CA2296336C - Analgesic compositions comprising anti-epileptic compounds and methods of using same - Google Patents
Analgesic compositions comprising anti-epileptic compounds and methods of using same Download PDFInfo
- Publication number
- CA2296336C CA2296336C CA002296336A CA2296336A CA2296336C CA 2296336 C CA2296336 C CA 2296336C CA 002296336 A CA002296336 A CA 002296336A CA 2296336 A CA2296336 A CA 2296336A CA 2296336 C CA2296336 C CA 2296336C
- Authority
- CA
- Canada
- Prior art keywords
- combination
- pain
- gabapentin
- pharmaceutically acceptable
- epileptic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 52
- 239000001961 anticonvulsive agent Substances 0.000 title claims abstract description 28
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- 238000000034 method Methods 0.000 title abstract description 9
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- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 claims description 17
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5820797P | 1997-09-08 | 1997-09-08 | |
| US60/058,207 | 1997-09-08 | ||
| PCT/US1998/017083 WO1999012537A1 (en) | 1997-09-08 | 1998-08-18 | Analgesic compositions comprising anti-epileptic compounds and methods of using same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2296336A1 CA2296336A1 (en) | 1999-03-18 |
| CA2296336C true CA2296336C (en) | 2004-04-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002296336A Expired - Fee Related CA2296336C (en) | 1997-09-08 | 1998-08-18 | Analgesic compositions comprising anti-epileptic compounds and methods of using same |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US6593368B2 (https=) |
| EP (1) | EP1011658B1 (https=) |
| JP (1) | JP3782935B2 (https=) |
| KR (1) | KR100537707B1 (https=) |
| AT (1) | ATE311867T1 (https=) |
| AU (1) | AU750578B2 (https=) |
| BR (1) | BR9812162A (https=) |
| CA (1) | CA2296336C (https=) |
| CU (1) | CU23226B7 (https=) |
| DE (1) | DE69832712T2 (https=) |
| DK (1) | DK1011658T3 (https=) |
| ES (1) | ES2253825T3 (https=) |
| HU (1) | HU226165B1 (https=) |
| IL (2) | IL134165A0 (https=) |
| IS (1) | IS5362A (https=) |
| NO (1) | NO324122B1 (https=) |
| NZ (1) | NZ502671A (https=) |
| PL (1) | PL339142A1 (https=) |
| WO (1) | WO1999012537A1 (https=) |
| ZA (1) | ZA988159B (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL126999A (en) | 1996-07-24 | 2002-03-10 | Warner Lambert Co | Pharmaceutical preparations containing isobutylgaba and its history for use in the treatment of pain |
| WO1999012537A1 (en) * | 1997-09-08 | 1999-03-18 | Warner-Lambert Company | Analgesic compositions comprising anti-epileptic compounds and methods of using same |
| EP1094817A1 (en) * | 1998-07-09 | 2001-05-02 | Warner-Lambert Company | Compositions comprising gaba analogs and caffeine |
| US6451857B1 (en) | 1999-03-10 | 2002-09-17 | Warner-Lambert Company | Analgesic compositions comprising anti-epileptic compounds and methods of using same |
| DE60022333T2 (de) | 1999-04-09 | 2006-07-06 | Euro-Celtique S.A. | Natrium kanalblocker zusammensetzungen und deren verwendung |
| AU5824800A (en) * | 1999-06-23 | 2001-01-31 | Warner-Lambert Company | Use of fosphenytoin for the treatment of acute neuropathic pain |
| HUP0203198A3 (en) * | 1999-08-20 | 2005-07-28 | Ortho Mcneil Pharm Inc | Pharmaceutical composition comprising a tramadol material and an anticonvulsant drug, process for its preparation and its use |
| IL160523A0 (en) | 2001-09-03 | 2004-07-25 | Newron Pharm Spa | PHARMACEUTICAL COMPOSITION COMPRISING GABAPENTIN OR AN ANALOGUE THEREOF AND AN alpha-AMINOAMIDE AND ITS ANALGESIC USE |
| US20070184104A1 (en) * | 2001-10-25 | 2007-08-09 | Depomed, Inc. | Gastric retentive gabapentin dosage forms and methods for using same |
| US7612112B2 (en) * | 2001-10-25 | 2009-11-03 | Depomed, Inc. | Methods of treatment using a gastric retained gabapentin dosage |
| TWI312285B (en) | 2001-10-25 | 2009-07-21 | Depomed Inc | Methods of treatment using a gastric retained gabapentin dosage |
| US20060159743A1 (en) * | 2001-10-25 | 2006-07-20 | Depomed, Inc. | Methods of treating non-nociceptive pain states with gastric retentive gabapentin |
| US6730667B2 (en) * | 2001-11-26 | 2004-05-04 | William R. Deagle | Iontophoresis disc pain blocker |
| WO2003066040A1 (en) | 2002-02-05 | 2003-08-14 | Ajinomoto Co.,Inc. | Medicinal compositions containing gabapentin or pregabalin and n-type calcium channel antagonist |
| RU2286151C2 (ru) * | 2002-02-22 | 2006-10-27 | Уорнер-Ламберт Компани Ллс | Комбинации альфа-2-дельта-лиганда с селективным ингибитором циклооксигеназы-2 |
| WO2004054560A1 (en) * | 2002-12-13 | 2004-07-01 | Warner-Lambert Company Llc | Alpha-2-delta ligand to treat lower urinary tract symptoms |
| FR2862875B1 (fr) * | 2003-12-02 | 2006-04-07 | Mathey Acoustique Service | Preparation pharmaceutique pour le traitement des acouphenes |
| KR20070086334A (ko) * | 2004-11-16 | 2007-08-27 | 리머릭 뉴로사이언스즈, 인크. | 통증을 치료하기 위한 방법 및 조성물 |
| US20070087977A1 (en) * | 2004-11-16 | 2007-04-19 | Wendye Robbins | Methods and compositions for treating pain |
| KR20070087596A (ko) | 2005-09-19 | 2007-08-28 | 테바 파마슈티컬 인더스트리즈 리미티드 | (ｓ)-(+)-3-(아미노메틸)-5-메틸헥산산의 비대칭 합성 |
| MXPA05011735A (es) * | 2005-11-01 | 2007-04-30 | Leopoldo Espinosa Abdala | Composiciones farmaceuticas que comprenden combinaciones de analgesicos y anticonvulsivantes para el tratamiento del dolor agudo y cronico. |
| US20090176882A1 (en) * | 2008-12-09 | 2009-07-09 | Depomed, Inc. | Gastric retentive gabapentin dosage forms and methods for using same |
| CA2673545A1 (en) * | 2006-12-22 | 2008-07-03 | Recordati Ireland Limited | Combination therapy of lower urinary tract disorders with .alpha.2.delta. ligands and nsaids |
| MX2007006091A (es) * | 2007-05-21 | 2009-02-25 | World Trade Imp Export Wtie Ag | Composicion farmaceutica que comprende la combinacion de un agente antiinflamatorio no esteroideo y un agente anticonvulsionante. |
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1998
- 1998-08-18 WO PCT/US1998/017083 patent/WO1999012537A1/en not_active Ceased
- 1998-08-18 HU HU0003705A patent/HU226165B1/hu not_active IP Right Cessation
- 1998-08-18 IL IL13416598A patent/IL134165A0/xx unknown
- 1998-08-18 EP EP98944449A patent/EP1011658B1/en not_active Expired - Lifetime
- 1998-08-18 DE DE69832712T patent/DE69832712T2/de not_active Expired - Fee Related
- 1998-08-18 PL PL98339142A patent/PL339142A1/xx not_active Application Discontinuation
- 1998-08-18 NZ NZ502671A patent/NZ502671A/xx unknown
- 1998-08-18 AT AT98944449T patent/ATE311867T1/de not_active IP Right Cessation
- 1998-08-18 AU AU91987/98A patent/AU750578B2/en not_active Ceased
- 1998-08-18 US US09/463,116 patent/US6593368B2/en not_active Expired - Fee Related
- 1998-08-18 DK DK98944449T patent/DK1011658T3/da active
- 1998-08-18 ES ES98944449T patent/ES2253825T3/es not_active Expired - Lifetime
- 1998-08-18 BR BR9812162-6A patent/BR9812162A/pt not_active Application Discontinuation
- 1998-08-18 JP JP2000510435A patent/JP3782935B2/ja not_active Expired - Fee Related
- 1998-08-18 KR KR10-2000-7002400A patent/KR100537707B1/ko not_active Expired - Fee Related
- 1998-08-18 CA CA002296336A patent/CA2296336C/en not_active Expired - Fee Related
- 1998-09-07 ZA ZA988159A patent/ZA988159B/xx unknown
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2000
- 2000-01-25 IS IS5362A patent/IS5362A/is unknown
- 2000-03-03 CU CU20000051A patent/CU23226B7/es not_active IP Right Cessation
- 2000-03-07 NO NO20001175A patent/NO324122B1/no not_active IP Right Cessation
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2002
- 2002-02-13 US US10/075,929 patent/US6942876B2/en not_active Expired - Fee Related
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2003
- 2003-04-04 US US10/407,888 patent/US20030176505A1/en not_active Abandoned
-
2007
- 2007-08-16 IL IL185345A patent/IL185345A0/en unknown
Also Published As
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|---|---|
| AU750578B2 (en) | 2002-07-25 |
| DK1011658T3 (da) | 2006-04-03 |
| DE69832712T2 (de) | 2006-06-22 |
| NO20001175L (no) | 2000-03-07 |
| CA2296336A1 (en) | 1999-03-18 |
| HU226165B1 (en) | 2008-05-28 |
| ES2253825T3 (es) | 2006-06-01 |
| HUP0003705A2 (hu) | 2001-04-28 |
| ATE311867T1 (de) | 2005-12-15 |
| CU23226B7 (es) | 2007-09-26 |
| ZA988159B (en) | 1999-03-11 |
| US20020115705A1 (en) | 2002-08-22 |
| US20030065028A1 (en) | 2003-04-03 |
| NZ502671A (en) | 2003-01-31 |
| IS5362A (is) | 2000-01-25 |
| KR20010023745A (ko) | 2001-03-26 |
| US6942876B2 (en) | 2005-09-13 |
| US6593368B2 (en) | 2003-07-15 |
| JP2001515859A (ja) | 2001-09-25 |
| NO324122B1 (no) | 2007-08-27 |
| KR100537707B1 (ko) | 2005-12-20 |
| IL185345A0 (en) | 2008-01-06 |
| NO20001175D0 (no) | 2000-03-07 |
| IL134165A0 (en) | 2001-04-30 |
| JP3782935B2 (ja) | 2006-06-07 |
| WO1999012537A1 (en) | 1999-03-18 |
| EP1011658B1 (en) | 2005-12-07 |
| AU9198798A (en) | 1999-03-29 |
| US20030176505A1 (en) | 2003-09-18 |
| DE69832712D1 (de) | 2006-01-12 |
| HUP0003705A3 (en) | 2002-01-28 |
| BR9812162A (pt) | 2000-07-18 |
| PL339142A1 (en) | 2000-12-04 |
| EP1011658A1 (en) | 2000-06-28 |
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