DE69940523D1 - Neue indenoisoquinoline als antineoplastische mittel - Google Patents

Neue indenoisoquinoline als antineoplastische mittel

Info

Publication number
DE69940523D1
DE69940523D1 DE69940523T DE69940523T DE69940523D1 DE 69940523 D1 DE69940523 D1 DE 69940523D1 DE 69940523 T DE69940523 T DE 69940523T DE 69940523 T DE69940523 T DE 69940523T DE 69940523 D1 DE69940523 D1 DE 69940523D1
Authority
DE
Germany
Prior art keywords
indeno
methylenedioxy
isoquinoline
dioxo
dimethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69940523T
Other languages
English (en)
Inventor
Mark S Cushman
Pamela M Nagafuji
Muthusamy Jayaraman
Yves G Pommier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Purdue Research Foundation
Original Assignee
US Department of Health and Human Services
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services, Purdue Research Foundation filed Critical US Department of Health and Human Services
Application granted granted Critical
Publication of DE69940523D1 publication Critical patent/DE69940523D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69940523T 1998-10-14 1999-10-14 Neue indenoisoquinoline als antineoplastische mittel Expired - Lifetime DE69940523D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10422698P 1998-10-14 1998-10-14
PCT/US1999/023900 WO2000021537A1 (en) 1998-10-14 1999-10-14 Novel indenoisoquinolines as antineoplastic agents

Publications (1)

Publication Number Publication Date
DE69940523D1 true DE69940523D1 (de) 2009-04-16

Family

ID=22299324

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69940523T Expired - Lifetime DE69940523D1 (de) 1998-10-14 1999-10-14 Neue indenoisoquinoline als antineoplastische mittel

Country Status (8)

Country Link
US (1) US6509344B1 (de)
EP (2) EP1123099B1 (de)
JP (1) JP4580556B2 (de)
AT (1) ATE424204T1 (de)
AU (1) AU765135B2 (de)
CA (1) CA2347100C (de)
DE (1) DE69940523D1 (de)
WO (1) WO2000021537A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6956035B2 (en) * 2001-08-31 2005-10-18 Inotek Pharmaceuticals Corporation Isoquinoline derivatives and methods of use thereof
US20030096833A1 (en) 2001-08-31 2003-05-22 Jagtap Prakash G. Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof
CA2467279A1 (en) * 2001-11-14 2003-06-26 Edmond J. Lavoie Solubilized topoisomerase poison agents
DE60228484D1 (de) * 2001-11-14 2008-10-02 Univ Rutgers Cytotoxische mittel
CA2467774C (en) * 2001-11-14 2011-09-20 Rutgers, The State University Solubilized topoisomerase poisons
ATE390923T1 (de) 2001-11-14 2008-04-15 Univ Rutgers Topoisomerase-giftmittel
US6992088B2 (en) * 2002-08-09 2006-01-31 Rutgers, The State University Of New Jersey Nitro and amino substituted heterocycles as topoisomerase I targeting agents
US6992089B2 (en) * 2002-08-09 2006-01-31 Rutgers, The University Of New Jersey Nitro and amino substituted topoisomerase agents
US6989387B2 (en) 2002-08-09 2006-01-24 Rutgers, The State University Of New Jersey Nitro and amino substituted topoisomerase agents
JP4774212B2 (ja) 2002-11-12 2011-09-14 ラトガーズ、ザ・ステイト・ユニバーシテイ・オブ・ニユー・ジヤージー トポイソメラーゼ−ターゲッティング剤
US7217709B2 (en) 2003-02-28 2007-05-15 Inotek Pharmaceuticals Corporation Tetracyclic benzamide derivatives and methods of use thereof
AU2004238329A1 (en) * 2003-05-12 2004-11-25 Purdue Research Foundation Cytotoxic indeno and isoindoloisoquinolones
EP2033645A1 (de) 2004-02-26 2009-03-11 Inotek Pharmaceuticals Corporation Isochinolin-Derivate und Verwendungsverfahren dafür
WO2005089294A2 (en) * 2004-03-17 2005-09-29 Purdue Research Foundation Synthesis of indenoisoquinoliniums and methods of use
US7495100B2 (en) * 2004-05-07 2009-02-24 Purdue Research Foundation Synthesis of indenoisoquinolines
WO2006093667A1 (en) 2005-02-25 2006-09-08 Inotek Pharmaceuticals Corporation Tetracyclic amino and carboxamido compounds and methods of use thereof
BRPI0615096A2 (pt) 2005-08-24 2009-07-14 Inotek Pharmaceuticals Corp análogos de indenoisoquinolinona e métodos de uso dos mesmos
US9399660B2 (en) 2005-11-14 2016-07-26 Purdue Research Foundation N-substituted indenoisoquinolines and syntheses thereof
EP1960366B1 (de) 2005-11-14 2016-07-20 Purdue Research Foundation N-substituierte indenoisochinoline und synthesen davon
AU2008221358A1 (en) 2007-02-28 2008-09-04 Inotek Pharmaceuticals Corporation Indenoisoquinolinone analogs and methods of use thereof
WO2010077663A2 (en) * 2008-12-08 2010-07-08 Inotek Pharmaceuticals Corporation Substituted tetracyclic 1h-indeno (1,2-b) pyridine-2 (5h)-one analogs thereof and uses thereof
WO2010102219A1 (en) 2009-03-06 2010-09-10 Rutgers, The State University Of New Jersey Methylenedioxybenzo [i] phenanthridine derivatives used to treat cancer
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
CA2788213A1 (en) * 2010-01-27 2011-08-04 Purdue Research Foundation Substituted norindenoisoquinolines, syntheses thereof, and methods of use
US9073920B2 (en) 2010-08-17 2015-07-07 Purdue Research Foundation Substituted dibenzonaphthyridines, pharmaceutical uses thereof and processes therfor
US9682990B2 (en) 2011-05-25 2017-06-20 Purdue Research Foundation Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors
WO2012162513A2 (en) * 2011-05-25 2012-11-29 Purdue Research Foundation Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase i inhibitors
US8912213B2 (en) 2012-04-13 2014-12-16 Purdue Research Foundation Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (TDP1)- topoisomerase I (TOP1) inhibitors
US8686146B2 (en) 2012-07-13 2014-04-01 Purdue Research Foundation Azaindenoisoquinoline topoisomerase I inhibitors
US9034870B2 (en) 2012-07-13 2015-05-19 Purdue Research Foundation Azaindenoisoquinoline topoisomerase I inhibitors
US10759795B2 (en) 2016-03-15 2020-09-01 Purdue Research Foundation Aza-A-ring indenoisoquinoline topoisomerase I poisons
JP2019515025A (ja) 2016-04-04 2019-06-06 ラトガース ザ ステイト ユニバーシティー オブ ニュージャージー トポイソメラーゼ毒
CN110167936A (zh) 2016-12-22 2019-08-23 珀杜研究基金会 氮杂茚并异喹啉化合物及其用途
EP3768266A4 (de) * 2018-03-20 2021-12-22 Merck Sharp & Dohme Corp. Oxo-tetrahydro-isochinolin-carboxylsäuren als sting-inhibitoren
WO2020023700A2 (en) * 2018-07-25 2020-01-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services OXYNITIDINE DERIVATIVES USEFUL AS INHIBITORS OF TOPOISOMERASE IB (Top1) AND TYROSYL-DNA PHOSPHODIESTERASE 1 (Tdp1)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3912740A (en) * 1974-02-28 1975-10-14 Us Health Method for the preparation of oxygenated benzo{8 c{9 phenanthridine compounds
US5597831A (en) * 1991-08-29 1997-01-28 Vufb A.S 6-[X-(2-hydroxyethyl) aminoalkyl]-5,11-dioxo-5,6-dihydro-11-H-indeno[1,2-c]isoquinolines and their use as antineoplastic agents
SK278794B6 (sk) * 1991-08-29 1998-03-04 V�Fb 2-hydroxyetylaminosubstituované deriváty 5,11-diox
JP3141148B2 (ja) * 1995-08-08 2001-03-05 大鵬薬品工業株式会社 縮合インダン誘導体及びその塩
JP3643916B2 (ja) * 1995-11-17 2005-04-27 大鵬薬品工業株式会社 新規な縮合インデン誘導体又はその塩

Also Published As

Publication number Publication date
EP1123099B1 (de) 2009-03-04
AU765135B2 (en) 2003-09-11
JP4580556B2 (ja) 2010-11-17
AU1204300A (en) 2000-05-01
EP1123099A4 (de) 2002-08-21
WO2000021537A1 (en) 2000-04-20
CA2347100C (en) 2010-12-14
EP1123099A1 (de) 2001-08-16
ATE424204T1 (de) 2009-03-15
CA2347100A1 (en) 2000-04-20
JP2002527396A (ja) 2002-08-27
EP2050452A1 (de) 2009-04-22
US6509344B1 (en) 2003-01-21

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