JP2002527396A5 - - Google Patents
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- Publication number
- JP2002527396A5 JP2002527396A5 JP2000575513A JP2000575513A JP2002527396A5 JP 2002527396 A5 JP2002527396 A5 JP 2002527396A5 JP 2000575513 A JP2000575513 A JP 2000575513A JP 2000575513 A JP2000575513 A JP 2000575513A JP 2002527396 A5 JP2002527396 A5 JP 2002527396A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydrogen
- alkoxy
- alkyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 description 18
- 239000001257 hydrogen Substances 0.000 description 18
- 150000002431 hydrogen Chemical class 0.000 description 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 7
- -1 Phenyl Chemical group 0.000 description 6
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 description 4
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 125000005191 hydroxyalkylamino group Chemical group 0.000 description 3
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 description 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 2
- 125000003342 alkenyl group Chemical group 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10422698P | 1998-10-14 | 1998-10-14 | |
| US60/104,226 | 1998-10-14 | ||
| PCT/US1999/023900 WO2000021537A1 (en) | 1998-10-14 | 1999-10-14 | Novel indenoisoquinolines as antineoplastic agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002527396A JP2002527396A (ja) | 2002-08-27 |
| JP2002527396A5 true JP2002527396A5 (https=) | 2006-12-14 |
| JP4580556B2 JP4580556B2 (ja) | 2010-11-17 |
Family
ID=22299324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000575513A Expired - Fee Related JP4580556B2 (ja) | 1998-10-14 | 1999-10-14 | 抗腫瘍薬である新規インデノイソキノリン類 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6509344B1 (https=) |
| EP (2) | EP2050452A1 (https=) |
| JP (1) | JP4580556B2 (https=) |
| AT (1) | ATE424204T1 (https=) |
| AU (1) | AU765135B2 (https=) |
| CA (1) | CA2347100C (https=) |
| DE (1) | DE69940523D1 (https=) |
| WO (1) | WO2000021537A1 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6956035B2 (en) | 2001-08-31 | 2005-10-18 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
| US20030096833A1 (en) | 2001-08-31 | 2003-05-22 | Jagtap Prakash G. | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
| WO2003041660A2 (en) | 2001-11-14 | 2003-05-22 | Rutgers, The State University | Solubilized topoisomerase poisons |
| ES2311639T3 (es) | 2001-11-14 | 2009-02-16 | Rutgers, The State University | Agentes citotoxicos. |
| JP4789414B2 (ja) * | 2001-11-14 | 2011-10-12 | ラトガーズ，ザ ステイト ユニバーシティ | 可溶化トポイソメラーゼ毒性剤 |
| ATE390923T1 (de) * | 2001-11-14 | 2008-04-15 | Univ Rutgers | Topoisomerase-giftmittel |
| US6992089B2 (en) | 2002-08-09 | 2006-01-31 | Rutgers, The University Of New Jersey | Nitro and amino substituted topoisomerase agents |
| WO2004014862A1 (en) * | 2002-08-09 | 2004-02-19 | Rutgers, The State University | Nitro and amino substituted heterocycles as topoisomerase i targeting agents |
| WO2004014918A1 (en) | 2002-08-09 | 2004-02-19 | Rutgers, The State University | Nitro and amino substituted topoisomerase agents |
| AU2003290818A1 (en) * | 2002-11-12 | 2004-06-03 | Edmond J. Lavoie | Topoisomerase-targeting agents |
| EP1603567A4 (en) * | 2003-02-28 | 2006-10-18 | Inotek Pharmaceuticals Corp | TETRACYCLIC BENZAMIDE DERIVATIVES AND METHOD OF USE THEREOF |
| WO2004100891A2 (en) * | 2003-05-12 | 2004-11-25 | Purdue Research Foundation | Cytotoxic indeno and isoindoloisoquinolones |
| US20050228007A1 (en) * | 2004-02-26 | 2005-10-13 | Prakash Jagtap | Isoquinoline derivatives and methods of use thereof |
| EP1735281A4 (en) * | 2004-03-17 | 2009-11-04 | Purdue Research Foundation | Synthesis of Indinoisoquinoline Compounds and Their Use |
| US7495100B2 (en) * | 2004-05-07 | 2009-02-24 | Purdue Research Foundation | Synthesis of indenoisoquinolines |
| JP2008531562A (ja) | 2005-02-25 | 2008-08-14 | イノテック ファーマシューティカルズ コーポレイション | 四環アミノ化合物および四環カルボキサミド化合物およびこれらの使用法 |
| CN101316592A (zh) | 2005-08-24 | 2008-12-03 | 伊诺泰克制药公司 | 茚并异喹啉酮类似物及其用法 |
| CA2629530C (en) * | 2005-11-14 | 2014-07-08 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | N-substituted indenoisoquinolines and syntheses thereof |
| US9399660B2 (en) | 2005-11-14 | 2016-07-26 | Purdue Research Foundation | N-substituted indenoisoquinolines and syntheses thereof |
| KR20090115879A (ko) | 2007-02-28 | 2009-11-09 | 이노텍 파마슈티컬스 코포레이션 | 인데노이소퀴놀리논 유사체와 이의 이용 방법 |
| WO2010077663A2 (en) * | 2008-12-08 | 2010-07-08 | Inotek Pharmaceuticals Corporation | Substituted tetracyclic 1h-indeno (1,2-b) pyridine-2 (5h)-one analogs thereof and uses thereof |
| DK2403856T3 (da) | 2009-03-06 | 2013-04-08 | Univ Rutgers | Methylendioxybenzo[i]phenanthridinderivater anvendt til behandling af cancer |
| WO2010127363A1 (en) | 2009-05-01 | 2010-11-04 | Rutgers, The State University Of New Jersey | Toposiomerase inhibitors |
| EP2528440A4 (en) * | 2010-01-27 | 2013-08-07 | Purdue Research Foundation | SUBSTITUTED NORINDEN ISOCHINOLINE, SYNTHESIS THEREOF AND METHOD OF USE THEREOF |
| US9073920B2 (en) | 2010-08-17 | 2015-07-07 | Purdue Research Foundation | Substituted dibenzonaphthyridines, pharmaceutical uses thereof and processes therfor |
| US9682990B2 (en) | 2011-05-25 | 2017-06-20 | Purdue Research Foundation | Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors |
| US9328073B2 (en) | 2011-05-25 | 2016-05-03 | Purdue Research Foundation | Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors |
| US8912213B2 (en) | 2012-04-13 | 2014-12-16 | Purdue Research Foundation | Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (TDP1)- topoisomerase I (TOP1) inhibitors |
| US9034870B2 (en) | 2012-07-13 | 2015-05-19 | Purdue Research Foundation | Azaindenoisoquinoline topoisomerase I inhibitors |
| US8686146B2 (en) | 2012-07-13 | 2014-04-01 | Purdue Research Foundation | Azaindenoisoquinoline topoisomerase I inhibitors |
| US10759795B2 (en) | 2016-03-15 | 2020-09-01 | Purdue Research Foundation | Aza-A-ring indenoisoquinoline topoisomerase I poisons |
| JP2019515025A (ja) | 2016-04-04 | 2019-06-06 | ラトガース ザ ステイト ユニバーシティー オブ ニュージャージー | トポイソメラーゼ毒 |
| CN110167936A (zh) | 2016-12-22 | 2019-08-23 | 珀杜研究基金会 | 氮杂茚并异喹啉化合物及其用途 |
| EP3768266A4 (en) * | 2018-03-20 | 2021-12-22 | Merck Sharp & Dohme Corp. | OXO-TETRAHYDRO-ISOCHINOLINE-CARBOXYLIC ACIDS AS STING INHIBITORS |
| WO2020023700A2 (en) * | 2018-07-25 | 2020-01-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | OXYNITIDINE DERIVATIVES USEFUL AS INHIBITORS OF TOPOISOMERASE IB (Top1) AND TYROSYL-DNA PHOSPHODIESTERASE 1 (Tdp1) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3912740A (en) * | 1974-02-28 | 1975-10-14 | Us Health | Method for the preparation of oxygenated benzo{8 c{9 phenanthridine compounds |
| US5597831A (en) * | 1991-08-29 | 1997-01-28 | Vufb A.S | 6-[X-(2-hydroxyethyl) aminoalkyl]-5,11-dioxo-5,6-dihydro-11-H-indeno[1,2-c]isoquinolines and their use as antineoplastic agents |
| CZ281473B6 (cs) * | 1991-08-29 | 1996-10-16 | Vúfb, A.S. | Deriváty 6-/X-(2-hydroxyethyl)aminoalkyl/-5,11 -dioxo-5,6-dihydro-11H-indeno/1,2-c/-isochinolinu a způsob jejich výroby |
| JP3141148B2 (ja) * | 1995-08-08 | 2001-03-05 | 大鵬薬品工業株式会社 | 縮合インダン誘導体及びその塩 |
| JP3643916B2 (ja) * | 1995-11-17 | 2005-04-27 | 大鵬薬品工業株式会社 | 新規な縮合インデン誘導体又はその塩 |
-
1999
- 1999-10-14 AU AU12043/00A patent/AU765135B2/en not_active Ceased
- 1999-10-14 EP EP09000858A patent/EP2050452A1/en not_active Withdrawn
- 1999-10-14 DE DE69940523T patent/DE69940523D1/de not_active Expired - Lifetime
- 1999-10-14 EP EP99970323A patent/EP1123099B1/en not_active Expired - Lifetime
- 1999-10-14 JP JP2000575513A patent/JP4580556B2/ja not_active Expired - Fee Related
- 1999-10-14 AT AT99970323T patent/ATE424204T1/de not_active IP Right Cessation
- 1999-10-14 US US09/807,340 patent/US6509344B1/en not_active Expired - Lifetime
- 1999-10-14 CA CA2347100A patent/CA2347100C/en not_active Expired - Fee Related
- 1999-10-14 WO PCT/US1999/023900 patent/WO2000021537A1/en not_active Ceased
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