DE69940523D1 - Neue indenoisoquinoline als antineoplastische mittel - Google Patents

Neue indenoisoquinoline als antineoplastische mittel

Info

Publication number
DE69940523D1
DE69940523D1 DE69940523T DE69940523T DE69940523D1 DE 69940523 D1 DE69940523 D1 DE 69940523D1 DE 69940523 T DE69940523 T DE 69940523T DE 69940523 T DE69940523 T DE 69940523T DE 69940523 D1 DE69940523 D1 DE 69940523D1
Authority
DE
Germany
Prior art keywords
indeno
methylenedioxy
isoquinoline
dioxo
dimethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69940523T
Other languages
German (de)
English (en)
Inventor
Mark S Cushman
Pamela M Nagafuji
Muthusamy Jayaraman
Yves G Pommier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Research Foundation
US Department of Health and Human Services
Original Assignee
Purdue Research Foundation
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation, US Department of Health and Human Services filed Critical Purdue Research Foundation
Application granted granted Critical
Publication of DE69940523D1 publication Critical patent/DE69940523D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69940523T 1998-10-14 1999-10-14 Neue indenoisoquinoline als antineoplastische mittel Expired - Lifetime DE69940523D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10422698P 1998-10-14 1998-10-14
PCT/US1999/023900 WO2000021537A1 (en) 1998-10-14 1999-10-14 Novel indenoisoquinolines as antineoplastic agents

Publications (1)

Publication Number Publication Date
DE69940523D1 true DE69940523D1 (de) 2009-04-16

Family

ID=22299324

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69940523T Expired - Lifetime DE69940523D1 (de) 1998-10-14 1999-10-14 Neue indenoisoquinoline als antineoplastische mittel

Country Status (8)

Country Link
US (1) US6509344B1 (https=)
EP (2) EP1123099B1 (https=)
JP (1) JP4580556B2 (https=)
AT (1) ATE424204T1 (https=)
AU (1) AU765135B2 (https=)
CA (1) CA2347100C (https=)
DE (1) DE69940523D1 (https=)
WO (1) WO2000021537A1 (https=)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6956035B2 (en) * 2001-08-31 2005-10-18 Inotek Pharmaceuticals Corporation Isoquinoline derivatives and methods of use thereof
US20030096833A1 (en) 2001-08-31 2003-05-22 Jagtap Prakash G. Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof
DE60235287D1 (de) * 2001-11-14 2010-03-25 Univ Rutgers Löslich gemachte topoisomerase-gifte
EP1453812B1 (en) * 2001-11-14 2008-08-20 Rutgers, The State University Cytotoxic agents
MXPA04004607A (es) 2001-11-14 2004-09-10 Univ Rutgers Agentes de venenos de topoisomerasa solubilizados.
AU2002364953A1 (en) * 2001-11-14 2003-06-17 Edmond J. Lavoie Topoisomerase poison agents
US6989387B2 (en) * 2002-08-09 2006-01-24 Rutgers, The State University Of New Jersey Nitro and amino substituted topoisomerase agents
AU2003268075A1 (en) * 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents
US6992088B2 (en) * 2002-08-09 2006-01-31 Rutgers, The State University Of New Jersey Nitro and amino substituted heterocycles as topoisomerase I targeting agents
CA2510337C (en) 2002-11-12 2013-01-08 Rutgers, The State University Of New Jersey Topoisomerase-targeting agents
JP2007501857A (ja) * 2003-02-28 2007-02-01 イノテック ファーマシューティカルズ コーポレーション 四環系ベンズアミド誘導体およびその使用方法
EP1646388A4 (en) * 2003-05-12 2007-04-18 Purdue Research Foundation CYTOTOXIC INDENO AND ISOINDOLOISOCHINOLONE
EA200601558A1 (ru) 2004-02-26 2007-08-31 Инотек Фармасьютикалз Корпорейшн Производные изохинолинов и способы их использования
EP1735281A4 (en) * 2004-03-17 2009-11-04 Purdue Research Foundation Synthesis of Indinoisoquinoline Compounds and Their Use
US7495100B2 (en) * 2004-05-07 2009-02-24 Purdue Research Foundation Synthesis of indenoisoquinolines
RU2007135362A (ru) 2005-02-25 2009-03-27 Инотек Фармасьютикалз Корпорейшн (Us) Тетрациклические амино- и карбоксамидосоединения и способ их применения
CN101316592A (zh) 2005-08-24 2008-12-03 伊诺泰克制药公司 茚并异喹啉酮类似物及其用法
US9399660B2 (en) 2005-11-14 2016-07-26 Purdue Research Foundation N-substituted indenoisoquinolines and syntheses thereof
CA2629530C (en) 2005-11-14 2014-07-08 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services N-substituted indenoisoquinolines and syntheses thereof
MX2009009183A (es) 2007-02-28 2009-09-07 Inotek Pharmaceuticals Corp Analogos de indenoisoquinolinona y metodos de utilizacion de los mismos.
WO2010077663A2 (en) * 2008-12-08 2010-07-08 Inotek Pharmaceuticals Corporation Substituted tetracyclic 1h-indeno (1,2-b) pyridine-2 (5h)-one analogs thereof and uses thereof
DK2403856T3 (da) 2009-03-06 2013-04-08 Univ Rutgers Methylendioxybenzo[i]phenanthridinderivater anvendt til behandling af cancer
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
WO2011094416A1 (en) * 2010-01-27 2011-08-04 Purdue Research Foundation Substituted norindenoisoquinolines, syntheses thereof, and methods of use
US9073920B2 (en) 2010-08-17 2015-07-07 Purdue Research Foundation Substituted dibenzonaphthyridines, pharmaceutical uses thereof and processes therfor
US9682990B2 (en) 2011-05-25 2017-06-20 Purdue Research Foundation Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors
US9328073B2 (en) 2011-05-25 2016-05-03 Purdue Research Foundation Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors
US8912213B2 (en) 2012-04-13 2014-12-16 Purdue Research Foundation Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (TDP1)- topoisomerase I (TOP1) inhibitors
US9034870B2 (en) 2012-07-13 2015-05-19 Purdue Research Foundation Azaindenoisoquinoline topoisomerase I inhibitors
US8686146B2 (en) 2012-07-13 2014-04-01 Purdue Research Foundation Azaindenoisoquinoline topoisomerase I inhibitors
US10759795B2 (en) 2016-03-15 2020-09-01 Purdue Research Foundation Aza-A-ring indenoisoquinoline topoisomerase I poisons
US11091498B2 (en) 2016-04-04 2021-08-17 Rutgers, The State University Of New Jersey Topoisomerase poisons
US10875860B2 (en) 2016-12-22 2020-12-29 Purdue Research Foundation Azaindenoisoquinoline compounds and uses thereof
US11311528B2 (en) * 2018-03-20 2022-04-26 Merck Sharp & Dohme Corp. Oxo-tetrahydro-isoquinoline carboxylic acids as STING inhibitors
WO2020023700A2 (en) * 2018-07-25 2020-01-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services OXYNITIDINE DERIVATIVES USEFUL AS INHIBITORS OF TOPOISOMERASE IB (Top1) AND TYROSYL-DNA PHOSPHODIESTERASE 1 (Tdp1)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3912740A (en) * 1974-02-28 1975-10-14 Us Health Method for the preparation of oxygenated benzo{8 c{9 phenanthridine compounds
SK278794B6 (sk) * 1991-08-29 1998-03-04 V�Fb 2-hydroxyetylaminosubstituované deriváty 5,11-diox
US5597831A (en) * 1991-08-29 1997-01-28 Vufb A.S 6-[X-(2-hydroxyethyl) aminoalkyl]-5,11-dioxo-5,6-dihydro-11-H-indeno[1,2-c]isoquinolines and their use as antineoplastic agents
JP3141148B2 (ja) * 1995-08-08 2001-03-05 大鵬薬品工業株式会社 縮合インダン誘導体及びその塩
JP3643916B2 (ja) * 1995-11-17 2005-04-27 大鵬薬品工業株式会社 新規な縮合インデン誘導体又はその塩

Also Published As

Publication number Publication date
EP1123099B1 (en) 2009-03-04
AU765135B2 (en) 2003-09-11
EP2050452A1 (en) 2009-04-22
JP2002527396A (ja) 2002-08-27
CA2347100A1 (en) 2000-04-20
WO2000021537A1 (en) 2000-04-20
ATE424204T1 (de) 2009-03-15
AU1204300A (en) 2000-05-01
EP1123099A4 (en) 2002-08-21
US6509344B1 (en) 2003-01-21
CA2347100C (en) 2010-12-14
EP1123099A1 (en) 2001-08-16
JP4580556B2 (ja) 2010-11-17

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