ATE424204T1 - Neue indenoisoquinoline als antineoplastische mittel - Google Patents
Neue indenoisoquinoline als antineoplastische mittelInfo
- Publication number
- ATE424204T1 ATE424204T1 AT99970323T AT99970323T ATE424204T1 AT E424204 T1 ATE424204 T1 AT E424204T1 AT 99970323 T AT99970323 T AT 99970323T AT 99970323 T AT99970323 T AT 99970323T AT E424204 T1 ATE424204 T1 AT E424204T1
- Authority
- AT
- Austria
- Prior art keywords
- indeno
- methylenedioxy
- isoquinoline
- dioxo
- dimethoxy
- Prior art date
Links
- 229940034982 antineoplastic agent Drugs 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- NMNDQBZTIMGTSF-UHFFFAOYSA-N 11h-indeno[1,2-h]isoquinoline Chemical class C1=CN=CC2=C3CC4=CC=CC=C4C3=CC=C21 NMNDQBZTIMGTSF-UHFFFAOYSA-N 0.000 abstract 2
- AHIJTWCJGCWHMT-UHFFFAOYSA-N 4-(5,11-dioxo-5h-indeno[1,2-c]isoquinolin-6(11h)-yl)butanoate Chemical compound C12=CC=CC=C2C(=O)N(CCCC(=O)O)C2=C1C(=O)C1=CC=CC=C12 AHIJTWCJGCWHMT-UHFFFAOYSA-N 0.000 abstract 2
- 229940123780 DNA topoisomerase I inhibitor Drugs 0.000 abstract 2
- 239000000365 Topoisomerase I Inhibitor Substances 0.000 abstract 2
- 230000003389 potentiating effect Effects 0.000 abstract 2
- NHKRDSRSZLLBTM-UHFFFAOYSA-N C1=CC=CC2=C3C=C(C=CC=C4)C4=C3NC=C21 Chemical compound C1=CC=CC2=C3C=C(C=CC=C4)C4=C3NC=C21 NHKRDSRSZLLBTM-UHFFFAOYSA-N 0.000 abstract 1
- 102000003915 DNA Topoisomerases Human genes 0.000 abstract 1
- 108090000323 DNA Topoisomerases Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000007537 Type II DNA Topoisomerases Human genes 0.000 abstract 1
- 108010046308 Type II DNA Topoisomerases Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- AAKJFXMHQQBKFI-UHFFFAOYSA-M chembl316437 Chemical compound [Cl-].C1C2=CC=3OCOC=3C=C2C2=C1C1=CC(OC)=C(OC)C=C1C=[N+]2CC AAKJFXMHQQBKFI-UHFFFAOYSA-M 0.000 abstract 1
- ZQOKSNOLDMYSAQ-UHFFFAOYSA-N chembl356262 Chemical compound O=C1C2=CC=3OCOC=3C=C2C2=C1C(C=C(C(=C1)OC)OC)=C1C(=O)N2CCCCO ZQOKSNOLDMYSAQ-UHFFFAOYSA-N 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10422698P | 1998-10-14 | 1998-10-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE424204T1 true ATE424204T1 (de) | 2009-03-15 |
Family
ID=22299324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99970323T ATE424204T1 (de) | 1998-10-14 | 1999-10-14 | Neue indenoisoquinoline als antineoplastische mittel |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6509344B1 (https=) |
| EP (2) | EP1123099B1 (https=) |
| JP (1) | JP4580556B2 (https=) |
| AT (1) | ATE424204T1 (https=) |
| AU (1) | AU765135B2 (https=) |
| CA (1) | CA2347100C (https=) |
| DE (1) | DE69940523D1 (https=) |
| WO (1) | WO2000021537A1 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6956035B2 (en) * | 2001-08-31 | 2005-10-18 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
| US20030096833A1 (en) | 2001-08-31 | 2003-05-22 | Jagtap Prakash G. | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
| DE60235287D1 (de) * | 2001-11-14 | 2010-03-25 | Univ Rutgers | Löslich gemachte topoisomerase-gifte |
| EP1453812B1 (en) * | 2001-11-14 | 2008-08-20 | Rutgers, The State University | Cytotoxic agents |
| MXPA04004607A (es) | 2001-11-14 | 2004-09-10 | Univ Rutgers | Agentes de venenos de topoisomerasa solubilizados. |
| AU2002364953A1 (en) * | 2001-11-14 | 2003-06-17 | Edmond J. Lavoie | Topoisomerase poison agents |
| US6989387B2 (en) * | 2002-08-09 | 2006-01-24 | Rutgers, The State University Of New Jersey | Nitro and amino substituted topoisomerase agents |
| AU2003268075A1 (en) * | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents |
| US6992088B2 (en) * | 2002-08-09 | 2006-01-31 | Rutgers, The State University Of New Jersey | Nitro and amino substituted heterocycles as topoisomerase I targeting agents |
| CA2510337C (en) | 2002-11-12 | 2013-01-08 | Rutgers, The State University Of New Jersey | Topoisomerase-targeting agents |
| JP2007501857A (ja) * | 2003-02-28 | 2007-02-01 | イノテック ファーマシューティカルズ コーポレーション | 四環系ベンズアミド誘導体およびその使用方法 |
| EP1646388A4 (en) * | 2003-05-12 | 2007-04-18 | Purdue Research Foundation | CYTOTOXIC INDENO AND ISOINDOLOISOCHINOLONE |
| EA200601558A1 (ru) | 2004-02-26 | 2007-08-31 | Инотек Фармасьютикалз Корпорейшн | Производные изохинолинов и способы их использования |
| EP1735281A4 (en) * | 2004-03-17 | 2009-11-04 | Purdue Research Foundation | Synthesis of Indinoisoquinoline Compounds and Their Use |
| US7495100B2 (en) * | 2004-05-07 | 2009-02-24 | Purdue Research Foundation | Synthesis of indenoisoquinolines |
| RU2007135362A (ru) | 2005-02-25 | 2009-03-27 | Инотек Фармасьютикалз Корпорейшн (Us) | Тетрациклические амино- и карбоксамидосоединения и способ их применения |
| CN101316592A (zh) | 2005-08-24 | 2008-12-03 | 伊诺泰克制药公司 | 茚并异喹啉酮类似物及其用法 |
| US9399660B2 (en) | 2005-11-14 | 2016-07-26 | Purdue Research Foundation | N-substituted indenoisoquinolines and syntheses thereof |
| CA2629530C (en) | 2005-11-14 | 2014-07-08 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | N-substituted indenoisoquinolines and syntheses thereof |
| MX2009009183A (es) | 2007-02-28 | 2009-09-07 | Inotek Pharmaceuticals Corp | Analogos de indenoisoquinolinona y metodos de utilizacion de los mismos. |
| WO2010077663A2 (en) * | 2008-12-08 | 2010-07-08 | Inotek Pharmaceuticals Corporation | Substituted tetracyclic 1h-indeno (1,2-b) pyridine-2 (5h)-one analogs thereof and uses thereof |
| DK2403856T3 (da) | 2009-03-06 | 2013-04-08 | Univ Rutgers | Methylendioxybenzo[i]phenanthridinderivater anvendt til behandling af cancer |
| WO2010127363A1 (en) | 2009-05-01 | 2010-11-04 | Rutgers, The State University Of New Jersey | Toposiomerase inhibitors |
| WO2011094416A1 (en) * | 2010-01-27 | 2011-08-04 | Purdue Research Foundation | Substituted norindenoisoquinolines, syntheses thereof, and methods of use |
| US9073920B2 (en) | 2010-08-17 | 2015-07-07 | Purdue Research Foundation | Substituted dibenzonaphthyridines, pharmaceutical uses thereof and processes therfor |
| US9682990B2 (en) | 2011-05-25 | 2017-06-20 | Purdue Research Foundation | Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors |
| US9328073B2 (en) | 2011-05-25 | 2016-05-03 | Purdue Research Foundation | Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors |
| US8912213B2 (en) | 2012-04-13 | 2014-12-16 | Purdue Research Foundation | Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (TDP1)- topoisomerase I (TOP1) inhibitors |
| US9034870B2 (en) | 2012-07-13 | 2015-05-19 | Purdue Research Foundation | Azaindenoisoquinoline topoisomerase I inhibitors |
| US8686146B2 (en) | 2012-07-13 | 2014-04-01 | Purdue Research Foundation | Azaindenoisoquinoline topoisomerase I inhibitors |
| US10759795B2 (en) | 2016-03-15 | 2020-09-01 | Purdue Research Foundation | Aza-A-ring indenoisoquinoline topoisomerase I poisons |
| US11091498B2 (en) | 2016-04-04 | 2021-08-17 | Rutgers, The State University Of New Jersey | Topoisomerase poisons |
| US10875860B2 (en) | 2016-12-22 | 2020-12-29 | Purdue Research Foundation | Azaindenoisoquinoline compounds and uses thereof |
| US11311528B2 (en) * | 2018-03-20 | 2022-04-26 | Merck Sharp & Dohme Corp. | Oxo-tetrahydro-isoquinoline carboxylic acids as STING inhibitors |
| WO2020023700A2 (en) * | 2018-07-25 | 2020-01-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | OXYNITIDINE DERIVATIVES USEFUL AS INHIBITORS OF TOPOISOMERASE IB (Top1) AND TYROSYL-DNA PHOSPHODIESTERASE 1 (Tdp1) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3912740A (en) * | 1974-02-28 | 1975-10-14 | Us Health | Method for the preparation of oxygenated benzo{8 c{9 phenanthridine compounds |
| SK278794B6 (sk) * | 1991-08-29 | 1998-03-04 | V�Fb | 2-hydroxyetylaminosubstituované deriváty 5,11-diox |
| US5597831A (en) * | 1991-08-29 | 1997-01-28 | Vufb A.S | 6-[X-(2-hydroxyethyl) aminoalkyl]-5,11-dioxo-5,6-dihydro-11-H-indeno[1,2-c]isoquinolines and their use as antineoplastic agents |
| JP3141148B2 (ja) * | 1995-08-08 | 2001-03-05 | 大鵬薬品工業株式会社 | 縮合インダン誘導体及びその塩 |
| JP3643916B2 (ja) * | 1995-11-17 | 2005-04-27 | 大鵬薬品工業株式会社 | 新規な縮合インデン誘導体又はその塩 |
-
1999
- 1999-10-14 CA CA2347100A patent/CA2347100C/en not_active Expired - Fee Related
- 1999-10-14 AT AT99970323T patent/ATE424204T1/de not_active IP Right Cessation
- 1999-10-14 WO PCT/US1999/023900 patent/WO2000021537A1/en not_active Ceased
- 1999-10-14 DE DE69940523T patent/DE69940523D1/de not_active Expired - Lifetime
- 1999-10-14 AU AU12043/00A patent/AU765135B2/en not_active Ceased
- 1999-10-14 EP EP99970323A patent/EP1123099B1/en not_active Expired - Lifetime
- 1999-10-14 US US09/807,340 patent/US6509344B1/en not_active Expired - Lifetime
- 1999-10-14 EP EP09000858A patent/EP2050452A1/en not_active Withdrawn
- 1999-10-14 JP JP2000575513A patent/JP4580556B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1123099B1 (en) | 2009-03-04 |
| AU765135B2 (en) | 2003-09-11 |
| EP2050452A1 (en) | 2009-04-22 |
| JP2002527396A (ja) | 2002-08-27 |
| CA2347100A1 (en) | 2000-04-20 |
| WO2000021537A1 (en) | 2000-04-20 |
| DE69940523D1 (de) | 2009-04-16 |
| AU1204300A (en) | 2000-05-01 |
| EP1123099A4 (en) | 2002-08-21 |
| US6509344B1 (en) | 2003-01-21 |
| CA2347100C (en) | 2010-12-14 |
| EP1123099A1 (en) | 2001-08-16 |
| JP4580556B2 (ja) | 2010-11-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |