HK1043117B - 多環的2-氨基噻唑體系、它們的製備方法和包含這些化合物的藥物 - Google Patents

多環的2-氨基噻唑體系、它們的製備方法和包含這些化合物的藥物 Download PDF

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Publication number
HK1043117B
HK1043117B HK02104079.4A HK02104079A HK1043117B HK 1043117 B HK1043117 B HK 1043117B HK 02104079 A HK02104079 A HK 02104079A HK 1043117 B HK1043117 B HK 1043117B
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HK
Hong Kong
Prior art keywords
alkyl
phenyl
acid
compounds
formula
Prior art date
Application number
HK02104079.4A
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English (en)
Chinese (zh)
Other versions
HK1043117A1 (en
Inventor
G‧杰恩
G‧傑恩
K‧盖森
H-J‧兰格
K‧蓋森
M‧毕克尔
H-J‧蘭格
M‧畢克爾
Original Assignee
阿文蒂斯药物德国有限公司
阿文蒂斯藥物德國有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 阿文蒂斯药物德国有限公司, 阿文蒂斯藥物德國有限公司 filed Critical 阿文蒂斯药物德国有限公司
Publication of HK1043117A1 publication Critical patent/HK1043117A1/xx
Publication of HK1043117B publication Critical patent/HK1043117B/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK02104079.4A 1999-02-26 2000-02-05 多環的2-氨基噻唑體系、它們的製備方法和包含這些化合物的藥物 HK1043117B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19908538.2 1999-02-26
DE19908538A DE19908538A1 (de) 1999-02-26 1999-02-26 Polycyclische 2-Amino-Thiazol Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen
PCT/EP2000/000924 WO2000051995A1 (de) 1999-02-26 2000-02-05 Polycyclische 2-amino-thiazol systeme, verfahren zu ihrer herstellung und arzneimittel enthaltend diese verbindungen

Publications (2)

Publication Number Publication Date
HK1043117A1 HK1043117A1 (en) 2002-09-06
HK1043117B true HK1043117B (zh) 2004-10-08

Family

ID=7899082

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02104079.4A HK1043117B (zh) 1999-02-26 2000-02-05 多環的2-氨基噻唑體系、它們的製備方法和包含這些化合物的藥物

Country Status (15)

Country Link
US (1) US6251922B1 (https=)
EP (1) EP1157015B1 (https=)
JP (1) JP4728484B2 (https=)
KR (1) KR20010102390A (https=)
CN (1) CN1148362C (https=)
AT (1) ATE295357T1 (https=)
AU (1) AU763111B2 (https=)
BR (1) BR0008510A (https=)
CA (1) CA2364900A1 (https=)
DE (2) DE19908538A1 (https=)
ES (1) ES2240070T3 (https=)
HK (1) HK1043117B (https=)
PT (1) PT1157015E (https=)
WO (1) WO2000051995A1 (https=)
ZA (1) ZA200106198B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19908537A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Verwendung von polycyclischen 2-Amino-Thiazol Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas
US7732484B2 (en) * 2000-08-01 2010-06-08 University Of Virginia Patent Foundation Use of selective adenosine A1 receptor allosteric enhancers to manipulate angiogenesis
JP2005529846A (ja) * 2002-01-16 2005-10-06 ユニバーシティ オブ バージニア パテント ファウンデーション Ａ１アデノシン受容体の２−アミノチアゾールアロステリックエンハンサ
ES2480994T3 (es) 2008-03-31 2014-07-29 Genentech, Inc. Compuestos de tipo benzopirano y benzoxepina inhibidores de PI3K y métodos de uso
ES2558742T3 (es) 2009-09-28 2016-02-08 F. Hoffmann-La Roche Ag Compuestos inhibidores de PI3K de benzoxepina y métodos de uso
ES2570569T3 (es) 2009-09-28 2016-05-19 Hoffmann La Roche Compuestos de benzoxazepina como inhibidores de la PI3K y métodos de uso
JP5728487B2 (ja) * 2009-10-29 2015-06-03 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 三環式ヘテロ環化合物
WO2012126901A1 (en) 2011-03-21 2012-09-27 F. Hoffmann-La Roche Ag Benzoxazepin compounds selective for pi3k p110 delta and methods of use
ES2859478T3 (es) 2016-09-02 2021-10-04 Bristol Myers Squibb Co Compuestos heterocíclicos tricíclicos sustituidos
WO2019032631A1 (en) 2017-08-09 2019-02-14 Bristol-Myers Squibb Company Oxime ether compounds
US11046646B2 (en) 2017-08-09 2021-06-29 Bristol-Myers Squibb Company Alkylphenyl compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4082773A (en) * 1972-07-03 1978-04-04 E. R. Squibb & Sons, Inc. Tricyclic tetrahydro naphthaleneols and related compounds
DE2640358A1 (de) * 1976-09-08 1978-03-16 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
CA1292226C (en) * 1986-01-16 1991-11-19 Terumi Hachiya Indenothiazole derivative and process for preparing the same
IE68593B1 (en) 1989-12-06 1996-06-26 Sanofi Sa Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them
TW416953B (en) * 1996-09-25 2001-01-01 Takeda Chemical Industries Ltd Tricyclic compounds for eliciting a prostaglandin I2 receptor agonistic effect, their production and use
AU3289299A (en) * 1998-02-19 1999-09-06 Tularik Inc. Antiviral agents
DE19831878C2 (de) * 1998-07-17 2001-05-17 Aventis Pharma Gmbh Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19908537A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Verwendung von polycyclischen 2-Amino-Thiazol Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas

Also Published As

Publication number Publication date
DE50010285D1 (de) 2005-06-16
AU763111B2 (en) 2003-07-10
CN1148362C (zh) 2004-05-05
JP4728484B2 (ja) 2011-07-20
ZA200106198B (en) 2002-05-03
BR0008510A (pt) 2002-02-05
DE19908538A1 (de) 2000-08-31
ES2240070T3 (es) 2005-10-16
JP2002538148A (ja) 2002-11-12
US6251922B1 (en) 2001-06-26
EP1157015A1 (de) 2001-11-28
ATE295357T1 (de) 2005-05-15
PT1157015E (pt) 2005-08-31
EP1157015B1 (de) 2005-05-11
KR20010102390A (ko) 2001-11-15
HK1043117A1 (en) 2002-09-06
CA2364900A1 (en) 2000-09-08
WO2000051995A1 (de) 2000-09-08
AU3278200A (en) 2000-09-21
CN1344263A (zh) 2002-04-10

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20080205