ATE424204T1 - Neue indenoisoquinoline als antineoplastische mittel - Google Patents
Neue indenoisoquinoline als antineoplastische mittelInfo
- Publication number
- ATE424204T1 ATE424204T1 AT99970323T AT99970323T ATE424204T1 AT E424204 T1 ATE424204 T1 AT E424204T1 AT 99970323 T AT99970323 T AT 99970323T AT 99970323 T AT99970323 T AT 99970323T AT E424204 T1 ATE424204 T1 AT E424204T1
- Authority
- AT
- Austria
- Prior art keywords
- indeno
- methylenedioxy
- isoquinoline
- dioxo
- dimethoxy
- Prior art date
Links
- 229940034982 antineoplastic agent Drugs 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- NMNDQBZTIMGTSF-UHFFFAOYSA-N 11h-indeno[1,2-h]isoquinoline Chemical class C1=CN=CC2=C3CC4=CC=CC=C4C3=CC=C21 NMNDQBZTIMGTSF-UHFFFAOYSA-N 0.000 abstract 2
- AHIJTWCJGCWHMT-UHFFFAOYSA-N 4-(5,11-dioxo-5h-indeno[1,2-c]isoquinolin-6(11h)-yl)butanoate Chemical compound C12=CC=CC=C2C(=O)N(CCCC(=O)O)C2=C1C(=O)C1=CC=CC=C12 AHIJTWCJGCWHMT-UHFFFAOYSA-N 0.000 abstract 2
- 229940123780 DNA topoisomerase I inhibitor Drugs 0.000 abstract 2
- 239000000365 Topoisomerase I Inhibitor Substances 0.000 abstract 2
- 230000003389 potentiating effect Effects 0.000 abstract 2
- NHKRDSRSZLLBTM-UHFFFAOYSA-N C1=CC=CC2=C3C=C(C=CC=C4)C4=C3NC=C21 Chemical compound C1=CC=CC2=C3C=C(C=CC=C4)C4=C3NC=C21 NHKRDSRSZLLBTM-UHFFFAOYSA-N 0.000 abstract 1
- 102000003915 DNA Topoisomerases Human genes 0.000 abstract 1
- 108090000323 DNA Topoisomerases Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000007537 Type II DNA Topoisomerases Human genes 0.000 abstract 1
- 108010046308 Type II DNA Topoisomerases Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- AAKJFXMHQQBKFI-UHFFFAOYSA-M chembl316437 Chemical compound [Cl-].C1C2=CC=3OCOC=3C=C2C2=C1C1=CC(OC)=C(OC)C=C1C=[N+]2CC AAKJFXMHQQBKFI-UHFFFAOYSA-M 0.000 abstract 1
- ZQOKSNOLDMYSAQ-UHFFFAOYSA-N chembl356262 Chemical compound O=C1C2=CC=3OCOC=3C=C2C2=C1C(C=C(C(=C1)OC)OC)=C1C(=O)N2CCCCO ZQOKSNOLDMYSAQ-UHFFFAOYSA-N 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10422698P | 1998-10-14 | 1998-10-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE424204T1 true ATE424204T1 (de) | 2009-03-15 |
Family
ID=22299324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99970323T ATE424204T1 (de) | 1998-10-14 | 1999-10-14 | Neue indenoisoquinoline als antineoplastische mittel |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6509344B1 (https=) |
| EP (2) | EP2050452A1 (https=) |
| JP (1) | JP4580556B2 (https=) |
| AT (1) | ATE424204T1 (https=) |
| AU (1) | AU765135B2 (https=) |
| CA (1) | CA2347100C (https=) |
| DE (1) | DE69940523D1 (https=) |
| WO (1) | WO2000021537A1 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6956035B2 (en) | 2001-08-31 | 2005-10-18 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
| US20030096833A1 (en) | 2001-08-31 | 2003-05-22 | Jagtap Prakash G. | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
| WO2003041660A2 (en) | 2001-11-14 | 2003-05-22 | Rutgers, The State University | Solubilized topoisomerase poisons |
| ES2311639T3 (es) | 2001-11-14 | 2009-02-16 | Rutgers, The State University | Agentes citotoxicos. |
| JP4789414B2 (ja) * | 2001-11-14 | 2011-10-12 | ラトガーズ，ザ ステイト ユニバーシティ | 可溶化トポイソメラーゼ毒性剤 |
| ATE390923T1 (de) * | 2001-11-14 | 2008-04-15 | Univ Rutgers | Topoisomerase-giftmittel |
| US6992089B2 (en) | 2002-08-09 | 2006-01-31 | Rutgers, The University Of New Jersey | Nitro and amino substituted topoisomerase agents |
| WO2004014862A1 (en) * | 2002-08-09 | 2004-02-19 | Rutgers, The State University | Nitro and amino substituted heterocycles as topoisomerase i targeting agents |
| WO2004014918A1 (en) | 2002-08-09 | 2004-02-19 | Rutgers, The State University | Nitro and amino substituted topoisomerase agents |
| AU2003290818A1 (en) * | 2002-11-12 | 2004-06-03 | Edmond J. Lavoie | Topoisomerase-targeting agents |
| EP1603567A4 (en) * | 2003-02-28 | 2006-10-18 | Inotek Pharmaceuticals Corp | TETRACYCLIC BENZAMIDE DERIVATIVES AND METHOD OF USE THEREOF |
| WO2004100891A2 (en) * | 2003-05-12 | 2004-11-25 | Purdue Research Foundation | Cytotoxic indeno and isoindoloisoquinolones |
| US20050228007A1 (en) * | 2004-02-26 | 2005-10-13 | Prakash Jagtap | Isoquinoline derivatives and methods of use thereof |
| EP1735281A4 (en) * | 2004-03-17 | 2009-11-04 | Purdue Research Foundation | Synthesis of Indinoisoquinoline Compounds and Their Use |
| US7495100B2 (en) * | 2004-05-07 | 2009-02-24 | Purdue Research Foundation | Synthesis of indenoisoquinolines |
| JP2008531562A (ja) | 2005-02-25 | 2008-08-14 | イノテック ファーマシューティカルズ コーポレイション | 四環アミノ化合物および四環カルボキサミド化合物およびこれらの使用法 |
| CN101316592A (zh) | 2005-08-24 | 2008-12-03 | 伊诺泰克制药公司 | 茚并异喹啉酮类似物及其用法 |
| CA2629530C (en) * | 2005-11-14 | 2014-07-08 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | N-substituted indenoisoquinolines and syntheses thereof |
| US9399660B2 (en) | 2005-11-14 | 2016-07-26 | Purdue Research Foundation | N-substituted indenoisoquinolines and syntheses thereof |
| KR20090115879A (ko) | 2007-02-28 | 2009-11-09 | 이노텍 파마슈티컬스 코포레이션 | 인데노이소퀴놀리논 유사체와 이의 이용 방법 |
| WO2010077663A2 (en) * | 2008-12-08 | 2010-07-08 | Inotek Pharmaceuticals Corporation | Substituted tetracyclic 1h-indeno (1,2-b) pyridine-2 (5h)-one analogs thereof and uses thereof |
| DK2403856T3 (da) | 2009-03-06 | 2013-04-08 | Univ Rutgers | Methylendioxybenzo[i]phenanthridinderivater anvendt til behandling af cancer |
| WO2010127363A1 (en) | 2009-05-01 | 2010-11-04 | Rutgers, The State University Of New Jersey | Toposiomerase inhibitors |
| EP2528440A4 (en) * | 2010-01-27 | 2013-08-07 | Purdue Research Foundation | SUBSTITUTED NORINDEN ISOCHINOLINE, SYNTHESIS THEREOF AND METHOD OF USE THEREOF |
| US9073920B2 (en) | 2010-08-17 | 2015-07-07 | Purdue Research Foundation | Substituted dibenzonaphthyridines, pharmaceutical uses thereof and processes therfor |
| US9682990B2 (en) | 2011-05-25 | 2017-06-20 | Purdue Research Foundation | Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors |
| US9328073B2 (en) | 2011-05-25 | 2016-05-03 | Purdue Research Foundation | Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors |
| US8912213B2 (en) | 2012-04-13 | 2014-12-16 | Purdue Research Foundation | Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (TDP1)- topoisomerase I (TOP1) inhibitors |
| US9034870B2 (en) | 2012-07-13 | 2015-05-19 | Purdue Research Foundation | Azaindenoisoquinoline topoisomerase I inhibitors |
| US8686146B2 (en) | 2012-07-13 | 2014-04-01 | Purdue Research Foundation | Azaindenoisoquinoline topoisomerase I inhibitors |
| US10759795B2 (en) | 2016-03-15 | 2020-09-01 | Purdue Research Foundation | Aza-A-ring indenoisoquinoline topoisomerase I poisons |
| JP2019515025A (ja) | 2016-04-04 | 2019-06-06 | ラトガース ザ ステイト ユニバーシティー オブ ニュージャージー | トポイソメラーゼ毒 |
| CN110167936A (zh) | 2016-12-22 | 2019-08-23 | 珀杜研究基金会 | 氮杂茚并异喹啉化合物及其用途 |
| EP3768266A4 (en) * | 2018-03-20 | 2021-12-22 | Merck Sharp & Dohme Corp. | OXO-TETRAHYDRO-ISOCHINOLINE-CARBOXYLIC ACIDS AS STING INHIBITORS |
| WO2020023700A2 (en) * | 2018-07-25 | 2020-01-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | OXYNITIDINE DERIVATIVES USEFUL AS INHIBITORS OF TOPOISOMERASE IB (Top1) AND TYROSYL-DNA PHOSPHODIESTERASE 1 (Tdp1) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3912740A (en) * | 1974-02-28 | 1975-10-14 | Us Health | Method for the preparation of oxygenated benzo{8 c{9 phenanthridine compounds |
| US5597831A (en) * | 1991-08-29 | 1997-01-28 | Vufb A.S | 6-[X-(2-hydroxyethyl) aminoalkyl]-5,11-dioxo-5,6-dihydro-11-H-indeno[1,2-c]isoquinolines and their use as antineoplastic agents |
| CZ281473B6 (cs) * | 1991-08-29 | 1996-10-16 | Vúfb, A.S. | Deriváty 6-/X-(2-hydroxyethyl)aminoalkyl/-5,11 -dioxo-5,6-dihydro-11H-indeno/1,2-c/-isochinolinu a způsob jejich výroby |
| JP3141148B2 (ja) * | 1995-08-08 | 2001-03-05 | 大鵬薬品工業株式会社 | 縮合インダン誘導体及びその塩 |
| JP3643916B2 (ja) * | 1995-11-17 | 2005-04-27 | 大鵬薬品工業株式会社 | 新規な縮合インデン誘導体又はその塩 |
-
1999
- 1999-10-14 AU AU12043/00A patent/AU765135B2/en not_active Ceased
- 1999-10-14 EP EP09000858A patent/EP2050452A1/en not_active Withdrawn
- 1999-10-14 DE DE69940523T patent/DE69940523D1/de not_active Expired - Lifetime
- 1999-10-14 EP EP99970323A patent/EP1123099B1/en not_active Expired - Lifetime
- 1999-10-14 JP JP2000575513A patent/JP4580556B2/ja not_active Expired - Fee Related
- 1999-10-14 AT AT99970323T patent/ATE424204T1/de not_active IP Right Cessation
- 1999-10-14 US US09/807,340 patent/US6509344B1/en not_active Expired - Lifetime
- 1999-10-14 CA CA2347100A patent/CA2347100C/en not_active Expired - Fee Related
- 1999-10-14 WO PCT/US1999/023900 patent/WO2000021537A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1123099A1 (en) | 2001-08-16 |
| US6509344B1 (en) | 2003-01-21 |
| DE69940523D1 (de) | 2009-04-16 |
| EP1123099A4 (en) | 2002-08-21 |
| AU765135B2 (en) | 2003-09-11 |
| JP2002527396A (ja) | 2002-08-27 |
| CA2347100C (en) | 2010-12-14 |
| JP4580556B2 (ja) | 2010-11-17 |
| EP1123099B1 (en) | 2009-03-04 |
| AU1204300A (en) | 2000-05-01 |
| EP2050452A1 (en) | 2009-04-22 |
| WO2000021537A1 (en) | 2000-04-20 |
| CA2347100A1 (en) | 2000-04-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |