CN1148362C - 多环的2-氨基噻唑体系、它们的制备方法和包含这些化合物的药物 - Google Patents

多环的2-氨基噻唑体系、它们的制备方法和包含这些化合物的药物 Download PDF

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Publication number
CN1148362C
CN1148362C CNB008042217A CN00804221A CN1148362C CN 1148362 C CN1148362 C CN 1148362C CN B008042217 A CNB008042217 A CN B008042217A CN 00804221 A CN00804221 A CN 00804221A CN 1148362 C CN1148362 C CN 1148362C
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CN
China
Prior art keywords
alkyl
phenyl
acid
compounds
compound
Prior art date
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Expired - Fee Related
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CNB008042217A
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English (en)
Chinese (zh)
Other versions
CN1344263A (zh
Inventor
G
G·杰恩
K·盖森
H－J·兰格
M·毕克尔
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Sanofi Aventis Deutschland GmbH
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Aventis Pharma Deutschland GmbH
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Publication of CN1344263A publication Critical patent/CN1344263A/zh
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Publication of CN1148362C publication Critical patent/CN1148362C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB008042217A 1999-02-26 2000-02-05 多环的2-氨基噻唑体系、它们的制备方法和包含这些化合物的药物 Expired - Fee Related CN1148362C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19908538.2 1999-02-26
DE19908538A DE19908538A1 (de) 1999-02-26 1999-02-26 Polycyclische 2-Amino-Thiazol Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen

Publications (2)

Publication Number Publication Date
CN1344263A CN1344263A (zh) 2002-04-10
CN1148362C true CN1148362C (zh) 2004-05-05

Family

ID=7899082

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008042217A Expired - Fee Related CN1148362C (zh) 1999-02-26 2000-02-05 多环的2-氨基噻唑体系、它们的制备方法和包含这些化合物的药物

Country Status (15)

Country Link
US (1) US6251922B1 (https=)
EP (1) EP1157015B1 (https=)
JP (1) JP4728484B2 (https=)
KR (1) KR20010102390A (https=)
CN (1) CN1148362C (https=)
AT (1) ATE295357T1 (https=)
AU (1) AU763111B2 (https=)
BR (1) BR0008510A (https=)
CA (1) CA2364900A1 (https=)
DE (2) DE19908538A1 (https=)
ES (1) ES2240070T3 (https=)
HK (1) HK1043117B (https=)
PT (1) PT1157015E (https=)
WO (1) WO2000051995A1 (https=)
ZA (1) ZA200106198B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19908537A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Verwendung von polycyclischen 2-Amino-Thiazol Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas
US7732484B2 (en) * 2000-08-01 2010-06-08 University Of Virginia Patent Foundation Use of selective adenosine A1 receptor allosteric enhancers to manipulate angiogenesis
JP2005529846A (ja) * 2002-01-16 2005-10-06 ユニバーシティ オブ バージニア パテント ファウンデーション Ａ１アデノシン受容体の２−アミノチアゾールアロステリックエンハンサ
ES2480994T3 (es) 2008-03-31 2014-07-29 Genentech, Inc. Compuestos de tipo benzopirano y benzoxepina inhibidores de PI3K y métodos de uso
ES2558742T3 (es) 2009-09-28 2016-02-08 F. Hoffmann-La Roche Ag Compuestos inhibidores de PI3K de benzoxepina y métodos de uso
ES2570569T3 (es) 2009-09-28 2016-05-19 Hoffmann La Roche Compuestos de benzoxazepina como inhibidores de la PI3K y métodos de uso
JP5728487B2 (ja) * 2009-10-29 2015-06-03 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 三環式ヘテロ環化合物
WO2012126901A1 (en) 2011-03-21 2012-09-27 F. Hoffmann-La Roche Ag Benzoxazepin compounds selective for pi3k p110 delta and methods of use
ES2859478T3 (es) 2016-09-02 2021-10-04 Bristol Myers Squibb Co Compuestos heterocíclicos tricíclicos sustituidos
WO2019032631A1 (en) 2017-08-09 2019-02-14 Bristol-Myers Squibb Company Oxime ether compounds
US11046646B2 (en) 2017-08-09 2021-06-29 Bristol-Myers Squibb Company Alkylphenyl compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4082773A (en) * 1972-07-03 1978-04-04 E. R. Squibb & Sons, Inc. Tricyclic tetrahydro naphthaleneols and related compounds
DE2640358A1 (de) * 1976-09-08 1978-03-16 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
CA1292226C (en) * 1986-01-16 1991-11-19 Terumi Hachiya Indenothiazole derivative and process for preparing the same
IE68593B1 (en) 1989-12-06 1996-06-26 Sanofi Sa Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them
TW416953B (en) * 1996-09-25 2001-01-01 Takeda Chemical Industries Ltd Tricyclic compounds for eliciting a prostaglandin I2 receptor agonistic effect, their production and use
AU3289299A (en) * 1998-02-19 1999-09-06 Tularik Inc. Antiviral agents
DE19831878C2 (de) * 1998-07-17 2001-05-17 Aventis Pharma Gmbh Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19908537A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Verwendung von polycyclischen 2-Amino-Thiazol Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas

Also Published As

Publication number Publication date
HK1043117B (zh) 2004-10-08
DE50010285D1 (de) 2005-06-16
AU763111B2 (en) 2003-07-10
JP4728484B2 (ja) 2011-07-20
ZA200106198B (en) 2002-05-03
BR0008510A (pt) 2002-02-05
DE19908538A1 (de) 2000-08-31
ES2240070T3 (es) 2005-10-16
JP2002538148A (ja) 2002-11-12
US6251922B1 (en) 2001-06-26
EP1157015A1 (de) 2001-11-28
ATE295357T1 (de) 2005-05-15
PT1157015E (pt) 2005-08-31
EP1157015B1 (de) 2005-05-11
KR20010102390A (ko) 2001-11-15
HK1043117A1 (en) 2002-09-06
CA2364900A1 (en) 2000-09-08
WO2000051995A1 (de) 2000-09-08
AU3278200A (en) 2000-09-21
CN1344263A (zh) 2002-04-10

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