|
US6008230A
(en)
*
|
1995-10-16 |
1999-12-28 |
Fujisawa Pharmaceutical Co., Ltd. |
Quinoline compounds as H+ -ATPases
|
|
GB9712761D0
(en)
*
|
1997-06-17 |
1997-08-20 |
Chiroscience Ltd |
Quinolines and their therapeutic use
|
|
US6262070B1
(en)
|
1998-11-04 |
2001-07-17 |
Darwin Discovery Ltd. |
Heterocyclic compounds and their therapeutic use
|
|
GB9824160D0
(en)
*
|
1998-11-04 |
1998-12-30 |
Darwin Discovery Ltd |
Heterocyclic compounds and their therapeutic use
|
|
SK287231B6
(sk)
*
|
1999-08-21 |
2010-04-07 |
Nycomed Gmbh |
Liečivo zahŕňajúce PDE inhibítor a agonistu beta2 adrenoreceptora
|
|
AU1053501A
(en)
*
|
1999-11-02 |
2001-05-14 |
Ajinomoto Co., Inc. |
Polyazanaphthalene compound and medicinal use thereof
|
|
JP4603646B2
(ja)
*
|
1999-11-15 |
2010-12-22 |
富士フイルムファインケミカルズ株式会社 |
新規なジピリジル誘導体
|
|
US7217722B2
(en)
|
2000-02-01 |
2007-05-15 |
Kirin Beer Kabushiki Kaisha |
Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
|
|
GB0003256D0
(en)
|
2000-02-11 |
2000-04-05 |
Darwin Discovery Ltd |
Heterocyclic compounds and their therapeutic use
|
|
US6521618B2
(en)
|
2000-03-28 |
2003-02-18 |
Wyeth |
3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
|
|
DE10035928A1
(de)
*
|
2000-07-21 |
2002-03-07 |
Asta Medica Ag |
Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
|
|
WO2002012189A1
(en)
*
|
2000-08-09 |
2002-02-14 |
Mitsubishi Pharma Corporation |
Fused bicyclic amide compounds and medicinal use thereof
|
|
US6953774B2
(en)
|
2000-08-11 |
2005-10-11 |
Applied Research Systems Ars Holding N.V. |
Methods of inducing ovulation
|
|
JP2002300373A
(ja)
*
|
2001-03-30 |
2002-10-11 |
Minolta Co Ltd |
画像処理方法、画像処理装置、記録媒体及びプログラム
|
|
MXPA03010679A
(es)
*
|
2001-05-23 |
2004-03-02 |
Tanabe Seiyaku Co |
Una composicion para acelerar la cicatrizacion de fractura osea.
|
|
CN1537018A
(zh)
*
|
2001-05-23 |
2004-10-13 |
田边制药株式会社 |
一种用于软骨疾病再生治疗的组合物
|
|
DE60215178T2
(de)
|
2001-07-16 |
2007-08-23 |
Astrazeneca Ab |
Quinolin-derivate und ihre verwendung als inhibitoren der tyrosine kinase
|
|
US7375232B2
(en)
*
|
2001-08-15 |
2008-05-20 |
E.I. Du Pont De Nemours And Company |
Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests
|
|
DK1463493T3
(da)
|
2001-12-14 |
2008-02-04 |
Serono Lab |
Fremgangsmåder til at inducere æglösning ved anvendelse af en ikke polypeptid-cAMP-niveaumodulator
|
|
MY140561A
(en)
|
2002-02-20 |
2009-12-31 |
Nycomed Gmbh |
Dosage form containing pde 4 inhibitor as active ingredient
|
|
SE0200920D0
(sv)
*
|
2002-03-25 |
2002-03-25 |
Astrazeneca Ab |
Novel compounds
|
|
ES2195785B1
(es)
*
|
2002-05-16 |
2005-03-16 |
Almirall Prodesfarma, S.A. |
Nuevos derivados de piridazin-3(2h)-ona.
|
|
AU2002950217A0
(en)
|
2002-07-16 |
2002-09-12 |
Prana Biotechnology Limited |
8- Hydroxy Quinoline Derivatives
|
|
ES2211344B1
(es)
*
|
2002-12-26 |
2005-10-01 |
Almirall Prodesfarma, S.A. |
Nuevos derivados de piridazin-3(2h)-ona.
|
|
TWI324150B
(en)
*
|
2003-02-28 |
2010-05-01 |
Novartis Ag |
Process for preparing 5-[(r)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1h)-quinolin-2-one salt
|
|
WO2004087211A2
(en)
|
2003-04-01 |
2004-10-14 |
Applied Research Systems Ars Holding N.V. |
Inhibitors of phosphodiesterases in infertility
|
|
TWI324151B
(en)
*
|
2003-04-02 |
2010-05-01 |
Novartis Ag |
Process for the preparation of 5-(haloacetyl)-8-substituted oxy-(1h)-quinolin-2-ones
|
|
EP1644041A1
(en)
*
|
2003-05-29 |
2006-04-12 |
AstraZeneca AB |
A pharmaceutical composition comprising a p2x7 antagonist and sulfasalazine
|
|
MXPA05012705A
(es)
*
|
2003-05-29 |
2006-02-08 |
Astrazeneca Ab |
Una composicion farmaceutica que comprende un antagonista del receptor p2x7 y un factor alfa de necrosis tumoral.
|
|
US20070281931A1
(en)
*
|
2003-05-29 |
2007-12-06 |
Nigel Boughton-Smith |
Pharmaceutical Composition Containing a P2x7 Receptor Antagonist and Methotrexate
|
|
GB0312609D0
(en)
*
|
2003-06-02 |
2003-07-09 |
Astrazeneca Ab |
Novel compounds
|
|
SE0302139D0
(sv)
*
|
2003-07-28 |
2003-07-28 |
Astrazeneca Ab |
Novel compounds
|
|
SE0302192D0
(sv)
*
|
2003-08-08 |
2003-08-08 |
Astrazeneca Ab |
Novel compounds
|
|
ATE366728T1
(de)
*
|
2003-09-15 |
2007-08-15 |
Schering Corp |
Synthese von für die herstellung von pde-iv- inhibitoren geeigneten chinolin-5-carboxamiden
|
|
SE0302488D0
(sv)
*
|
2003-09-18 |
2003-09-18 |
Astrazeneca Ab |
New combination
|
|
RU2006124843A
(ru)
|
2003-12-12 |
2008-01-20 |
Уайт (Us) |
Хинолины, пригодные для лечения сердечно-сосудистого заболевания
|
|
KR101122708B1
(ko)
*
|
2003-12-26 |
2012-03-26 |
마사토시 하기와라 |
Ｓｒ 단백질 인산화 제어 방법, 및 유효성분으로서 ｓｒ 단백질 활성 제어제를 함유하는 항바이러스제
|
|
CA2555133A1
(en)
*
|
2004-02-04 |
2005-09-01 |
Pfizer Products Inc. |
Substituted quinoline compounds
|
|
US20070191404A1
(en)
*
|
2004-04-01 |
2007-08-16 |
Pierre Bartsch |
Pharmaceutical compositions of pyrimidine-2,4,6-triones
|
|
WO2005116009A1
(en)
*
|
2004-05-18 |
2005-12-08 |
Schering Corporation |
Substituted 2-quinolyl-oxazoles useful as pde4 inhibitors
|
|
ES2251866B1
(es)
*
|
2004-06-18 |
2007-06-16 |
Laboratorios Almirall S.A. |
Nuevos derivados de piridazin-3(2h)-ona.
|
|
ES2251867B1
(es)
*
|
2004-06-21 |
2007-06-16 |
Laboratorios Almirall S.A. |
Nuevos derivados de piridazin-3(2h)-ona.
|
|
GB0413960D0
(en)
*
|
2004-06-22 |
2004-07-28 |
Novartis Ag |
Organic compounds
|
|
CN104788328B
(zh)
|
2004-06-24 |
2017-09-12 |
沃泰克斯药物股份有限公司 |
Atp‑结合弹夹转运蛋白的调控剂
|
|
US8354427B2
(en)
|
2004-06-24 |
2013-01-15 |
Vertex Pharmaceutical Incorporated |
Modulators of ATP-binding cassette transporters
|
|
SA05260265A
(ar)
*
|
2004-08-30 |
2005-12-03 |
استرازينيكا ايه بي |
مركبات جديدة
|
|
AU2005293196B2
(en)
*
|
2004-10-12 |
2012-03-22 |
Actelion Pharmaceuticals Ltd |
1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea as crystalline sulfate salt
|
|
ES2367515T3
(es)
*
|
2004-10-19 |
2011-11-04 |
F. Hoffmann-La Roche Ag |
Derivados de quinolina.
|
|
SE0402925D0
(sv)
*
|
2004-11-30 |
2004-11-30 |
Astrazeneca Ab |
Novel Compounds
|
|
US8686002B2
(en)
|
2005-08-21 |
2014-04-01 |
AbbVie Deutschland GmbH & Co. KG |
Heterocyclic compounds and their use as binding partners for 5-HT5 receptors
|
|
EP2258359A3
(en)
|
2005-08-26 |
2011-04-06 |
Braincells, Inc. |
Neurogenesis by muscarinic receptor modulation with sabcomelin
|
|
CA2620333A1
(en)
|
2005-08-26 |
2007-03-01 |
Braincells, Inc. |
Neurogenesis by muscarinic receptor modulation
|
|
AU2006304787A1
(en)
|
2005-10-21 |
2007-04-26 |
Braincells, Inc. |
Modulation of neurogenesis by PDE inhibition
|
|
EP2314289A1
(en)
|
2005-10-31 |
2011-04-27 |
Braincells, Inc. |
Gaba receptor mediated modulation of neurogenesis
|
|
EP1979367A2
(en)
*
|
2005-12-24 |
2008-10-15 |
Vertex Pharmaceuticals Incorporated |
Quinolin-4-one derivatives as modulators of abc transporters
|
|
WO2007079139A2
(en)
|
2005-12-28 |
2007-07-12 |
Vertex Pharmaceuticals, Inc. |
Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
|
|
KR100821649B1
(ko)
*
|
2006-01-24 |
2008-04-11 |
서울시립대학교 산학협력단 |
클리오퀴놀을 유효성분으로 포함하는 ＨＩＦ-1α 활성제
|
|
US20100216734A1
(en)
|
2006-03-08 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis by nootropic agents
|
|
EP2021000A2
(en)
|
2006-05-09 |
2009-02-11 |
Braincells, Inc. |
Neurogenesis by modulating angiotensin
|
|
CA2657902A1
(en)
*
|
2006-07-11 |
2008-01-17 |
Schering Corporation |
Xinafoate salt of a substituted 5-oxazol-2-yl-quinoline compound
|
|
JPWO2008026687A1
(ja)
|
2006-09-01 |
2010-01-21 |
杏林製薬株式会社 |
ピラゾロピリジンカルボキサミド誘導体及びそれらを含有するホスホジエステラーゼ（ｐｄｅ）阻害剤
|
|
US20100184806A1
(en)
|
2006-09-19 |
2010-07-22 |
Braincells, Inc. |
Modulation of neurogenesis by ppar agents
|
|
CL2007003874A1
(es)
*
|
2007-01-03 |
2008-05-16 |
Boehringer Ingelheim Int |
Compuestos derivados de benzamida; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades cardiovasculares, hipertension, aterosclerosis, reestenosis, ictus, insuficiencia cardiaca, lesion isquemica, hipertensio
|
|
ES2306595B1
(es)
*
|
2007-02-09 |
2009-09-11 |
Laboratorios Almirall S.A. |
Sal de napadisilato de 5-(2-((6-(2,2-difluoro-2-feniletoxi)hexil)amino)-1-hidroxietil)-8-hidroxiquinolin-2(1h)-ona como agonista del receptor adrenergico beta2.
|
|
ES2320954B1
(es)
*
|
2007-03-02 |
2010-03-16 |
Laboratorio Almirall S.A. |
Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo (3,4-d)iridazin-7(6h)-ona.
|
|
EP2139879B1
(en)
*
|
2007-03-22 |
2012-07-11 |
AstraZeneca AB |
Quinoline derivatives for the treatment of inflammatory diseases
|
|
US9493419B2
(en)
|
2007-08-21 |
2016-11-15 |
The Hong Kong Polytechnic University |
Quinoline derivatives as anti-cancer agents
|
|
US9321730B2
(en)
|
2007-08-21 |
2016-04-26 |
The Hong Kong Polytechnic University |
Method of making and administering quinoline derivatives as anti-cancer agents
|
|
PE20091036A1
(es)
|
2007-11-30 |
2009-08-15 |
Astrazeneca Ab |
Derivado de quinolina como antagonista del receptor p2x7
|
|
US20100074949A1
(en)
|
2008-08-13 |
2010-03-25 |
William Rowe |
Pharmaceutical composition and administration thereof
|
|
US12458635B2
(en)
|
2008-08-13 |
2025-11-04 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical composition and administrations thereof
|
|
US20100216805A1
(en)
|
2009-02-25 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis using d-cycloserine combinations
|
|
SG10201504084QA
(en)
|
2009-03-20 |
2015-06-29 |
Vertex Pharma |
Process for making modulators of cystic fibrosis transmembrane conductance regulator
|
|
JP2011042643A
(ja)
*
|
2009-07-24 |
2011-03-03 |
Bayer Cropscience Ag |
殺虫性カルボキサミド類
|
|
WO2011143106A1
(en)
|
2010-05-10 |
2011-11-17 |
Gilead Sciences, Inc. |
Bi - functional pyrazolopyridine compounds
|
|
AU2011253203A1
(en)
|
2010-05-10 |
2012-11-22 |
Gilead Sciences, Inc. |
Bifunctional quinoline derivatives
|
|
US20140275224A1
(en)
*
|
2010-11-05 |
2014-09-18 |
Regents Of The University Of Minnesota |
Cytosine deaminase modulators for enhancement of dna transfection
|
|
US8802700B2
(en)
|
2010-12-10 |
2014-08-12 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-Binding Cassette transporters
|
|
WO2013106547A1
(en)
|
2012-01-10 |
2013-07-18 |
President And Fellows Of Harvard College |
Beta-cell replication promoting compounds and methods of their use
|
|
CN109966264A
(zh)
|
2012-02-27 |
2019-07-05 |
沃泰克斯药物股份有限公司 |
药物组合物及其施用
|
|
CN103285373A
(zh)
*
|
2013-05-30 |
2013-09-11 |
苏州普罗达生物科技有限公司 |
肿瘤坏死因子-α多肽抑制剂制备及其应用
|
|
CN103254291B
(zh)
*
|
2013-05-30 |
2014-06-25 |
常州亚当生物技术有限公司 |
肿瘤坏死因子-α多肽抑制剂及其应用
|
|
JP6223563B2
(ja)
*
|
2013-10-14 |
2017-11-01 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
選択的に置換されたキノリン化合物
|
|
US9701639B2
(en)
|
2014-10-07 |
2017-07-11 |
Vertex Pharmaceuticals Incorporated |
Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
|
|
RU2624906C2
(ru)
*
|
2015-12-22 |
2017-07-10 |
федеральное государственное бюджетное учреждение "Федеральный научно-исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации |
Производные 2-хинальдинкарбоновой кислоты и их противогриппозная активность
|
|
US11266146B2
(en)
|
2017-09-13 |
2022-03-08 |
Syngenta Participations Ag |
Microbiocidal quinoline (thio)carboxamide derivatives
|
|
CN107812006A
(zh)
*
|
2017-11-13 |
2018-03-20 |
全椒先奇医药科技有限公司 |
一种治疗急性肾衰药物组合物及其应用
|