JP2002538148A5 - - Google Patents
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- Publication number
- JP2002538148A5 JP2002538148A5 JP2000602222A JP2000602222A JP2002538148A5 JP 2002538148 A5 JP2002538148 A5 JP 2002538148A5 JP 2000602222 A JP2000602222 A JP 2000602222A JP 2000602222 A JP2000602222 A JP 2000602222A JP 2002538148 A5 JP2002538148 A5 JP 2002538148A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- conh
- substituted
- coo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 161
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 33
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 description 25
- 229910052731 fluorine Inorganic materials 0.000 description 24
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 20
- 229910052739 hydrogen Inorganic materials 0.000 description 12
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 10
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 description 8
- -1 biphenylyl Chemical group 0.000 description 8
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 6
- 125000003342 alkenyl group Chemical group 0.000 description 6
- 125000000217 alkyl group Chemical group 0.000 description 6
- 125000000304 alkynyl group Chemical group 0.000 description 6
- 239000011737 fluorine Substances 0.000 description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 6
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- 125000004076 pyridyl group Chemical group 0.000 description 4
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 description 3
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 description 3
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 description 3
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 description 3
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 description 3
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 description 3
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 description 3
- 101100294106 Caenorhabditis elegans nhr-3 gene Proteins 0.000 description 3
- 125000002541 furyl group Chemical group 0.000 description 3
- 125000001624 naphthyl group Chemical group 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 125000001544 thienyl group Chemical group 0.000 description 3
- 125000006528 (C2-C6) alkyl group Chemical group 0.000 description 2
- 125000001506 1,2,3-triazol-5-yl group Chemical group [H]N1N=NC([H])=C1[*] 0.000 description 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 description 2
- 125000003831 tetrazolyl group Chemical group 0.000 description 2
- 125000001425 triazolyl group Chemical group 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19908538.2 | 1999-02-26 | ||
| DE19908538A DE19908538A1 (de) | 1999-02-26 | 1999-02-26 | Polycyclische 2-Amino-Thiazol Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen |
| PCT/EP2000/000924 WO2000051995A1 (de) | 1999-02-26 | 2000-02-05 | Polycyclische 2-amino-thiazol systeme, verfahren zu ihrer herstellung und arzneimittel enthaltend diese verbindungen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002538148A JP2002538148A (ja) | 2002-11-12 |
| JP2002538148A5 true JP2002538148A5 (https=) | 2007-04-05 |
| JP4728484B2 JP4728484B2 (ja) | 2011-07-20 |
Family
ID=7899082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000602222A Expired - Fee Related JP4728484B2 (ja) | 1999-02-26 | 2000-02-05 | 多環２−アミノチアゾール系、その製造方法およびそれを含む医薬 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6251922B1 (https=) |
| EP (1) | EP1157015B1 (https=) |
| JP (1) | JP4728484B2 (https=) |
| KR (1) | KR20010102390A (https=) |
| CN (1) | CN1148362C (https=) |
| AT (1) | ATE295357T1 (https=) |
| AU (1) | AU763111B2 (https=) |
| BR (1) | BR0008510A (https=) |
| CA (1) | CA2364900A1 (https=) |
| DE (2) | DE19908538A1 (https=) |
| ES (1) | ES2240070T3 (https=) |
| HK (1) | HK1043117B (https=) |
| PT (1) | PT1157015E (https=) |
| WO (1) | WO2000051995A1 (https=) |
| ZA (1) | ZA200106198B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19908537A1 (de) * | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Verwendung von polycyclischen 2-Amino-Thiazol Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas |
| US7732484B2 (en) * | 2000-08-01 | 2010-06-08 | University Of Virginia Patent Foundation | Use of selective adenosine A1 receptor allosteric enhancers to manipulate angiogenesis |
| JP2005529846A (ja) * | 2002-01-16 | 2005-10-06 | ユニバーシティ オブ バージニア パテント ファウンデーション | Ａ１アデノシン受容体の２−アミノチアゾールアロステリックエンハンサ |
| ES2480994T3 (es) | 2008-03-31 | 2014-07-29 | Genentech, Inc. | Compuestos de tipo benzopirano y benzoxepina inhibidores de PI3K y métodos de uso |
| ES2558742T3 (es) | 2009-09-28 | 2016-02-08 | F. Hoffmann-La Roche Ag | Compuestos inhibidores de PI3K de benzoxepina y métodos de uso |
| ES2570569T3 (es) | 2009-09-28 | 2016-05-19 | Hoffmann La Roche | Compuestos de benzoxazepina como inhibidores de la PI3K y métodos de uso |
| JP5728487B2 (ja) * | 2009-10-29 | 2015-06-03 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 三環式ヘテロ環化合物 |
| WO2012126901A1 (en) | 2011-03-21 | 2012-09-27 | F. Hoffmann-La Roche Ag | Benzoxazepin compounds selective for pi3k p110 delta and methods of use |
| ES2859478T3 (es) | 2016-09-02 | 2021-10-04 | Bristol Myers Squibb Co | Compuestos heterocíclicos tricíclicos sustituidos |
| WO2019032631A1 (en) | 2017-08-09 | 2019-02-14 | Bristol-Myers Squibb Company | Oxime ether compounds |
| US11046646B2 (en) | 2017-08-09 | 2021-06-29 | Bristol-Myers Squibb Company | Alkylphenyl compounds |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4082773A (en) * | 1972-07-03 | 1978-04-04 | E. R. Squibb & Sons, Inc. | Tricyclic tetrahydro naphthaleneols and related compounds |
| DE2640358A1 (de) * | 1976-09-08 | 1978-03-16 | Hoechst Ag | Thiazolidinderivate und verfahren zu ihrer herstellung |
| CA1292226C (en) * | 1986-01-16 | 1991-11-19 | Terumi Hachiya | Indenothiazole derivative and process for preparing the same |
| IE68593B1 (en) | 1989-12-06 | 1996-06-26 | Sanofi Sa | Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them |
| TW416953B (en) * | 1996-09-25 | 2001-01-01 | Takeda Chemical Industries Ltd | Tricyclic compounds for eliciting a prostaglandin I2 receptor agonistic effect, their production and use |
| AU3289299A (en) * | 1998-02-19 | 1999-09-06 | Tularik Inc. | Antiviral agents |
| DE19831878C2 (de) * | 1998-07-17 | 2001-05-17 | Aventis Pharma Gmbh | Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE19908537A1 (de) * | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Verwendung von polycyclischen 2-Amino-Thiazol Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas |
-
1999
- 1999-02-26 DE DE19908538A patent/DE19908538A1/de not_active Withdrawn
-
2000
- 2000-02-05 AU AU32782/00A patent/AU763111B2/en not_active Ceased
- 2000-02-05 BR BR0008510-3A patent/BR0008510A/pt not_active IP Right Cessation
- 2000-02-05 CN CNB008042217A patent/CN1148362C/zh not_active Expired - Fee Related
- 2000-02-05 AT AT00910642T patent/ATE295357T1/de not_active IP Right Cessation
- 2000-02-05 ES ES00910642T patent/ES2240070T3/es not_active Expired - Lifetime
- 2000-02-05 JP JP2000602222A patent/JP4728484B2/ja not_active Expired - Fee Related
- 2000-02-05 PT PT00910642T patent/PT1157015E/pt unknown
- 2000-02-05 DE DE50010285T patent/DE50010285D1/de not_active Expired - Lifetime
- 2000-02-05 CA CA002364900A patent/CA2364900A1/en not_active Abandoned
- 2000-02-05 EP EP00910642A patent/EP1157015B1/de not_active Expired - Lifetime
- 2000-02-05 KR KR1020017010839A patent/KR20010102390A/ko not_active Ceased
- 2000-02-05 WO PCT/EP2000/000924 patent/WO2000051995A1/de not_active Ceased
- 2000-02-05 HK HK02104079.4A patent/HK1043117B/zh not_active IP Right Cessation
- 2000-02-10 US US09/501,208 patent/US6251922B1/en not_active Expired - Lifetime
-
2001
- 2001-07-27 ZA ZA200106198A patent/ZA200106198B/en unknown