JP2000502055A5 - - Google Patents

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Publication number
JP2000502055A5
JP2000502055A5 JP1997520123A JP52012397A JP2000502055A5 JP 2000502055 A5 JP2000502055 A5 JP 2000502055A5 JP 1997520123 A JP1997520123 A JP 1997520123A JP 52012397 A JP52012397 A JP 52012397A JP 2000502055 A5 JP2000502055 A5 JP 2000502055A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1997520123A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000502055A (ja
JP3987575B2 (ja
Filing date
Publication date
Priority claimed from US08/562,652 external-priority patent/US5843903A/en
Application filed filed Critical
Publication of JP2000502055A publication Critical patent/JP2000502055A/ja
Publication of JP2000502055A5 publication Critical patent/JP2000502055A5/ja
Application granted granted Critical
Publication of JP3987575B2 publication Critical patent/JP3987575B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP52012397A 1995-11-27 1996-11-14 標的細胞毒性アントラサイクリン類似体 Expired - Lifetime JP3987575B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/562,652 US5843903A (en) 1995-11-27 1995-11-27 Targeted cytotoxic anthracycline analogs
US08/562,652 1995-11-27
PCT/EP1996/005029 WO1997019954A1 (en) 1995-11-27 1996-11-14 Targeted cytotoxic anthracycline analogs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2006309698A Division JP4778405B2 (ja) 1995-11-27 2006-11-15 標的細胞毒性アントラサイクリン類似体の合成方法

Publications (3)

Publication Number Publication Date
JP2000502055A JP2000502055A (ja) 2000-02-22
JP2000502055A5 true JP2000502055A5 (enExample) 2004-09-16
JP3987575B2 JP3987575B2 (ja) 2007-10-10

Family

ID=24247176

Family Applications (2)

Application Number Title Priority Date Filing Date
JP52012397A Expired - Lifetime JP3987575B2 (ja) 1995-11-27 1996-11-14 標的細胞毒性アントラサイクリン類似体
JP2006309698A Expired - Lifetime JP4778405B2 (ja) 1995-11-27 2006-11-15 標的細胞毒性アントラサイクリン類似体の合成方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2006309698A Expired - Lifetime JP4778405B2 (ja) 1995-11-27 2006-11-15 標的細胞毒性アントラサイクリン類似体の合成方法

Country Status (27)

Country Link
US (2) US5843903A (enExample)
EP (2) EP1384710B1 (enExample)
JP (2) JP3987575B2 (enExample)
KR (2) KR100467899B1 (enExample)
CN (2) CN1137136C (enExample)
AT (2) ATE401305T1 (enExample)
AU (1) AU709539B2 (enExample)
BR (1) BR9611647B1 (enExample)
CA (2) CA2238574C (enExample)
CZ (1) CZ297297B6 (enExample)
DE (2) DE69637604D1 (enExample)
DK (2) DK1384710T3 (enExample)
EA (1) EA001372B1 (enExample)
ES (2) ES2310222T3 (enExample)
HK (1) HK1052920B (enExample)
HU (1) HU229870B1 (enExample)
IL (3) IL119691A (enExample)
IS (2) IS2178B (enExample)
MX (1) MX9804119A (enExample)
NO (2) NO324035B1 (enExample)
NZ (1) NZ322054A (enExample)
PL (3) PL191781B1 (enExample)
PT (2) PT1384710E (enExample)
SK (2) SK284672B6 (enExample)
UA (1) UA67722C2 (enExample)
WO (1) WO1997019954A1 (enExample)
ZA (1) ZA969709B (enExample)

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FR2786397B1 (fr) * 1998-11-30 2003-01-10 Synt Em Vecteurs peptidiques de substances a travers la barriere hematoencephalique pour etre utilises dans le diagnostic ou la therapie d'une affection du snc
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6528481B1 (en) 1999-02-16 2003-03-04 The Burnam Institute NG2/HM proteoglycan-binding peptides that home to angiogenic vasculature and related methods
US6380161B1 (en) 1999-06-21 2002-04-30 Inkine Pharmaceutical Company, Inc. Compositions for treating chemotherapy-resistant tumor cells and targeted chemotherapy compositions
CA2388844A1 (en) * 1999-11-12 2001-05-25 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors
CA2395660A1 (en) 1999-12-29 2001-07-12 Immunogen, Inc. Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
AU4267700A (en) * 2000-01-13 2001-07-19 Academia Sinica Application of somatostatin analogs to specific delivery of anti-tumor drugs into tumor cells
EP1452543A3 (en) * 2000-04-26 2005-08-03 BioSynthema, Inc RGD (ARG-GLY-ASP) coupled to (neuro)peptides
US7420030B2 (en) 2000-09-08 2008-09-02 The Board Of Regents Of The University Of Texas System Aminopeptidase A (APA) targeting peptides for the treatment of cancer
US20040170955A1 (en) 2000-09-08 2004-09-02 Wadih Arap Human and mouse targeting peptides identified by phage display
US7452964B2 (en) 2001-09-07 2008-11-18 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides against placenta and adipose tissues
KR100420007B1 (ko) * 2001-04-25 2004-03-02 노영쇠 안트라사이클린 유도체 및 이를 포함하는 항암제
IL160993A0 (en) * 2001-09-21 2004-08-31 Univ Tulane Diagnostic or therapeutic somatostatin or bombesin analog conjugates and uses thereof
EP1531846A4 (en) * 2002-02-27 2006-04-19 Us Gov Health & Human Serv Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use
WO2003074551A2 (en) 2002-03-01 2003-09-12 The Administrators Of The Tulane Educational Fund Conjugates of therapeutic or cytotoxic agents and biologically active peptides
US7544767B2 (en) 2002-04-05 2009-06-09 Burnham Institute For Medical Research HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells
JP5000848B2 (ja) * 2002-05-21 2012-08-15 第一三共株式会社 グレリン含有医薬組成物
US8313760B2 (en) 2002-05-24 2012-11-20 Angiotech International Ag Compositions and methods for coating medical implants
US20040043052A1 (en) 2002-05-24 2004-03-04 Angiotech Pharmaceuticals, Inc. Compositions and methods for coating medical implants
DE60325240D1 (de) 2002-09-26 2009-01-22 Angiotech Int Ag Perivaskuläre hüllen
CA2511521C (en) 2002-12-30 2012-02-07 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US20040202666A1 (en) * 2003-01-24 2004-10-14 Immunomedics, Inc. Anti-cancer anthracycline drug-antibody conjugates
US20050043215A1 (en) 2003-02-19 2005-02-24 Tamara Minko Complex drug delivery composition and method for treating cancer
AU2007221964B2 (en) * 2003-04-22 2008-12-11 Ipsen Pharma S.A.S. Peptide vectors
RU2361876C2 (ru) * 2003-04-22 2009-07-20 Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик С.А.С. Пептидные векторы
US7097993B2 (en) 2003-06-25 2006-08-29 Wisconsin Alumni Research Foundation Method for identifying an agent that modulates type 1 phosphatidylinositol phosphate kinase isoform β661 activity
US20080132458A1 (en) * 2004-03-10 2008-06-05 Threshold Pharmaceuticals, Inc. Hypoxia-Activated Anti-Cancer Agents
US20070060534A1 (en) * 2005-06-30 2007-03-15 Threshold Pharmaceuticals, Inc. Anthracycline analogs
JP5340155B2 (ja) * 2006-09-06 2013-11-13 エテルナ ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング 細胞結合分子を有するジソラゾールのコンジュゲート及びそれらの誘導体、新規ジソラゾール誘導体、それらの製法ならびに使用
EP1900742A1 (en) 2006-09-07 2008-03-19 AEterna Zentaris GmbH Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof
WO2008100591A2 (en) * 2007-02-14 2008-08-21 The General Hospital Corporation Modulation of nitric oxide signaling to normalize tumor vasculature
RU2377247C2 (ru) * 2007-12-27 2009-12-27 Федеральное государственное образовательное учреждение высшего профессионального образования Санкт-Петербургский государственный университет Молекулярный конъюгат на основе синтетических аналогов люлиберина и его применение в качестве средства доставки днк в клетки гормон-чувствительных опухолей (варианты)
WO2009099741A1 (en) * 2008-02-01 2009-08-13 Genentech, Inc. Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
ES2655243T3 (es) * 2008-04-11 2018-02-19 Tianjin Hemay Oncology Pharmaceutical Co., Ltd Derivados antibióticos de antraciclina con alta actividad, métodos de preparación y usos de los mismos
AU2009235897B2 (en) * 2008-04-11 2012-04-12 Tianjin Hemay Oncology Pharmaceutical Co., Ltd Anthracycline antibiotic derivatives with high activity, preparation methods and uses thereof
MX2011000509A (es) 2008-07-15 2011-04-05 Genentech Inc Conjugados derivados de antraciclina, proceso para su preparacion y su uso como compuestos antitumorales.
CA2752608A1 (en) 2009-02-20 2010-08-26 Ipsen Pharma S.A.S. Cytotoxic conjugates having neuropeptide y receptor binding compound
CN102050856B (zh) * 2009-11-03 2014-04-30 天津和美生物技术有限公司 具有高活性的表阿霉素的衍生物及其制备和应用
KR101897307B1 (ko) 2010-12-02 2018-09-10 네르비아노 메디칼 사이언시스 에스.알.엘. 모르폴리닐 안트라사이클린 유도체의 제조 방법
CN105198966B (zh) * 2014-06-26 2019-06-21 中国人民解放军军事医学科学院毒物药物研究所 GnRH类似物-细胞毒分子缀合物、其制备方法及用途
KR102062025B1 (ko) * 2014-06-30 2020-01-03 타베다 세라퓨틱스, 인코포레이티드 표적화된 콘주게이트 및 입자 및 그것의 제형
EP3045540A1 (en) 2015-01-19 2016-07-20 Æterna Zentaris GmbH Enzymatic process for the regioselective manufacturing of N-Fmoc-doxorubicin-14-O-dicarboxylic acid mono esters
WO2017075495A1 (en) 2015-10-28 2017-05-04 Tarveda Therapeutics, Inc. Sstr-targeted conjugates and particles and formulations thereof
US10450340B2 (en) 2017-02-16 2019-10-22 Monopar Therapeutics Inc. 3′-deamino-3′-(2″-pyrroline-1″-yl)-5-imino-13-deoxyanthracyclines and methods of preparation
CA3118743A1 (en) * 2018-11-13 2021-04-15 Provincial Health Services Authority Radiolabeled bombesin-derived compounds for in vivo imaging of gastrin-releasing peptide receptor (grpr) and treatment of grpr-related disorders
AU2023239751A1 (en) 2022-03-25 2024-09-05 Provincial Health Services Authority Radiolabeled compounds for in vivo imaging of gastrin-releasing peptide receptor (grpr) and treatment of grpr-related disorders

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IL106992A (en) * 1988-02-11 1994-06-24 Bristol Myers Squibb Co Acylhydrazone derivatives of anthracycline and methods for their preparation
US5217955A (en) * 1989-09-15 1993-06-08 Biomeasure, Inc. Treatment of cancer with peptide analog of bombesin, grp, litorin or neuromedin
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