|
US6500948B1
(en)
|
1995-12-08 |
2002-12-31 |
Agouron Pharmaceuticals, Inc. |
Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
|
|
ES2233275T3
(es)
*
|
1995-12-08 |
2005-06-16 |
Agouron Pharmaceuticals, Inc. |
Intermediarios que sirven para la preparacion de inhibidores de metaloproteinasas.
|
|
FR2748026B1
(fr)
*
|
1996-04-26 |
1998-06-05 |
Adir |
Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
EP0923561B1
(en)
*
|
1996-08-28 |
2002-10-23 |
The Procter & Gamble Company |
Heterocyclic metalloprotease inhibitors
|
|
US5977408A
(en)
*
|
1996-10-16 |
1999-11-02 |
American Cyanamid Company |
Preparation and use of β-sulfonamido hydroxamic acids as matrix metalloproteinase and TACE inhibitors
|
|
US5929097A
(en)
*
|
1996-10-16 |
1999-07-27 |
American Cyanamid Company |
Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
|
|
US5962481A
(en)
|
1996-10-16 |
1999-10-05 |
American Cyanamid Company |
Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
|
|
US6228869B1
(en)
|
1996-10-16 |
2001-05-08 |
American Cyanamid Company |
Ortho-sulfonamido bicyclic hydroxamic acids as matrix metalloproteinase and TACE inhibitors
|
|
US6548524B2
(en)
|
1996-10-16 |
2003-04-15 |
American Cyanamid Company |
Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors
|
|
US5804593A
(en)
*
|
1996-10-22 |
1998-09-08 |
Pharmacia & Upjohn Company |
α-Amino sulfonyl hydroxamic acids as matrix metalloproteinase inhibitors
|
|
US6174915B1
(en)
|
1997-03-25 |
2001-01-16 |
Agouron Pharmaceuticals, Inc. |
Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
|
|
US6008243A
(en)
*
|
1996-10-24 |
1999-12-28 |
Agouron Pharmaceuticals, Inc. |
Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
|
|
SG88737A1
(en)
*
|
1996-10-30 |
2002-05-21 |
Tanabe Seiyaku Co |
S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
|
|
US6376506B1
(en)
|
1997-01-23 |
2002-04-23 |
Syntex (U.S.A.) Llc |
Sulfamide-metalloprotease inhibitors
|
|
ATE223909T1
(de)
*
|
1997-01-23 |
2002-09-15 |
Hoffmann La Roche |
Sulfamide-metalloprotease inhibitoren
|
|
ZA98376B
(en)
*
|
1997-01-23 |
1998-07-23 |
Hoffmann La Roche |
Sulfamide-metalloprotease inhibitors
|
|
US5985900A
(en)
*
|
1997-04-01 |
1999-11-16 |
Agouron Pharmaceuticals, Inc. |
Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
|
|
DE19719817A1
(de)
*
|
1997-05-13 |
1998-11-19 |
Hoechst Ag |
Substituierte 6- und 7-Aminotetrahydroisochinolincarbonsäuren
|
|
AU8766498A
(en)
*
|
1997-08-04 |
1999-02-22 |
Amgen, Inc. |
Hydroxamic acid substituted fused heterocyclic metalloproteinase inhibitors
|
|
PT1021413E
(pt)
*
|
1997-10-06 |
2003-10-31 |
Wyeth Corp |
A preparacao e utilizacao de acidos orto-sulfonamido heterociclicos biciclicos hidroxamicos como inibidores de metaloproteinases de matriz e de tace
|
|
US6130220A
(en)
*
|
1997-10-16 |
2000-10-10 |
Syntex (Usa) Inc. |
Sulfamide-metalloprotease inhibitors
|
|
FR2771095B1
(fr)
*
|
1997-11-14 |
1999-12-17 |
Adir |
Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
US6335329B1
(en)
|
1997-12-19 |
2002-01-01 |
Amgen Inc. |
Carboxylic acid substituted heterocycles, derivatives thereof and methods of use
|
|
US6107291A
(en)
*
|
1997-12-19 |
2000-08-22 |
Amgen Inc. |
Azepine or larger medium ring derivatives and methods of use
|
|
US6071903A
(en)
*
|
1998-01-27 |
2000-06-06 |
American Cyanamid Company |
2,3,4,5-tetrahydro-1H-[1,4]-benzodiazepine-3-hydroxyamic acids
|
|
EP1051407A1
(en)
*
|
1998-01-27 |
2000-11-15 |
American Cyanamid Company |
2,3,4,5-tetrahydro-1h-[1,4]-benzodiazepine-3-hydroxamic acids as matrix metalloproteinase inhibitors
|
|
BR9910678A
(pt)
|
1998-05-14 |
2001-10-02 |
Du Pont Pharm Co |
Composto, composição farmacêutica, método para traramento ou prevenção de uma doença inflamatória, método para tratamento de uma condição ou uma doença mediada por mmps, tnf, agrecanase, ou um composto dos mesmos, em um mamìfero, método de redução de nìveis de tnf em pacientes, sem a inibição de mmps, método para tratamento de uma condição ou uma doença e uso de um novo composto
|
|
WO2000023443A1
(en)
*
|
1998-10-22 |
2000-04-27 |
Akzo Nobel N.V. |
Tetrahydropyridopyridine derivatives and intermediates for producing the same
|
|
US20040122011A1
(en)
*
|
1998-12-23 |
2004-06-24 |
Pharmacia Corporation |
Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy
|
|
US6544984B1
(en)
|
1999-01-27 |
2003-04-08 |
American Cyanamid Company |
2,3,4,5-tetrahydro-1H-(1,4)benzodiazepine-3-hydroxamic acids
|
|
BR0007784A
(pt)
|
1999-01-27 |
2002-02-05 |
American Cyanamid Co |
Composto, método para inibir mudanças patológicas mediadas pela enzima que converte o tnf-alfa (tace) em um mamìfero, composição farmacêutica, e, processo para preparar um composto
|
|
US6753337B2
(en)
|
1999-01-27 |
2004-06-22 |
Wyeth Holdings Corporation |
Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
|
|
US6946473B2
(en)
|
1999-01-27 |
2005-09-20 |
Wyeth Holdings Corporation |
Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors
|
|
US6200996B1
(en)
|
1999-01-27 |
2001-03-13 |
American Cyanamid Company |
Heteroaryl acetylenic sulfonamide and phosphinic acid amide hydroxamic acid tace inhibitors
|
|
US6277885B1
(en)
|
1999-01-27 |
2001-08-21 |
American Cyanamid Company |
Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors
|
|
US6340691B1
(en)
|
1999-01-27 |
2002-01-22 |
American Cyanamid Company |
Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors
|
|
US6313123B1
(en)
|
1999-01-27 |
2001-11-06 |
American Cyanamid Company |
Acetylenic sulfonamide thiol tace inhibitors
|
|
US6326516B1
(en)
|
1999-01-27 |
2001-12-04 |
American Cyanamid Company |
Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors
|
|
US6225311B1
(en)
|
1999-01-27 |
2001-05-01 |
American Cyanamid Company |
Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors
|
|
AR022423A1
(es)
*
|
1999-01-27 |
2002-09-04 |
American Cyanamid Co |
Compuestos derivados de acidos 2,3,4,5-tetrahidro-1h-[1,4]benzodiazepina-3-hidroxamicos, composicion farmaceutica que los comprenden, y el uso de losmismos para la manufactura de un medicamento
|
|
US6762178B2
(en)
|
1999-01-27 |
2004-07-13 |
Wyeth Holdings Corporation |
Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors
|
|
GB9903598D0
(en)
*
|
1999-02-18 |
1999-04-07 |
Univ Manchester |
Connective tissue healing
|
|
DOP2000000107A
(es)
|
1999-12-01 |
2002-09-16 |
Agouron Pharmaceutical Inc |
Compuestos, composiciones y metodos para estimular el crecimiento y alongamiento de las neuronas
|
|
GB0011409D0
(en)
*
|
2000-05-11 |
2000-06-28 |
Smithkline Beecham Plc |
Novel compounds
|
|
MXPA01013172A
(es)
|
2001-02-14 |
2002-08-21 |
Warner Lambert Co |
Inhibidores sulfonamida de metaloproteinasa de matriz.
|
|
FR2821842B1
(fr)
*
|
2001-03-07 |
2003-05-09 |
Servier Lab |
Nouveaux derives d'inhibiteurs de mettalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
WO2003016248A2
(en)
|
2001-08-17 |
2003-02-27 |
Bristol-Myers Squibb Company Patent Department |
Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or tnf-$g(a) converting enzyme (tace)
|
|
CA2464727A1
(en)
|
2001-11-01 |
2003-05-08 |
Wyeth Holdings Corporation |
Allenic aryl sulfonamide hydroxamic acids as matrix metalloproteinase and tace inhibitors
|
|
RU2223703C2
(ru)
*
|
2002-02-13 |
2004-02-20 |
Иркутский государственный институт усовершенствования врачей |
Способ лечения передней хронической нестабильности коленного сустава
|
|
US6716853B2
(en)
|
2002-03-02 |
2004-04-06 |
Aventis Pharma Deutschland Gmbh |
Cyclic N-substituted alpha-imino carboxylic acids for selective inhibition of collogenase
|
|
DE10209299A1
(de)
|
2002-03-02 |
2003-09-18 |
Aventis Pharma Gmbh |
Cyclische N-substituierte alpha-Iminocarbonsäuren zur selektiven Inhibierung von Kollagenase
|
|
WO2005021489A2
(en)
|
2002-12-23 |
2005-03-10 |
Wyeth Holdings Corporation |
Acetylenic aryl sulfonate hydroxamic acid tace and matrix metalloproteinase inhibitors
|
|
WO2004060892A1
(ja)
*
|
2002-12-27 |
2004-07-22 |
Japan Tobacco Inc. |
縮合ｎ含有ヘテロ環化合物及びその医薬用途
|
|
DE10300015A1
(de)
*
|
2003-01-03 |
2004-07-15 |
Aventis Pharma Deutschland Gmbh |
Iminosäurederivate als Inhibitoren von Matrix-Metallproteinasen
|
|
US7205315B2
(en)
|
2003-09-27 |
2007-04-17 |
Sanofi-Aventis Deutschland Gmbh |
Bicyclic imino acid derivatives as inhibitors of matrix metalloproteinases
|
|
DE10344936A1
(de)
|
2003-09-27 |
2005-04-21 |
Aventis Pharma Gmbh |
Bicyclische Iminosäurederivate als Inhibitoren von Matrix-Metalloproteinasen
|
|
US7244845B2
(en)
*
|
2003-11-06 |
2007-07-17 |
Sanofi-Aventis Deutschland Gmbh |
Process for preparing cyclic N-substituted alpha-imino carboxylic acids
|
|
DE10351904A1
(de)
*
|
2003-11-06 |
2005-06-09 |
Aventis Pharma Deutschland Gmbh |
Verfahren zur Herstellung von cyclischen N-substituierten alpha-Iminocarbonsäure
|
|
DE102004004974A1
(de)
*
|
2004-01-31 |
2005-08-18 |
Aventis Pharma Deutschland Gmbh |
Thieno-Iminosäure-Derivate als Inhibitoren von Matrix-Metalloproteinasen
|
|
WO2005108367A1
(en)
*
|
2004-05-03 |
2005-11-17 |
Envivo Pharmaceuticals, Inc. |
Compounds for treatment of neurodegenerative diseases
|
|
DE102004031850A1
(de)
*
|
2004-06-30 |
2006-01-26 |
Sanofi-Aventis Deutschland Gmbh |
Substituirte Tetrahydroisochinoline als MMP-Inhibitoren, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
|
|
DE102004031620A1
(de)
*
|
2004-06-30 |
2006-02-02 |
Sanofi-Aventis Deutschland Gmbh |
4-Trifluormethoxyphenoxybenzol-4`-sulfonsäuren, Verfahren zu ihrer Herstellung und Verwendung in Arzneimitteln
|
|
US7601838B2
(en)
*
|
2004-12-28 |
2009-10-13 |
Council Of Scientific And Industrial Research |
2-Alkyl/aryl sulphonyl-1,2,3,4-tetrahydro-9H-pyrido (3,4-b) indole-3-carboxylic acid esters/amides useful as antithrombotic agents
|
|
DE102005002500A1
(de)
*
|
2005-01-19 |
2006-07-27 |
Sanofi-Aventis Deutschland Gmbh |
Tetrahydrofuranderivate als Inhibitoren von Matrix-Metalloproteinasen
|
|
DE102005015040A1
(de)
|
2005-03-31 |
2006-10-05 |
Sanofi-Aventis Deutschland Gmbh |
Substituierte Tetrahydroisochinoline als MMP-Inhibitoren, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
|
|
EP1901729B1
(en)
|
2005-05-13 |
2012-01-25 |
TopoTarget UK Limited |
Pharmaceutical formulations of hdac inhibitors
|
|
EP1938106A1
(en)
*
|
2005-10-20 |
2008-07-02 |
Nordic Bioscience A/S |
Detection or quantification of aggrecan and its fragments
|
|
GB0526257D0
(en)
*
|
2005-12-22 |
2006-02-01 |
Novartis Ag |
Organic compounds
|
|
WO2007141029A1
(en)
*
|
2006-06-08 |
2007-12-13 |
Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) |
Specific protease inhibitors and their use in cancer therapy
|
|
US8790714B2
(en)
*
|
2007-08-03 |
2014-07-29 |
Nucitec, S.A. De C.V. |
Compositions and methods for treatment and prevention of osteoarthritis
|
|
NZ581986A
(en)
|
2007-08-07 |
2012-02-24 |
Abbott Gmbh & Co Kg |
Quinoline compounds suitable for treating disorders that respond to modulation of the serotonin 5-HT6 receptor
|
|
AU2008338631A1
(en)
|
2007-12-14 |
2009-06-25 |
Georgetown University |
Histone deacetylase inhibitors
|
|
JP5501226B2
(ja)
*
|
2008-04-24 |
2014-05-21 |
Ｍｓｄ株式会社 |
アリールスルホニル誘導体を有効成分とする長鎖脂肪酸伸長酵素阻害剤
|
|
US20110112076A1
(en)
|
2008-07-14 |
2011-05-12 |
Mcquire Leslie Wighton |
Selective hydroxamic acid based mmp-12 and mmp-13 inhibitors
|
|
FR2947270B1
(fr)
|
2009-06-30 |
2011-08-26 |
Galderma Res & Dev |
Nouveaux composes benzene-sulfonamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique
|
|
FR2947268B1
(fr)
|
2009-06-30 |
2011-08-26 |
Galderma Res & Dev |
Nouveaux composes benzene-sulfonamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique
|
|
US20140275108A1
(en)
|
2013-03-15 |
2014-09-18 |
Galderma Research & Development |
Novel benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics
|
|
US20190008828A1
(en)
|
2015-12-28 |
2019-01-10 |
The U.S.A., As Represented By The Secretary Department Of Health And Human Services |
Methods for inhibiting human immunodeficiency virus (hiv) release from infected cells
|
|
ES2695533T3
(es)
|
2016-02-01 |
2019-01-08 |
Galderma Res & Dev |
Compuestos de bencenosulfonamida, método para su síntesis y uso de los mismos en medicina y cosméticos
|
|
EP3717481B1
(en)
|
2017-11-27 |
2023-03-01 |
Council of Scientific & Industrial Research |
Indole (sulfomyl) n-hydroxy benzamide derivatives as selective hdac inhibitors
|
|
WO2025224168A1
(en)
|
2024-04-24 |
2025-10-30 |
Idorsia Pharmaceuticals Ltd |
Aryl sulfone and sulfanone derivatives as orexin receptor modulators
|
|
CN119565781B
(zh)
*
|
2024-12-20 |
2026-01-02 |
中南大学 |
一种金属离子-含氮芳杂环配合物捕收剂及其制备方法和在钨矿浮选中的应用
|