JP2001519413A5 - - Google Patents
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- Publication number
- JP2001519413A5 JP2001519413A5 JP2000515872A JP2000515872A JP2001519413A5 JP 2001519413 A5 JP2001519413 A5 JP 2001519413A5 JP 2000515872 A JP2000515872 A JP 2000515872A JP 2000515872 A JP2000515872 A JP 2000515872A JP 2001519413 A5 JP2001519413 A5 JP 2001519413A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- hydrogen
- alkoxy
- embedded image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 26
- 229910052739 hydrogen Inorganic materials 0.000 description 16
- 239000001257 hydrogen Substances 0.000 description 16
- 229910052736 halogen Inorganic materials 0.000 description 9
- 150000002367 halogens Chemical class 0.000 description 9
- 125000000217 alkyl group Chemical group 0.000 description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 7
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 7
- 150000002431 hydrogen Chemical class 0.000 description 7
- 229910052760 oxygen Inorganic materials 0.000 description 7
- 239000001301 oxygen Substances 0.000 description 7
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 3
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 3
- 239000000825 pharmaceutical preparation Substances 0.000 description 3
- 102100024349 Alpha-1A adrenergic receptor Human genes 0.000 description 2
- 108020004102 alpha-1 Adrenergic Receptor Proteins 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 description 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 150000001924 cycloalkanes Chemical class 0.000 description 1
- 125000004970 halomethyl group Chemical group 0.000 description 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- -1 t-butyldiphenylsilyloxymethyl Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6161897P | 1997-10-09 | 1997-10-09 | |
| US60/061,618 | 1997-10-09 | ||
| PCT/US1998/021470 WO1999019299A1 (en) | 1997-10-09 | 1998-10-09 | Heterocycles useful in the treatment of benign prostatic hyperplasia and intermediates thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001519413A JP2001519413A (ja) | 2001-10-23 |
| JP2001519413A5 true JP2001519413A5 (https=) | 2006-01-05 |
Family
ID=22036961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000515872A Ceased JP2001519413A (ja) | 1997-10-09 | 1998-10-09 | 良性の前立腺過形成の治療に有用な複素環化合物およびそれらの中間体 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6384035B1 (https=) |
| EP (1) | EP1025085B1 (https=) |
| JP (1) | JP2001519413A (https=) |
| AT (2) | ATE235466T1 (https=) |
| AU (1) | AU1078399A (https=) |
| CA (1) | CA2305353A1 (https=) |
| DE (2) | DE69812676T2 (https=) |
| DK (2) | DK1273572T3 (https=) |
| ES (2) | ES2233769T3 (https=) |
| PT (2) | PT1025085E (https=) |
| WO (1) | WO1999019299A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1531822T3 (da) * | 2002-06-12 | 2009-12-07 | Chemocentryx Inc | 1-aryl-4-substituerede piperazin derivater til anvendelse som CCR1 antagonister til behandlingen af inflammation og immunforstyrrelser |
| US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
| US7842693B2 (en) * | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
| US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
| US7223749B2 (en) * | 2003-02-20 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them |
| US7435830B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| WO2006051399A1 (en) * | 2004-11-11 | 2006-05-18 | Ranbaxy Laboratories Limited | Piperazine derivatives useful as adrenergic receptor antagonists |
| GB0516313D0 (en) * | 2005-08-08 | 2005-09-14 | Argenta Discovery Ltd | Azole derivatives and their uses |
| WO2008017827A2 (en) * | 2006-08-08 | 2008-02-14 | Argenta Discovery Limited | Azole and thiazole derivatives and their uses |
| WO2014128723A2 (en) * | 2013-02-19 | 2014-08-28 | Council Of Scientific And Industrial Research | Anticancer compounds and process for the preparation thereof |
| CN103484498B (zh) * | 2013-09-04 | 2016-08-24 | 广州医科大学 | 一种α1-AR亚型选择性拮抗剂的高通量筛选细胞模型及其构建方法与应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH078795B2 (ja) | 1989-09-06 | 1995-02-01 | 日立化成工業株式会社 | 排尿障害治療剤 |
| US5605896A (en) * | 1992-02-25 | 1997-02-25 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities |
| US5332732A (en) | 1992-09-11 | 1994-07-26 | Mcneilab, Inc. | Thiophene and pyridine antipsychotic agents |
| US5403847A (en) | 1992-11-13 | 1995-04-04 | Synaptic Pharmaceutical Corporation | Use of α1C specific compounds to treat benign prostatic hyperlasia |
-
1998
- 1998-10-09 PT PT98953393T patent/PT1025085E/pt unknown
- 1998-10-09 PT PT02078537T patent/PT1273572E/pt unknown
- 1998-10-09 ES ES02078537T patent/ES2233769T3/es not_active Expired - Lifetime
- 1998-10-09 US US09/169,571 patent/US6384035B1/en not_active Expired - Lifetime
- 1998-10-09 DE DE69812676T patent/DE69812676T2/de not_active Expired - Fee Related
- 1998-10-09 AT AT98953393T patent/ATE235466T1/de not_active IP Right Cessation
- 1998-10-09 DE DE69828207T patent/DE69828207T2/de not_active Expired - Fee Related
- 1998-10-09 AT AT02078537T patent/ATE284869T1/de not_active IP Right Cessation
- 1998-10-09 AU AU10783/99A patent/AU1078399A/en not_active Abandoned
- 1998-10-09 DK DK02078537T patent/DK1273572T3/da active
- 1998-10-09 JP JP2000515872A patent/JP2001519413A/ja not_active Ceased
- 1998-10-09 WO PCT/US1998/021470 patent/WO1999019299A1/en not_active Ceased
- 1998-10-09 EP EP98953393A patent/EP1025085B1/en not_active Expired - Lifetime
- 1998-10-09 ES ES98953393T patent/ES2195410T3/es not_active Expired - Lifetime
- 1998-10-09 CA CA002305353A patent/CA2305353A1/en not_active Abandoned
- 1998-10-09 DK DK98953393T patent/DK1025085T3/da active
-
2001
- 2001-11-26 US US09/994,153 patent/US6841682B2/en not_active Expired - Lifetime
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