리즈 리미티드 | (ｓ)-(+)-3-(아미노메틸)-5-메틸헥산산의 비대칭 합성 |
| MXPA05011735A (es) * | 2005-11-01 | 2007-04-30 | Leopoldo Espinosa Abdala | Composiciones farmaceuticas que comprenden combinaciones de analgesicos y anticonvulsivantes para el tratamiento del dolor agudo y cronico. |
| US20090176882A1 (en) * | 2008-12-09 | 2009-07-09 | Depomed, Inc. | Gastric retentive gabapentin dosage forms and methods for using same |
| CA2673545A1 (en) * | 2006-12-22 | 2008-07-03 | Recordati Ireland Limited | Combination therapy of lower urinary tract disorders with .alpha.2.delta. ligands and nsaids |
| MX2007006091A (es) * | 2007-05-21 | 2009-02-25 | World Trade Imp Export Wtie Ag | Composicion farmaceutica que comprende la combinacion de un agente antiinflamatorio no esteroideo y un agente anticonvulsionante. |
| WO2009021058A2 (en) * | 2007-08-06 | 2009-02-12 | Trinity Labortories, Inc. | Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy |
| JP2010043063A (ja) | 2008-05-09 | 2010-02-25 | Agency For Science Technology & Research | 川崎病の診断及び治療 |
| US20100087525A1 (en) * | 2008-06-23 | 2010-04-08 | Lilach Hedvati | Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester |
| FR2934267B1 (fr) * | 2008-07-23 | 2010-08-13 | Pharmaleads | Derives aminophosphiniques utiles dans le traitement de la douleur |
| US20100190752A1 (en) | 2008-09-05 | 2010-07-29 | Gruenenthal Gmbh | Pharmaceutical Combination |
| EP2334176A4 (en) | 2008-09-27 | 2012-05-02 | Taraxos Inc | TOPICAL FORMULATIONS FOR THE TREATMENT OF NERVE DISEASES |
| CN105330603A (zh) | 2008-10-08 | 2016-02-17 | 凯飞药业公司 | Gaba偶联物及其使用方法 |
| CA2805371C (en) * | 2010-07-30 | 2017-10-31 | Toray Industries, Inc. | Therapeutic agent or prophylactic agent for neuropathic pain |
| WO2013076339A1 (es) * | 2011-11-22 | 2013-05-30 | Servicio Andaluz De Salud | Composiciones y preparaciones combinadas para el tratamiento de la fibromialgia |
| WO2013103826A1 (en) * | 2012-01-06 | 2013-07-11 | Skyview Enterprise Ltd. | Anti-inflammatory compounds in combination with hydrogen for the treatment of inflammation |
| FR2998892B1 (fr) | 2012-12-04 | 2015-01-02 | Pf Medicament | Derives d'aminocyclobutane, leur procede de preparation et leur utilisation a titre de medicaments |
| MX378004B (es) | 2015-12-02 | 2025-03-10 | Jaime Samuel CHAIT AUERBACH | Composición oral veterinaria con gabapentina. |
| KR102631399B1 (ko) * | 2018-03-30 | 2024-02-01 | 씨지인바이츠 주식회사 | 폴마콕시브 및 프레가발린을 포함하는 통증 치료용 약제학적 조성물 |
| MX384760B (es) | 2018-07-04 | 2025-03-14 | Federico Amezcua Amezcua | Combinación farmacéutica sinérgica del enantiómero activo s-ketorolaco y gabapentina para el tratamiento del dolor neuropático. |
| MX388067B (es) * | 2019-07-16 | 2025-03-19 | Federico Amezcua Amezcua | Combinacion sinergica de s-ketorolaco y pregabalina en una composicion farmaceutica para el tratamiento del dolor neuropatico |
| US11147780B2 (en) * | 2020-02-24 | 2021-10-19 | Algia Pharma, Llc | Multidrug pain management package |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE634102A (https=) * | ||||
| DE1963925C3 (de) * | 1969-12-20 | 1975-07-10 | Desitin-Werk, Carl Klinke Gmbh, 2000 Hamburg | Verfahren zur Herstellung von N hoch 3-Carbalkoxyderivaten des 5,5-Diphenylhydantoins |
| DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US4087544A (en) * | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
| JPS54110334A (en) * | 1978-02-16 | 1979-08-29 | Fuji Chem Ind Co Ltd | Novel compounded anodyne and antiiinflammatory agent |
| JPS61221121A (ja) * | 1985-03-27 | 1986-10-01 | Nitto Electric Ind Co Ltd | テ−プ製剤 |
| US4694010A (en) * | 1985-08-16 | 1987-09-15 | New York University | Anticonvulsant compositions and method |
| AU2929489A (en) | 1987-12-22 | 1989-07-19 | John W. FERKANY | Dextrorphan potentiator for anticonvulsant composition and method |
| US6197819B1 (en) * | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
| GB9108362D0 (en) * | 1991-04-18 | 1991-06-05 | Radoslavov Alexander | A pharmaceutical composition suitable for alleviation of headaches,migraine and other painful conditions |
| JP3856816B2 (ja) | 1992-05-20 | 2006-12-13 | ノースウェスターン ユニヴァーシティ | 抗発作治療用のｇａｂａ及びｌ−グルタミン酸類縁体 |
| US5234929A (en) * | 1992-07-20 | 1993-08-10 | William Chelen | Method of treating motion sickness with anticonvulsants and antitussive agents |
| JPH06100468A (ja) | 1992-09-25 | 1994-04-12 | Kibun Food Chemifa Co Ltd | 徐放性組成物 |
| US5321012A (en) | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
| JPH06227969A (ja) * | 1993-02-02 | 1994-08-16 | Masayasu Sugihara | 薬品の腸溶性改善方法およびそれにより得られた薬品組成物 |
| US5420270A (en) * | 1993-10-07 | 1995-05-30 | G. D. Searle & Co. | Aryl substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use |
| US5466823A (en) * | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
| US5352638A (en) | 1994-02-22 | 1994-10-04 | Corning Incorporated | Nickel aluminosilicate glass-ceramics |
| FI970865A7 (fi) | 1994-09-02 | 1997-03-14 | Univ Virginia Commonwealth | Ei-huumaavaa kipulääkeainetta sekä kivun poistamisen tehostajaa sisält ävä, kipua lievittävä koostumus |
| CN1046199C (zh) * | 1994-12-13 | 1999-11-10 | 凌吉安 | 复方消炎止痛霜剂 |
| IL126999A (en) * | 1996-07-24 | 2002-03-10 | Warner Lambert Co | Pharmaceutical preparations containing isobutylgaba and its history for use in the treatment of pain |
| CA2264182A1 (en) * | 1996-08-23 | 1998-02-26 | Algos Pharmaceutical Corporation | Anticonvulsant containing composition for treating neuropathic pain |
| US6057373A (en) | 1997-05-22 | 2000-05-02 | Synchroneuron, Llc | Methods of treating tardive dyskinesia and other movement disorders using NMDA receptor antagonists |
| US6127418A (en) * | 1997-08-20 | 2000-10-03 | Warner-Lambert Company | GABA analogs to prevent and treat gastrointestinal damage |
| WO1999008670A1 (en) * | 1997-08-20 | 1999-02-25 | Guglietta, Antonio | Gaba analogs to prevent and treat gastrointestinal damage |
| WO1999012537A1 (en) | 1997-09-08 | 1999-03-18 | Warner-Lambert Company | Analgesic compositions comprising anti-epileptic compounds and methods of using same |
| US6451857B1 (en) | 1999-03-10 | 2002-09-17 | Warner-Lambert Company | Analgesic compositions comprising anti-epileptic compounds and methods of using same |
-
1998
- 1998-08-18 WO PCT/US1998/017083 patent/WO1999012537A1/en not_active Ceased
- 1998-08-18 HU HU0003705A patent/HU226165B1/hu not_active IP Right Cessation
- 1998-08-18 IL IL13416598A patent/IL134165A0/xx unknown
- 1998-08-18 EP EP98944449A patent/EP1011658B1/en not_active Expired - Lifetime
- 1998-08-18 DE DE69832712T patent/DE69832712T2/de not_active Expired - Fee Related
- 1998-08-18 PL PL98339142A patent/PL339142A1/xx not_active Application Discontinuation
- 1998-08-18 NZ NZ502671A patent/NZ502671A/xx unknown
- 1998-08-18 AT AT98944449T patent/ATE311867T1/de not_active IP Right Cessation
- 1998-08-18 AU AU91987/98A patent/AU750578B2/en not_active Ceased
- 1998-08-18 US US09/463,116 patent/US6593368B2/en not_active Expired - Fee Related
- 1998-08-18 DK DK98944449T patent/DK1011658T3/da active
- 1998-08-18 ES ES98944449T patent/ES2253825T3/es not_active Expired - Lifetime
- 1998-08-18 BR BR9812162-6A patent/BR9812162A/pt not_active Application Discontinuation
- 1998-08-18 JP JP2000510435A patent/JP3782935B2/ja not_active Expired - Fee Related
- 1998-08-18 KR KR10-2000-7002400A patent/KR100537707B1/ko not_active Expired - Fee Related
- 1998-08-18 CA CA002296336A patent/CA2296336C/en not_active Expired - Fee Related
- 1998-09-07 ZA ZA988159A patent/ZA988159B/xx unknown
-
2000
- 2000-01-25 IS IS5362A patent/IS5362A/is unknown
- 2000-03-03 CU CU20000051A patent/CU23226B7/es not_active IP Right Cessation
- 2000-03-07 NO NO20001175A patent/NO324122B1/no not_active IP Right Cessation
-
2002
- 2002-02-13 US US10/075,929 patent/US6942876B2/en not_active Expired - Fee Related
-
2003
- 2003-04-04 US US10/407,888 patent/US20030176505A1/en not_active Abandoned
-
2007
- 2007-08-16 IL IL185345A patent/IL185345A0/en unknown
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