JP2001502005A - 限外濾過、逆浸透及びナノ濾過を利用する炭水化物の精製 - Google Patents
限外濾過、逆浸透及びナノ濾過を利用する炭水化物の精製Info
- Publication number
- JP2001502005A JP2001502005A JP10517808A JP51780898A JP2001502005A JP 2001502005 A JP2001502005 A JP 2001502005A JP 10517808 A JP10517808 A JP 10517808A JP 51780898 A JP51780898 A JP 51780898A JP 2001502005 A JP2001502005 A JP 2001502005A
- Authority
- JP
- Japan
- Prior art keywords
- membrane
- feed solution
- group
- nanofiltration
- carbohydrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000001728 nano-filtration Methods 0.000 title claims abstract description 64
- 235000014633 carbohydrates Nutrition 0.000 title claims abstract description 61
- 150000001720 carbohydrates Chemical class 0.000 title claims abstract description 47
- 238000001223 reverse osmosis Methods 0.000 title claims abstract description 43
- 238000000108 ultra-filtration Methods 0.000 title claims abstract description 24
- 238000000746 purification Methods 0.000 title claims description 55
- 238000000034 method Methods 0.000 claims abstract description 103
- 235000000346 sugar Nutrition 0.000 claims abstract description 69
- -1 nucleotide sugars Chemical class 0.000 claims abstract description 61
- 150000001875 compounds Chemical class 0.000 claims abstract description 57
- 239000000356 contaminant Substances 0.000 claims abstract description 47
- 229920001542 oligosaccharide Polymers 0.000 claims abstract description 41
- 150000002482 oligosaccharides Chemical class 0.000 claims abstract description 41
- 239000002773 nucleotide Substances 0.000 claims abstract description 25
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 22
- 238000003786 synthesis reaction Methods 0.000 claims abstract description 22
- 239000011541 reaction mixture Substances 0.000 claims abstract description 14
- 239000012528 membrane Substances 0.000 claims description 206
- 239000000243 solution Substances 0.000 claims description 67
- 239000012466 permeate Substances 0.000 claims description 51
- 239000012527 feed solution Substances 0.000 claims description 40
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims description 38
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims description 28
- WQZGKKKJIJFFOK-FPRJBGLDSA-N beta-D-galactose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-FPRJBGLDSA-N 0.000 claims description 25
- 229910019142 PO4 Inorganic materials 0.000 claims description 22
- 229910052739 hydrogen Inorganic materials 0.000 claims description 20
- 239000001257 hydrogen Substances 0.000 claims description 20
- 235000021317 phosphate Nutrition 0.000 claims description 20
- 229940060155 neuac Drugs 0.000 claims description 18
- 125000003729 nucleotide group Chemical group 0.000 claims description 18
- 150000008163 sugars Chemical class 0.000 claims description 18
- 150000002431 hydrogen Chemical class 0.000 claims description 17
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 15
- 102000004169 proteins and genes Human genes 0.000 claims description 15
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- 239000004952 Polyamide Substances 0.000 claims description 14
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- 239000000203 mixture Substances 0.000 claims description 13
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 12
- 229910052799 carbon Inorganic materials 0.000 claims description 12
- 238000001914 filtration Methods 0.000 claims description 11
- 125000005630 sialyl group Chemical group 0.000 claims description 11
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims description 10
- FZHXIRIBWMQPQF-UHFFFAOYSA-N Glc-NH2 Natural products O=CC(N)C(O)C(O)C(O)CO FZHXIRIBWMQPQF-UHFFFAOYSA-N 0.000 claims description 10
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- TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 claims description 8
- PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 claims description 8
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims description 8
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- PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 claims description 8
- 239000012535 impurity Substances 0.000 claims description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 7
- 125000003545 alkoxy group Chemical group 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
- 238000005342 ion exchange Methods 0.000 claims description 6
- 230000007935 neutral effect Effects 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 claims description 6
- 125000001424 substituent group Chemical group 0.000 claims description 6
- 150000001768 cations Chemical class 0.000 claims description 5
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- 238000006911 enzymatic reaction Methods 0.000 claims description 5
- 239000008103 glucose Substances 0.000 claims description 5
- QIKYZXDTTPVVAC-UHFFFAOYSA-N 4-Aminobenzamide Chemical compound NC(=O)C1=CC=C(N)C=C1 QIKYZXDTTPVVAC-UHFFFAOYSA-N 0.000 claims description 4
- HSCJRCZFDFQWRP-UHFFFAOYSA-N Uridindiphosphoglukose Natural products OC1C(O)C(O)C(CO)OC1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-UHFFFAOYSA-N 0.000 claims description 4
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims description 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 4
- 125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 4
- 125000001475 halogen functional group Chemical group 0.000 claims description 4
- 150000002772 monosaccharides Chemical class 0.000 claims description 4
- JVXXKQIRGQDWOJ-UHFFFAOYSA-N naphthalene-2-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)N)=CC=C21 JVXXKQIRGQDWOJ-UHFFFAOYSA-N 0.000 claims description 4
- 125000003835 nucleoside group Chemical group 0.000 claims description 4
- ZESWUEBPRPGMTP-UHFFFAOYSA-N 4-nitrobenzamide Chemical compound NC(=O)C1=CC=C([N+]([O-])=O)C=C1 ZESWUEBPRPGMTP-UHFFFAOYSA-N 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
- 125000002947 alkylene group Chemical group 0.000 claims description 3
- 230000007515 enzymatic degradation Effects 0.000 claims description 3
- 150000004676 glycans Chemical class 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 3
- 229920001282 polysaccharide Polymers 0.000 claims description 3
- 239000005017 polysaccharide Substances 0.000 claims description 3
- 230000000717 retained effect Effects 0.000 claims description 3
- QMYMOARPAJVXDF-UHFFFAOYSA-N 5,6,7,8-tetrahydronaphthalene-2-carboxamide Chemical compound C1CCCC2=CC(C(=O)N)=CC=C21 QMYMOARPAJVXDF-UHFFFAOYSA-N 0.000 claims description 2
- LQEBEXMHBLQMDB-UHFFFAOYSA-N GDP-L-fucose Natural products OC1C(O)C(O)C(C)OC1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C3=C(C(N=C(N)N3)=O)N=C2)O1 LQEBEXMHBLQMDB-UHFFFAOYSA-N 0.000 claims description 2
- LQEBEXMHBLQMDB-JGQUBWHWSA-N GDP-beta-L-fucose Chemical group O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=C(C(NC(N)=N3)=O)N=C2)O1 LQEBEXMHBLQMDB-JGQUBWHWSA-N 0.000 claims description 2
- USAZACJQJDHAJH-KDEXOMDGSA-N [[(2r,3s,4r,5s)-5-(2,4-dioxo-1h-pyrimidin-6-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hydrogen phosphate Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](C=2NC(=O)NC(=O)C=2)O1 USAZACJQJDHAJH-KDEXOMDGSA-N 0.000 claims description 2
- QIGJYVCQYDKYDW-SDOYDPJRSA-N alpha-D-galactosyl-(1->3)-D-galactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@H]1[C@@H](O)[C@@H](CO)OC(O)[C@@H]1O QIGJYVCQYDKYDW-SDOYDPJRSA-N 0.000 claims description 2
- 150000001540 azides Chemical class 0.000 claims description 2
- 150000003857 carboxamides Chemical class 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 125000002668 chloroacetyl group Chemical group ClCC(=O)* 0.000 claims description 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 2
- 229910001410 inorganic ion Inorganic materials 0.000 claims description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 2
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- 125000003107 substituted aryl group Chemical group 0.000 claims description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
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- 229940126062 Compound A Drugs 0.000 claims 1
- MVMSCBBUIHUTGJ-GDJBGNAASA-N GDP-alpha-D-mannose Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H]1O)O)N1C=2N=C(NC(=O)C=2N=C1)N)OP(O)(=O)OP(O)(=O)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O MVMSCBBUIHUTGJ-GDJBGNAASA-N 0.000 claims 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical class CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 claims 1
- LFTYTUAZOPRMMI-NESSUJCYSA-N UDP-N-acetyl-alpha-D-galactosamine Chemical compound O1[C@H](CO)[C@H](O)[C@H](O)[C@@H](NC(=O)C)[C@H]1O[P@](O)(=O)O[P@](O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 LFTYTUAZOPRMMI-NESSUJCYSA-N 0.000 claims 1
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
-
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13B—PRODUCTION OF SUCROSE; APPARATUS SPECIALLY ADAPTED THEREFOR
- C13B20/00—Purification of sugar juices
- C13B20/16—Purification of sugar juices by physical means, e.g. osmosis or filtration
- C13B20/165—Purification of sugar juices by physical means, e.g. osmosis or filtration using membranes, e.g. osmosis, ultrafiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
- B01D61/025—Reverse osmosis; Hyperfiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
- B01D61/027—Nanofiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
- B01D61/029—Multistep processes comprising different kinds of membrane processes selected from reverse osmosis, hyperfiltration or nanofiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
- B01D61/04—Feed pretreatment
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
- C13K13/00—Sugars not otherwise provided for in this class
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/04—Specific process operations in the feed stream; Feed pretreatment
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
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- Chemical & Material Sciences (AREA)
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- Water Supply & Treatment (AREA)
- Nanotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Sustainable Development (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2822696P | 1996-10-10 | 1996-10-10 | |
| US60/028,226 | 1996-10-10 | ||
| PCT/US1997/018801 WO1998015581A1 (fr) | 1996-10-10 | 1997-10-09 | Purification de glucides par ultrafiltration, osmose inverse et nanofiltration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001502005A true JP2001502005A (ja) | 2001-02-13 |
| JP2001502005A5 JP2001502005A5 (fr) | 2005-05-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10517808A Ceased JP2001502005A (ja) | 1996-10-10 | 1997-10-09 | 限外濾過、逆浸透及びナノ濾過を利用する炭水化物の精製 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US6454946B1 (fr) |
| EP (1) | EP0931097B1 (fr) |
| JP (1) | JP2001502005A (fr) |
| KR (1) | KR100490507B1 (fr) |
| AT (1) | ATE304546T1 (fr) |
| AU (1) | AU735695B2 (fr) |
| CA (1) | CA2268168C (fr) |
| DE (1) | DE69734205T2 (fr) |
| DK (1) | DK0931097T3 (fr) |
| HU (1) | HUP0001634A2 (fr) |
| IL (2) | IL129363A (fr) |
| NZ (1) | NZ335203A (fr) |
| WO (1) | WO1998015581A1 (fr) |
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| JP2006512336A (ja) * | 2002-12-18 | 2006-04-13 | アベシア・リミテッド | オリゴヌクレオチド・シントン類を精製する方法 |
| JP2010075185A (ja) * | 2003-11-24 | 2010-04-08 | Millipore Corp | 合成生体分子の精製及び濃縮 |
| JP2014526371A (ja) * | 2011-09-01 | 2014-10-06 | 中外製薬株式会社 | 限外ろ過によって高度に濃縮された抗体を含む組成物を調製するための方法 |
| JP2020531039A (ja) * | 2017-08-29 | 2020-11-05 | イェネヴァイン ビオテヒノロギー ゲーエムベーハー | シアリル化オリゴ糖を精製する工程 |
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| BE1007425A3 (nl) | 1993-08-30 | 1995-06-13 | Holland Sweetener Co | Werkwijze en inrichting voor de terugwinning van grondstoffen in het aspartaambereidingsproces. |
| EP0727073A4 (fr) | 1993-10-28 | 1998-08-26 | Valeriy S Maisotsenko | Procede pour la determination du deplacement de fluides de travail et la conception de structures d'ecoulement pour ceux-ci |
| ES2173976T3 (es) | 1994-09-12 | 2002-11-01 | Aeci Ltd | Procedimiento para recuperar acido citrico. |
| US5728554A (en) * | 1995-04-11 | 1998-03-17 | Cytel Corporation | Enzymatic synthesis of glycosidic linkages |
| US6030815A (en) * | 1995-04-11 | 2000-02-29 | Neose Technologies, Inc. | Enzymatic synthesis of oligosaccharides |
| US5876980A (en) | 1995-04-11 | 1999-03-02 | Cytel Corporation | Enzymatic synthesis of oligosaccharides |
| US5676980A (en) * | 1995-09-29 | 1997-10-14 | Continental General Tire, Inc. | Center split segmented mold for curing pneumatic tires |
| US6454946B1 (en) * | 1996-10-10 | 2002-09-24 | Neose Technologies, Inc. | Carbohydrate purification using ultrafiltration, reverse osmosis and nanofiltration |
| US6288222B1 (en) * | 2000-02-16 | 2001-09-11 | Neose Technologies, Inc. | Method of filtration of a dairy stream |
-
1997
- 1997-10-09 US US08/947,775 patent/US6454946B1/en not_active Expired - Fee Related
- 1997-10-09 AU AU50816/98A patent/AU735695B2/en not_active Ceased
- 1997-10-09 KR KR10-1999-7003128A patent/KR100490507B1/ko not_active IP Right Cessation
- 1997-10-09 JP JP10517808A patent/JP2001502005A/ja not_active Ceased
- 1997-10-09 HU HU0001634A patent/HUP0001634A2/hu unknown
- 1997-10-09 EP EP97913687A patent/EP0931097B1/fr not_active Expired - Lifetime
- 1997-10-09 DK DK97913687T patent/DK0931097T3/da active
- 1997-10-09 CA CA002268168A patent/CA2268168C/fr not_active Expired - Fee Related
- 1997-10-09 NZ NZ335203A patent/NZ335203A/xx unknown
- 1997-10-09 DE DE69734205T patent/DE69734205T2/de not_active Expired - Fee Related
- 1997-10-09 WO PCT/US1997/018801 patent/WO1998015581A1/fr active IP Right Grant
- 1997-10-09 IL IL12936397A patent/IL129363A/xx not_active IP Right Cessation
- 1997-10-09 AT AT97913687T patent/ATE304546T1/de not_active IP Right Cessation
-
2002
- 2002-03-22 US US10/104,609 patent/US6936173B2/en not_active Expired - Lifetime
- 2002-04-22 IL IL149275A patent/IL149275A/en not_active IP Right Cessation
- 2002-06-27 US US10/184,211 patent/US20030029799A1/en not_active Abandoned
-
2005
- 2005-08-04 US US11/198,839 patent/US20050269265A1/en not_active Abandoned
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006512336A (ja) * | 2002-12-18 | 2006-04-13 | アベシア・リミテッド | オリゴヌクレオチド・シントン類を精製する方法 |
| JP4824931B2 (ja) * | 2002-12-18 | 2011-11-30 | アベシア・バイオテクノロジー・インコーポレーテッド | オリゴヌクレオチド・シントン類を精製する方法 |
| JP2005147788A (ja) * | 2003-11-13 | 2005-06-09 | Inst Nuclear Energy Research Rocaec | 逆浸透分離法を用いたほう酸純化及び再利用システム及び方法 |
| JP2010075185A (ja) * | 2003-11-24 | 2010-04-08 | Millipore Corp | 合成生体分子の精製及び濃縮 |
| JP2012245002A (ja) * | 2003-11-24 | 2012-12-13 | Emd Millipore Corp | 合成生体分子の精製及び濃縮 |
| JP2014526371A (ja) * | 2011-09-01 | 2014-10-06 | 中外製薬株式会社 | 限外ろ過によって高度に濃縮された抗体を含む組成物を調製するための方法 |
| US10590164B2 (en) | 2011-09-01 | 2020-03-17 | Chugai Seiyaku Kabushiki Kaisha | Method for preparing a composition comprising highly concentrated antibodies by ultrafiltration |
| JP2020531039A (ja) * | 2017-08-29 | 2020-11-05 | イェネヴァイン ビオテヒノロギー ゲーエムベーハー | シアリル化オリゴ糖を精製する工程 |
| JP7330171B2 (ja) | 2017-08-29 | 2023-08-21 | クリスチャン．ハンセン・ハー・エム・オー・ゲー・エム・ベー・ハー | シアリル化オリゴ糖を精製する工程 |
| US11912735B2 (en) | 2017-08-29 | 2024-02-27 | Chr Hansen Hmo Gmbh | Process for purifying sialylated oligosaccharides |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2268168A1 (fr) | 1998-04-16 |
| AU5081698A (en) | 1998-05-05 |
| DE69734205T2 (de) | 2006-07-06 |
| EP0931097B1 (fr) | 2005-09-14 |
| US6936173B2 (en) | 2005-08-30 |
| IL149275A (en) | 2007-07-04 |
| US20030029799A1 (en) | 2003-02-13 |
| DE69734205D1 (de) | 2005-10-20 |
| US20050269265A1 (en) | 2005-12-08 |
| IL129363A (en) | 2003-02-12 |
| US6454946B1 (en) | 2002-09-24 |
| KR100490507B1 (ko) | 2005-05-19 |
| IL129363A0 (en) | 2000-02-17 |
| HUP0001634A2 (hu) | 2000-09-28 |
| EP0931097A4 (fr) | 2000-01-12 |
| KR20000049057A (ko) | 2000-07-25 |
| CA2268168C (fr) | 2008-04-29 |
| ATE304546T1 (de) | 2005-09-15 |
| NZ335203A (en) | 2000-10-27 |
| DK0931097T3 (da) | 2006-01-16 |
| AU735695B2 (en) | 2001-07-12 |
| EP0931097A1 (fr) | 1999-07-28 |
| WO1998015581A1 (fr) | 1998-04-16 |
| US20020148791A1 (en) | 2002-10-17 |
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